Canadian Journal of Psychiatry-Revue Canadienne De Psychiatrie最新文献

{"title":"Impact of Comorbid Posttraumatic Stress-Related Symptoms on Repetitive Transcranial Magnetic Stimulation for Depression in Civilians: Incidence des symptômes du trouble de stress post-traumatique (TSPT) comorbide sur la stimulation magnétique transcrânienne répétitive pour traiter la dépression.","authors":"Enoch Ng, Sean M Nestor, Jennifer S Rabin, Clement Hamani, Nir Lipsman, Peter Giacobbe","doi":"10.1177/07067437251342277","DOIUrl":"https://doi.org/10.1177/07067437251342277","url":null,"abstract":"<p><p>ObjectivesThe impact of comorbid posttraumatic stress disorder (PTSD) symptoms on the anti-depressive outcomes of repetitive transcranial magnetic stimulation (rTMS) for civilians with major depressive disorder (MDD) is poorly studied. We aimed to understand whether proximal PTSD symptoms would interact with distal traumas in impacting depression outcomes from rTMS treatment.MethodsA retrospective analysis was performed on 133 patients with MDD receiving open-label high-frequency rTMS to the left dorsolateral prefrontal cortex for 4 weeks. Probable PTSD was defined as scoring ≥ 4 on the Primary Care PTSD Screen for DSM-5. Distal traumas were quantified using the Adverse Childhood Experiences (ACE-10) questionnaire. Primary outcomes were improvement in Hamilton Rating Scale for Depression 17 item scale (HAMD-17) scores from baseline to 4 weeks as well as remission (HAMD-17 ≤ 7) and response (greater than 50% improvement from baseline).Results29/133 had probable PTSD. Patients with probable PTSD had more ACEs, as well as higher depression, anxiety and medical comorbidity scores. Neither probable PTSD status nor its interaction with ACEs significantly impacted depression outcomes. However, having more ACEs was associated with greater odds of remission and response.ConclusionsOur findings suggest neither co-morbid PTSD symptoms nor distal childhood adversities should preclude patients with MDD from receiving rTMS for depression.</p>","PeriodicalId":55283,"journal":{"name":"Canadian Journal of Psychiatry-Revue Canadienne De Psychiatrie","volume":" ","pages":"7067437251342277"},"PeriodicalIF":3.3,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144182747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Criminal Justice System Contacts among Suicide Decedents in Toronto, 1998-2020: An Observational Study: Démêlés avec le système de justice pénale parmi les personnes décédées par suicide à Toronto, entre 1998 et 2020 : Une étude d'observation.","authors":"Daniel Sanchez-Morales, Samantha Mason, Prudence Po Ming Chan, Rohan Borschmann, Alexander Simpson, Lauren M Weinstock, Jennifer M Dmetrichuk, Ayal Schaffer, Rachel H B Mitchell, Rosalie Steinberg, Mark Sinyor","doi":"10.1177/07067437251342276","DOIUrl":"10.1177/07067437251342276","url":null,"abstract":"<p><p>ObjectiveThis exploratory correlational study explored the demographic, clinical, and offence-type characteristics of people with documented past-year contact with the criminal justice system (CJS) in Toronto, Canada who died by suicide. We aimed to compare demographic and clinical factors among individuals with CJS contact who died by suicide to those without recorded CJS contact who died by suicide.MethodsCoroners' final death reports from all recorded suicide deaths in Toronto between 1 January 1998 and 31 December 2020 were retrieved by research staff and coded at the Office of the Chief Coroner (OCC) of Ontario. A series of bivariate analyses and binary logistic regression analyses were performed to compare demographic and clinically relevant characteristics between these groups. Descriptive statistics relating to demographic, clinical, and offence-type characteristics were reported.ResultsA total of 5,288 people died by suicide, of whom 251 (4.7% of all suicides) had recorded CJS contact prior to death. Assault, physical assault, impaired driving, serious/death threats, and sexual assault were the most common criminal charges among those in the CJS contact group. When compared with the no recorded CJS contact group, the CJS contact group was slightly younger (<i>M</i> = 40.0, SD = ±13.4 vs. <i>M</i> = 47.5, SD = ±18.1, <i>p</i> <i><</i> <i>0</i><i>.001</i>), had a higher proportion of males (85.6% vs. 69.9%, <i>p</i> <i><</i> <i>0</i><i>.001</i>), more commonly experienced interpersonal (36.3% vs. 14.5%, <i>p</i> <i><</i> <i>0</i><i>.001</i>) and/or relationship break-up/breakdown stressors (16.7% vs. 7.5%, <i>p</i> <i><</i> <i>0</i><i>.001</i>), and substance misuse or substance use disorders (37.5% vs. 18%, <i>p</i> <i><</i> <i>0</i><i>.001</i>).ConclusionsOur findings highlight that younger men with interpersonal stressors and/or substance misuse characterize suicide decedents with recorded CJS contact in Toronto, Canada. Suicide prevention efforts and strategies should consider the profile differences among those navigating the CJS.