{"title":"Feasibility and Safety of Using Carbon Dioxide Exclusively in Regular Endovascular Aortic Aneurysm Repair: Results of a Multicentre, Prospective, Zero Iodine Contrast Endovascular Aneurysm Repair Study.","authors":"Emiliano Chisci, Emanuele Ferrero, Michele Antonello, Luca Mezzetto, Raffaele Pulli, Giacomo Isernia, Mauro Gargiulo, Giovanni Pratesi, Domenico Angiletta, Luca Bertoglio, Sara Simongini, Simone Panci, Tommaso Lazzarotto, Lorenza Chiera, Michelangelo Ferri, Andrea Gaggiano, Simona Marrocco, Elda Chiara Colacchio, Michele Piazza, Franco Grego, Lorenzo Grosso, Gian Franco Veraldi, Aaron Thomas Fargion, Roberto Falso, Gioele Simonte, Gianbattista Parlani, Massimo Lenti, Enrico Gallitto, Chiara Mascoli, Caterina Melani, Sergio Zacà, Lucia Di Stefano, Stefano Bonardelli, Apollonia Verrengia, Stefano Michelagnoli","doi":"10.1016/j.ejvs.2024.11.011","DOIUrl":"10.1016/j.ejvs.2024.11.011","url":null,"abstract":"<p><strong>Objective: </strong>Carbon dioxide (CO<sub>2</sub>) angiography has emerged as a viable alternative to regular iodinated contrast medium (ICM) for guiding endovascular aneurysm repair (EVAR) procedures. This study aimed to evaluate the feasibility and safety of a standardised EVAR procedure using only CO<sub>2</sub> angiography.</p><p><strong>Methods: </strong>A prospective, multicentre, national study enrolled consecutive patients between January 2023 and January 2024 with asymptomatic abdominal aortic aneurysms measuring ≥ 55 mm and for whom a standard endovascular graft (instructions for use) was anatomically feasible. The study involved the use of an automatic CO<sub>2</sub> injector to standardise intra-operative imaging. A strategy comprising five standardised steps was devised to visualise a target vessel (TV) that could not be seen during the first CO<sub>2</sub> angiogram. The five steps were: (A) place the introducer closer to the TV; (B) tilt the table by 5 - 10° in the direction opposite to the TV; (C) selectively cannulate the TV; (D) cannulate the contralateral gate (only for repositionable devices); CO<sub>2</sub> angiography was repeated in steps 1 - 2; and (E) use ICM.</p><p><strong>Results: </strong>Two hundred and ninety-three patients were enrolled (10 centres), with a median age of 78 (interquartile range [IQR] 72, 83) years; 256 (87.4%) were male. The overall procedure time, fluoroscopy time, and injected CO<sub>2</sub> volume were 90 (IQR 65, 125) minutes, 15 (IQR 10, 22) minutes, and 600 (IQR 400, 800) mL, respectively. The 30 day mortality, complication, and re-intervention rates were 0.3% (n = 1), 6.8% (n = 20), and 2.4% (n = 7), respectively. CO<sub>2</sub> related adverse events were rare (1%; n = 3) and minor. A zero iodine contrast EVAR procedure was feasible in 240 (patients 81.9%). The five standardised steps were used extensively: step A, 170 procedures (58.0%); step B, 109 procedures (37.2%); step C, 21 procedures (7.2%); step D, 14 procedures (4.8%); and step E, 53 procedures (18.1%), with a median volume of 20 (IQR 10, 35) mL. Significant predictors for ICM use were aneurysm diameter > 70 mm and a lowermost renal artery positioned between 3 and 9 o'clock.</p><p><strong>Conclusion: </strong>This study demonstrated that the standardised zero iodine contrast EVAR protocol reported here is both safe and feasible and is applicable in 82% of consecutive non-selected patients. Limitations primarily arose from anatomical factors, and adjunctive standardised manoeuvres can effectively address these challenges in most cases.</p>","PeriodicalId":55160,"journal":{"name":"European Journal of Vascular and Endovascular Surgery","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142669733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Off the Shelf Percutaneous Deep Vein Arterialisation for No-Option Chronic Limb Threatening Ischaemia.","authors":"Ahmad Naga, Narayanan Thulasidasan, Hany Zayed","doi":"10.1016/j.ejvs.2024.11.015","DOIUrl":"10.1016/j.ejvs.2024.11.015","url":null,"abstract":"","PeriodicalId":55160,"journal":{"name":"European Journal of Vascular and Endovascular Surgery","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142669754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Duygu Harmankaya, Koen J Vree Egberts, Flores M Metz, Harry G M Vaassen, Sharon Slagboom-van Eeden Petersman, Marjolein Brusse-Keizer, Pum le Haen, Marco J Bruno, Bob H Geelkerken, Desiree van Noord
