Cell Communication and Adhesion最新文献_第2页

Prognostic Value of the Tumour-Infiltrating Dendritic Cells in Colorectal Cancer: A Systematic Review. 肿瘤浸润性树突状细胞在结直肠癌中的预后价值:系统综述。

Cell Communication and Adhesion Pub Date : 2015-01-01 Epub Date: 2015-05-30 DOI: 10.3109/15419061.2015.1036859

George Malietzis, Gui H Lee, John T Jenkins, David Bernardo, Morgan Moorghen, Stella C Knight, Hafid O Al-Hassi

引用次数: 19

Involvement of retrotransposon L1 in stemness and cellular plasticity. 反转录转座子L1参与干细胞和细胞可塑性。

Cell Communication and Adhesion Pub Date : 2015-01-01 Epub Date: 2014-10-20 DOI: 10.3109/15419061.2014.970270

Panagiotis Apostolou, Maria Toloudi, Marina Chatziioannou, Eleni Kourtidou, Georgia Mimikakou, Ioanna Vlachou, Aikaterini Chlichlia, Ioannis Papasotiriou

{"title":"Involvement of retrotransposon L1 in stemness and cellular plasticity.","authors":"Panagiotis Apostolou, Maria Toloudi, Marina Chatziioannou, Eleni Kourtidou, Georgia Mimikakou, Ioanna Vlachou, Aikaterini Chlichlia, Ioannis Papasotiriou","doi":"10.3109/15419061.2014.970270","DOIUrl":"https://doi.org/10.3109/15419061.2014.970270","url":null,"abstract":"Epithelial-to-mesenchymal transition (EMT) as well as the reverse process, mesenchymal-to-epithelial transition (MET) is important during embryogenesis. EMT is also involved in cancer invasion and metastasis, and can generate cells with properties similar to those of stem cells. Retrotransposons can rearrange the genome by inserting DNA in new loci, thus inducing mutations. This study examines the gene expression of transcription factors involved in EMT and MET. In the second experimental panel, the gene expression of L1 retrotransposon was studied. L1-open reading frame (ORF) 2 mRNA was found to be expressed both in cancer and cancer stem cells, while L1-ORF1 mRNA was expressed only in cancer cells. The suppression of L1-ORF2 gene expression demonstrated that this retrotransposon might affect EMT in colon cancer stem cells. This study highlights that the EMT process seems to differ between cancer cells and cancer stem cells, and that transposable elements seem to be involved in the process, influencing cellular plasticity. ","PeriodicalId":55269,"journal":{"name":"Cell Communication and Adhesion","volume":"22 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/15419061.2014.970270","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32758027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

150th Anniversary Series: Desmosomes and the Hallmarks of Cancer. 150周年纪念系列:桥粒和癌症的特征。

Cell Communication and Adhesion Pub Date : 2015-01-01 Epub Date: 2015-07-02 DOI: 10.3109/15419061.2015.1039642

Otmar Huber, Iver Petersen

{"title":"150th Anniversary Series: Desmosomes and the Hallmarks of Cancer.","authors":"Otmar Huber, Iver Petersen","doi":"10.3109/15419061.2015.1039642","DOIUrl":"https://doi.org/10.3109/15419061.2015.1039642","url":null,"abstract":"Desmosomes represent adhesive, spot-like intercellular junctions that in association with intermediate filaments mechanically link neighboring cells and stabilize tissue architecture. In addition to this structural function, desmosomes also act as signaling platforms involved in the regulation of cell proliferation, differentiation, migration, morphogenesis, and apoptosis. Thus, deregulation of desmosomal proteins has to be considered to contribute to tumorigenesis. Proteolytic fragmentation and downregulation of desmosomal cadherins and plaque proteins by transcriptional or epigenetic mechanisms were observed in different cancer entities suggesting a tumor-suppressive role. However, discrepant data in the literature indicate that context-dependent differences based on alternative intracellular, signal transduction lead to altered outcome. Here, modulation of Wnt/β-catenin signaling by plakoglobin or desmoplakin and of epidermal growth factor receptor signaling appears to be of special relevance. This review summarizes current evidence on how desmosomal proteins participate in carcinogenesis, and depicts the molecular mechanisms involved. ","PeriodicalId":55269,"journal":{"name":"Cell Communication and Adhesion","volume":"22 1","pages":"15-28"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/15419061.2015.1039642","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33974021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 44