</p>","PeriodicalId":55283,"journal":{"name":"Canadian Journal of Psychiatry-Revue Canadienne De Psychiatrie","volume":" ","pages":"7067437251342276"},"PeriodicalIF":3.3,"publicationDate":"2025-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12106378/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144144534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Static and Dynamic Variables Associated with Inpatient Aggression: A Two-Year Retrospective Study: Variables statiques et dynamiques associées au comportement agressif des patients hospitalisés : étude rétrospective de deux ans.","authors":"Roland M Jones, Lavanya Vangala, Farhat Farrokhi, Mario Moscovici, Stephanie Penney, Alexander I F Simpson, Paul Kurdyak","doi":"10.1177/07067437251343293","DOIUrl":"10.1177/07067437251343293","url":null,"abstract":"<p><p>BackgroundAggressive behaviour is common in mental health inpatient units, and can cause physical and psychological harm, low work satisfaction among staff and be disruptive to the clinical care of patients. Identification of static and dynamic variables associated with inpatient aggression may help identify opportunities for intervention to reduce such incidents.MethodWe carried out a two-year retrospective study of consecutive admissions to the Centre for Addiction and Mental Health, the largest mental health facility in Canada. We created a multivariable model of risk factors associated with aggression, which included static and dynamic variables, as well as the Dynamic Appraisal of Situational Aggression (DASA), which was measured daily.ResultsWe included 4419 consecutive admissions comprising 88,124 patient-days. We found that High and Medium DASA scores were strongly associated with subsequent aggression (HR = 9.64, 95% CI = 7.75-11.99, and HR = 3.51, 95% CI = 2.82-4.37, respectively) after controlling for other variables. Other variables associated with aggression included the Aggressive Behaviour Scale of the Resident Assessment Instrument-Mental Health (RAI-ABS), male gender, younger age, ethnicity, PRN (as needed medication) administration, unit type, involuntary admission, medication refusal and self-harm. However, these variables were more weakly associated with subsequent aggression as compared to the DASA score categories.ConclusionsHigher DASA scores are strongly associated with aggression after controlling for a range of other patient variables. Frequent structured measurement of dynamic variables using the DASA may help identify patients most at risk of aggression and assist clinical staff in directing interventions to where they are most needed to reduce aggression on inpatient units.</p>","PeriodicalId":55283,"journal":{"name":"Canadian Journal of Psychiatry-Revue Canadienne De Psychiatrie","volume":" ","pages":"7067437251343293"},"PeriodicalIF":3.3,"publicationDate":"2025-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12106376/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144144397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Randomized Prospective Survey to Understand Readiness for Participation in Dementia Research Studies Across Diverse Communities: Une enquête prospective à répartition aléatoire visant à comprendre la disposition à participer à des études de recherche sur la démence dans diverses communautés.","authors":"Martha Sajatovic, Lynn Katherine Herrmann, Clara Knebusch, Nicole Fiorelli, Joy Yala, David Silva, Alan J Lerner, Edna Fuentes-Casiano, Christopher J Burant","doi":"10.1177/07067437251343294","DOIUrl":"10.1177/07067437251343294","url":null,"abstract":"<p><p>ObjectiveEven with recruitment efforts for racial and ethnic minorities in dementia research, there is still underrepresentation in these communities. Targeting barriers and facilitators to research participation, we developed and tested a culturally tailored communication approach tailored for Hispanics.MethodsAn iterative process informed by input from the minority advisory board of an Alzheimer's Disease Research Center, developed 2 brief health communication videos, featuring Hispanic actors/Spanish language sub-titles. The experimental video (POWER) focused on barriers, facilitators, and readiness to participate in dementia research. The control video focused on education only. A randomized prospective survey compared POWER vs. control. While race or ethnicity were not inclusion criteria for enrollment, we oversampled Hispanic and non-white communities. We examined change pre- vs. post-video on dementia knowledge, cumulative barriers, and facilitators to research participation, as well as change in research readiness measured by the Transtheoretical behavior change model.ResultsThe analyzable sample (<i>N</i> = 184) had a mean age of 40.0 (SD = 13.2) years, 57.4% (<i>n</i> = 105) female, 47.2% (<i>n</i> = 85) non-white, 21.2% (<i>n</i> = 39) Hispanic, with 88 individuals randomized to POWER and 96 to control. Unadjusted evaluation of change from pre- vs. post-video showed significant improvements in dementia knowledge, research facilitators and research barriers (all <i>p</i>s < .001) but no significant difference between POWER vs. controls. Adjusted for age, gender, race, ethnicity and education, only change in dementia knowledge remained significantly improved for the group as a whole, with no significant difference between POWER vs. controls. In the entire sample, Hispanics had significantly more improvement in research readiness (<i>r</i> = .217, <i>p</i> = .003). Exploratory analysis of positive change predictors in those randomized to POWER and to control suggests Hispanics in POWER may be at a disadvantage with respect to dementia knowledge (<i>r</i> = -.248, <i>p</i> = .02) and research facilitators (<i>r</i> = -.342, <i>p</i> = .001).ConclusionsHealth communications can improve dementia knowledge across diverse communities.