癌症患者心脏功能障碍的代谢基础。

IF 2 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Current Opinion in Cardiology Pub Date : 2024-05-01 Epub Date: 2024-02-21 DOI:10.1097/HCO.0000000000001118

Jane C Figueiredo, Neil Adri Bhowmick, Anja Karlstaedt

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引用次数: 0

摘要

综述的目的：新陈代谢与心血管疾病之间的关系是复杂和双向的。心脏细胞必须调整代谢途径，以满足生物合成需求和能量需求，从而维持收缩功能。在癌症期间，这种平衡受到增殖的癌细胞代谢需求增加的挑战：肿瘤对全身代谢的影响超出了肿瘤微环境。脂质代谢对癌细胞增殖、代谢适应和心血管风险增加至关重要。代谢物可作为信号，为心血管肿瘤患者的诊断和预后提供洞察力。摘要：代谢过程显示了癌细胞状态与心血管重塑之间的复杂关系，具有治疗干预的潜力。

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Metabolic basis of cardiac dysfunction in cancer patients.

Purpose of review: The relationship between metabolism and cardiovascular diseases is complex and bidirectional. Cardiac cells must adapt metabolic pathways to meet biosynthetic demands and energy requirements to maintain contractile function. During cancer, this homeostasis is challenged by the increased metabolic demands of proliferating cancer cells.

Recent findings: Tumors have a systemic metabolic impact that extends beyond the tumor microenvironment. Lipid metabolism is critical to cancer cell proliferation, metabolic adaptation, and increased cardiovascular risk. Metabolites serve as signals which provide insights for diagnosis and prognosis in cardio-oncology patients.

Summary: Metabolic processes demonstrate a complex relationship between cancer cell states and cardiovascular remodeling with potential for therapeutic interventions.

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来源期刊

Current Opinion in Cardiology 医学-心血管系统

CiteScore

4.20

自引率

4.30%

发文量

审稿时长

6-12 weeks

期刊介绍： Current Opinion in Cardiology is a bimonthly publication offering a unique and wide ranging perspective on the key developments in the field. Each issue features hand-picked review articles from our team of expert editors. With fourteen disciplines published across the year – including arrhythmias, molecular genetics, HDL cholesterol and clinical trials – every issue also contains annotated reference detailing the merits of the most important papers.