Clinical & Developmental Immunology最新文献_第9页

The controversial role of microglia in malignant gliomas. 小胶质细胞在恶性胶质瘤中有争议的作用。

Clinical & Developmental Immunology Pub Date : 2013-01-01 Epub Date: 2013-07-24 DOI: 10.1155/2013/285246

Jun Wei, Konrad Gabrusiewicz, Amy Heimberger

引用次数: 182

Costimulatory pathways: physiology and potential therapeutic manipulation in systemic lupus erythematosus. 共刺激途径:系统性红斑狼疮的生理学和潜在的治疗手法。

Clinical & Developmental Immunology Pub Date : 2013-01-01 Epub Date: 2013-07-29 DOI: 10.1155/2013/245928

Nien Yee Kow, Anselm Mak

{"title":"Costimulatory pathways: physiology and potential therapeutic manipulation in systemic lupus erythematosus.","authors":"Nien Yee Kow, Anselm Mak","doi":"10.1155/2013/245928","DOIUrl":"https://doi.org/10.1155/2013/245928","url":null,"abstract":"System lupus erythematosus (SLE) is an immune-complex-mediated autoimmune condition with protean immunological and clinical manifestation. While SLE has classically been advocated as a B-cell or T-cell disease, it is unlikely that a particular cell type is more pathologically predominant than the others. Indeed, SLE is characterized by an orchestrated interplay amongst different types of immunopathologically important cells participating in both innate and adaptive immunity including the dendritic cells, macrophages, neutrophils and lymphocytes, as well as traditional nonimmune cells such as endothelial, epithelial, and renal tubular cells. Amongst the antigen-presenting cells and lymphocytes, and between lymphocytes, the costimulatory pathways which involve mutual exchange of information and signalling play an essential role in initiating, perpetuating, and, eventually, attenuating the proinflammatory immune response. In this review, advances in the knowledge of established costimulatory pathways such as CD28/CTLA-4-CD80/86, ICOS-B7RP1, CD70-CD27, OX40-OX40L, and CD137-CD137L as well as their potential roles involved in the pathophysiology of SLE will be discussed. Attempts to target these costimulatory pathways therapeutically will pave more potential treatment avenues for patients with SLE. Preliminary laboratory and clinical evidence of the potential therapeutic value of manipulating these costimulatory pathways in SLE will also be discussed in this review.","PeriodicalId":55254,"journal":{"name":"Clinical & Developmental Immunology","volume":"2013 ","pages":"245928"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/245928","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31703021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 45

The use of (18)F-FDG-PET/CT for diagnosis and treatment monitoring of inflammatory and infectious diseases. (18)F-FDG-PET/CT在炎性和感染性疾病诊断和治疗监测中的应用

Clinical & Developmental Immunology Pub Date : 2013-01-01 Epub Date: 2013-08-21 DOI: 10.1155/2013/623036

Andor W J M Glaudemans, Erik F J de Vries, Filippo Galli, Rudi A J O Dierckx, Riemer H J A Slart, Alberto Signore

引用次数: 173

Autoantibodies and the immune hypothesis in psychotic brain diseases: challenges and perspectives. 精神病性脑疾病的自身抗体和免疫假说:挑战和观点。

Clinical & Developmental Immunology Pub Date : 2013-01-01 Epub Date: 2013-08-24 DOI: 10.1155/2013/257184

Karrnan Pathmanandavel, Jean Starling, Russell C Dale, Fabienne Brilot

{"title":"Autoantibodies and the immune hypothesis in psychotic brain diseases: challenges and perspectives.","authors":"Karrnan Pathmanandavel, Jean Starling, Russell C Dale, Fabienne Brilot","doi":"10.1155/2013/257184","DOIUrl":"10.1155/2013/257184","url":null,"abstract":"The pathophysiology of psychosis is poorly understood, with both the cognitive and cellular changes of the disease process remaining mysterious. There is a growing body of evidence that points to dysfunction of the immune system in a subgroup of patients with psychosis. Recently, autoantibodies directed against neuronal cell surface targets have been identified in a range of syndromes that feature psychosis. Of interest is the detection of autoantibodies in patients whose presentations are purely psychiatric, such as those suffering from schizophrenia. Autoantibodies have been identified in a minority of patients, suggesting that antibody-associated mechanisms of psychiatric disease likely only account for a subgroup of cases. Recent work has been based on the application of cell-based assays-a paradigm whose strength lies in the expression of putative antigens in their natural conformation on the surface of live cells. The responsiveness of some of these newly described clinical syndromes to immune therapy supports the hypothesis that antibody-associated mechanisms play a role in the pathogenesis of psychotic disease. However, further investigation is required to establish the scope and significance of antibody pathology in psychosis. The identification of a subgroup of patients with antibody-mediated disease would promise more effective approaches to the treatment of these high-morbidity conditions.","PeriodicalId":55254,"journal":{"name":"Clinical & Developmental Immunology","volume":"2013 ","pages":"257184"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/257184","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31755617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 27

