Clinical & Developmental Immunology最新文献_第8页

Evidence of stage- and age-related heterogeneity of non-HLA SNPs and risk of islet autoimmunity and type 1 diabetes: the diabetes autoimmunity study in the young. 非hla snp的分期和年龄相关异质性与胰岛自身免疫和1型糖尿病风险的证据:年轻人的糖尿病自身免疫研究

Clinical & Developmental Immunology Pub Date : 2013-01-01 Epub Date: 2013-12-04 DOI: 10.1155/2013/417657

Brittni N Frederiksen, Andrea K Steck, Miranda Kroehl, Molly M Lamb, Randall Wong, Marian Rewers, Jill M Norris

{"title":"Evidence of stage- and age-related heterogeneity of non-HLA SNPs and risk of islet autoimmunity and type 1 diabetes: the diabetes autoimmunity study in the young.","authors":"Brittni N Frederiksen, Andrea K Steck, Miranda Kroehl, Molly M Lamb, Randall Wong, Marian Rewers, Jill M Norris","doi":"10.1155/2013/417657","DOIUrl":"https://doi.org/10.1155/2013/417657","url":null,"abstract":"Previously, we examined 20 non-HLA SNPs for association with islet autoimmunity (IA) and/or progression to type 1 diabetes (T1D). Our objective was to investigate fourteen additional non-HLA T1D candidate SNPs for stage- and age-related heterogeneity in the etiology of T1D. Of 1634 non-Hispanic white DAISY children genotyped, 132 developed IA (positive for GAD, insulin, or IA-2 autoantibodies at two or more consecutive visits); 50 IA positive children progressed to T1D. Cox regression was used to analyze risk of IA and progression to T1D in IA positive children. Restricted cubic splines were used to model SNPs when there was evidence that risk was not constant with age. C1QTNF6 (rs229541) predicted increased IA risk (HR: 1.57, CI: 1.20-2.05) but not progression to T1D (HR: 1.13, CI: 0.75-1.71). SNP (rs10517086) appears to exhibit an age-related effect on risk of IA, with increased risk before age 2 years (age 2 HR: 1.67, CI: 1.08-2.56) but not older ages (age 4 HR: 0.84, CI: 0.43-1.62). C1QTNF6 (rs229541), SNP (rs10517086), and UBASH3A (rs3788013) were associated with development of T1D. This prospective investigation of non-HLA T1D candidate loci shows that some SNPs may exhibit stage- and age-related heterogeneity in the etiology of T1D. ","PeriodicalId":55254,"journal":{"name":"Clinical & Developmental Immunology","volume":"2013 ","pages":"417657"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/417657","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31979986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 24

Elevated 1- α hydroxylase activity in monocytes from patients with active tuberculosis. 活动性肺结核患者单核细胞中1- α羟化酶活性升高。

Clinical & Developmental Immunology Pub Date : 2013-01-01 Epub Date: 2013-11-25 DOI: 10.1155/2013/928138

Yi-Ching Tung, Tsan-Teng Ou, Wen-Chan Tsai

引用次数: 7

New insights into the role of the immune microenvironment in breast carcinoma. 免疫微环境在乳腺癌中的作用的新见解。

Clinical & Developmental Immunology Pub Date : 2013-01-01 Epub Date: 2013-06-03 DOI: 10.1155/2013/785317

Luis de la Cruz-Merino, Antonio Barco-Sánchez, Fernando Henao Carrasco, Esteban Nogales Fernández, Ana Vallejo Benítez, Javier Brugal Molina, Antonio Martínez Peinado, Ana Grueso López, Manuel Ruiz Borrego, Manuel Codes Manuel de Villena, Víctor Sánchez-Margalet, Adoración Nieto-García, Emilio Alba Conejo, Noelia Casares Lagar, José Ibáñez Martínez

