Frontiers of Radiation Therapy and Oncology最新文献_第7页

Stereotactic body radiotherapy for unresectable pancreatic cancer. 立体定向放射治疗不可切除的胰腺癌。

Frontiers of Radiation Therapy and Oncology Pub Date : 2007-08-06 DOI: 10.1159/0000106048

S. Chang, K. Goodman, George P. Yang, A. Koong

引用次数: 18

New technologies in the radiotherapy clinic. 放射治疗临床新技术。

Frontiers of Radiation Therapy and Oncology Pub Date : 2007-01-01 DOI: 10.1159/000106025

J L Meyer, L Verhey, P Xia, J Wong

引用次数: 0

Four-dimensional imaging and treatment planning of moving targets. 运动目标的四维成像与治疗方案。

Frontiers of Radiation Therapy and Oncology Pub Date : 2007-01-01 DOI: 10.1159/000106028

George T Y Chen, Jong H Kung, Eike Rietzel

引用次数: 17

Spinal and paraspinal lesions: the role of stereotactic body radiotherapy. 脊柱和棘旁病变:立体定向放射治疗的作用。

Frontiers of Radiation Therapy and Oncology Pub Date : 2007-01-01 DOI: 10.1159/000106050

Iris C Gibbs

引用次数: 24

New technologies for the radiotherapy of prostate cancer. A discussion of clinical treatment programs. 前列腺癌放射治疗新技术。临床治疗方案的讨论。

Frontiers of Radiation Therapy and Oncology Pub Date : 2007-01-01 DOI: 10.1159/0000106044

J. Meyer, S. Leibel, M. Roach, S. Vijayakumar

引用次数: 3

Prostate cancer: image guidance and adaptive therapy. 前列腺癌:影像引导与适应性治疗。

Frontiers of Radiation Therapy and Oncology Pub Date : 2007-01-01 DOI: 10.1159/000106043

Patrick Kupelian, John L Meyer

引用次数: 17

New technologies for the radiotherapy of prostate cancer. A discussion of clinical treatment programs. 前列腺癌放射治疗新技术。临床治疗方案的讨论。

Frontiers of Radiation Therapy and Oncology Pub Date : 2007-01-01 DOI: 10.1159/000106044

J L Meyer, S Leibel, M Roach, S Vijayakumar

引用次数: 2

Optimizing dose and fractionation for stereotactic body radiation therapy. Normal tissue and tumor control effects with large dose per fraction. 立体定向放射治疗的最佳剂量和分级。对正常组织和肿瘤的控制作用，每组分大剂量。

Frontiers of Radiation Therapy and Oncology Pub Date : 2007-01-01 DOI: 10.1159/000106046

Robert Timmerman, Michael Bastasch, Debabrata Saha, Ramzi Abdulrahman, William Hittson, Michael Story

{"title":"Optimizing dose and fractionation for stereotactic body radiation therapy. Normal tissue and tumor control effects with large dose per fraction.","authors":"Robert Timmerman, Michael Bastasch, Debabrata Saha, Ramzi Abdulrahman, William Hittson, Michael Story","doi":"10.1159/000106046","DOIUrl":"https://doi.org/10.1159/000106046","url":null,"abstract":"Stereotactic body radiation therapy (SBRT) is a potent noninvasive means of administering high-dose radiation to demarcated tumor deposits in extracranial locations. The treatments use image guidance and related treatment delivery technology for the purpose of escalating the radiation dose to the tumor itself with as little radiation dose to the surrounding normal tissue as possible. The local tumor control for SBRT has been higher than anything previously published for radiotherapy in treating typical carcinomas. In addition, the pattern, timing and severity of toxicity have been very different than what was seen with conventional radiotherapy. In this review, the clinical characteristics and outcomes of SBRT are presented in the context of their underlying mechanisms. While much of the material is unproven and speculative, it at least qualitatively searches for understanding as to the biological basis for the observed clinical effects. Hopefully, it will serve as a motivation for more sophisticated biological research into the effects of SBRT.","PeriodicalId":55140,"journal":{"name":"Frontiers of Radiation Therapy and Oncology","volume":"40 ","pages":"352-365"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000106046","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26840127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 45

Liver, renal, and retroperitoneal tumors: stereotactic radiotherapy. 肝、肾、腹膜后肿瘤:立体定向放疗。