{"title":"Mesenteric Artery Stenosis is a Risk Factor for Anastomotic Leakage in Colorectal Surgery.","authors":"Duygu Harmankaya, Koen J Vree Egberts, Flores M Metz, Harry G M Vaassen, Sharon Slagboom-van Eeden Petersman, Marjolein Brusse-Keizer, Pum le Haen, Marco J Bruno, Bob H Geelkerken, Desiree van Noord","doi":"10.1016/j.ejvs.2024.11.013","DOIUrl":"10.1016/j.ejvs.2024.11.013","url":null,"abstract":"<p><strong>Objective: </strong>Anastomotic leakage (AL) after colorectal surgery leads to substantial morbidity and mortality. Theoretically, compromised blood flow caused by mesenteric artery (MA) stenosis may create suboptimal healing conditions at the anastomotic site, increasing susceptibility to AL. The association between MA stenosis on pre-operative computed tomography (CT) scans and AL in patients undergoing colorectal surgery was investigated.</p><p><strong>Methods: </strong>A multicentre, retrospective, frequency matched, nested 1:5 case control study was conducted in the Netherlands. For each patient with AL, five controls without AL were recruited from the same database matched for age and body mass index. Pre-operative CT scans were blindly assessed to identify MA stenosis ≥ 50% as the primary outcome and atherosclerotic burden and vascular pathology as secondary outcomes.</p><p><strong>Results: </strong>A total of 130 patients with AL and 627 matched controls without AL were included. The prevalence of stenosis ≥ 50% in the superior mesenteric artery (SMA) was higher in patients with AL compared with controls (13.8% vs. 2.2%; p < .001). Stenosis ≥ 50% in the inferior mesenteric artery (IMA) also showed a higher prevalence in patients with AL (24.6% vs. 12.1%; p < .001). Multivariate regression analysis showed a 5.9 times higher risk (95% confidence interval [CI] 2.78 - 12.60,; p < .001) of AL in patients with SMA stenosis and 2.1 times higher risk for patients with IMA stenosis (95% CI 1.11 - 3.63; p = .007). Stenosis ≥ 50% of the coeliac artery showed no association with the occurrence of AL.</p><p><strong>Conclusion: </strong>The presence of SMA or IMA stenosis ≥ 50% on pre-operative CT scans is associated with a six and two times higher odds for AL, respectively, when corrected for known risk factors for AL. Whether preventive stent placement reduces the risk of AL still needs to be investigated.</p>","PeriodicalId":55160,"journal":{"name":"European Journal of Vascular and Endovascular Surgery","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142669742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Victor Mill, Carl Magnus Wahlgren, Nuno Dias, Peter Gillgren, Anders Wanhainen, Johnny Steuer
{"title":"Long Term Outcomes of Endovascular Repair in Blunt Traumatic Aortic Injury: A Twenty Year Multicentre Follow Up Study.","authors":"Victor Mill, Carl Magnus Wahlgren, Nuno Dias, Peter Gillgren, Anders Wanhainen, Johnny Steuer","doi":"10.1016/j.ejvs.2024.10.048","DOIUrl":"https://doi.org/10.1016/j.ejvs.2024.10.048","url":null,"abstract":"<p><strong>Objective: </strong>This retrospective, multicentre, observational study analysed patients who underwent endovascular repair for blunt traumatic aortic injury at four tertiary trauma referral centres over twenty years. It aimed to determine early and long term survival, analyse aortic and device related complications, and assess the re-intervention rate after endovascular repair for blunt traumatic aortic injury.</p><p><strong>Methods: </strong>All patients treated from 1 January 2001 to 31 October 2021 were identified using local hospital registries and two national registries: the Swedish vascular registry (Swedvasc) and Swedish trauma registry (SweTrau). Patient, treatment, and follow up data were extracted from medical records and radiology data by review of congregated imaging. The report was structured according to the STROBE checklist.</p><p><strong>Results: </strong>Ninety five patients were included: 80 were male (84%), median age was 42 years (IQR 27, 64), and median follow up time was 6.1 years (IQR 0.7, 12.4). Thirty day mortality was 16% (15 of 93), 40% of these were caused by traumatic brain injury and 33% of aortic related causes. Estimated overall survival was 57% (SE 6.6) at fifteen years after index treatment. Aortic re-intervention procedures (re-stenting, coiling, or explantation) were performed in 14 of 86 (16%) patients, six of whom underwent stent graft explantation. Seven of the 14 patients (50%) who underwent aortic re-intervention presented with symptoms and six of 14 had a device related complication. All complications that required aortic re-intervention were diagnosed within 18 months after the index procedure. There was no association between injury grade and aortic re-intervention.