{"title":"New insights into the role of the immune microenvironment in breast carcinoma.","authors":"Luis de la Cruz-Merino, Antonio Barco-Sánchez, Fernando Henao Carrasco, Esteban Nogales Fernández, Ana Vallejo Benítez, Javier Brugal Molina, Antonio Martínez Peinado, Ana Grueso López, Manuel Ruiz Borrego, Manuel Codes Manuel de Villena, Víctor Sánchez-Margalet, Adoración Nieto-García, Emilio Alba Conejo, Noelia Casares Lagar, José Ibáñez Martínez","doi":"10.1155/2013/785317","DOIUrl":"https://doi.org/10.1155/2013/785317","url":null,"abstract":"Recently, immune edition has been recognized as a new hallmark of cancer. In this respect, some clinical trials in breast cancer have reported imppressive outcomes related to laboratory immune findings, especially in the neoadjuvant and metastatic setting. Infiltration by tumor infiltrating lymphocytes (TIL) and their subtypes, tumor-associated macrophages (TAM) and myeloid-derived suppressive cells (MDSC) seem bona fide prognostic and even predictive biomarkers, that will eventually be incorporated into diagnostic and therapeutic algorithms of breast cancer. In addition, the complex interaction of costimulatory and coinhibitory molecules on the immune synapse and the different signals that they may exert represent another exciting field to explore. In this review we try to summarize and elucidate these new concepts and knowledge from a translational perspective focusing on breast cancer, paying special attention to those aspects that might have more significance in clinical practice and could be useful to design successful therapeutic strategies in the future. ","PeriodicalId":55254,"journal":{"name":"Clinical & Developmental Immunology","volume":"2013 ","pages":"785317"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/785317","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31199462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 73

RANKL cytokine: from pioneer of the osteoimmunology era to cure for a rare disease. RANKL细胞因子:从骨免疫学时代的先驱到罕见疾病的治疗。

Clinical & Developmental Immunology Pub Date : 2013-01-01 Epub Date: 2013-05-15 DOI: 10.1155/2013/412768

Nadia Lo Iacono, Alessandra Pangrazio, Mario Abinun, Robbert Bredius, Marco Zecca, Harry C Blair, Paolo Vezzoni, Anna Villa, Cristina Sobacchi

{"title":"RANKL cytokine: from pioneer of the osteoimmunology era to cure for a rare disease.","authors":"Nadia Lo Iacono, Alessandra Pangrazio, Mario Abinun, Robbert Bredius, Marco Zecca, Harry C Blair, Paolo Vezzoni, Anna Villa, Cristina Sobacchi","doi":"10.1155/2013/412768","DOIUrl":"https://doi.org/10.1155/2013/412768","url":null,"abstract":"Since its identification, the RANKL cytokine has been demonstrated to play a crucial role in bone homeostasis and lymphoid tissue organization. Genetic defects impairing its function lead to a peculiar form of autosomal recessive osteopetrosis (ARO), a rare genetic bone disease presenting early in life and characterized by increased bone density due to failure in bone resorption by the osteoclasts. Hematopoietic stem cell transplantation (HSCT) is the only option for the majority of patients affected by this life-threatening disease. However, the RANKL-dependent ARO does not gain any benefit from this approach, because the genetic defect is not intrinsic to the hematopoietic osteoclast lineage but rather to the mesenchymal one. Of note, we recently provided proof of concept of the efficacy of a pharmacological RANKL-based therapy to cure this form of the disease. Here we provide an overview of the diverse roles of RANKL in the bone and immune systems and review the clinical features of RANKL-deficient ARO patients and the results of our preclinical studies. We emphasize that these patients present a continuous worsening of the disease in the absence of a cure and strongly wish that the therapy we propose will be further developed.","PeriodicalId":55254,"journal":{"name":"Clinical & Developmental Immunology","volume":"2013 ","pages":"412768"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/412768","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31502450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 32

TRAF1-C5 affects quality of life in patients with primary biliary cirrhosis. TRAF1-C5影响原发性胆汁性肝硬化患者的生活质量。

Clinical & Developmental Immunology Pub Date : 2013-01-01 Epub Date: 2013-04-28 DOI: 10.1155/2013/510547