Ex vivo restimulation of human PBMC expands a CD3+CD4-CD8- γδ+ T cell population that can confound the evaluation of CD4 and CD8 T cell responses to vaccination. 体外再刺激人PBMC扩大CD3+CD4-CD8- γδ+ T细胞群，这可能混淆CD4和CD8 T细胞对疫苗应答的评估。

Clinical & Developmental Immunology Pub Date : 2013-01-01 Epub Date: 2013-08-26 DOI: 10.1155/2013/186420

B J Sedgmen, L Papalia, L Wang, A R Dyson, H A McCallum, C M Simson, M J Pearse, E Maraskovsky, D Hung, P P Eomois, G Hartel, M J Barnden, S P Rockman

{"title":"Ex vivo restimulation of human PBMC expands a CD3+CD4-CD8- γδ+ T cell population that can confound the evaluation of CD4 and CD8 T cell responses to vaccination.","authors":"B J Sedgmen, L Papalia, L Wang, A R Dyson, H A McCallum, C M Simson, M J Pearse, E Maraskovsky, D Hung, P P Eomois, G Hartel, M J Barnden, S P Rockman","doi":"10.1155/2013/186420","DOIUrl":"https://doi.org/10.1155/2013/186420","url":null,"abstract":"The measurement of vaccine-induced humoral and CD4(+) and CD8(+) cellular immune responses represents an important correlate of vaccine efficacy. Accurate and reliable assays evaluating such responses are therefore critical during the clinical development phase of vaccines. T cells play a pivotal role both in coordinating the adaptive and innate immune responses and as effectors. During the assessment of cell-mediated immunity (CMI) in subjects participating in a large-scale influenza vaccine trial, we identified the expansion of an IFN-γ-producing CD3(+)CD4(-)CD8(-) γδ (+) T cell population in the peripheral blood of 90/610 (15%) healthy subjects. The appearance of CD3(+)CD4(-)CD8(-) γδ (+) T cells in the blood of subjects was transient and found to be independent of the study cohort, vaccine group, subject gender and ethnicity, and ex vivo restimulation conditions. Although the function of this population and relevance to vaccination are unclear, their inclusion in the total vaccine-specific T-cell response has the potential to confound data interpretation. It is thus recommended that when evaluating the induction of IFN-γ-producing CD4(+) and CD8(+) immune responses following vaccination, the CD3(+)CD4(-)CD8(-) γδ (+) T cells are either excluded or separately enumerated from the overall frequency determination. ","PeriodicalId":55254,"journal":{"name":"Clinical & Developmental Immunology","volume":"2013 ","pages":"186420"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/186420","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31758820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Rapamycin ameliorates proteinuria and restores nephrin and podocin expression in experimental membranous nephropathy. 雷帕霉素改善实验性膜性肾病的蛋白尿并恢复肾素和足素的表达。

Clinical & Developmental Immunology Pub Date : 2013-01-01 Epub Date: 2013-08-31 DOI: 10.1155/2013/941893

Stavros Stratakis, Kostas Stylianou, Ioannis Petrakis, Vasiliki Mavroeidi, Rafaela Poulidaki, Christina Petra, Demitrios Moisiadis, Spyros Stratigis, Eleftheria Vardaki, Lydia Nakopoulou, Eugene Daphnis

