Canadian Journal of Psychiatry-Revue Canadienne De Psychiatrie最新文献

{"title":"WITHDRAWAL - Administrative Duplicate Publication: Substance Use and Concurrent Disorders: Current Context and the Need for Treatment Integration.","authors":"","doi":"10.1177/07067437251318522","DOIUrl":"10.1177/07067437251318522","url":null,"abstract":"","PeriodicalId":55283,"journal":{"name":"Canadian Journal of Psychiatry-Revue Canadienne De Psychiatrie","volume":" ","pages":"7067437251318522"},"PeriodicalIF":3.3,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11846087/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143470009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Depressive Symptoms and Epistemological Approaches: A Qualitative Study Among Psychiatrists: Symptômes dépressifs et approches épistémologiques : une étude qualitative auprès de psychiatres.","authors":"Clémence Piaux, Céline Bourquin, Friedrich Stiefel","doi":"10.1177/07067437251317245","DOIUrl":"10.1177/07067437251317245","url":null,"abstract":"<p><strong>Background: </strong>The study aimed to investigate how psychiatrists handle the diagnosis and treatment of depression in the adult.</p><p><strong>Participants: </strong>Psychiatrists (<i>N</i> = 17) of the French-speaking Canton of Vaud (Switzerland), working in public institutions or in private sector (cabinets), having different theoretical backgrounds depending on their training (systemic, cognitive-behavioural or psychodynamic) and different duration of clinical experiences were included in the study.</p><p><strong>Methods: </strong>A clinical vignette presenting a young man with depressive symptoms of moderate intensity having experienced multiples losses during the development and recent past was presented to the participants. Participants were invited to read the vignette and react (\"thinking aloud\"), followed by an invitation to elaborate on the diagnosis and treatment.</p><p><strong>Results: </strong>A heterogeneous approach towards the diagnosis and treatment of depression was observed. Without a consensus regarding the diagnosis of depressions, two distinct ways to understand the clinical vignette emerged: one pathogenic, identifying the underlying causes of the depressive symptoms, and the other nosological, based on diagnostic criteria. Consequently, proposition for treatment also diverged ranging from psychotherapy, psychotropic medication, complementary and alternative treatments, and paramedical approaches such as ergo- and socio-therapy, at times leaving the choice up to the patient. Possible explanations for this diversity are a more or less strict adherence to diagnostic criteria used by the psychiatrists, be they ICD or DSM, the double training as psychiatrist and psychotherapist which is mandatory in Switzerland, a certain prudence regarding psychiatric diagnoses by fear of stigmatisation, attention to the therapeutic alliance or divergent views on the theoretical and conceptual understanding of depression.</p><p><strong>Conclusion: </strong>The results of this study underline the importance to include the epistemology of psychiatric disorders in training to raise awareness and conscientization regarding the influence of epistemological aspects on attitudes and approaches to the diagnosis and treatment of depression and other psychiatric disorders.</p>","PeriodicalId":55283,"journal":{"name":"Canadian Journal of Psychiatry-Revue Canadienne De Psychiatrie","volume":" ","pages":"7067437251317245"},"PeriodicalIF":3.3,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11831609/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143434409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Canadian Network for Mood and Anxiety Treatments 2024 Clinical Practice Guideline for the Management of Perinatal Mood, Anxiety, and Related Disorders: Guide de pratique 2024 du Canadian Network for Mood and Anxiety Treatments pour le traitement des troubles de l'humeur, des troubles anxieux et des troubles connexes périnatals.","authors":"Simone N Vigod, Benicio N Frey, Crystal T Clark, Sophie Grigoriadis, Lucy C Barker, Hilary K Brown, Jaime Charlebois, Cindy-Lee Dennis, Nichole Fairbrother, Sheryl M Green, Nicole L Letourneau, Tim F Oberlander, Verinder Sharma, Daisy R Singla, Donna E Stewart, Patricia Tomasi, Brittany D Ellington, Cathleen Fleury, Lesley A Tarasoff, Lianne M Tomfohr-Madsen, Deborah Da Costa, Serge Beaulieu, Elisa Brietzke, Sidney H Kennedy, Raymond W Lam, Roumen V Milev, Sagar V Parikh, Arun V Ravindran, Zainab Samaan, Ayal Schaffer, Valerie H Taylor, Smadar V Tourjman, Michael Van, Lakshmi N Yatham, Ryan J Van Lieshout","doi":"10.1177/07067437241303031","DOIUrl":"https://doi.org/10.1177/07067437241303031","url":null,"abstract":"<p><strong>Background: </strong>The Canadian Network for Mood and Anxiety Treatments (CANMAT) publishes clinical practice guidelines for mood and anxiety disorders. This CANMAT guideline aims to provide comprehensive clinical guidance for the pregnancy and postpartum (perinatal) management of mood, anxiety and related disorders.