Canadian Journal of Psychiatry-Revue Canadienne De Psychiatrie最新文献

{"title":"Alignment of Lived Experience Questions with the Medical Literature in Bipolar Disorder: A Topic Modelling Approach: Adéquation entre les questions relatives à l'expérience vécue et la littérature médicale concernant le trouble bipolaire : Une approche de modélisation de sujets.","authors":"Varsha D Badal, John-Jose Nunez, Colin A Depp, Adrienne Benediktsson, Erin E Michalak","doi":"10.1177/07067437261448751","DOIUrl":"https://doi.org/10.1177/07067437261448751","url":null,"abstract":"<p><p>ObjectiveThe priorities of people with mental health challenges should be reflected in the research conducted on their behalf. Quantifying alignment of priorities with the unmet needs of people with lived experience is challenging, and to our knowledge, such alignment has not been extensively studied in bipolar disorder (BD). Natural language processing approaches comparing common topics derived from public forums to those of biomedical research could help in identifying topics that are underaddressed.MethodsWe contrasted 5 years of lived experience questions posed during a Collaborative RESearch Team to study psychosocial issues in Bipolar Disorder (CREST.BD) \"Ask Me Anything\" (AMA) event hosted via Reddit (2019-2023) with topics labelled from abstracts extracted from PubMed with the search term BD during the same period. We applied topic modelling using BERTopic to identify dominant themes within each corpus and compared their semantic similarity using vector-based cosine similarity analyses.ResultsThe Reddit AMA data included 6159 comments, and the medical literature from this period included 9188 abstracts. Topic modelling and similarity analyses indicated that shared and frequent topics in both corpuses were sleep, BD medication safety in pregnancy, and lithium treatment. Topics with comparatively higher frequency in the Reddit forums than in medical research included BD misdiagnosis, marijuana and BD, and coping with daily challenges.DiscussionNotwithstanding limitations, comparing a corpus of lived experience questions with contemporaneous medical literature revealed areas of overlap, but some lived experience queries were not well covered in the biomedical literature. Natural language processing of public forums may facilitate identifying unmet priorities in BD.</p>","PeriodicalId":55283,"journal":{"name":"Canadian Journal of Psychiatry-Revue Canadienne De Psychiatrie","volume":" ","pages":"7067437261448751"},"PeriodicalIF":3.8,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147846254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Geriatric Psychiatry has Come a Long Way and has a Bright Future.","authors":"Benoit H Mulsant, Martha Sajatovic","doi":"10.1177/07067437261449768","DOIUrl":"https://doi.org/10.1177/07067437261449768","url":null,"abstract":"","PeriodicalId":55283,"journal":{"name":"Canadian Journal of Psychiatry-Revue Canadienne De Psychiatrie","volume":" ","pages":"7067437261449768"},"PeriodicalIF":3.8,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147846448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methodological Concerns Regarding a Meta-Analysis of the Subjective Scale to Investigate Cognition in Schizophrenia (SSTICS).","authors":"Torill Ueland, Merete Glenne Øie, Anja Vaskinn","doi":"10.1177/07067437261448737","DOIUrl":"https://doi.org/10.1177/07067437261448737","url":null,"abstract":"","PeriodicalId":55283,"journal":{"name":"Canadian Journal of Psychiatry-Revue Canadienne De Psychiatrie","volume":" ","pages":"7067437261448737"},"PeriodicalIF":3.8,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147846451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"When Do Antidepressants \"Kick In\": Addressing the 2-4-Week Myth.","authors":"Stefani Mihilli, Anthony Levitt, Marco Solmi, Mark Sinyor, Ayal Schaffer","doi":"10.1177/07067437261449898","DOIUrl":"https://doi.org/10.1177/07067437261449898","url":null,"abstract":"","PeriodicalId":55283,"journal":{"name":"Canadian Journal of Psychiatry-Revue Canadienne De Psychiatrie","volume":" ","pages":"7067437261449898"},"PeriodicalIF":3.8,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147846454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Which Residual Symptoms Predict Relapse in major Depression? A Scoping Review: Quels