</p>","PeriodicalId":55283,"journal":{"name":"Canadian Journal of Psychiatry-Revue Canadienne De Psychiatrie","volume":" ","pages":"7067437251343294"},"PeriodicalIF":3.3,"publicationDate":"2025-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12106381/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144144533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Longitudinal Study of the Relationship Among Cognition, Mood Symptoms, and Markers of Brain Health in Older Age Bipolar Disorder: Une étude longitudinale de la relation entre la cognition, les symptômes thymiques, et les marqueurs de la santé du cerveau en présence de troubles bipolaires du sujet âgé.","authors":"Ariel G Gildengers, Meryl A Butters, Howard J Aizenstein, James Emanuel, Tianyu Ding, Stewart J Anderson, James T Becker, Oscar Lopez, Charles F Reynolds, Benoit H Mulsant","doi":"10.1177/07067437251343295","DOIUrl":"10.1177/07067437251343295","url":null,"abstract":"<p><p>ObjectivesAn emerging literature has assessed cognition or imaging markers of brain health in in older age bipolar disorder (OABD). In this context, we conducted the first longitudinal study (to our knowledge) that assessed the relationship among cognition, mood symptoms, and imaging markers of brain health in OABD.Methods99 participants with OABD were enrolled, underwent baseline assessment, and were followed annually for up to 3 years. They completed comprehensive assessments that included evaluation of general medical status, vascular disease burden, mental status, cognitive performance. A subset of participants (<i>n</i> = 58) completed magnetic resonance imaging (MRI) at one or two time-points, yielding three measures of brain health: gray matter volume, fractional anisotropy (FA), and burden of white matter hyperintensities (WMH).ResultsGroup-based trajectory modelling (GBTM) of overall cognitive performance revealed two groups: a group with higher cognitive performance (63 of 99, 63.6%) and a group with lower cognitive performance (36 of 99, 36.4%). GBTM also revealed two groups based on each of the three imaging markers of brain health. The higher cognitive performance group was associated with the groups with higher measure of total gray matter or higher FA. We found no relationship between the cognitive groups and level of mood symptoms during longitudinal follow-up or WMH burden.ConclusionsIn this first longitudinal study of cognition, mood symptoms, and markers of brain health in OABD, cognitive performance was related to brain health and not to mood symptoms over a follow-up of up to three years. Almost two-thirds of participants with OABD had cognitive performance comparable to older adults without OABD. Larger future studies will need to replicate and extend these findings.</p>","PeriodicalId":55283,"journal":{"name":"Canadian Journal of Psychiatry-Revue Canadienne De Psychiatrie","volume":" ","pages":"7067437251343295"},"PeriodicalIF":3.3,"publicationDate":"2025-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12106387/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144144532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morbidity, Suicidal Ideation and Suicide Attempts Among Youth in Canada: A Nationally-Representative Study: Morbidité, idées suicidaires et tentatives de suicide chez les jeunes au Canada : Une étude représentative à l'échelle nationale.","authors":"Danielle Fearon, Alex Luther, Dillon Browne, Ian Colman, Joel A Dubin, Laura Duncan, Mark A Ferro","doi":"10.1177/07067437251343292","DOIUrl":"10.1177/07067437251343292","url":null,"abstract":"<p><p>BackgroundSuicide is a leading cause of mortality among youth globally. Evidence suggests that individuals with physical illness, mental illness, or neurodevelopmental disorders are at increased risk of suicide. However, few studies have estimated the prevalence of suicidal ideation and suicide attempts among youth with compounding health burdens. The purpose of this study is to estimate the prevalence of suicidal ideation and suicide attempts and their associations across morbidity status among youth in Canada.MethodsData come from 6,915 youth aged 15-17 years (49% female) enrolled in the 2019 Canadian Health Survey on Children and Youth. The person most knowledgeable or the youth themselves provided responses regarding sociodemographic characteristics, morbidity status, and