</p><p><strong>Methods: </strong>CANMAT convened a core editorial group of interdisciplinary academic clinicians and persons with lived experience (PWLE), and 3 advisory panels of PWLE and perinatal health and perinatal mental health clinicians. We searched for systematic reviews of prevention and treatment interventions for perinatal depressive, bipolar, anxiety, obsessive-compulsive and post-traumatic stress disorders (January 2013-October 2023). We prioritized evidence from reviews of randomized controlled trials (RCTs), except for the perinatal safety of medications where reviews of large high-quality observational studies were prioritized due to the absence of RCT data. Targeted searches for individual studies were conducted when systematic reviews were limited or absent. Recommendations were organized by lines of treatment based on CANMAT-defined levels of evidence quality, supplemented by editorial group consensus to balance efficacy, safety, tolerability and feasibility considerations.</p><p><strong>Results: </strong>The guideline covers 10 clinical sections in a question-and-answer format that maps onto the patient care journey: case identification; organization and delivery of care; non-pharmacological (lifestyle, psychosocial, psychological), pharmacological, neuromodulation and complementary and alternative medicine interventions; high-risk clinical situations; and mental health of the father or co-parent. Equity, diversity and inclusion considerations are provided.</p><p><strong>Conclusions: </strong>This guideline's detailed evidence-based recommendations provide clinicians with key information to promote the delivery of effective and safe perinatal mental healthcare. It is hoped that the guideline will serve as a valuable tool for clinicians in Canada and around the world to help optimize clinical outcomes in the area of perinatal mental health.</p>","PeriodicalId":55283,"journal":{"name":"Canadian Journal of Psychiatry-Revue Canadienne De Psychiatrie","volume":" ","pages":"7067437241303031"},"PeriodicalIF":3.3,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143400851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing Integrated Treatment Programs for Severe Concurrent Substance Use and Mental Disorders: Insights on Overdose from the ROAR CANADA Project: Améliorer les programmes de traitement intégré pour les troubles mentaux et les troubles liés à l'usage de substances psychoactives graves et concomitants : aperçu de la problématique des surdoses dans le cadre du projet ROAR CANADA.","authors":"Christian G Schütz, Tonia Nicholls, Laura Schmid, Sydney Penner, Myra Massey, Karina A Thiessen, Stefanie Todesco, Reza Rafizadeh, Kiefer Cowie, Sabrina K Syan, James MacKillop","doi":"10.1177/07067437251315516","DOIUrl":"10.1177/07067437251315516","url":null,"abstract":"<p><strong>Objective: </strong>This paper summarizes methods and initial overdose-related results from the Reducing Overdose and Relapse: Concurrent Attention to Neuropsychiatric Ailments and Drug Addiction (ROAR CANADA) project. ROAR CANADA is a longitudinal observational study of individuals with severe concurrent substance use and mental disorders (also called dual disorders or dual diagnosis). The study sampled patients treated at two tertiary treatment centres in British Columbia, Red Fish Healing Centre and Heartwood Centre, along with a concurrent treatment unit at St. Joseph's in Ontario. These facilities have implemented evidence-based integrated treatment programs. Our first analysis explores selected baseline characteristics as potential risk factors for drug overdose in this population.</p><p><strong>Method: </strong>Sociodemographic factors, trauma history, and impulsivity were part of a more comprehensive longitudinal assessment. In this first investigation, we use bivariate analysis and logistic and linear regression modelling to examine these variables in relation to overdose history.</p><p><strong>Results: </strong>Overall, 291 of 450 participants (64.7%) reported a history of ≥1 overdose. Across the three centres, patients had a lifetime average of 7.6 (<i>SD</i> = 12.9) overdoses. The prevalence and mean number of overdoses were somewhat higher among Red Fish patients (74.5% and 8.5, respectively). Adverse childhood events, lifetime trauma history, and impulsivity were all high, but only lifetime trauma history emerged as significantly associated with overdose across all treatment centres. Impulsivity indicators were selectively associated with overdose by site, but not consistently within the overall sample.</p><p><strong>Conclusions: </strong>These results highlight the importance of prioritizing trauma-informed care in the treatment of individuals with severe concurrent substance use and mental disorders, who are at high risk of overdose. The integration of trauma treatment into existing programs may enhance patient outcomes and contribute to the ongoing evolution of effective care strategies for this complex population. These findings are particularly relevant in light of the overdose crisis.