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Frontiers of Radiation Therapy and Oncology最新文献

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Delineating neck targets for intensity- modulated radiation therapy of head and neck cancer. What we learned from marginal recurrences? 头颈癌调强放射治疗颈部靶点的划定。我们从边际递归式中学到了什么?
Frontiers of Radiation Therapy and Oncology Pub Date : 2007-01-01 DOI: 10.1159/000106036
Merav Ben David, Avraham Eisbruch
{"title":"Delineating neck targets for intensity- modulated radiation therapy of head and neck cancer. What we learned from marginal recurrences?","authors":"Merav Ben David,&nbsp;Avraham Eisbruch","doi":"10.1159/000106036","DOIUrl":"https://doi.org/10.1159/000106036","url":null,"abstract":"<p><p>Delineation of the targets for intensity-modulated radiation therapy (IMRT) of the head and neck is a crucial step in treatment planning, determining the risks of marginal or out-of-field local/regional recurrences. Delineation of the gross tumor volumes needs to take into account both radiological (CT, MRI, PET) and clinical findings, discussed in this paper. In contrast, the delineation of the clinical target volumes depends solely on the physician's judgement and knowledge of the natural history and spread pattern of head and neck cancer. While much of this information exists in older literature, new information has been gained from the pattern of recurrences observed after IMRT of head and neck cancer. This review concentrates on this information and on the lessons gained from these recurrences at our institution.</p>","PeriodicalId":55140,"journal":{"name":"Frontiers of Radiation Therapy and Oncology","volume":"40 ","pages":"193-207"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000106036","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26838975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New technologies in the radiotherapy clinic. 放射治疗临床新技术。
Frontiers of Radiation Therapy and Oncology Pub Date : 2007-01-01 DOI: 10.1159/0000106025
John L. Meyer, L. Verhey, P. Xia, J. Wong
{"title":"New technologies in the radiotherapy clinic.","authors":"John L. Meyer, L. Verhey, P. Xia, J. Wong","doi":"10.1159/0000106025","DOIUrl":"https://doi.org/10.1159/0000106025","url":null,"abstract":"What are the limitations to the accuracy of our current technologies in radiation oncology? The immobilization of the patient, definition of the target, motion of the target and localization of the target are the major concerns that must be addressed. Current approaches to meet these needs have brought new technical systems with greater precision and new clinical procedures with higher expectations of practice. This text offers discussions on these issues, including advances in intensity-modulated radiotherapy planning, clinical target definition for the major tumor sites, management of organ motion, target localization and image guidance systems, and the expanding applications of high-precision treatment with stereotactic body radiotherapy.","PeriodicalId":55140,"journal":{"name":"Frontiers of Radiation Therapy and Oncology","volume":"40 1","pages":"1-17"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64391261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 19
A discussion of the clinical use of advanced technologies in head and neck radiotherapy. 先进技术在头颈部放射治疗中的临床应用探讨。
Frontiers of Radiation Therapy and Oncology Pub Date : 2007-01-01 DOI: 10.1159/000106038
J L Meyer, A Eisbruch, Q-T Le
{"title":"A discussion of the clinical use of advanced technologies in head and neck radiotherapy.","authors":"J L Meyer,&nbsp;A Eisbruch,&nbsp;Q-T Le","doi":"10.1159/000106038","DOIUrl":"https://doi.org/10.1159/000106038","url":null,"abstract":"","PeriodicalId":55140,"journal":{"name":"Frontiers of Radiation Therapy and Oncology","volume":"40 ","pages":"232-238"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000106038","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26838977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lung cancer: intensity-modulated radiation therapy, four-dimensional imaging and mobility management. 肺癌:调强放射治疗，四维成像和活动管理。
Frontiers of Radiation Therapy and Oncology Pub Date : 2007-01-01 DOI: 10.1159/000106039
Frank J Lagerwaard, Suresh Senan
{"title":"Lung cancer: intensity-modulated radiation therapy, four-dimensional imaging and mobility management.","authors":"Frank J Lagerwaard,&nbsp;Suresh Senan","doi":"10.1159/000106039","DOIUrl":"https://doi.org/10.1159/000106039","url":null,"abstract":"The use of image-guided radiotherapy (IGRT) for lung cancer improves target coverage and potentially reduces the risk of treatment-related toxicity. Four-dimensional radiotherapy (which refers to the explicit inclusion of temporal changes in anatomy during imaging) treatment planning and treatment delivery are important components of IGRT for lung cancer. Four-dimensional CT (4DCT) scanning is a major breakthrough that has transformed radiotherapy planning for lung cancer. Individualized internal target volumes can be directly obtained from these 4DCT scans, e.g. using maximum intensity projections. Color intensity projections of 4DCT scans provide temporal information on organ mobility within a single composite image. As only a minority of patients are likely to benefit from respiratory gating, patient-specific assessment of tumor mobility is essential.","PeriodicalId":55140,"journal":{"name":"Frontiers of Radiation Therapy and Oncology","volume":"40 ","pages":"239-252"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000106039","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26838978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 13
