Canadian Journal of Psychiatry-Revue Canadienne De Psychiatrie最新文献

{"title":"GLP-1 Receptor Agonists as a Novel Solution for Antipsychotic-Induced Weight Gain in Severe and Persistent Mental Illness.","authors":"Samantha Jacobson, Noah Margolese, Howard C Margolese","doi":"10.1177/07067437251386626","DOIUrl":"10.1177/07067437251386626","url":null,"abstract":"<p><p>Patients with severe and persistent mental illness (SPMI) experience significant metabolic side effects from antipsychotic medications, including antipsychotic-induced weight gain (AIWG). This contributes to a high prevalence of obesity, insulin resistance, and type 2 diabetes in this population, ultimately reducing life expectancy. Traditional weight management strategies, such as behavioural interventions, are often less feasible in this group. Glucagon-like peptide-1 receptor agonists (GLP-1RAs), initially developed for type 2 diabetes, have shown promise in addressing AIWG by reducing weight, improving metabolic parameters, and offering potential neuroprotective and psychiatric benefits. Evidence supports the efficacy of GLP-1RAs in managing AIWG, with studies demonstrating substantial reductions in weight and body mass index without exacerbating psychiatric symptoms. However, access to these medications remains limited due to high costs and restrictive healthcare policies. Expanding access to GLP-1RAs could bridge a critical gap in care for patients with SPMI, improving both physical and mental health outcomes. Future research should focus on evaluating long-term efficacy and cost-effectiveness, particularly in the Canadian healthcare context, to inform policy changes and optimize treatment strategies.Plain Language Summary TitleCan diabetes medications help treat weight gain caused by antipsychotics?</p>","PeriodicalId":55283,"journal":{"name":"Canadian Journal of Psychiatry-Revue Canadienne De Psychiatrie","volume":" ","pages":"413-419"},"PeriodicalIF":3.8,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12528064/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145304531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cannabis Legalization Outcomes in Canada: Trading Off Increased Health Problem for Reduced Crime Burdens Is Not Good Enough.","authors":"Benedikt Fischer, Wayne Hall, Didier Jutras-Aswad, Bernard Le Foll, Daniel T Myran","doi":"10.1177/07067437261454772","DOIUrl":"10.1177/07067437261454772","url":null,"abstract":"","PeriodicalId":55283,"journal":{"name":"Canadian Journal of Psychiatry-Revue Canadienne De Psychiatrie","volume":" ","pages":"7067437261454772"},"PeriodicalIF":4.4,"publicationDate":"2026-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13190369/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147977409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acceptance and Commitment Therapy for the Parents of Children and Adolescents with Autism Spectrum Disorder: A Systematic Review and Meta-Analysis of Randomized Controlled Trials: La thérapie d'acceptation et d'engagement pour les parents d'enfants et d'adolescents atteints de troubles du spectre de l'autisme : une revue systématique et une méta-analyse d'essais contrôlés à répartition aléatoire.","authors":"Abdullah M Alharran, Abdulrahman Hamad Aldousari, Shekha Alnajdi, Layal T Alwazzan, Munawer A Alsaid, Dana K Alkandari, Khaled Alsalem, Waleed Bader Alazemi","doi":"10.1177/07067437261450738","DOIUrl":"10.1177/07067437261450738","url":null,"abstract":"<p><p>BackgroundParents of children with autism spectrum disorder (ASD) experience significantly higher levels of stress, anxiety and depression. Acceptance and Commitment Therapy (ACT) has emerged as a promising intervention; however, the evidence remains inconsistent. This meta-analysis aims to evaluate the efficacy of ACT-based interventions in parents of children and adolescents with ASD.MethodsIn February 2026, we conducted a systematic search of PubMed, Scopus, Web of Science, Cochrane Library and Embase for randomized controlled trials (RCTs) assessing ACT-based interventions in parents of children/adolescents with ASD. For the meta-analysis, we used R software (version 4.5.0) with RStudio (2024.12.1 + 563) and the meta package.ResultsWe included seven RCTs with a total of 698 participants. Acceptance and Commitment Therapy significantly reduced parenting stress compared to control conditions, as measured by the Parenting Stress Index - Short Form Total Stress (mean difference [MD] = -7.05, 95 per cent CI -9.90 to -4.19, <i>p</i> < 0.0001, <i>I</i>² = 0 per cent), with consistent improvements across all subscales (Parental Distress, Parent-Child Dysfunctional Interaction and Difficult Child). Acceptance and Commitment Therapy also significantly improved psychological flexibility on the Acceptance and Action Questionnaire-II and Parenting Sense of Competence scale. For child outcomes assessed in our analysis, ACT significantly reduced total difficulties on the Strengths and Difficulties Questionnaire (MD = -2.80, 95 per cent CI -4.71 to -0.88, <i>P</i> = 0.004, <i>I</i>² = 0 per cent) and conduct problems (MD = -0.98, 95 per cent CI -1.62 to -0.33, <i>P</i> = 0.003, <i>I</i>² = 0 per cent).ConclusionAcceptance and Commitment Therapy-based interventions may be effective for reducing parenting stress, improving psychological flexibility, enhancing parenting competence and reducing child behavioural difficulties in parents of children with ASD. However, the limited number of studies and clinical heterogeneity might limit our findings, highlighting the need for future large-scale RCTs with longer follow-up.