</p><p><strong>Conclusion: </strong>Thoracic endovascular aortic repair is an effective treatment for patients with blunt traumatic aortic injury needing intervention. It carries low rates of device related complications and mortality, and the long term outcomes are acceptable. As all aortic complications requiring re-intervention were identified during the first two years after index treatment, with half of the patients reporting symptoms, future follow up protocols should be adjusted accordingly.</p>","PeriodicalId":55160,"journal":{"name":"European Journal of Vascular and Endovascular Surgery","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142640350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alex Murigu, Kitty H F Wong, Ross T Mercer, Robert J Hinchliffe, Christopher P Twine
{"title":"Reporting and Methodological Quality of Systematic Reviews Underpinning Clinical Practice Guidelines for Vascular Surgery: A Systematic Review.","authors":"Alex Murigu, Kitty H F Wong, Ross T Mercer, Robert J Hinchliffe, Christopher P Twine","doi":"10.1016/j.ejvs.2024.11.010","DOIUrl":"10.1016/j.ejvs.2024.11.010","url":null,"abstract":"<p><strong>Objective: </strong>Clinical practice guideline recommendations are often informed by systematic reviews. This review aimed to appraise the reporting and methodological quality of systematic reviews informing clinical practice recommendations relevant to vascular surgery.</p><p><strong>Data sources: </strong>MEDLINE and Embase.</p><p><strong>Methods: </strong>MEDLINE and Embase were searched from 1 January 2021 to 5 May 2023 for clinical practice guidelines relevant to vascular surgery. Guidelines were then screened for systematic reviews informing recommendations. The reporting and methodological quality of these systematic reviews were assessed using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 statement and Assessment of Multiple Systematic Reviews 2 (AMSTAR 2) 2017 tool. Pearson correlation and multiple regression analyses were performed to determine associations between these scores and extracted study characteristics.</p><p><strong>Results: </strong>Eleven clinical practice guidelines were obtained, containing 1 783 references informing guideline recommendations. From these, 215 systematic reviews were included for synthesis. PRISMA item completeness ranged 14 - 100%, with a mean of 63% across reviews. AMSTAR 2 item completeness ranged 2 - 95%, with a mean of 50%. Pearson correlation highlighted a statistically significant association between a review's PRISMA and AMSTAR 2 score (r = 0.85, p < .001). A more recent publication year was associated with a statistically significant increase in both scores (PRISMA coefficient 1.28, p < .001; and AMSTAR 2 coefficient 1.31, p < .001). Similarly, the presence of funding in a systematic review was shown to be statistically significantly associated with an increase in both PRISMA and AMSTAR 2 scores (coefficient 4.93, p = .024; and coefficient 6.07, p = .019, respectively).</p><p><strong>Conclusion: </strong>Systematic reviews informing clinical practice guidelines relevant to vascular surgery were of moderate quality at best. Organisations producing clinical practice guidelines should consider funding systematic reviews to improve the quality of their recommendations.</p>","PeriodicalId":55160,"journal":{"name":"European Journal of Vascular and Endovascular Surgery","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142640353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tijmen F C M Nederstigt, Daphne van der Veen, Jan-Willem Lardenoije, Michel Reijnen