Joanna Raszeja-Wyszomirska, Ewa Wunsch, Agnieszka Kempinska-Podhorodecka, Daniel S Smyk, Dimitrios P Bogdanos, Malgorzata Milkiewicz, Piotr Milkiewicz

{"title":"TRAF1-C5 affects quality of life in patients with primary biliary cirrhosis.","authors":"Joanna Raszeja-Wyszomirska, Ewa Wunsch, Agnieszka Kempinska-Podhorodecka, Daniel S Smyk, Dimitrios P Bogdanos, Malgorzata Milkiewicz, Piotr Milkiewicz","doi":"10.1155/2013/510547","DOIUrl":"https://doi.org/10.1155/2013/510547","url":null,"abstract":"Background: Previous studies reported associations between specific alleles of non-HLA immunoregulatory genes and higher fatigue scores in patients with primary biliary cirrhosis (PBC).Aim: To study the relationship between variables of health-related quality of life (HRQoL) and single nucleotide polymorphisms of TRAF1-C5, a member of the tumor necrosis factor receptor family.Patients and methods: TRAF1-C5 gene polymorphisms, rs2900180 and rs3761847, were analysed in 120 Caucasian PBCs. The HRQoL was assessed with SF-36, PBC-40, and PBC-27 questionnaires.Results: We found a negative association between TT genotype of rs2900180 and SF-36's domains vitality (P < 0.05), mental health (P < 0.05), and mental component summary score (P < 0.05). GG homozygotes of rs3761847 had lower vitality (P < 0.05), mental health (P < 0.05), mental component summary score (P < 0.05) and impairment of social functioning (P < 0.01). Allelic analysis has shown that T allele of rs2900180 and G allele of rs3761847 related to SF-36's vitality (P < 0.05 and P < 0.01), social functioning (P < 0.05 and P < 0.05), mental health (P < 0.01 and P < 0.05), and mental component summary score (P < 0.01 and P < 0.05), respectively. Genotyping and allelic analysis did not reveal correlation with PBC-40 and PBC-27 domains.Conclusion: The association between rs2900180 and rs3761847 polymorphisms and HRQoL variables indicates that TRAF1 is involved in the induction of impaired QoL in PBC.","PeriodicalId":55254,"journal":{"name":"Clinical & Developmental Immunology","volume":"2013 ","pages":"510547"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/510547","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31552042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

The benefits and detriments of macrophages/microglia in models of multiple sclerosis. 巨噬细胞/小胶质细胞在多发性硬化症模型中的利与弊。

Clinical & Developmental Immunology Pub Date : 2013-01-01 Epub Date: 2013-06-12 DOI: 10.1155/2013/948976

Khalil S Rawji, V Wee Yong

{"title":"The benefits and detriments of macrophages/microglia in models of multiple sclerosis.","authors":"Khalil S Rawji, V Wee Yong","doi":"10.1155/2013/948976","DOIUrl":"https://doi.org/10.1155/2013/948976","url":null,"abstract":"The central nervous system (CNS) is immune privileged with access to leukocytes being limited. In several neurological diseases, however, infiltration of immune cells from the periphery into the CNS is largely observed and accounts for the increased representation of macrophages within the CNS. In addition to extensive leukocyte infiltration, the activation of microglia is frequently observed. The functions of activated macrophages/microglia within the CNS are complex. In three animal models of multiple sclerosis (MS), namely, experimental autoimmune encephalomyelitis (EAE) and cuprizone- and lysolecithin-induced demyelination, there have been many reported detrimental roles associated with the involvement of macrophages and microglia. Such detriments include toxicity to neurons and oligodendrocyte precursor cells, release of proteases, release of inflammatory cytokines and free radicals, and recruitment and reactivation of T lymphocytes in the CNS. Many studies, however, have also reported beneficial roles of macrophages/microglia, including axon regenerative roles, assistance in promoting remyelination, clearance of inhibitory myelin debris, and the release of neurotrophic factors. This review will discuss the evidence supporting the detrimental and beneficial aspects of macrophages/microglia in models of MS, provide a discussion of the mechanisms underlying the dichotomous roles, and describe a few therapies in clinical use in MS that impinge on the activity of macrophages/microglia. ","PeriodicalId":55254,"journal":{"name":"Clinical & Developmental Immunology","volume":"2013 ","pages":"948976"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/948976","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31568446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 196