symptômes résiduels constituent des prédicteurs de rechute de dépression majeure? Un examen de la portée.","authors":"David Borghgraef, Pascal Sienaert, Simon Lambrichts","doi":"10.1177/07067437261448747","DOIUrl":"10.1177/07067437261448747","url":null,"abstract":"<p><p>BackgroundPreventing relapse following a successful acute treatment of major depressive disorder (MDD) remains a clinical challenge. The presence of residual depressive symptoms seems to be a reliable predictor of relapse. However, few studies have systematically evaluated the relative contribution of specific residual symptoms to relapse risk.ObjectiveThis review synthesizes studies investigating the association between individual residual depressive symptoms and relapse risk following a successful acute treatment of MDD.MethodsA scoping review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews guidelines. A systematic literature search was performed using terms related to depression, residual symptoms and relapse.ResultsEleven studies were included. Residual sleep disturbance and anxiety showed a statistically significant association with increased relapse risk in most studies assessing these symptoms. Most studies assessing residual fatigue, appetite, weight change, depressed mood or diminished interest did not observe statistically significant associations with relapse risk. Findings regarding agitation or restlessness and decreased libido were mixed, with some studies reporting statistically significant associations while others did not. A variety of symptom rating scales was used to assess residual depressive symptoms, resulting in substantial heterogeneity.ConclusionSpecific residual depressive symptoms, notably sleep disturbance and anxiety, may serve as predictors of increased relapse risk and should alert clinicians. However, substantial heterogeneity across studies limits the consistency and generalizability of these findings. Standardized and multidimensional assessment strategies, integrating both clinician-rated and self-report instruments, are needed to comprehensively capture the residual symptom burden and improve relapse risk prediction.</p>","PeriodicalId":55283,"journal":{"name":"Canadian Journal of Psychiatry-Revue Canadienne De Psychiatrie","volume":" ","pages":"7067437261448747"},"PeriodicalIF":3.8,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13149350/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147846520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seclusion in Canada: Time for a Radical Change.","authors":"Gary Chaimowitz, Nick Kates, Mary Davoren","doi":"10.1177/07067437261448740","DOIUrl":"https://doi.org/10.1177/07067437261448740","url":null,"abstract":"","PeriodicalId":55283,"journal":{"name":"Canadian Journal of Psychiatry-Revue Canadienne De Psychiatrie","volume":" ","pages":"7067437261448740"},"PeriodicalIF":3.8,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13144284/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147846536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rising Escitalopram Use in British Columbia: Is it Rational and Evidence-Informed?","authors":"Dionzie Ong, Simroop Ladhar, Thomas Perry, Greg Carney, Wade Thompson, Doug Salzwedel, Aaron M Tejani","doi":"10.1177/07067437251405975","DOIUrl":"10.1177/07067437251405975","url":null,"abstract":"<p><p>Plain Language Summary TitleCitalopram vs. Escitalopram for major depression: No Real Difference in Efficacy or Safety, Just Higher Cost.</p>","PeriodicalId":55283,"journal":{"name":"Canadian Journal of Psychiatry-Revue Canadienne De Psychiatrie","volume":" ","pages":"406-408"},"PeriodicalIF":3.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13092817/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145835333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Canadian Network for Mood and Anxiety Treatments Task Force Recommendations for the Use of Probiotics, Prebiotics, Synbiotics, and Fecal Microbiota Transplants in Adults With Major Depressive Disorder: Recommandations du Groupe de travail du Réseau canadien pour le traitement des troubles de l'humeur et de l'anxiété (Canadian Network for Mood and Anxiety Treatments, CANMAT) concernant l'utilisation des probiotiques, des prébiotiques, des symbiotiques et de la transplantation de microbiote fécal chez les adultes atteints de