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Current Opinion in Cardiology最新文献

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Treatment of transthyretin cardiac amyloidosis. 治疗转甲状腺素心脏淀粉样变性病。
IF 2.3 4区 医学
Current Opinion in Cardiology Pub Date : 2024-04-22 DOI: 10.1097/HCO.0000000000001156
Dimitrios Bampatsias, Abdirahman Wardhere, M. S. Maurer
{"title":"Treatment of transthyretin cardiac amyloidosis.","authors":"Dimitrios Bampatsias, Abdirahman Wardhere, M. S. Maurer","doi":"10.1097/HCO.0000000000001156","DOIUrl":"https://doi.org/10.1097/HCO.0000000000001156","url":null,"abstract":"PURPOSE OF REVIEW\u0000Tafamidis is currently the only approved disease-modifying treatment for ATTR-CM. However, there have been important developments in the treatment of ATTR-CM, as the results of two phase 3 trials were published and several other trials are in their final stages. In this review, we summarize current and future therapies for ATTR-CM.\u0000\u0000\u0000RECENT FINDINGS\u0000Recently, acoramidis, a TTR stabilizer has been proven to be effective in reducing mortality and morbidity compared to placebo in the ATTRibute-CM trial. Additionally, patisiran, an RNA silencer, preserved functional capacity and quality of life compared to placebo in the APOLLO-B trial. However, the FDA declined to approve patisiran for ATTR-CM. The results of phase 1 trial of ALXN2220, an antiamyloid antibody raise hope for reversal of myocardial damage by amyloid depletion. Phase 3 trials evaluating the efficacy of different RNA silencers, gene editing with CRISPR-Cas9, and other anti-amyloid antibodies are ongoing.\u0000\u0000\u0000SUMMARY\u0000Therapies targeting different mechanism in the pathophysiology of ATTR-CM provide new alternatives for treating patients with ATTR-CM. Future research should focus on comparing their effectiveness, the potential of combined treatment with agents from different classes and on identifying the patients who will benefit most from each class of medication.","PeriodicalId":55197,"journal":{"name":"Current Opinion in Cardiology","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140672960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recent advances in multimodal imaging in tetralogy of fallot and double outlet right ventricle. 法洛氏四联症和右心室双出口多模式成像的最新进展。
IF 2.3 4区 医学
Current Opinion in Cardiology Pub Date : 2024-04-17 DOI: 10.1097/HCO.0000000000001154
Aakansha Ajay Vir Singh, Shi-Joon Yoo, Mike Seed, Christopher Z. Lam, Israel Valverde
{"title":"Recent advances in multimodal imaging in tetralogy of fallot and double outlet right ventricle.","authors":"Aakansha Ajay Vir Singh, Shi-Joon Yoo, Mike Seed, Christopher Z. Lam, Israel Valverde","doi":"10.1097/HCO.0000000000001154","DOIUrl":"https://doi.org/10.1097/HCO.0000000000001154","url":null,"abstract":"PURPOSE OF REVIEW\u0000In the ever-evolving field of medical imaging, this review highlights significant advancements in preoperative and postoperative imaging for Tetralogy of Fallot (TOF) and double outlet right ventricle (DORV) over the past 18 months.\u0000\u0000\u0000RECENT FINDINGS\u0000This review showcases innovations in echocardiography such as 3D speckle tracking echocardiography (3DSTE) for assessing right ventricle-pulmonary artery coupling (RVPAC) and Doppler velocity reconstruction (DoVeR) for intracardiac flow fields evaluation. Furthermore, advances in assessment of cardiovascular anatomy using computed tomography (CT) improve the integration of imaging in ablation procedures. Additionally, the inclusion of cardiac magnetic resonance (CMR) parameters as risk score predictors for morbidity, and mortality and for timing of pulmonary valve replacement (PVR) indicates its significance in clinical management. The utilization of 4D flow techniques for postoperative hemodynamic assessment promises new insights into pressure mapping. Lastly, emerging technologies such as 3D printing and 3D virtual reality are expected to improve image quality and surgical confidence in preoperative planning.\u0000\u0000\u0000SUMMARY\u0000Developments in multimodality imaging in TOF and DORV are poised to shape the future of clinical practice in this field.","PeriodicalId":55197,"journal":{"name":"Current Opinion in Cardiology","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140692378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Closing the care gap: combining enhanced recovery with minimally invasive valve surgery. 缩小护理差距：将加强康复与微创瓣膜手术相结合。
IF 2.3 4区 医学
Current Opinion in Cardiology Pub Date : 2024-04-09 DOI: 10.1097/hco.0000000000001147
Alexander J Gregory, William D T Kent, Corey Adams, Rakesh C Arora