</p>","PeriodicalId":55283,"journal":{"name":"Canadian Journal of Psychiatry-Revue Canadienne De Psychiatrie","volume":" ","pages":"7067437261450738"},"PeriodicalIF":3.8,"publicationDate":"2026-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13186929/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147977429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alignment of Lived Experience Questions with the Medical Literature in Bipolar Disorder: A Topic Modelling Approach: Adéquation entre les questions relatives à l'expérience vécue et la littérature médicale concernant le trouble bipolaire : Une approche de modélisation de sujets.","authors":"Varsha D Badal, John-Jose Nunez, Colin A Depp, Adrienne Benediktsson, Erin E Michalak","doi":"10.1177/07067437261448751","DOIUrl":"10.1177/07067437261448751","url":null,"abstract":"<p><p>ObjectiveThe priorities of people with mental health challenges should be reflected in the research conducted on their behalf. Quantifying alignment of priorities with the unmet needs of people with lived experience is challenging, and to our knowledge, such alignment has not been extensively studied in bipolar disorder (BD). Natural language processing approaches comparing common topics derived from public forums to those of biomedical research could help in identifying topics that are underaddressed.MethodsWe contrasted 5 years of lived experience questions posed during a Collaborative RESearch Team to study psychosocial issues in Bipolar Disorder (CREST.BD) \"Ask Me Anything\" (AMA) event hosted via Reddit (2019-2023) with topics labelled from abstracts extracted from PubMed with the search term BD during the same period. We applied topic modelling using BERTopic to identify dominant themes within each corpus and compared their semantic similarity using vector-based cosine similarity analyses.ResultsThe Reddit AMA data included 6159 comments, and the medical literature from this period included 9188 abstracts. Topic modelling and similarity analyses indicated that shared and frequent topics in both corpuses were sleep, BD medication safety in pregnancy, and lithium treatment. Topics with comparatively higher frequency in the Reddit forums than in medical research included BD misdiagnosis, marijuana and BD, and coping with daily challenges.DiscussionNotwithstanding limitations, comparing a corpus of lived experience questions with contemporaneous medical literature revealed areas of overlap, but some lived experience queries were not well covered in the biomedical literature. Natural language processing of public forums may facilitate identifying unmet priorities in BD.</p>","PeriodicalId":55283,"journal":{"name":"Canadian Journal of Psychiatry-Revue Canadienne De Psychiatrie","volume":" ","pages":"7067437261448751"},"PeriodicalIF":4.4,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13157470/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147846254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methodological Concerns Regarding a Meta-Analysis of the Subjective Scale to Investigate Cognition in Schizophrenia (SSTICS).","authors":"Torill Ueland, Merete Glenne Øie, Anja Vaskinn","doi":"10.1177/07067437261448737","DOIUrl":"10.1177/07067437261448737","url":null,"abstract":"","PeriodicalId":55283,"journal":{"name":"Canadian Journal of Psychiatry-Revue Canadienne De Psychiatrie","volume":" ","pages":"7067437261448737"},"PeriodicalIF":3.8,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13152998/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147846451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"When Do Antidepressants \"Kick In\": Addressing the 2-4-Week Myth.","authors":"Stefani Mihilli, Anthony Levitt, Marco Solmi, Mark Sinyor, Ayal Schaffer","doi":"10.1177/07067437261449898","DOIUrl":"10.1177/07067437261449898","url":null,"abstract":"","PeriodicalId":55283,"journal":{"name":"Canadian Journal of Psychiatry-Revue Canadienne De Psychiatrie","volume":" ","pages":"7067437261449898"},"PeriodicalIF":4.4,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13152993/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147846454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Which Residual Symptoms Predict Relapse in major Depression? A Scoping Review: Quels symptômes résiduels constituent des prédicteurs de rechute de dépression majeure? Un examen de la portée.","authors":"David Borghgraef, Pascal Sienaert, Simon Lambrichts","doi":"10.1177/07067437261448747","DOIUrl":"10.1177/07067437261448747","url":null,"abstract":"<p><p>BackgroundPreventing relapse following a successful acute treatment of major depressive disorder (MDD) remains a clinical challenge. The presence of residual depressive symptoms seems to be a reliable predictor of relapse. However, few studies have systematically evaluated the relative contribution of specific residual symptoms to relapse risk.ObjectiveThis review synthesizes studies investigating the association between individual residual depressive symptoms and relapse risk following a successful acute treatment of MDD.MethodsA scoping review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews guidelines. A systematic literature search was performed using terms related to depression, residual symptoms and relapse.ResultsEleven studies were included. Residual sleep disturbance and anxiety showed a statistically significant association with increased relapse risk in most studies assessing these symptoms. Most studies assessing residual fatigue, appetite, weight change, depressed mood or diminished interest did not observe statistically significant associations with relapse risk. Findings regarding agitation or restlessness and decreased libido were mixed, with some studies reporting statistically significant associations while others did not. A variety of symptom rating scales was used to assess residual depressive symptoms, resulting in substantial heterogeneity.ConclusionSpecific residual depressive symptoms, notably sleep disturbance and anxiety, may serve as predictors of increased relapse risk and should alert clinicians. However, substantial heterogeneity across studies limits the consistency and generalizability of these findings. Standardized and multidimensional assessment strategies, integrating both clinician-rated and self-report instruments, are needed to comprehensively capture the residual symptom burden and improve relapse risk prediction.