indicators of suicide. The prevalence of suicidal ideation (past year) and suicide attempts (lifetime) were compared across morbidities (none, physical illness only, mental illness only, neurodevelopmental disorder only, and multimorbidity). Logistic regression models estimated adjusted associations between morbidity status and suicidal behaviour.ResultsSuicidal ideation and suicide attempts were most commonly reported by youth with mental illness only (32%, 18%) and multimorbidity (28%, 19%). While all morbidities were associated with indicators of suicide, the strongest association was found between multimorbidity and suicide attempts odds ratio = 5.2 (3.4, 8.0).ConclusionsThese contemporary estimates of youth in Canada suggest that suicidal ideation and suicide attempts are common and reinforce the need for integrated physical and mental health services for youth with multimorbidity to reduce the incidence. Research investigating causal mechanisms of the intersections between physical illness, mental illness, neurodevelopmental disorders, and suicide is needed.</p>","PeriodicalId":55283,"journal":{"name":"Canadian Journal of Psychiatry-Revue Canadienne De Psychiatrie","volume":" ","pages":"7067437251343292"},"PeriodicalIF":3.3,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12098303/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144121412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Use and Misuse of Over-the-Counter Melatonin in Children and Adolescents: A Commentary.","authors":"Chris Y Kim, Persis Yousef, Royi Gilad, Colin M Shapiro","doi":"10.1177/07067437251340683","DOIUrl":"10.1177/07067437251340683","url":null,"abstract":"","PeriodicalId":55283,"journal":{"name":"Canadian Journal of Psychiatry-Revue Canadienne De Psychiatrie","volume":" ","pages":"7067437251340683"},"PeriodicalIF":3.3,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12095219/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144113134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors Associated with Medico-Legal Events Resulting from Attempted Suicide by Patients in Care: Facteurs associés aux événements médico-légaux résultant de tentatives de suicide de patients en soins.","authors":"Rana Aslanova, Sharman J Robertson, Kate Barbosa, Elaine G Rose, Jacqueline H Fortier, Gary E Garber","doi":"10.1177/07067437251342281","DOIUrl":"10.1177/07067437251342281","url":null,"abstract":"<p><p>ObjectivesThis study provides an overview of the key medico-legal issues associated with attempted or completed suicide in Canada. Specifically, we identify factors that were criticized and found to contribute to medico-legal risk in these cases.MethodsA national repository was retrospectively searched for cases involving patients who attempted or completed suicide while under the care of a physician. The study included cases closed at the Canadian Medical Protective Association between 2013 and 2023. The study involved in- and outpatients who attempted or completed suicide. The frequencies and proportions of patient safety events and medico-legal risks for physicians were calculated by exploring factors that contributed to each incident.ResultsA total of 378 cases were identified, involving 460 physicians. The majority of patients in these cases experienced a healthcare-related harm (224/378, 59%). Psychiatrists were involved in 61% (231/378) of cases. The most common reasons for patient/family complaints were deficient assessments, diagnostic errors, and communication breakdowns with the patient or their family. The most common contributing factors identified by peer experts were deficient assessments of a suicidal patient and inadequate documentation.ConclusionsThis study addressed the gap in the published literature of healthcare-related contributing risk factors associated with a patient safety incident from Canadian medico-legal cases. The most common omissions identified by peer experts were comprehensive assessment and clear documentation. Physicians treating suicidal patients may reduce their medico-legal risk by completing and documenting thorough and timely suicide risk assessments.</p>","PeriodicalId":55283,"journal":{"name":"Canadian Journal of Psychiatry-Revue Canadienne De Psychiatrie","volume":" ","pages":"7067437251342281"},"PeriodicalIF":3.3,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12092420/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144103248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Digital Dialectical Behaviour Therapy Intervention for Acute Suicidality in Psychiatric Inpatients: A Feasibility Randomised Controlled Study: Intervention numérique en thérapie comportementale dialectique en cas de suicidabilité aiguë de patients hospitalisés en psychiatrie : Étude de faisabilité contrôlée à répartition aléatoire.","authors":"Brett D M Jones, Mary E Kittur, Michael S B Mak, Wei Wang, Juveria Zaheer, Shelley McMain, M Omair Husain, Anne Sonley, David Gratzer, Benoit H Mulsant, Daniel M Blumberger, M Ishrat