{"title":"Closing the care gap: combining enhanced recovery with minimally invasive valve surgery.","authors":"Alexander J Gregory, William D T Kent, Corey Adams, Rakesh C Arora","doi":"10.1097/hco.0000000000001147","DOIUrl":"https://doi.org/10.1097/hco.0000000000001147","url":null,"abstract":"Patients with advanced age and frailty require interventions for structural heart disease at an increasing rate. These patients typically experience higher rates of postoperative morbidity, mortality and prolonged hospital length of stay, loss of independence as well as associated increased costs to the healthcare system. Therefore, it is becoming critically important to raise awareness and develop strategies to improve clinical outcomes in the contemporary, high-risk patient population undergoing cardiacprocedures.","PeriodicalId":55197,"journal":{"name":"Current Opinion in Cardiology","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140576333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mitral annular disjunction and mitral valve prolapse extrapolating adult data to an adolescent cohort? 二尖瓣环脱节和二尖瓣脱垂将成人数据推断到青少年队列？
IF 2.3 4区 医学
Current Opinion in Cardiology Pub Date : 2024-04-09 DOI: 10.1097/hco.0000000000001141
Mitchell I Cohen, Melany B Atkins, Christopher P Jordan
{"title":"Mitral annular disjunction and mitral valve prolapse extrapolating adult data to an adolescent cohort?","authors":"Mitchell I Cohen, Melany B Atkins, Christopher P Jordan","doi":"10.1097/hco.0000000000001141","DOIUrl":"https://doi.org/10.1097/hco.0000000000001141","url":null,"abstract":"The aim of this study is to provide an update on mitral valve prolapse (MVP) and mitral annular disjunction (MAD) and who may be at risk for ventricular arrhythmias and sudden cardiac death.","PeriodicalId":55197,"journal":{"name":"Current Opinion in Cardiology","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140576823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epigenetic regulation of heart failure. 心力衰竭的表观遗传调控。
IF 2.3 4区 医学
Current Opinion in Cardiology Pub Date : 2024-04-08 DOI: 10.1097/hco.0000000000001150
Manisha Deogharia, Priyatansh Gurha
{"title":"Epigenetic regulation of heart failure.","authors":"Manisha Deogharia, Priyatansh Gurha","doi":"10.1097/hco.0000000000001150","DOIUrl":"https://doi.org/10.1097/hco.0000000000001150","url":null,"abstract":"The studies on chromatin-modifying enzymes and how they respond to different stimuli within the cell have revolutionized our understanding of epigenetics. In this review, we provide an overview of the recent studies on epigenetic mechanisms implicated in heart failure.","PeriodicalId":55197,"journal":{"name":"Current Opinion in Cardiology","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140576330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
No-touch saphenous vein: current understanding of the conduit 'less handled'. 无触点隐静脉：目前对 "少处理 "导管的理解。
IF 2.3 4区 医学
Current Opinion in Cardiology Pub Date : 2024-04-05 DOI: 10.1097/hco.0000000000001149
Mimi X Deng, Grace S Lee, Dominique Vervoort, Stephen E Fremes
{"title":"No-touch saphenous vein: current understanding of the conduit 'less handled'.","authors":"Mimi X Deng, Grace S Lee, Dominique Vervoort, Stephen E Fremes","doi":"10.1097/hco.0000000000001149","DOIUrl":"https://doi.org/10.1097/hco.0000000000001149","url":null,"abstract":"The no-touch technique is an established method to harvest the saphenous vein (NT-SV), which is the most commonly used conduit in coronary artery bypass grafting. Herein, we summarize the foundational evidence, as well as highlight recent innovations and ongoing clinical trials involving NT-SV.","PeriodicalId":55197,"journal":{"name":"Current Opinion in Cardiology","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140576402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial: Gene-based renaming of human diseases. 社论：基于基因的人类疾病重新命名。
IF 2.3 4区 医学
Current Opinion in Cardiology Pub Date : 2024-04-04 DOI: 10.1097/HCO.0000000000001123
Ali J Marian
{"title":"Editorial: Gene-based renaming of human diseases.","authors":"Ali J Marian","doi":"10.1097/HCO.0000000000001123","DOIUrl":"https://doi.org/10.1097/HCO.0000000000001123","url":null,"abstract":"","PeriodicalId":55197,"journal":{"name":"Current Opinion in Cardiology","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140745679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Controversies related to renal artery denervation and devices. 与肾动脉去神经化和设备有关的争议。
IF 2.3 4区 医学
Current Opinion in Cardiology Pub Date : 2024-04-04 DOI: 10.1097/hco.0000000000001146
Chibuike Charles Agwuegbo, Akanimo Usen Antia, Garba Rimamskep Shamaki, Tamunoinemi Bob-Manuel
