{"title":"Off the Shelf Percutaneous Deep Vein Arterialisation for No Option Chronic Limb Threatening Ischaemia","authors":"Ahmad Naga , Narayanan Thulasidasan , Hany Zayed","doi":"10.1016/j.ejvs.2024.11.015","DOIUrl":"10.1016/j.ejvs.2024.11.015","url":null,"abstract":"","PeriodicalId":55160,"journal":{"name":"European Journal of Vascular and Endovascular Surgery","volume":"69 3","pages":"Page 508"},"PeriodicalIF":5.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142669754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"One Year on: Test Your Knowledge from March 2024","authors":"Stavros Kakkos","doi":"10.1016/j.ejvs.2025.01.002","DOIUrl":"10.1016/j.ejvs.2025.01.002","url":null,"abstract":"","PeriodicalId":55160,"journal":{"name":"European Journal of Vascular and Endovascular Surgery","volume":"69 3","pages":"Pages 509-512"},"PeriodicalIF":5.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143609320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bryan Cass MD, Courtney Hanak MD, Ryan Ellis MD, Ahmed Sorour MD, Jon Quatromoni MD, Ali Khalifeh MD, Ravi Ambani MD, Levester Kirksey MD, Patrick Vargo MD, Eric Roselli MD, Sean Lyden MD, Francis Caputo MD
{"title":"Thoracic endovascular aortic repair in connective tissue disease patients is not a definitive option","authors":"Bryan Cass MD, Courtney Hanak MD, Ryan Ellis MD, Ahmed Sorour MD, Jon Quatromoni MD, Ali Khalifeh MD, Ravi Ambani MD, Levester Kirksey MD, Patrick Vargo MD, Eric Roselli MD, Sean Lyden MD, Francis Caputo MD","doi":"10.1016/j.ejvs.2025.02.022","DOIUrl":"10.1016/j.ejvs.2025.02.022","url":null,"abstract":"","PeriodicalId":55160,"journal":{"name":"European Journal of Vascular and Endovascular Surgery","volume":"69 3","pages":"Pages e243-e244"},"PeriodicalIF":5.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143611005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Boshra Al Ibraheem MD , Tiziano Tallarita MD , Sasha A. Mansukhani MD , Mokhshan Ramachandran MD , James W. Manz MD , Jenny Lau OD , Bayan Moustafa DO , Andrew D. Calvin MD, MPH , Thomas Carmody MD , Indrani Sen MBBS
{"title":"Neuro-ophthalmic outcomes after carotid intervention for ocular symptoms","authors":"Boshra Al Ibraheem MD , Tiziano Tallarita MD , Sasha A. Mansukhani MD , Mokhshan Ramachandran MD , James W. Manz MD , Jenny Lau OD , Bayan Moustafa DO , Andrew D. Calvin MD, MPH , Thomas Carmody MD , Indrani Sen MBBS","doi":"10.1016/j.ejvs.2025.02.024","DOIUrl":"10.1016/j.ejvs.2025.02.024","url":null,"abstract":"","PeriodicalId":55160,"journal":{"name":"European Journal of Vascular and Endovascular Surgery","volume":"69 3","pages":"Pages e244-e245"},"PeriodicalIF":5.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143611007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Reply to: Social Workers in Clinical Management Pathways for Outcome Improvement of Patients with Chronic Limb Threatening Ischaemia","authors":"John S.M. Houghton, Anna Meffen, Rob D. Sayers","doi":"10.1016/j.ejvs.2024.11.358","DOIUrl":"10.1016/j.ejvs.2024.11.358","url":null,"abstract":"","PeriodicalId":55160,"journal":{"name":"European Journal of Vascular and Endovascular Surgery","volume":"69 3","pages":"Page 501"},"PeriodicalIF":5.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142787829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The New European Society for Vascular Surgery Clinical Practice Guidelines Recommendation Grading System","authors":"Christopher P. Twine, Anders Wanhainen","doi":"10.1016/j.ejvs.2024.08.013","DOIUrl":"10.1016/j.ejvs.2024.08.013","url":null,"abstract":"","PeriodicalId":55160,"journal":{"name":"European Journal of Vascular and Endovascular Surgery","volume":"69 3","pages":"Pages 345-346"},"PeriodicalIF":5.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142019656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tara A.R. van Merrienboer , Karlijn B. Rombouts , Natalija Bogunovic , Arnout Mieremet , Jorn P. Meekel , Ron Balm , Vivian de Waard , Kak K. Yeung
{"title":"Metformin Improves the Function of Abdominal Aortic Aneurysm Patient-Derived Aortic Smooth Muscle Cells","authors":"Tara A.R. van Merrienboer , Karlijn B. Rombouts , Natalija Bogunovic , Arnout Mieremet , Jorn P. Meekel , Ron Balm , Vivian de Waard , Kak K. Yeung","doi":"10.1016/j.ejvs.2024.09.022","DOIUrl":"10.1016/j.ejvs.2024.09.022","url":null,"abstract":"<div><h3>Objective</h3><div>Type 2 diabetes mellitus (T2DM) is a cardiovascular risk factor. Paradoxically, a decreased risk of abdominal aortic aneurysm (AAA) presence and growth rate is described among patients with T2DM, associated with metformin use. This study aimed to investigate the effect of metformin on AAA patient-derived aortic smooth muscle cell (SMC) function.</div></div><div><h3>Methods</h3><div>Aortic biopsies were obtained from patients with AAA (<em>n</em> = 21) and controls (<em>n</em> = 17) during surgery. The SMCs of non-pathological aortic controls, non-diabetic patients with AAA, and diabetic patients with AAA were cultured from explants and treated with or without metformin. The SMC contractility was measured upon ionomycin stimulation, as well as metabolic activity, proliferation, and migration. mRNA and protein expression of markers for contraction, metabolic activity, proliferation, and inflammation were measured.