Kilovoltage volumetric imaging in the treatment room. 治疗室的千伏容积成像。
Frontiers of Radiation Therapy and Oncology Pub Date : 2007-01-01 DOI: 10.1159/000106031
D A Jaffray
{"title":"Kilovoltage volumetric imaging in the treatment room.","authors":"D A Jaffray","doi":"10.1159/000106031","DOIUrl":"https://doi.org/10.1159/000106031","url":null,"abstract":"<p><p>Flat-panel cone beam CT is maturing to a stable imaging modality. Applications are being developed for radiotherapy, volumetric diagnostic scanning, rotational angiography and mobile C-arm technologies with soft tissue imaging capabilities. Volumetric image-guided radiotherapy is technologically feasible, and has been proven clinically useful with cone beam CT, CT on rails and tomotherapy design configurations. Soft-tissue-based guidance of field placement is now possible for many sites. Evaluation of the relative merits of these technologies requires that the objective of imaging be well defined. Relevant questions include: Can the target or normal structure of interest be localized with the desired precision and accuracy? Can the patient's position be adjusted based on this information within the time constraints of the clinical workload? We must be prepared to compromise diverse clinical objectives and technical features in order to achieve systems with defined and useful functionality. These imaging technologies will lead to a better understanding of the weaknesses, and provide opportunity to reduce errors and improve technical execution of radiotherapy delivery.</p>","PeriodicalId":55140,"journal":{"name":"Frontiers of Radiation Therapy and Oncology","volume":"40 ","pages":"116-131"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000106031","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26839076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 23
Stereotactic body radiotherapy for unresectable pancreatic cancer. 立体定向放射治疗不可切除的胰腺癌。
Frontiers of Radiation Therapy and Oncology Pub Date : 2007-01-01 DOI: 10.1159/000106048
Stephanie T Chang, Karyn A Goodman, George P Yang, Albert C Koong
{"title":"Stereotactic body radiotherapy for unresectable pancreatic cancer.","authors":"Stephanie T Chang,&nbsp;Karyn A Goodman,&nbsp;George P Yang,&nbsp;Albert C Koong","doi":"10.1159/000106048","DOIUrl":"https://doi.org/10.1159/000106048","url":null,"abstract":"<p><p>Pancreatic cancer is a devastating disease with few effective treatment modalities. Recent technological advances have made possible the delivery of single-fraction stereotactic body radiotherapy (SBRT) to patients with locally advanced pancreatic tumors. This paper presents experience at Stanford University with SBRT for patients with unresectable pancreatic cancer. Pancreatic tumors of up to 100 cm3 could be treated. Patients achieved greater than 90% local control for the remainder of their lives. Currently, the standard dose for pancreatic tumors treated at this institution is 25 Gy given in a single fraction. Four-dimensional CT and PET scans have been essential for optimal treatment planning. PET-CT scanning may be a more effective method for evaluating tumor response than conventional CT scanning. Adjuvant systemic therapies could be administered in coordination with SBRT. SBRT is an effective method of treating patients resulting in excellent local control. Current research is aimed at defining the optimal method of combining this treatment with other cancer therapies.</p>","PeriodicalId":55140,"journal":{"name":"Frontiers of Radiation Therapy and Oncology","volume":"40 ","pages":"386-394"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000106048","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26840129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Partial breast irradiation. Patient selection, guidelines for treatment, and current results. 部分乳房照射。患者选择，治疗指南，和目前的结果。
Frontiers of Radiation Therapy and Oncology Pub Date : 2007-01-01 DOI: 10.1159/0000106040
Peter Y. Chen, F. Vicini
{"title":"Partial breast irradiation. Patient selection, guidelines for treatment, and current results.","authors":"Peter Y. Chen, F. Vicini","doi":"10.1159/0000106040","DOIUrl":"https://doi.org/10.1159/0000106040","url":null,"abstract":"Studies evaluating selected patients treated with partial breast irradiation (PBI) in accelerated fractionation schemes have demonstrated the equivalence of PBI with traditional whole-breast irradiation. The major advantage of PBI is the time compression of treatment down to less than 1 week compared with 6.5 weeks for whole-breast external beam treatments. Four techniques are available to deliver PBI. These include interstitial brachytherapy multicatheter systems, the Mammosite Radiation Therapy System applicator, external beam three-dimensional conformal radiation therapy and intraoperative radiation therapy. For the two brachytherapy techniques of multicatheter implantation and the Mammosite, accurate placement is achieved with image guidance via intraoperative ultrasonography, mammography, and/or CT scanning. Technologies such as image-guided cone beam CT assure accurate delivery of PBI with external beam three-dimensional conformal radiation therapy. Results of PBI show excellent control rates with mild toxicities; cosmetic outcomes are good to excellent in the vast majority of patients.","PeriodicalId":55140,"journal":{"name":"Frontiers of Radiation Therapy and Oncology","volume":"40 1","pages":"253-71"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64391469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 16