Frontiers of Radiation Therapy and Oncology Pub Date : 2007-01-01 DOI: 10.1159/000106051

Brian D Kavanagh, Tracey E Scheftera, Peter J Wersäll

{"title":"Liver, renal, and retroperitoneal tumors: stereotactic radiotherapy.","authors":"Brian D Kavanagh, Tracey E Scheftera, Peter J Wersäll","doi":"10.1159/000106051","DOIUrl":"https://doi.org/10.1159/000106051","url":null,"abstract":"Stereotactic body radiation therapy (SBRT) is currently under active study at numerous centers for clinical application in the management of patients with primary or metastatic tumors of the liver, primary or metastatic tumors of the kidney, and selected other retroperitoneal tumors. Accurate patient positioning and tumor relocalization are essential for SBRT use in the liver and other abdominal and retroperitoneal sites, as at other tumor sites. In a phase I clinical trial at the University of Colorado, patients with liver metastases have received SBRT. Eligible patients had 1-3 discrete liver metastases and no prior radiotherapy to the liver. The aggregate tumor diameter (sum of diameters) was <6 cm. Respiratory control was used. Normal liver volume to be preserved was determined prior to therapy. Dose was prescribed to a planning target volume that included the gross tumor volume plus at least a 5-mm radial and 10-mm superior-inferior margin. SBRT was administered with 6- to 15-MV beams through either dynamic conformal arcs or a combination of multiple noncoplanar static beams. The dose was safely escalated to 60 Gy in 3 fractions. After SBRT to hepatic lesions, it is extremely difficult to radiographically evaluate tumor response within the first few months, and radiographic response analysis may require 4-6 months after SBRT. Care must be taken to avoid focal high-dose therapy to the gastrointestinal mucosa, where the maximum point dose is likely to be the major limitation rather than the mean dose. SBRT has a potential role in the management of renal cell carcinoma, either as an alternative to surgery to the primary site or as cytoreductive therapy directed toward metastatic sites, and in the management of selected retroperitoneal tumors.","PeriodicalId":55140,"journal":{"name":"Frontiers of Radiation Therapy and Oncology","volume":"40 ","pages":"415-426"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000106051","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26840132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

From new frontiers to new standards of practice: advances in radiotherapy planning and delivery. 从新的领域到新的实践标准:放射治疗计划和交付的进展。

Frontiers of Radiation Therapy and Oncology Pub Date : 2007-01-01 DOI: 10.1159/000106026

James A Purdy

{"title":"From new frontiers to new standards of practice: advances in radiotherapy planning and delivery.","authors":"James A Purdy","doi":"10.1159/000106026","DOIUrl":"https://doi.org/10.1159/000106026","url":null,"abstract":"Radiation therapy treatment planning and delivery capabilities have changed dramatically since the introduction of three-dimensional treatment planning in the 1980s and continue to change in response to the implementation of new technologies. CT simulation and three-dimensional radiation treatment planning systems have become the standard of practice in clinics around the world. Medical accelerator manufacturers have employed advanced computer technology to produce treatment planning/delivery systems capable of precise shaping of dose distributions via computer-controlled multileaf collimators, in which the beam fluence is varied optimally to achieve the plan prescription. This mode of therapy is referred to as intensity-modulated radiation therapy (IMRT), and is capable of generating extremely conformal dose distributions including concave isodose volumes that provide conformal target volume coverage and avoidance of specific sensitive normal structures. IMRT is rapidly being implemented in clinics throughout the USA. This increasing use of IMRT has focused attention on the need to better account for both intrafraction and interfraction spatial uncertainties, which has helped spur the development of treatment machines with integrated planar and volumetric advanced imaging capabilities. In addition, advances in both anatomical and functional imaging provide improved ability to define the tumor volumes. Advances in all these technologies are occurring at a record pace and again pushing the cutting-edge frontiers of radiation oncology from IMRT to what is now referred to as image-guided IMRT, or simply image-guided radiation therapy (IGRT). A brief overview is presented of these latest advancements in conformal treatment planning and treatment delivery.","PeriodicalId":55140,"journal":{"name":"Frontiers of Radiation Therapy and Oncology","volume":"40 ","pages":"18-39"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000106026","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26838585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 36