trouble dépressif majeur.","authors":"Anees Bahji, Elisa Brietzke, Noah C A Cooke, Fiona Clement, Benicio N Frey, Mark Hofmeister, Sidney H Kennedy, Raymond Lam, Roumen Milev, Dina Moinul, Sagar V Parikh, Scott Patten, Arun Ravindran, Joshua D Rosenblat, Zainab Samaan, Ayal Schaffer, April Saleem, Serge Beaulieu, Valérie Tourjman, Michael Van Ameringen, Simone Vigod, Lakshmi N Yatham, Valerie Taylor","doi":"10.1177/07067437251394363","DOIUrl":"10.1177/07067437251394363","url":null,"abstract":"<p><p>BackgroundApproximately one-third of adults with major depressive disorder (MDD) experience limited response or intolerable side effects with existing pharmacotherapies. As such, innovative treatments targeting novel biological pathways are under investigation. One promising area of research is the gut microbiome and its influence on mood through the microbiota-gut-brain axis. Clinical studies have begun evaluating microbiome-targeted interventions such as probiotics, prebiotics, synbiotics, and fecal microbiota transplantation (FMT) as potential treatments for MDD. The Canadian Network for Mood and Anxiety Treatments (CANMAT) convened a task force to evaluate the evidence for microbiome-targeted interventions in adults with MDD and to provide updated clinical recommendations.MethodsA systematic review of randomized controlled trials (RCTs) and meta-analyses was conducted, assessing interventions such as probiotics, prebiotics, synbiotics, and FMT in adults with MDD. The CANMAT methodology was used to determine levels of evidence and treatment line recommendations, which were presented in a question-and-answer format.ResultsTwenty-three RCTs and eight meta-analyses were included. Probiotics have been the most extensively studied and have demonstrated modest improvements in depressive symptoms, particularly when used in an adjunctive manner. However, recent high-quality trials yielded mixed results. Evidence for prebiotics and FMT was limited and inconclusive, while synbiotics were assessed in only one small RCT. Most interventions were well tolerated, with few serious adverse events.ConclusionsProbiotics may be cautiously considered as third-line adjunctive treatments for MDD, though findings remain inconsistent. There is currently insufficient evidence to recommend prebiotics, synbiotics, or FMT in clinical practice. Further large-scale, well-controlled trials are needed to clarify efficacy, safety, and optimal patient subgroups.</p>","PeriodicalId":55283,"journal":{"name":"Canadian Journal of Psychiatry-Revue Canadienne De Psychiatrie","volume":" ","pages":"346-358"},"PeriodicalIF":3.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12626857/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145551903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health-Related Outcome Improvements Via the ACCESS Open Minds Youth Mental Health Service Transformation Project in Edmonton, Canada: Amélioration des résultats en matière de santé grâce au projet de transformation des services de santé mentale jeunes d'ACCESS Open Minds/Esprits ouverts à Edmonton, Canada.","authors":"Jai L Shah, Nguyen Xuan Thanh, Shireen Surood, April Gusnowski, Surya Poudel, Liana Urichuk, Giuseppe D'Andrea, Srividya N Iyer, Ashok K Malla, Eric Latimer, Philip Jacobs","doi":"10.1177/07067437251412570","DOIUrl":"10.1177/07067437251412570","url":null,"abstract":"<p><p>ObjectiveGrowing efforts to transform youth mental health (YMH) services rest on the assumption that they will produce superior outcomes to those of traditional services. We therefore aimed to determine whether implementation of a broad YMH service model in Edmonton, Alberta (the largest site in the pan-Canadian ACCESS Open Minds [AOM] network) resulted in greater improvements in individual-level outcomes compared to a matched control group seen at non-AOM community mental health services.MethodThis retrospective cohort study used data on the Health of Nation Outcomes Scale (HoNOS) collected by trained clinicians, in youth aged 15-25 attending AOM or comparator services for any mental health problem between April 2016 and September 2019. A difference-in-differences approach compared HoNOS outcomes pre- versus post-exposure to the AOM service over a 1-year time horizon, in relation to youth attending a non-transformed service. Propensity score matching and sensitivity