</p>","PeriodicalId":55283,"journal":{"name":"Canadian Journal of Psychiatry-Revue Canadienne De Psychiatrie","volume":" ","pages":"7067437251315516"},"PeriodicalIF":3.3,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11795578/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143124218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Relationship Between Family Dynamics and Help-Seeking and Disclosure of Adolescent Self-Harm and Suicidality: A Population-Representative Study: Relation entre dynamique familiale et recherche d'aide, et dévoilement des actes d'automutilation et de la suicidalité chez les adolescents : étude représentative de la population.","authors":"Nicole G Hammond, Christopher Gravel, Mark A Ferro, Hannah Landry, Marie-Claude Geoffroy, Nicole Racine, Ian Colman","doi":"10.1177/07067437251315526","DOIUrl":"10.1177/07067437251315526","url":null,"abstract":"<p><strong>Background: </strong>Few studies have explored the potential for family dynamics to hinder or promote help-seeking and disclosure behaviours among adolescents who self-harm or experience suicidality. We sought to examine whether family dynamics may influence self-harm-related disclosure to parents or other family members and online help-seeking.</p><p><strong>Methods: </strong>We identified youths, 14-17 years, in the 2014 Ontario Child Health Study (OCHS) who self-reported past-year suicidal ideation (with or without a suicide plan or past suicide attempt[s]) and/or non-suicidal self-harm. The OCHS is a provincially representative, cross-sectional survey. The person most knowledgeable about the adolescent, usually the mother, reported family dynamics: family dysfunction and positive and negative parenting practices. We used logistic regression to generate adjusted odds ratios.</p><p><strong>Results: </strong>A total of 359 adolescents positively endorsed past-year suicidal ideation and/or non-suicidal self-harm. Disclosure and help-seeking were common (≥67.3% and ≥25.6%, respectively). Adolescents experiencing suicidal ideation and greater family dysfunction were more likely to share their suicidal thoughts with non-family compared to not telling anyone (OR = 1.09, 95% CI: 1.01 to 1.18) and were less likely to tell their parents or other family members about their suicidal thoughts when compared to non-family such as teachers, partners, or friends (OR = 0.82, 95% CI: 0.71 to 0.94). Positive parenting was not associated with any form of disclosure or online help-seeking for non-suicidal self-harm or suicidal ideation. As adolescent exposure to negative parenting increased, so did the likelihood that they would seek help online for their suicidal thoughts (OR = 1.22, 95% CI: 1.08 to 1.37). Sensitivity analyses replicated or were very similar to findings from the main models.</p><p><strong>Conclusion: </strong>We found that negative family dynamics were related to reduced sharing of suicidal thoughts with parents or other family members and greater online help-seeking. Our findings suggest that the importance of negative family dynamics to disclosure and support-seeking for adolescent suicidality may be under-recognized.</p>","PeriodicalId":55283,"journal":{"name":"Canadian Journal of Psychiatry-Revue Canadienne De Psychiatrie","volume":" ","pages":"7067437251315526"},"PeriodicalIF":3.3,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11795579/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143124154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Relationship Between Frontal Cortical Thickness and Externalizing Psychopathology is Associated with Treatment Outcomes in Children with Externalizing Problems: A Preliminary Pilot Study: La relation entre l'épaisseur du cortex frontal et les troubles extériorisés est associée aux résultats thérapeutiques chez les enfants ayant des problèmes extériorisés : une étude pilote préliminaire.","authors":"Lee Propp, Hajer Nakua, Anne-Claude V Bedard, Marcos Sanches, Stephanie H Ameis, Brendan F Andrade","doi":"10.1177/07067437251315519","DOIUrl":"10.1177/07067437251315519","url":null,"abstract":"<p><strong>Objectives: </strong>Children with externalizing disorders commonly show emotion dysregulation and callous-unemotional (CU) traits. However, it is unclear whether emotion dysregulation and CU traits share underlying neurobiology that can be predictive of psychosocial treatment outcomes. In this preliminary study, we examined neural correlates of externalizing psychopathology dimensions and their prediction of treatment outcomes.</p><p><strong>Methods: </strong>We analyzed a pilot sample of 17 children with an externalizing disorder (9-12 years; 10.45 ± 1.02) who underwent structural magnetic resonance imaging (MRI) before participating in a 15-week psychosocial group intervention targeting conduct problems. We examined cross-sectional associations between emotion dysregulation or CU traits and cortical thickness (anterior cingulate cortex [ACC] and insula) and amygdala volume at baseline. We then examined whether the pre-treatment brain-behaviour relationships were linked to reduction in conduct problems post-treatment.</p><p><strong>Results: </strong>Lower ACC and insula thickness as well as amygdala volume was associated with greater levels of emotion dysregulation and CU traits at baseline (pre-treatment, <i>r</i> = |0.36-0.61|). There was a significant three-way interaction between emotion dysregulation/CU traits, left insula/right rostral ACC, and treatment (pre/post; β = -1.01 to 3.6). Overall, greater baseline insular and rostral ACC thickness was related to reductions in conduct problems following group-based psychosocial intervention regardless of baseline emotion dysregulation and CU trait levels.