{"title":"Rapamycin ameliorates proteinuria and restores nephrin and podocin expression in experimental membranous nephropathy.","authors":"Stavros Stratakis, Kostas Stylianou, Ioannis Petrakis, Vasiliki Mavroeidi, Rafaela Poulidaki, Christina Petra, Demitrios Moisiadis, Spyros Stratigis, Eleftheria Vardaki, Lydia Nakopoulou, Eugene Daphnis","doi":"10.1155/2013/941893","DOIUrl":"https://doi.org/10.1155/2013/941893","url":null,"abstract":"Objective: Recent studies have shown a beneficial effect of rapamycin in passive and active Heymann Nephritis (HN). However, the mechanisms underlying this beneficial effect have not been elucidated.Methods: Passive Heymann Nephritis (PHN) was induced by a single intravenous infusion of anti-Fx1 in 12 Sprague-Dawley male rats. One week later, six of these rats were commenced on daily treatment with subcutaneous rapamycin 0.5 mgr/kg (PHN-Rapa). The remaining six rats were used as the proteinuric control group (PHN) while six more rats without PHN were given the rapamycin solvent and served as the healthy control group (HC). All rats were sacrificed at the end of the 7th week.Results: Rapamycin significantly reduced proteinuria during the autologous phase of PHN. Histological lesions were markedly improved by rapamycin. Immunofluorescence revealed attenuated deposits of autologous alloantibodies in treated rats. Untreated rats showed decreased glomerular content of both nephrin and podocin whereas rapamycin restored their expression.Conclusions: Rapamycin monotherapy significantly improves proteinuria and histological lesions in experimental membranous nephropathy. This beneficial effect may be mediated by inhibition of the alloimmune response during the autologous phase of PHN and by restoration of the normal expression of the podocyte proteins nephrin and podocin.","PeriodicalId":55254,"journal":{"name":"Clinical & Developmental Immunology","volume":"2013 ","pages":"941893"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/941893","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31760706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Sphingolipids and brain resident macrophages in neuroinflammation: an emerging aspect of nervous system pathology. 神经炎症中的磷脂和脑驻留巨噬细胞：神经系统病理学的一个新方面。

Clinical & Developmental Immunology Pub Date : 2013-01-01 Epub Date: 2013-09-02 DOI: 10.1155/2013/309302

Emma Assi, Denise Cazzato, Clara De Palma, Cristiana Perrotta, Emilio Clementi, Davide Cervia

引用次数: 0

Replication of british rheumatoid arthritis susceptibility Loci in two unrelated chinese population groups. 英国类风湿关节炎易感位点在两个无亲缘关系的中国人群中的复制。

Clinical & Developmental Immunology Pub Date : 2013-01-01 Epub Date: 2013-09-03 DOI: 10.1155/2013/891306

Hua Li, Yonghe Hu, Tao Zhang, Yang Liu, Yantang Wang, Tai Yang, Minhui Li, Qiaoli Luo, Yu Cheng, Qiang Zou

{"title":"Replication of british rheumatoid arthritis susceptibility Loci in two unrelated chinese population groups.","authors":"Hua Li, Yonghe Hu, Tao Zhang, Yang Liu, Yantang Wang, Tai Yang, Minhui Li, Qiaoli Luo, Yu Cheng, Qiang Zou","doi":"10.1155/2013/891306","DOIUrl":"https://doi.org/10.1155/2013/891306","url":null,"abstract":"Previous genome-wide association study by WTCCC identified many susceptibility loci of common autoimmune diseases in British, including rheumatoid arthritis (RA). Because of the genetic heterogeneity of RA, it is necessary to replicate these susceptibility loci in other populations. Here, three SNPs with strong RA association signal in the British were analyzed in Han Chinese, and two SNPs (rs6457617 and rs11761231) were genotyped in the test cohort firstly. The rs6457617 was significantly associated with RA in the test cohort. The individuals bearing the homozygous genotype CC had 0.39-fold risk than these bearing the wild-type genotype TT (P = 0.004, OR 0.39, [95% CI 0.21-0.74]). And the protective effect of allele C was confirmed in another validation cohort with 1514 samples (P genotye CC/TT = 5.9 × 10(-10), OR 0.34, [95% CI 0.24-0.48]). The rs6457617 can be used as a tagSNP of HLA-DQA1∗03 which encoded MHC-II α chain. Since MHC restriction is important for primary T-cells in positive selection and negative selection stages, MHC protein polymorphisms may be implicated in shaping the T-cell repertoire, including the emergence of a T-cell clone involved in the inflammatory arthritis. ","PeriodicalId":55254,"journal":{"name":"Clinical & Developmental Immunology","volume":"2013 ","pages":"891306"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/891306","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31772155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

P53 and expression of immunological markers may identify early stage thyroid tumors. P53和免疫标记物的表达可以识别早期甲状腺肿瘤。