Nasopharyngeal and oropharyngeal carcinomas: target delineation, therapy delivery and stereotactic boost procedures with intensity-modulated/ image-guided radiation therapy. 鼻咽癌和口咽癌:靶点划定、治疗递送和立体定向增强程序与强度调节/图像引导放射治疗。
Frontiers of Radiation Therapy and Oncology Pub Date : 2007-01-01 DOI: 10.1159/000106037
Quynh-Thu Le
{"title":"Nasopharyngeal and oropharyngeal carcinomas: target delineation, therapy delivery and stereotactic boost procedures with intensity-modulated/ image-guided radiation therapy.","authors":"Quynh-Thu Le","doi":"10.1159/000106037","DOIUrl":"https://doi.org/10.1159/000106037","url":null,"abstract":"<p><p>Radiation therapy is a key component of the multidisciplinary treatment of nasopharyngeal and oropharyngeal carcinomas, which are ideal tumors for intensity-modulated radiation therapy (IMRT) because of their location and intimate relationship to the surrounding critical structures. Several studies have suggested that IMRT is superior to conventional radiation therapy in salivary preservation and holds promise for improved locoregional control of these tumors. Target delineation for IMRT in these tumors is complex and requires detailed knowledge of head and neck anatomy and pathways of tumor spread. This article focuses on target delineation for IMRT for oropharyngeal and nasopharyngeal carcinomas. In addition, we also present data on the use of stereotactic radiotherapy as a boost to improve local control of nasopharyngeal carcinomas.</p>","PeriodicalId":55140,"journal":{"name":"Frontiers of Radiation Therapy and Oncology","volume":"40 ","pages":"208-231"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000106037","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26838976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Partial breast irradiation. Patient selection, guidelines for treatment, and current results. 部分乳房照射。患者选择，治疗指南，和目前的结果。
Frontiers of Radiation Therapy and Oncology Pub Date : 2007-01-01 DOI: 10.1159/000106040
Peter Y Chen, Frank A Vicini
{"title":"Partial breast irradiation. Patient selection, guidelines for treatment, and current results.","authors":"Peter Y Chen,&nbsp;Frank A Vicini","doi":"10.1159/000106040","DOIUrl":"https://doi.org/10.1159/000106040","url":null,"abstract":"<p><p>Studies evaluating selected patients treated with partial breast irradiation (PBI) in accelerated fractionation schemes have demonstrated the equivalence of PBI with traditional whole-breast irradiation. The major advantage of PBI is the time compression of treatment down to less than 1 week compared with 6.5 weeks for whole-breast external beam treatments. Four techniques are available to deliver PBI. These include interstitial brachytherapy multicatheter systems, the Mammosite Radiation Therapy System applicator, external beam three-dimensional conformal radiation therapy and intraoperative radiation therapy. For the two brachytherapy techniques of multicatheter implantation and the Mammosite, accurate placement is achieved with image guidance via intraoperative ultrasonography, mammography, and/or CT scanning. Technologies such as image-guided cone beam CT assure accurate delivery of PBI with external beam three-dimensional conformal radiation therapy. Results of PBI show excellent control rates with mild toxicities; cosmetic outcomes are good to excellent in the vast majority of patients.</p>","PeriodicalId":55140,"journal":{"name":"Frontiers of Radiation Therapy and Oncology","volume":"40 ","pages":"253-271"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000106040","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26838979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
The promise of stereotactic body radiation therapy in a new era of oncology. 立体定向全身放射治疗在肿瘤学新时代的前景。
Frontiers of Radiation Therapy and Oncology Pub Date : 2007-01-01 DOI: 10.1159/000106045
Brian D Kavanagh, Karen Kelly, Madeleine Kane
{"title":"The promise of stereotactic body radiation therapy in a new era of oncology.","authors":"Brian D Kavanagh,&nbsp;Karen Kelly,&nbsp;Madeleine Kane","doi":"10.1159/000106045","DOIUrl":"https://doi.org/10.1159/000106045","url":null,"abstract":"<p><p>The fusion of state-of-the-art tumor imaging with precision radiation treatment delivery systems provides the technical platform from which stereotactic body radiation therapy (SBRT) has arisen. SBRT offers an opportunity to depart from classic radiation therapy paradigms involving many weeks of treatment toward more efficient and more potent treatment schedules in a variety of clinical settings. Here, the history of SBRT is briefly reviewed, and a projection of the anticipated role of SBRT within the context of multimodality cancer treatment regimens of the future is presented.</p>","PeriodicalId":55140,"journal":{"name":"Frontiers of Radiation Therapy and Oncology","volume":"40 ","pages":"340-351"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000106045","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26838983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
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