Th17 cells in immunity and autoimmunity. 免疫和自身免疫中的Th17细胞。

Clinical & Developmental Immunology Pub Date : 2013-01-01 Epub Date: 2013-12-26 DOI: 10.1155/2013/986789

Simone Kennedy Bedoya, Brandon Lam, Kenneth Lau, Joseph Larkin

引用次数: 152

Cell-mediated immune responses in paraneoplastic neurological syndromes. 副肿瘤神经综合征中细胞介导的免疫反应。

Clinical & Developmental Immunology Pub Date : 2013-01-01 Epub Date: 2013-12-30 DOI: 10.1155/2013/630602

Mikolaj Piotr Zaborowski, Slawomir Michalak

{"title":"Cell-mediated immune responses in paraneoplastic neurological syndromes.","authors":"Mikolaj Piotr Zaborowski, Slawomir Michalak","doi":"10.1155/2013/630602","DOIUrl":"https://doi.org/10.1155/2013/630602","url":null,"abstract":"Paraneoplastic neurological syndromes (PNS) are disorders of the nervous system that are associated with remote effects of malignancy. PNS are considered to have an autoimmune pathology. It has been suggested that immune antitumor responses are the origin of improved outcome in PNS. We describe cell-mediated immune responses in PNS and their potential contributions to antitumor reactions. Experimental and neuropathological studies have revealed infiltrates in nervous tissue and disturbances in lymphocyte populations in both cerebrospinal fluid and peripheral blood. A predominance of cytotoxic T lymphocytes (CTLs) over T helper cells has been observed. CTLs can be specifically aggressive against antigens shared by tumors and nervous tissue. Based on genetic studies, a common clonal origin of lymphocytes from blood, tumor, and nervous tissue is suggested. Suppressive regulatory T (Treg) lymphocytes are dysfunctional. Simultaneously, in tumor tissue, more intense cell-mediated immune responses are observed, which often coincide with a less aggressive course of neoplastic disease. An increased titer of onconeural antibodies is also related to better prognoses in patients without PNS. The evaluation of onconeural and neuronal surface antibodies was recommended in current guidelines. The link between PNS emergence and antitumor responses may result from more active CTLs and less functional Treg lymphocytes. ","PeriodicalId":55254,"journal":{"name":"Clinical & Developmental Immunology","volume":"2013 ","pages":"630602"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/630602","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32157921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 27

Detection of antiphosphatidylserine/prothrombin antibodies and their potential diagnostic value. 抗磷脂酰丝氨酸/凝血酶原抗体的检测及其潜在诊断价值。

Clinical & Developmental Immunology Pub Date : 2013-01-01 Epub Date: 2013-09-26 DOI: 10.1155/2013/724592

Polona Žigon, Saša Čučnik, Aleš Ambrožič, Tanja Kveder, Snežna Sodin Šemrl, Blaž Rozman, Borut Božič

{"title":"Detection of antiphosphatidylserine/prothrombin antibodies and their potential diagnostic value.","authors":"Polona Žigon, Saša Čučnik, Aleš Ambrožič, Tanja Kveder, Snežna Sodin Šemrl, Blaž Rozman, Borut Božič","doi":"10.1155/2013/724592","DOIUrl":"https://doi.org/10.1155/2013/724592","url":null,"abstract":"Antiprothrombin antibodies, measured with phosphatidylserine/prothrombin complex (aPS/PT) ELISA, have been reported to be associated with antiphospholipid syndrome (APS). They are currently being evaluated as a potential classification criterion for this autoimmune disease, characterized by thromboses and obstetric complications. Given the present lack of clinically useful tests for the accurate diagnosis of APS, we aimed to evaluate in-house and commercial assays for determination of aPS/PT as a potential serological marker for APS. We screened 156 patients with systemic autoimmune diseases for antibodies against PS/PT, β₂-glycoprotein I, cardiolipin and for lupus anticoagulant activity. We demonstrated a high degree of concordance between the concentrations of aPS/PT measured with the in-house and commercial assays. Both assays performed comparably relating to the clinical manifestations of APS, such as arterial and venous thromboses and obstetric complications. IgG aPS/PT represented the strongest independent risk factor for the presence of obstetric complications, among all tested aPL. Both IgG and IgM aPS/PT were associated with venous thrombosis, but not with arterial thrombosis. Most importantly, the association between the presence of IgG/IgM aPS/PT and lupus anticoagulant activity was highly significant. Taken together, aPS/PT antibodies detected with the in-house or commercial ELISA represent a promising serological marker for APS and its subsets.","PeriodicalId":55254,"journal":{"name":"Clinical & Developmental Immunology","volume":"2013 ","pages":"724592"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/724592","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31830310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 36