</p>","PeriodicalId":55283,"journal":{"name":"Canadian Journal of Psychiatry-Revue Canadienne De Psychiatrie","volume":" ","pages":"7067437261448747"},"PeriodicalIF":3.8,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13149350/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147846520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seclusion in Canada: Time for a Radical Change.","authors":"Gary Chaimowitz, Nick Kates, Mary Davoren","doi":"10.1177/07067437261448740","DOIUrl":"https://doi.org/10.1177/07067437261448740","url":null,"abstract":"","PeriodicalId":55283,"journal":{"name":"Canadian Journal of Psychiatry-Revue Canadienne De Psychiatrie","volume":" ","pages":"7067437261448740"},"PeriodicalIF":3.8,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13144284/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147846536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rising Escitalopram Use in British Columbia: Is it Rational and Evidence-Informed?","authors":"Dionzie Ong, Simroop Ladhar, Thomas Perry, Greg Carney, Wade Thompson, Doug Salzwedel, Aaron M Tejani","doi":"10.1177/07067437251405975","DOIUrl":"10.1177/07067437251405975","url":null,"abstract":"<p><p>Plain Language Summary TitleCitalopram vs. Escitalopram for major depression: No Real Difference in Efficacy or Safety, Just Higher Cost.</p>","PeriodicalId":55283,"journal":{"name":"Canadian Journal of Psychiatry-Revue Canadienne De Psychiatrie","volume":" ","pages":"406-408"},"PeriodicalIF":4.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13092817/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145835333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Canadian Network for Mood and Anxiety Treatments Task Force Recommendations for the Use of Probiotics, Prebiotics, Synbiotics, and Fecal Microbiota Transplants in Adults With Major Depressive Disorder: Recommandations du Groupe de travail du Réseau canadien pour le traitement des troubles de l'humeur et de l'anxiété (Canadian Network for Mood and Anxiety Treatments, CANMAT) concernant l'utilisation des probiotiques, des prébiotiques, des symbiotiques et de la transplantation de microbiote fécal chez les adultes atteints de trouble dépressif majeur.","authors":"Anees Bahji, Elisa Brietzke, Noah C A Cooke, Fiona Clement, Benicio N Frey, Mark Hofmeister, Sidney H Kennedy, Raymond Lam, Roumen Milev, Dina Moinul, Sagar V Parikh, Scott Patten, Arun Ravindran, Joshua D Rosenblat, Zainab Samaan, Ayal Schaffer, April Saleem, Serge Beaulieu, Valérie Tourjman, Michael Van Ameringen, Simone Vigod, Lakshmi N Yatham, Valerie Taylor","doi":"10.1177/07067437251394363","DOIUrl":"10.1177/07067437251394363","url":null,"abstract":"<p><p>BackgroundApproximately one-third of adults with major depressive disorder (MDD) experience limited response or intolerable side effects with existing pharmacotherapies. As such, innovative treatments targeting novel biological pathways are under investigation. One promising area of research is the gut microbiome and its influence on mood through the microbiota-gut-brain axis. Clinical studies have begun evaluating microbiome-targeted interventions such as probiotics, prebiotics, synbiotics, and fecal microbiota transplantation (FMT) as potential treatments for MDD. The Canadian Network for Mood and Anxiety Treatments (CANMAT) convened a task force to evaluate the evidence for microbiome-targeted interventions in adults with MDD and to provide updated clinical recommendations.MethodsA systematic review of randomized controlled trials (RCTs) and meta-analyses was conducted, assessing interventions such as probiotics, prebiotics, synbiotics, and FMT in adults with MDD. The CANMAT methodology was used to determine levels of evidence and treatment line recommendations, which were presented in a question-and-answer format.ResultsTwenty-three RCTs and eight meta-analyses were included. Probiotics have been the most extensively studied and have demonstrated modest improvements in depressive symptoms, particularly when used in an adjunctive manner. However, recent high-quality trials yielded mixed results. Evidence for prebiotics and FMT was limited and inconclusive, while synbiotics were assessed in only one small RCT. Most interventions were well tolerated, with few serious adverse events.ConclusionsProbiotics may be cautiously considered as third-line adjunctive treatments for MDD, though findings remain inconsistent. There is currently insufficient evidence to recommend prebiotics, synbiotics, or FMT in clinical practice. Further large-scale, well-controlled trials are needed to clarify efficacy, safety, and optimal patient subgroups.</p>","PeriodicalId":55283,"journal":{"name":"Canadian Journal of Psychiatry-Revue Canadienne De Psychiatrie","volume":" ","pages":"346-358"},"PeriodicalIF":3.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12626857/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145551903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}