Clinical & Developmental Immunology Pub Date : 2013-01-01 Epub Date: 2013-09-19 DOI: 10.1155/2013/846584

Marjory Alana Marcello, Elaine Cristina Morari, Lucas Leite Cunha, Aline Carolina De Nadai Silva, Dirce Maria Carraro, André Lopes Carvalho, Fernando Augusto Soares, José Vassallo, Laura Sterian Ward

{"title":"P53 and expression of immunological markers may identify early stage thyroid tumors.","authors":"Marjory Alana Marcello, Elaine Cristina Morari, Lucas Leite Cunha, Aline Carolina De Nadai Silva, Dirce Maria Carraro, André Lopes Carvalho, Fernando Augusto Soares, José Vassallo, Laura Sterian Ward","doi":"10.1155/2013/846584","DOIUrl":"https://doi.org/10.1155/2013/846584","url":null,"abstract":"Background: Besides its major role in cell proliferation, DNA repair, and apoptosis, functional p53 protein is involved in the induction of antitumor cytotoxic-T-cell activity against carcinoma cells. We aimed to investigate p53 and immune cell markers utility as diagnostic and prognostic markers of differentiated thyroid cancer (DTC).Methods: ACIS-III system was used to evaluate p53 and immune cell markers including tumor-associated macrophages (TAM); CD68 and tumor-infiltrating lymphocytes (TIL) subsets such as CD3, CD4, CD8, and CD20 in 206 thyroid carcinomas, 105 benign nodules, and 18 normal tissues. Also, TP53 was sequenced in 78 out of 164 patients with papillary thyroid carcinoma.Results: P53 expression was observed more frequently in malignant than in benign lesions (P < 0.0001) and helped discriminate follicular patterned lesions. In addition, p53 was more frequent in smaller (P = 0.0015), unique tumors (P = 0.0286), with thyroiditis (P = 0.0486) and without metastasis at diagnosis (P = 0.0201). TAM was more frequent in P53 negative tumors (P = 0.002). Infiltration of CD8+ TIL was found in 61.7% of P53 positive and 25.6% of P53 negative DTC (P < 0.001).Conclusions: We suggest that p53 and CD8+ TIL immune profile analysis might be useful in DTC.","PeriodicalId":55254,"journal":{"name":"Clinical & Developmental Immunology","volume":" ","pages":"846584"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/846584","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40276453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 24

Initial immunopathogenesis of multiple sclerosis: innate immune response. 多发性硬化的初始免疫发病机制:先天免疫反应。

Clinical & Developmental Immunology Pub Date : 2013-01-01 Epub Date: 2013-09-24 DOI: 10.1155/2013/413465

Norma Y Hernández-Pedro, Guillermo Espinosa-Ramirez, Verónica Pérez de la Cruz, Benjamín Pineda, Julio Sotelo

{"title":"Initial immunopathogenesis of multiple sclerosis: innate immune response.","authors":"Norma Y Hernández-Pedro, Guillermo Espinosa-Ramirez, Verónica Pérez de la Cruz, Benjamín Pineda, Julio Sotelo","doi":"10.1155/2013/413465","DOIUrl":"https://doi.org/10.1155/2013/413465","url":null,"abstract":"Multiple sclerosis (MS) is an inflammatory, demyelinating, and neurodegenerative disease of the central nervous system. The hallmark to MS is the demyelinated plaque, which consists of a well-demarcated hypocellular area characterized by the loss of myelin, the formation of astrocytic scars, and the mononuclear cell infiltrates concentrated in perivascular spaces composed of T cells, B lymphocytes, plasma cells, and macrophages. Activation of resident cells initiates an inflammatory cascade, leading to tissue destruction, demyelination, and neurological deficit. The immunological phenomena that lead to the activation of autoreactive T cells to myelin sheath components are the result of multiple and complex interactions between environment and genetic background conferring individual susceptibility. Within the CNS, an increase of TLR expression during MS is observed, even in the absence of any apparent microbial involvement. In the present review, we focus on the role of the innate immune system, the first line of defense of the organism, as promoter and mediator of cross reactions that generate molecular mimicry triggering the inflammatory response through an adaptive cytotoxic response in MS. ","PeriodicalId":55254,"journal":{"name":"Clinical & Developmental Immunology","volume":" ","pages":"413465"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/413465","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40277214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 86