</div></div><div><h3>Results</h3><div>mRNA expression of <em>KLF4</em> and <em>GYS1</em>, genes involved in metabolic activity, differed between SMCs from non-diabetic and diabetic patients with AAA before metformin stimulation (<em>p</em> < .041). However, the effect of metformin on the various SMC functions was similar between non-diabetic and diabetic patients with AAA. Upon stimulation, metformin increased the contractility of AAA patient SMCs (<em>p</em> = .001). mRNA expression of smoothelin, a marker for the contractile phenotype, increased in SMCs of patients with AAA after treatment with metformin (<em>p</em> = .006). An increase in metabolic activity (<em>p</em> < .001) and a decrease in proliferation (<em>p</em> < .001) and migration were found in the SMCs of controls and patients with AAA with metformin. Increased mRNA expression of <em>PPARγ</em>, a nuclear receptor involved in mitochondrial biogenesis (<em>p</em> < .009), and a decrease in gene expression of <em>Ki-67</em>, a marker for proliferation (<em>p</em> < .005), were observed. Gene expression of inflammation markers <em>MCP-1</em> and <em>IL-6</em>, and protein expression of NF-κB p65 decreased after treatment with metformin in patients with AAA.</div></div><div><h3>Conclusion</h3><div>This study found that metformin increases contractility and metabolic activity, and reduces proliferation, migration, and inflammation in aortic SMCs <em>in vitro.</em></div></div>","PeriodicalId":55160,"journal":{"name":"European Journal of Vascular and Endovascular Surgery","volume":"69 3","pages":"Pages 485-495"},"PeriodicalIF":5.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142332700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Squaring the Circle: Coils Do the Trick?","authors":"Tristan R.A. Lane","doi":"10.1016/j.ejvs.2024.10.015","DOIUrl":"10.1016/j.ejvs.2024.10.015","url":null,"abstract":"","PeriodicalId":55160,"journal":{"name":"European Journal of Vascular and Endovascular Surgery","volume":"69 3","pages":"Pages 483-484"},"PeriodicalIF":5.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142481377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Eric Steinmetz , Jonathan Cottenet , Anne-Sophie Mariet , Lucas Morin , Alain Bernard , Yannick Béjot , Catherine Quantin
{"title":"Editor's Choice – Stroke and Death Following Carotid Endarterectomy or Carotid Artery Stenting: A Ten Year Nationwide Study in France","authors":"Eric Steinmetz , Jonathan Cottenet , Anne-Sophie Mariet , Lucas Morin , Alain Bernard , Yannick Béjot , Catherine Quantin","doi":"10.1016/j.ejvs.2024.10.031","DOIUrl":"10.1016/j.ejvs.2024.10.031","url":null,"abstract":"<div><h3>Objective</h3><div>This retrospective, nationwide cohort study aimed to compare peri-procedural stroke or death within 30 days of the procedure (PPSD30) in patients who underwent carotid endarterectomy (CEA) or carotid stenting (CAS).</div></div><div><h3>Methods</h3><div>This retrospective cohort study used data from the French hospital database PMSI. All patients who underwent CEA or CAS between 2010 and 2019 in France were included. Information on individual patients and hospital characteristics was retrieved. A random effects logistic regression model compared the occurrence of PPSD30 after CEA or CAS. High surgical risk was accounted for by using propensity score matching and adjusted for patient and hospital characteristics. Analyses were also stratified to consider symptomatic and asymptomatic patients separately.</div></div><div><h3>Results</h3><div>Between 2010 and 2019, 164 248 patients underwent a carotid artery procedure in France: 156 561 CEA and 7 687 CAS (including about 25% asymptomatic women and 40% high risk patients). The PPSD30 rate was 1.5% overall (<em>n</em> = 2 514 patients) (1.5% after CEA <em>vs</em>. 2.4% after CAS), 1.3% in asymptomatic patients (1.2% after CEA <em>vs</em>. 1.8% after CAS), and 3.3% in symptomatic patients (3.1% after CEA <em>vs</em>. 6.5% after CAS). After matching and adjustment, the risk of PPSD30 was statistically significantly greater in patients who underwent CAS than in patients who underwent CEA (adjusted OR [aOR] 1.4, 95% confidence interval [CI] 1.1 – 1.8 overall; aOR 1.4, 95% CI 1.1 – 1.8 in asymptomatic patients; and aOR 2.7, 95% CI 1.8 – 4.0 in symptomatic patients).</div></div><div><h3>Conclusion</h3><div>This nationwide real life study showed that CEA performed better than CAS, more markedly in symptomatic patients, but also in asymptomatic patients. Moreover, many patients received procedures that were more likely to be harmful than beneficial according to conclusions from past randomised trials (i.e., all asymptomatic women, all high surgical risk patients, and all who had undergone CAS).</div></div>","PeriodicalId":55160,"journal":{"name":"European Journal of Vascular and Endovascular Surgery","volume":"69 3","pages":"Pages 359-370"},"PeriodicalIF":5.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142568638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}