</p><p><strong>Conclusions: </strong>The results provide preliminary evidence of shared neural signatures underlying both emotion dysregulation and CU traits. Additionally, alterations in frontolimbic brain structure may be useful predictors of pre-treatment associations with externalizing psychopathology dimensions and post-treatment behavioural outcomes.</p>","PeriodicalId":55283,"journal":{"name":"Canadian Journal of Psychiatry-Revue Canadienne De Psychiatrie","volume":" ","pages":"7067437251315519"},"PeriodicalIF":3.3,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11795581/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143124158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Limitations and Future Directions in Pharmacological Treatment for Amphetamine-Type Stimulant Use Disorder.","authors":"Anees Bahji","doi":"10.1177/07067437241312683","DOIUrl":"10.1177/07067437241312683","url":null,"abstract":"<p><p>Plain Language Summary<i><b>Why Current Treatments for Stimulant Addiction Often Fall Short: Insights and Future Directions</b></i> Stimulant addiction, such as addiction to drugs like amphetamines, is a growing public health concern, but there are very few effective medications to treat it. A recent study reviewed a drug called modafinil and found it didn't help reduce drug use, cravings, or improve treatment outcomes. This article discusses why treatments that work for other addictions, like opioids, are less effective for stimulants. It also highlights the challenges researchers face, such as differences in study methods and overlooking common issues like mental health problems or using multiple substances. The focus on complete abstinence as a treatment goal is another issue. Harm reduction, which involves reducing drug use and improving health and social well-being, could be more realistic and beneficial for many people. Finally, while therapy remains the most effective treatment, it's not always accessible. This article calls for new, innovative approaches that prioritize harm reduction, safety, and long-term recovery.</p>","PeriodicalId":55283,"journal":{"name":"Canadian Journal of Psychiatry-Revue Canadienne De Psychiatrie","volume":" ","pages":"136-137"},"PeriodicalIF":3.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11748372/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143016822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Time-Series Analysis of News Media Coverage of Suicide in Canada from 2019 to 2023: Une analyse de séries chronologiques de la couverture responsable du suicide par les médias au Canada de 2019 à 2023.","authors":"Juliette Careau, Justin Bélair, Rob Whitley","doi":"10.1177/07067437241309677","DOIUrl":"10.1177/07067437241309677","url":null,"abstract":"<p><strong>Objective: </strong>Evidence suggests that the media can play a role in preventing suicide, as well as contributing to suicide contagion. As such, the primary objective is to assess adherence to responsible reporting of suicide recommendations in news articles about suicide over time. A secondary objective is to assess whether reporting changed significantly during the COVID-19 pandemic. The tertiary objective is to assess overall patterns regarding types of suicide reported.</p><p><strong>Methods: </strong>We collected news articles with the keyword \"suicide\" from 47 Canadian news sources between April 1, 2019, and March 31, 2023. Articles were coded for adherence to key responsible reporting of suicide guidelines. Frequency counts and percentages of adherence were calculated for all key variables. Time series analyses using a Generalized Linear Autoregressive Moving Average model assessed for adherence trends over time, including measuring for any changes during the COVID-19 years.</p><p><strong>Results: </strong>Study procedures resulted in 3,232 coded news articles. Overall, the results indicate that adherence to the guidelines has moderately improved over the course of the 4-year period. This is especially true for recommendations regarding avoiding putatively harmful content, such as detailed descriptions of the suicide method. Similar improvements were seen in adherence to guidelines related to the inclusion of putatively helpful content, with significantly more articles providing help-seeking information. However, in the final year of the study, less than a third of articles included educational content about suicide, help-seeking information, or quotes from suicide experts. Reporting of suicide during the COVID-19 period showed some positive improvements; however, these were not sustained after the pandemic ended.</p><p><strong>Conclusions: </strong>On the plus side, adherence to responsible suicide reporting guidelines improved over the 4-year period, especially for recommendations concerning putatively helpful content. However, there remains room for improvement regarding the inclusion of putatively protective content such as including help-seeking information, educating about suicide, and quoting experts.