{"title":"Open Conversion of a Giant Ruptured Hypogastric Aneurysm after Previous Endovascular Repair.","authors":"Lorenzo Mortola, Guido Carignano","doi":"10.1016/j.ejvs.2025.06.035","DOIUrl":"https://doi.org/10.1016/j.ejvs.2025.06.035","url":null,"abstract":"","PeriodicalId":55160,"journal":{"name":"European Journal of Vascular and Endovascular Surgery","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144369605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Luiza Máximo Cunha Pinto, Gaudêncio Espinosa Lopez
{"title":"Transaxillary Thoracic Endovascular Aneurysm Repair Using Endoanchors for Short Distal Landing Zones.","authors":"Luiza Máximo Cunha Pinto, Gaudêncio Espinosa Lopez","doi":"10.1016/j.ejvs.2025.06.039","DOIUrl":"https://doi.org/10.1016/j.ejvs.2025.06.039","url":null,"abstract":"","PeriodicalId":55160,"journal":{"name":"European Journal of Vascular and Endovascular Surgery","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144369608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Robbert B M Wiggers, Marijn H A Groen, Gert J de Borst, Emad Ebbini, Thijs Grünhagen, René van Es, Pieter A F M Doevendans, Constantijn E V B Hazenberg
{"title":"First in Human Use of Non-invasive, Robot Assisted, High Intensity Focused Ultrasound Treatment of Femoral Atherosclerosis: A Safety and Feasibility Pilot Study.","authors":"Robbert B M Wiggers, Marijn H A Groen, Gert J de Borst, Emad Ebbini, Thijs Grünhagen, René van Es, Pieter A F M Doevendans, Constantijn E V B Hazenberg","doi":"10.1016/j.ejvs.2025.06.038","DOIUrl":"https://doi.org/10.1016/j.ejvs.2025.06.038","url":null,"abstract":"<p><strong>Objective: </strong>Currently available open or endovascular revascularisation options for peripheral arterial disease (PAD) have limited long term patency rates and pose a risk of peri-operative complications. Robot assisted, high intensity focused ultrasound (HIFU) enables precise targeting of atherosclerotic plaques, creating thermal lesions with submillimetre resolution. As a non-invasive alternative, HIFU may be associated with fewer peri-operative risks. Pre-clinical studies in healthy and atherosclerotic animals have demonstrated the safety of HIFU treatment. This first in human study investigated the safety and feasibility of HIFU therapy for PAD.</p><p><strong>Methods: </strong>This first in human, single centre, non-randomised pilot study included patients with symptomatic PAD (Rutherford 2 - 4) with a common femoral and or proximal superficial femoral artery stenosis. Lesions with a calcified volume > 80% or localised at a depth of > 35 mm from the skin were excluded. Included patients were treated under sedation with a dual mode ultrasound array (DMUA) system connected to a robotic arm to precisely deliver imaging guided HIFU to the atherosclerotic plaque. Primary outcomes were: the major complication rate, defined as the composite of any complication requiring re-intervention, amputation, or death and adjudicated by two independent medical monitors; and technical feasibility, defined as successful targeting of the complete lesion. Secondary outcomes included any other procedure related complications, clinical endpoints such as ankle brachial index, and imaging parameters.</p><p><strong>Results: </strong>Between June 2019 and April 2024, 232 limbs in 205 patients were screened. Twelve patients with unilateral lesions underwent HIFU treatment by the same team. The mean treatment time was 113 ± 28.2 minutes, and technical success was achieved in all patients. No major complications or other procedure related complications occurred within 30 days post-procedure or during three months of follow up. No clear differences were observed throughout follow up relative to baseline for the secondary outcomes.</p><p><strong>Conclusion: </strong>HIFU treatment using a DMUA transducer appears safe and feasible for the treatment of selected patients with PAD localised in the femoral artery.