analyses were conducted to ensure bias reduction and robustness of observations, respectively.ResultsThe number of referrals to AOM Edmonton increased over time (36.3% [95%CI = 11.0%-68.0%] per month), and the site met benchmarks for rapid assessment (within 72 hours) and time to appropriate care (within 30 days). Of 1,078 youth (344 in the intervention [AOM] group and 734 in the control [non-AOM] group) aged 15-25 visiting community mental health centres, the intervention group had statistically greater improvements (7.4% absolute improvement or 1.2× relative improvement) in total HoNOS scores and its behavioural and symptom subscales.ConclusionsIn addition to improving the reach and timeliness of YMH services, AOM Edmonton produced greater improvements in HoNOS total scores (and two of four subscale scores) compared to a matched control group. Comparative evaluations such as these are essential to demonstrating the value of such services and generating continuous cycles of learning and improvement.Plain Language Summary TitleWhat are the outcomes of transforming youth mental health services in community settings?</p>","PeriodicalId":55283,"journal":{"name":"Canadian Journal of Psychiatry-Revue Canadienne De Psychiatrie","volume":" ","pages":"359-368"},"PeriodicalIF":3.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12867713/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146114970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What Matters Most When Visiting a Rapid Access Addiction Medicine Clinic in Canada for Alcohol Use Care: A National eDelphi Study: Ce qui compte le plus lorsque l'on visite une clinique d'accès rapide au traitement médical de la toxicomanie (RAAM) au Canada pour des soins liés à la consommation d'alcool : une étude eDelphi nationale.","authors":"Mackenzie Dowson, Kednapa Thavorn, Amelia Palumbo, Melanie Willows, Kelly Suschinsky, Gord Garner, Brianne Peters, Tanisse Epp, Brian Hutton, Dianna Wolfe, Nathorn Chaiyakunapruk, Surachat Ngorsuraches, Surapon Nochaiwong, Mary Bartram, Alyssa Grant, Chau Tran, Amy Porath, Kim Corace, Justin Presseau","doi":"10.1177/07067437251412555","DOIUrl":"10.1177/07067437251412555","url":null,"abstract":"<p><p>ObjectiveThis study explored the importance of various aspects of Rapid Access Addiction Medicine (RAAM) based care for alcohol use health from the perspectives of people across Canada, including those who had and had not accessed RAAM services.DesignParticipants (<i>n</i> = 160) responded to items in rounds of an eDelphi survey, with each progressive round aiming to reach a consensus on the most important components of care at a RAAM clinic. Thirty-eight evidence-informed components were organized into five domains of healthcare accessibility. Ranking was conducted on a 5-point scale, with options ranging from \"not at all important\" to \"critical\". Consensus was defined a priori as 75% or greater ranking agreement. The survey was designed to close after 10 components reached consensus or following four rounds.ResultsEighty-nine participants (mean AUDIT = 13.9, SD = 5.4; mean age = 53.1, SD = 16.1; women = 43%) completed three rounds of the eDelphi. Seven per cent of participants reported having visited a RAAM clinic. The top ten components of care included compassionate care, RAAM team collaboration and effective communication, prompt care, low costs, easy contact, accessible clinic information, strength-focused care, shared decision making and availability of services for individuals across the substance use health spectrum.ConclusionsFindings highlight client-prioritized features of alcohol use health services and offer actionable insights that can help enhance care across care settings. Future research should focus on under-represented populations to ensure that their specific needs are addressed and incorporated into service planning and policy development.Plain Language Summary TitleWhat Matters Most About Alcohol Use Health Services? Insights from People Across Canada.</p>","PeriodicalId":55283,"journal":{"name":"Canadian Journal of Psychiatry-Revue Canadienne De Psychiatrie","volume":" ","pages":"369-382"},"PeriodicalIF":3.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12893931/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146168101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}