150(th) anniversary series: Desmosomes and autoimmune disease, perspective of dynamic desmosome remodeling and its impairments in pemphigus. 150周年纪念系列:桥粒与自身免疫性疾病，天疱疮中动态桥粒重塑及其损伤的观点。

Cell Communication and Adhesion Pub Date : 2014-12-01 Epub Date: 2014-07-31 DOI: 10.3109/15419061.2014.943397

Yasuo Kitajima

{"title":"150(th) anniversary series: Desmosomes and autoimmune disease, perspective of dynamic desmosome remodeling and its impairments in pemphigus.","authors":"Yasuo Kitajima","doi":"10.3109/15419061.2014.943397","DOIUrl":"https://doi.org/10.3109/15419061.2014.943397","url":null,"abstract":"Desmosomes are the most important intercellular adhering junctions that adhere two adjacent keratinocytes directly with desmosomal cadherins, that is, desmogleins (Dsgs) and desmocollins, forming an epidermal sheet. Recently, two cell-cell adhesion states of desmosomes, that is, \"stable hyper-adhesion\" and \"dynamic weak-adhesion\" conditions have been recognized. They are mutually reversible through cell signaling events involving protein kinase C (PKC), Src and epidermal growth factor receptor (EGFR) during Ca(2+)-switching and wound healing. This remodeling is impaired in pemphigus vulgaris (PV, an autoimmune blistering disease), caused by anti-Dsg3 antibodies. The antibody binding to Dsg3 activates PKC, Src and EGFR, linked to generation of dynamic weak-adhesion desmosomes, followed by p38MAPK-mediated endocytosis of Dsg3, resulting in the specific depletion of Dsg3 from desmosomes and acantholysis. A variety of pemphigus outside-in signaling may explain different clinical (non-inflammatory, inflammatory, and necrolytic) types of pemphigus. Pemphigus could be referred to a \"desmosome-remodeling disease involving pemphigus IgG-activated outside-in signaling events\".","PeriodicalId":55269,"journal":{"name":"Cell Communication and Adhesion","volume":"21 6","pages":"269-80"},"PeriodicalIF":0.0,"publicationDate":"2014-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/15419061.2014.943397","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32547413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 45

Correction to: N-Cadherin/Catenin Complex as a Master Regulator of Intercalated Disc Function 修正:n -钙粘蛋白/连环蛋白复合物作为插入式椎间盘功能的主要调节因子

Cell Communication and Adhesion Pub Date : 2014-12-01 DOI: 10.3109/15419061.2014.930274

引用次数: 0

Molecular cloning of peroxinectin gene and its expression in response to peptidoglycan and Vibrio harveyi in Indian white shrimp Fenneropenaeus indicus. 印度对虾过氧化物酶基因的克隆及其对肽聚糖和哈维弧菌的表达。

Cell Communication and Adhesion Pub Date : 2014-12-01 Epub Date: 2014-07-29 DOI: 10.3109/15419061.2014.943396

Sathappan Shanthi, Sivalingam Manju, Perumal Rajakumaran, Baskaralingam Vaseeharan