Husain","doi":"10.1177/07067437251337607","DOIUrl":"10.1177/07067437251337607","url":null,"abstract":"<p><p>ObjectiveTo evaluate the feasibility and preliminary efficacy of a digital dialectical behaviour therapy (d-DBT) skills intervention in suicidal psychiatric inpatients.MethodsA parallel arm, assessor-blinded, randomized controlled trial (RCT) was conducted to compare d-DBT to standard care among psychiatric inpatients. Participants included adults admitted for suicidality (i.e., suicidal ideation or suicide attempt). The intervention group received a d-DBT intervention encompassing 5 online modules completed over 5 to 10 days, covering mindfulness, emotion regulation, and distress tolerance skills. Participants received an initial orientation but no formal therapy sessions. Daily check-ins were available for technical-related queries. Feasibility outcomes included recruitment, adherence (≥3 modules completed), retention, and acceptability (client satisfaction questionnaire-8). Efficacy outcomes included suicidality (Columbia-Suicide Severity Rating Scale [C-SSRS] total score), psychological distress (K10), emotion regulation (Difficulties in Emotion Regulation Scale-16 [DERS-16]), and clinical global impression (CGI). Linear regression models analysed group differences.ResultsA total of 65 participants were recruited, of which 42 were randomized, with high d-DBT adherence rates in the intervention arm (75%). The d-DBT intervention demonstrated significant reductions in C-SSRS scores (Cohen's -1.0) compared to standard of care. No significant group differences were observed in K10, DERS-16, or CGI. High acceptability and satisfaction were reported among participants randomized to d-DBT. Challenges and limitations included maintaining follow-up postdischarge and the small sample size.Conclusiond-DBT is feasible to implement through an RCT and may reduce suicidality and improve mental health among psychiatric inpatients. The study highlights the importance of developing accessible, evidence-based interventions for this population. Future research should focus on long-term efficacy and expanding the intervention's appeal and accessibility.</p>","PeriodicalId":55283,"journal":{"name":"Canadian Journal of Psychiatry-Revue Canadienne De Psychiatrie","volume":" ","pages":"7067437251337607"},"PeriodicalIF":3.3,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12092405/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144103239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early Psychoeducational Intervention for Youth and Young Adults at Risk for Bipolar Disorder: A Feasibility Study: Intervention psychoéducative précoce pour les adolescents et les jeunes adultes à risque de trouble bipolaire : Une étude de faisabilité.","authors":"Kamyar Keramatian, Alexander Levit, Heeva Chavoshi-Nejad, Clara Westwell-Roper, John-Jose Nunez, Ashley Forbes, Emma Morton, Erin E Michalak, Eduard Vieta, Lakshmi N Yatham","doi":"10.1177/07067437251342278","DOIUrl":"10.1177/07067437251342278","url":null,"abstract":"<p><p>ObjectiveBipolar disorder (BD) often goes unrecognized and untreated for several years leading to serious consequences. We have recently developed a manualized telehealth-based group psychoeducational and resilience enhancement program for individuals at high risk for bipolar disorder (PREP-BD). The primary objective of this study was to assess the feasibility of implementing PREP-BD to enhance help-seeking intentions among high-risk individuals.MethodThe intervention consisted of eight weekly, 60-minute group psychoeducation sessions conducted via Zoom. Participants (<i>N</i> = 21), aged 17 to 24 years, who met the bipolar at-risk criteria, were assigned to one of four cohorts. Primary outcomes for this feasibility trial included sign-up rate, completion rate, and acceptability as measured by the Client Satisfaction Questionnaire (CSQ-8). Preliminary efficacy was assessed using validated measures of help-seeking intentions, resilience, quality of life, and stigma, with pre- and post-intervention comparisons.ResultsOur findings indicate excellent feasibility as evidenced by timely recruitment, 100% sign-up rate, and 76.19% completion rate (defined as attending at least 75% of group sessions). The intervention showed preliminary improvements in help-seeking intentions, particularly for a hypomanic scenario. Quality of life also demonstrated significant improvement, while resilience and self-stigma showed non-significant trends toward improvement.ConclusionOur findings suggest the feasibility of implementing psychoeducation as an early identification strategy in individuals at risk for BD. Future randomized controlled trials are needed to investigate the effectiveness of PREP-BD.</p>","PeriodicalId":55283,"journal":{"name":"Canadian Journal of Psychiatry-Revue Canadienne De Psychiatrie","volume":" ","pages":"7067437251342278"},"PeriodicalIF":3.3,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12092411/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144103242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}