</p>","PeriodicalId":55160,"journal":{"name":"European Journal of Vascular and Endovascular Surgery","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144369603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Addressing Methodological Considerations in a Prospective Study on High Sensitivity C Reactive Protein and Risk of Abdominal Aortic Aneurysm.","authors":"Aslak Bryne Håland, Linn Åldstedt Nyrønning","doi":"10.1016/j.ejvs.2025.06.042","DOIUrl":"https://doi.org/10.1016/j.ejvs.2025.06.042","url":null,"abstract":"","PeriodicalId":55160,"journal":{"name":"European Journal of Vascular and Endovascular Surgery","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144369601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Regarding Methodological Considerations and Unresolved Questions in the Association between High Sensitivity C Reactive Protein and Abdominal Aortic Aneurysm Risk.","authors":"Yimao Wu, Yalun Liang, Jintao Liang","doi":"10.1016/j.ejvs.2025.06.043","DOIUrl":"https://doi.org/10.1016/j.ejvs.2025.06.043","url":null,"abstract":"","PeriodicalId":55160,"journal":{"name":"European Journal of Vascular and Endovascular Surgery","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144369606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Why Giraffes Do Not Get Venous Leg Ulcers?","authors":"Paula O'Malley","doi":"10.1016/j.ejvs.2025.06.040","DOIUrl":"https://doi.org/10.1016/j.ejvs.2025.06.040","url":null,"abstract":"","PeriodicalId":55160,"journal":{"name":"European Journal of Vascular and Endovascular Surgery","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144369610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Daniel C Norvell, Joseph M Czerniecki, Alison W Henderson, Aaron J Baraff, Amy Y Jeon, Aaron P Turner, Rhonda Williams, Gale Tang, Joseph Webster
{"title":"AMPREDICT Mobility-4: A Novel Four Category Mobility Outcome Prediction Model for Patients Undergoing Dysvascular Amputation.","authors":"Daniel C Norvell, Joseph M Czerniecki, Alison W Henderson, Aaron J Baraff, Amy Y Jeon, Aaron P Turner, Rhonda Williams, Gale Tang, Joseph Webster","doi":"10.1016/j.ejvs.2025.06.041","DOIUrl":"https://doi.org/10.1016/j.ejvs.2025.06.041","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to create a new mobility outcome prediction model (AMPREDICT Mobility-4) which can be applied at the time a decision is made that amputation is necessary due to underlying dysvascular aetiology. It can be used to predict mobility outcome in patients undergoing transmetatarsal (TM), transtibial (TT), or transfemoral (TF) amputation.</p><p><strong>Methods: </strong>A cohort study retrospectively identified persons with lower limb amputation (LLA) through a large Veterans Affairs dataset, then prospectively enrolled participants to obtain their 12 month post-amputation self reported mobility. Seven hundred and four patients with incident unilateral TM, TT, or TF amputation secondary to diabetes and or peripheral arterial disease were identified between February 2021 and September 2022. Potential predictors incorporated factors from the following domains: prior revascularisation; amputation level; demographics; comorbidities; mental health; and health behaviour factors. The predicted mobility outcome included four functional levels: wheelchair mobility; household ambulatory mobility; basic community ambulation; and advanced community ambulation. Multinomial logistic regression was used to fit one year post-incident amputation risk prediction models. Variable selection was performed using lasso, a machine learning methodology.</p><p><strong>Results: </strong>Variable selection led to a final model of 15 predictors that successfully discriminated between all categories of mobility, except household vs. basic community mobility. The model discriminated best when comparing wheelchair mobility vs. at least some community ambulatory mobility (optimism adjusted c index = 0.71), a basic level of community mobility vs. less than a community ambulator (optimism adjusted c index = 0.70), and advanced community mobility vs. not (optimism adjusted c index = 0.73).</p><p><strong>Conclusion: </strong>The AMPREDICT Mobility-4 model predicts four categories of functional mobility at each of three LLA levels using predictors available in the electronic health record. The model can augment clinical personalised mobility outcome prediction, enhancing both surgeon and patient awareness of the consequences of amputation level on mobility, to facilitate patient/surgeon amputation level shared decision making-and assisting in setting appropriate patient outcome expectations.</p>","PeriodicalId":55160,"journal":{"name":"European Journal of Vascular and Endovascular Surgery","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144369602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}