{"title":"Molecular cloning of peroxinectin gene and its expression in response to peptidoglycan and Vibrio harveyi in Indian white shrimp Fenneropenaeus indicus.","authors":"Sathappan Shanthi, Sivalingam Manju, Perumal Rajakumaran, Baskaralingam Vaseeharan","doi":"10.3109/15419061.2014.943396","DOIUrl":"https://doi.org/10.3109/15419061.2014.943396","url":null,"abstract":"The cDNA sequence of peroxinectin was obtained from the haemocytes of Indian white shrimp Fenneropenaeus indicus using RT-PCR and RACE. Fenneropenaeus indicus peroxinectin (Fi-Pxn) sequence has an open reading frame (ORF) of 2415 bp encoding a protein of 804 amino acids with 21 residues signal sequence. The mature protein has molecular mass of 89.8 kDa with an estimated pI of 8.6. Two putative integrin-binding motifs, RGD and KGD, were observed at the basic N-terminal and C-terminal part of the mature aminoacid sequence. Fi-Pxn nucleotide sequence comparison showed high homology to mud crab Scylla serrata (89%) and to various vertebrate and invertebrate species. qRT-PCR showed peroxinectin mRNA transcript in haemocytes of F. indicus increased at 6 h post injection of peptidoglycan and Vibrio harveyi. The Fi-Pxn was mainly expressed in the tissues of haemocytes and the heart. The moulting stage responses showed Fi-Pxn expression in premoult stages D0/1 and D0/2.","PeriodicalId":55269,"journal":{"name":"Cell Communication and Adhesion","volume":"21 6","pages":"281-9"},"PeriodicalIF":0.0,"publicationDate":"2014-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/15419061.2014.943396","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32543329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Communication of γ phage lysin plyG enzymes binding toward SrtA for inhibition of Bacillus anthracis: protein-protein interaction and molecular dynamics study. γ噬菌体裂解素plyG酶结合SrtA抑制炭疽芽孢杆菌的通讯:蛋白-蛋白相互作用和分子动力学研究。

Cell Communication and Adhesion Pub Date : 2014-10-01 Epub Date: 2014-06-30 DOI: 10.3109/15419061.2014.927444

Chandrabose Selvaraj, Ramanathan Bharathi Priya, Sanjeev Kumar Singh

{"title":"Communication of γ phage lysin plyG enzymes binding toward SrtA for inhibition of Bacillus anthracis: protein-protein interaction and molecular dynamics study.","authors":"Chandrabose Selvaraj, Ramanathan Bharathi Priya, Sanjeev Kumar Singh","doi":"10.3109/15419061.2014.927444","DOIUrl":"https://doi.org/10.3109/15419061.2014.927444","url":null,"abstract":"Bacillus anthracis is a pathogenic, Gram-positive bacterium which chiefly affects the livestock of animals and humans through acute disease anthrax. All around the globe this bio-threat organism damages millions of lives in every year and also most of the drugs were not responding properly in inhibition against this diseased pathogen. In recent development, phage therapy is considered as alternative solution to treat this serious infectious disease. In this study, we elucidated the binding of γ phage lysin plyG enzymes toward the SrtA along with its activator peptide LPXTG. Through protein-protein docking and molecular dynamics simulation studies, we showed the distinguished structure complementarity of SrtA and plyG complex. Especially, MD simulation relates strong and stable interaction occurs between the protein complex structures. These results suggest that additional experimental studies on our approach will lead to availability of better inhibitor against the SrtA.","PeriodicalId":55269,"journal":{"name":"Cell Communication and Adhesion","volume":"21 5","pages":"257-65"},"PeriodicalIF":0.0,"publicationDate":"2014-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/15419061.2014.927444","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32465826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Bisphosphonates and connexin 43: a critical review of evidence. 双膦酸盐和连接蛋白43:证据的批判性回顾。

Cell Communication and Adhesion Pub Date : 2014-10-01 Epub Date: 2014-06-19 DOI: 10.3109/15419061.2014.927869

Pooyan Sadr-Eshkevari, Sajjad Ashnagar, Ashkan Rashad, Marisa Dietz, Jochen Jackowski, Amr Abdulazim, Nora Prochnow

引用次数: 7

Hyper-adhesion: a unique property of desmosomes. 超粘附:桥粒的独特性质。

Cell Communication and Adhesion Pub Date : 2014-10-01 Epub Date: 2014-06-30 DOI: 10.3109/15419061.2014.930133

David Garrod, Lydia Tabernero

引用次数: 23

CXCL12-CXCR7 signaling activates ERK and Akt pathways in human choriocarcinoma cells. CXCL12-CXCR7信号激活人绒毛膜癌细胞中的ERK和Akt通路。

Cell Communication and Adhesion Pub Date : 2014-08-01 Epub Date: 2014-01-23 DOI: 10.3109/15419061.2013.876013

Vishwas Tripathi, Romsha Kumar, Amit K Dinda, Jagdeep Kaur, Kalpana Luthra

引用次数: 17