</p>","PeriodicalId":55283,"journal":{"name":"Canadian Journal of Psychiatry-Revue Canadienne De Psychiatrie","volume":" ","pages":"98-108"},"PeriodicalIF":3.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11705304/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142958672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation de L’échelle Unidimensionnelle D’Estime de Soi de Ducher (ESD): Validation of Ducher's Unidimensional Self-Esteem Scale (SES).","authors":"I de Chazeron, J-L Ducher, M Renoux, G Brousse, P-M Llorca","doi":"10.1177/07067437241301712","DOIUrl":"10.1177/07067437241301712","url":null,"abstract":"<p><strong>Background: </strong>Although self-esteem is a relatively new concept, first developed in the field of social psychology, it has gained increasing importance in psychiatry, especially as a diagnostic criterion. However, it is poorly evaluated in clinical practice. The lack of an instrument allowing an easy global assessment may be the reason for this. It is therefore a question of validating a short, one-dimensional self-esteem scale in French, possibly allowing an evolutionary follow-up by self-correction.</p><p><strong>Methods: </strong>The study involved 106 patients with various psychiatric disorders, except psychotic disorder, stabilized or of varying severity. The creation of the original tool included 10 items. It was submitted to the selection of items followed by an exploratory factor analysis. The correlation between the items and the measurement of consistency and convergent validity were then performed.</p><p><strong>Result: </strong>The evaluation of acceptability and distribution of results led to the selection of 6 items. Exploratory factor analysis revealed a unique dimension and good reliability (Tucker-Lewis Index = 0.89). No item displays correlations with a total score of less than 0.50 and the concept of construct is consistent. There is also a good internal consistency which confirms that the 6-item ESD version is optimal.</p><p><strong>Conclusion: </strong>This new, validated scale will allow therapists to more accurately investigate the notion of self-esteem in a clinical or research setting.</p>","PeriodicalId":55283,"journal":{"name":"Canadian Journal of Psychiatry-Revue Canadienne De Psychiatrie","volume":" ","pages":"109-116"},"PeriodicalIF":3.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11705292/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142958807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-stratified Genomic Structural Equation Models of Posttraumatic Stress Inform PTSD Etiology: L'utilisation de la modélisation génomique par équations structurelles stratifiée par sexe du stress post-traumatique pour expliquer l'étiologie du TSPT.","authors":"Ashley Moo-Choy, Murray B Stein, Joel Gelernter, Frank R Wendt","doi":"10.1177/07067437241301016","DOIUrl":"10.1177/07067437241301016","url":null,"abstract":"<p><strong>Objective: </strong>Posttraumatic stress disorder (PTSD) affects 3.9%-5.6% of the worldwide population, with well-documented sex-related differences. While psychosocial and hormonal factors affecting sex differences in PTSD and posttraumatic stress (PTS) symptom etiology have been explored, there has been limited focus on the genetic bases of these differences. Many symptom combinations may confer a PTSD diagnosis. We hypothesized that these symptom combinations have sex-specific patterns, the examination of which could inform etiological differences in PTSD genetics between males and females.</p><p><strong>Methods: </strong>To investigate this, we performed a sex-stratified multivariate genome-wide association study (GWAS) in unrelated UK Biobank (UKB) individuals of European ancestry. Using GWAS summary association data, genomic structural equation modelling was performed to generate sex-specific factor models using 6 indicator variables: trouble concentrating, feeling distant from others, irritability, disturbing thoughts, upset feelings, and avoidance of places/activities which remind the individual of a traumatic event.</p><p><strong>Results: </strong>Models of male and female PTSD symptoms differed substantially (local standardized root mean square difference = 3.12) and significantly (χ²(5) = 28.03, <i>P</i> = 3.6 × 10^-5). Independent 2-factor models best fit the data in both males and females; these factors were subjected to GWAS in each sex, revealing 3 genome-wide significant loci in females, mapping to <i>SCAND3</i>, <i>WDPCP</i>, and <i>FAM120A</i>. No genome-wide significant loci were identified in males. All 4 PTS factors (2 in males and 2 in females) were heritable.</p><p><strong>Conclusions: </strong>By assessing the relationship between sex and PTSD symptoms, this study informs correlative and putatively causal etiological differences between males and females which support further investigation of sex differences in PTSD genetics.</p>","PeriodicalId":55283,"journal":{"name":"Canadian Journal of Psychiatry-Revue Canadienne De Psychiatrie","volume":" ","pages":"117-126"},"PeriodicalIF":3.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11629358/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142803508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}