{"title":"Long Term Quality of Life, Health Status, and Residential Destination after Emergency Abdominal Aortic Aneurysm Repair.","authors":"Tijmen F C M Nederstigt, Daphne van der Veen, Jan-Willem Lardenoije, Michel Reijnen","doi":"10.1016/j.ejvs.2024.11.002","DOIUrl":"https://doi.org/10.1016/j.ejvs.2024.11.002","url":null,"abstract":"<p><strong>Objective: </strong>This retrospective, multicentre, observational cohort study aimed to assess the long term quality of life, health status, and residential destination after successful treatment of a ruptured abdominal aortic aneurysm (rAAA) treated with endovascular aneurysm repair (EVAR) or open surgical repair (OSR).</p><p><strong>Methods: </strong>Consecutive patients from five large teaching hospitals with a computed tomography confirmed rAAA from 1 January 2013 to 31 December 2018 were included. Mortality, morbidity, discharge destination, and residential destination through follow up were registered. Quality of life (QoL) was measured with the World Health Organization Quality of Life BREF questionnaire, and health status with the 5 Level EuroQoL 5 Dimension (EQ-5D-5L) questionnaire. Subgroup analyses were performed between OSR and EVAR, and age < 80 years and ≥ 80 years (octogenarians).</p><p><strong>Results: </strong>A total of 349 patients were enrolled: 168 (48.1%) were treated with EVAR. The overall 30 day, one year, and five year survival rates were 74.2% 66.0%, and 45.0%, respectively. At follow up (59.5 ± 2.1 months), the residential destination was home for 46.7% of patients. Of the patients, 48% were treated with EVAR and 49.6% with OSR (p = .48). More patients aged < 80 years (55.9%) where living at home (p < .001) at follow up. The mean QoL subscore for environment was 16.4 ± 2.1, physical health 14.5 ± 3.0, psychological health 15.5 ± 2.3, and social relationships 15.0 ± 2.6. Analyses of treatment modalities showed no statistically significant differences. Patients aged < 80 years had a higher mean physical health subscore (14.8 ± 2.8; p = .015). The median health score on the EQ-5D-5L was 72.3 ± 19.2. No difference was found between treatments. Daily activities favoured the younger cohort (p = .019).</p><p><strong>Conclusion: </strong>There was no difference regarding QoL and last residential destination in both treatment arms over the long term. Both EVAR and OSR are justified in treating rAAA. Age alone should not be a decisive argument, but elderly patients have a lower likelihood of return to their home situation. Patients should be informed that if they survive the peri-operative period, the chances are that they will experience life comparable with the general elderly population living at home.</p>","PeriodicalId":55160,"journal":{"name":"European Journal of Vascular and Endovascular Surgery","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142632887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jasper F de Kort, Tim J Mandigers, Daniele Bissacco, Maurizio Domanin, Gabriele Piffaretti, Christopher P Twine, Anders Wanhainen, Joost A van Herwaarden, Santi Trimarchi, Carlo de Vincentiis
{"title":"Outcomes of Endovascular Repair Confined to the Ascending Thoracic Aorta: A Systematic Review and Meta-Analysis.","authors":"Jasper F de Kort, Tim J Mandigers, Daniele Bissacco, Maurizio Domanin, Gabriele Piffaretti, Christopher P Twine, Anders Wanhainen, Joost A van Herwaarden, Santi Trimarchi, Carlo de Vincentiis","doi":"10.1016/j.ejvs.2024.10.049","DOIUrl":"10.1016/j.ejvs.2024.10.049","url":null,"abstract":"<p><strong>Objective: </strong>High risk, inoperable patients with ascending aortic disease are increasingly managed with thoracic endovascular aortic repair (TEVAR). The aim of this study was to assess the available literature on TEVAR confined to the ascending aorta (a-TEVAR), describing study and patient characteristics, procedural and stent graft details, and outcomes.</p><p><strong>Data sources: </strong>This was a systematic review and meta-analysis. MEDLINE, Web of Science, and Scopus were systematically searched for eligible studies reporting on outcomes after a-TEVAR (PROSPERO ID: CRD42023440826). Eligible studies reported outcomes after a-TEVAR without adjunctive supra-aortic vessel treatment.</p><p><strong>Review methods: </strong>The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement was followed. The ROBINS-I and Joanna Briggs Institute Critical Appraisal Checklist were used as quality assessment tools. A Grading of Recommendations Assessment, Development, and Evaluation (GRADE) evidence certainty analysis was performed for the main outcomes. The main outcome was death. A proportional meta-analysis was performed with a mean and 95% confidence interval (CI) for the main outcomes. All articles were included up to 1 January 2024.