Lymphoid progenitor cells from childhood acute lymphoblastic leukemia are functionally deficient and express high levels of the transcriptional repressor Gfi-1. 来自儿童急性淋巴母细胞白血病的淋巴样祖细胞功能缺陷，表达高水平的转录抑制因子Gfi-1。

Clinical & Developmental Immunology Pub Date : 2013-01-01 Epub Date: 2013-10-03 DOI: 10.1155/2013/349067

Jessica Purizaca, Adriana Contreras-Quiroz, Elisa Dorantes-Acosta, Eduardo Vadillo, Lourdes Arriaga-Pizano, Silvestre Fuentes-Figueroa, Horacio Villagomez-Barragán, Patricia Flores-Guzmán, Antonio Alvarado-Moreno, Hector Mayani, Isaura Meza, Rosaura Hernandez, Sara Huerta-Yepez, Rosana Pelayo

{"title":"Lymphoid progenitor cells from childhood acute lymphoblastic leukemia are functionally deficient and express high levels of the transcriptional repressor Gfi-1.","authors":"Jessica Purizaca, Adriana Contreras-Quiroz, Elisa Dorantes-Acosta, Eduardo Vadillo, Lourdes Arriaga-Pizano, Silvestre Fuentes-Figueroa, Horacio Villagomez-Barragán, Patricia Flores-Guzmán, Antonio Alvarado-Moreno, Hector Mayani, Isaura Meza, Rosaura Hernandez, Sara Huerta-Yepez, Rosana Pelayo","doi":"10.1155/2013/349067","DOIUrl":"https://doi.org/10.1155/2013/349067","url":null,"abstract":"Acute lymphoblastic leukemia (ALL) is the most frequent malignancy of childhood. Substantial progress on understanding the cell hierarchy within ALL bone marrow (BM) has been recorded in the last few years, suggesting that both primitive cell fractions and committed lymphoid blasts with immature stem cell-like properties contain leukemia-initiating cells. Nevertheless, the biology of the early progenitors that initiate the lymphoid program remains elusive. The aim of the present study was to investigate the ability of lymphoid progenitors from B-cell precursor ALL BM to proliferate and undergo multilineage differentiation. By phenotype analyses, in vitro proliferation assays, and controlled culture systems, the lymphoid differentiation potentials were evaluated in BM primitive populations from B-cell precursor ALL pediatric patients. When compared to their normal counterparts, functional stem and progenitor cell contents were substantially reduced in ALL BM. Moreover, neither B nor NK or dendritic lymphoid-cell populations developed recurrently from highly purified ALL-lymphoid progenitors, and their proliferation and cell cycle status revealed limited proliferative capacity. Interestingly, a number of quiescence-associated transcription factors were elevated, including the transcriptional repressor Gfi-1, which was highly expressed in primitive CD34⁺ cells. Together, our findings reveal major functional defects in the primitive hematopoietic component of ALL BM. A possible contribution of high levels of Gfi-1 expression in the regulation of the stem/progenitor cell biology is suggested.","PeriodicalId":55254,"journal":{"name":"Clinical & Developmental Immunology","volume":"2013 ","pages":"349067"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/349067","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31839823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17