{"title":"Controversies related to renal artery denervation and devices.","authors":"Chibuike Charles Agwuegbo, Akanimo Usen Antia, Garba Rimamskep Shamaki, Tamunoinemi Bob-Manuel","doi":"10.1097/hco.0000000000001146","DOIUrl":"https://doi.org/10.1097/hco.0000000000001146","url":null,"abstract":"This review article discusses the controversies, strengths, and limitations of the current literature on renal artery denervation in the management of resistant hypertension, as well as the future directions of this intervention.","PeriodicalId":55197,"journal":{"name":"Current Opinion in Cardiology","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140576398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Integration of palliative care across the spectrum of heart failure care and therapies: considerations, contemporary data, and challenges 在心力衰竭护理和治疗中整合姑息关怀：考虑因素、当代数据和挑战
IF 2.3 4区 医学
Current Opinion in Cardiology Pub Date : 2024-03-14 DOI: 10.1097/hco.0000000000001120
Sarah Chuzi, Katharine Manning
{"title":"Integration of palliative care across the spectrum of heart failure care and therapies: considerations, contemporary data, and challenges","authors":"Sarah Chuzi, Katharine Manning","doi":"10.1097/hco.0000000000001120","DOIUrl":"https://doi.org/10.1097/hco.0000000000001120","url":null,"abstract":"\u0000 \u0000 Heart failure (HF) is characterized by significant symptoms, compromised quality of life, frequent hospital admissions, and high mortality, and is therefore well suited to palliative care (PC) intervention. This review elaborates the current PC needs of patients with HF across the spectrum of disease, including patients who undergo advanced HF surgical therapies, and reviews the current data and future directions for PC integration in HF care.\u0000 \u0000 \u0000 \u0000 Patients with chronic HF, as well as those who are being evaluated for or who have undergone advanced HF surgical therapies such as left ventricular assist device or heart transplantation, have a number of PC needs, including decision-making, symptoms and quality of life, caregiver support, and end-of-life care. Available data primarily supports the use of PC interventions in chronic HF to improve quality of life and symptoms. PC skills and teams may also help address preparedness planning, adverse events, and psychosocial barriers in patients who have had HF surgeries, but more data are needed to determine association with outcomes.\u0000 \u0000 \u0000 \u0000 Patients with HF have tremendous PC needs across the spectrum of disease. Despite this, more data are needed to determine the optimal timing and structure of PC interventions in patients with chronic HF, left ventricular assist device, and heart transplantation. Future steps must be taken in clinical, research, and policy domains in order to optimize care.\u0000","PeriodicalId":55197,"journal":{"name":"Current Opinion in Cardiology","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140242863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Implementation of remote monitoring strategies to improve chronic heart failure management 实施远程监控策略，改善慢性心力衰竭管理
IF 2.3 4区 医学
Current Opinion in Cardiology Pub Date : 2024-03-12 DOI: 10.1097/hco.0000000000001119
Vinh Q. Chau, T. Imamura, N. Narang
{"title":"Implementation of remote monitoring strategies to improve chronic heart failure management","authors":"Vinh Q. Chau, T. Imamura, N. Narang","doi":"10.1097/hco.0000000000001119","DOIUrl":"https://doi.org/10.1097/hco.0000000000001119","url":null,"abstract":"\u0000 \u0000 The goal of this review is to describe the current evidence available for remote monitoring devices available for patients with chronic heart failure, and also detail practical clinical recommendations for implementing these tools in daily clinical practice.\u0000 \u0000 \u0000 \u0000 Several devices ranging from sophisticated multiparametric algorithms in defibrillators, implantable pulmonary artery pressure sensors, and wearable devices to measure thoracic impedance can be utilized as important adjunctive tools to reduce the risk of heart failure hospitalization in patients with chronic heart failure. Pulmonary artery pressure sensors provide the most granular data regarding hemodynamic status, while alerts from wearable devices for thoracic impedance and defibrillator-based algorithms increase the likelihood of worsening clinical status while also having high negative predictive value when values are within normal range.\u0000 \u0000 \u0000 \u0000 Multiple device-based monitoring strategies are available to reduce longitudinal risk in patients with chronic heart failure. Further studies are needed to best understand a practical pathway to integrate multiple signals of data for early clinical decompensation risk prediction\u0000 Video abstract: http://links.lww.com/HCO/A95.\u0000","PeriodicalId":55197,"journal":{"name":"Current Opinion in Cardiology","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140250144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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