</p><p><strong>Results: </strong>Ninety four studies were included (19 cohort studies, 75 case reports or series), reporting on 259 patients (57.8% male). The mean age was 69.1 (95% CI 65.0 - 73.1) years and mean follow up 19.6 (95% CI 14.5 - 24.6) months. The most common comorbidity was prior cardiac or thoracic surgery (n = 191). The most frequent indications for a-TEVAR (52.1% urgent a-TEVAR) were type A aortic dissection (43.6%) and pseudoaneurysm (38.6%). The most commonly deployed stent grafts were Gore (44.5%), Cook (23.5%), and Medtronic (17.0%). The in hospital mortality rate was 7.3% (95% CI 4.7 - 11.2%), 30 day mortality rate 7.7% (95% CI 5.1 - 11.6%), and overall mortality rate 17.0% (95% CI 12.9 - 22.0%) during follow up. GRADE showed very low evidence certainty for all outcomes. Eighty eight complications were reported and there was a re-operation rate of 13.1% (95% CI 9.5 - 17.8%). In hospital and 30 day mortality rates for type A dissection were 12.4% (95% CI 7.5 - 19.7%) (n = 14) and 13.3% (95% CI 8.2 - 20.8%) (n = 15), respectively, and for pseudoaneurysm 4.0% (95% CI 1.6 - 9.8%) (n = 4) and 4.0% (95% CI 1.6 - 9.8) (n = 4), respectively.</p><p><strong>Conclusion: </strong>Despite heterogeneous literature and very low GRADE evidence certainty, a-TEVAR seems technically feasible in high risk patients. In addition, there is need for a consensus on when and how to use a-TEVAR and a need for a specific endograft for use in the ascending aorta.</p>","PeriodicalId":55160,"journal":{"name":"European Journal of Vascular and Endovascular Surgery","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142632953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Sealing Zone Failures and Durability of Endovascular Aneurysm Repair: Is it Time to Update Instructions for Use, Extend Repairs, or Change Follow Up Protocols?","authors":"Paolo Spath, Jos C van den Berg","doi":"10.1016/j.ejvs.2024.10.041","DOIUrl":"10.1016/j.ejvs.2024.10.041","url":null,"abstract":"","PeriodicalId":55160,"journal":{"name":"European Journal of Vascular and Endovascular Surgery","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142632956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kadri Eerik, Teele Kasepalu, Holger Post, Jaan Eha, Mart Kals, Jaak Kals
{"title":"Daily Remote Ischaemic Preconditioning for Intermittent Claudication: A Sham Controlled Randomised Trial.","authors":"Kadri Eerik, Teele Kasepalu, Holger Post, Jaan Eha, Mart Kals, Jaak Kals","doi":"10.1016/j.ejvs.2024.10.047","DOIUrl":"10.1016/j.ejvs.2024.10.047","url":null,"abstract":"<p><strong>Objective: </strong>Remote ischaemic preconditioning (RIPC) is a promising non-invasive strategy in which brief episodes of ischaemia and reperfusion can increase skeletal muscle resistance to ischaemia and improve mobility. This study aimed to determine whether 28 consecutive days of RIPC improved intermittent claudication (IC) symptoms compared with sham intervention.</p><p><strong>Methods: </strong>This single centre, parallel, randomised, sham controlled, double blind trial was conducted from January 2022 to April 2023 in outpatient settings. Forty two patients with stable IC Fontaine stage IIa or IIb were randomised to RIPC or sham for 28 days. The pre-specified primary outcome was a change in the maximum walking distance (MWD) after 28 days measured with a treadmill test. A > 10% change in MWD was considered clinically significant. Change in intermittent claudication distance (ICD), time to relief from claudication (TRC), and health related quality of life (HRQoL) measured with the VascuQoL-6 questionnaire were the secondary outcomes (ClinicalTrials.gov ID: NCT05084066).</p><p><strong>Results: </strong>Forty one men (RIPC = 23, sham = 18) aged 64.9 ± 7.4 years were analysed. A change of > 10% in MWD occurred in 14 patients in the RIPC group vs. eight patients in the sham group (relative risk 1.37, 95% confidence interval 0.74 - 2.25; p = .35). Changes in ICD, TRC, and HRQoL between the groups were not statistically significant.</p><p><strong>Conclusion: </strong>In this trial, RIPC did not significantly improve MWD, ICD, or TRC compared with treatment with a sham device.</p>","PeriodicalId":55160,"journal":{"name":"European Journal of Vascular and Endovascular Surgery","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142632940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Type II Endoleaks and Aneurysm Sac Growth: Can We Really Crack the Piñata?","authors":"Nelson Oliveira, José Oliveira-Pinto","doi":"10.1016/j.ejvs.2024.11.001","DOIUrl":"10.1016/j.ejvs.2024.11.001","url":null,"abstract":"","PeriodicalId":55160,"journal":{"name":"European Journal of Vascular and Endovascular Surgery","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142632958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}