Gold Bulletin最新文献

Drug release properties of amphoteric HES/p(AETAC-co-IA) hydrogels decorated with gold nanoparticles 纳米金修饰两性HES/p（AETAC-co-IA）水凝胶的释药性能

IF 2.2 4区工程技术

Gold Bulletin Pub Date : 2023-09-16 DOI: 10.1007/s13404-023-00334-2

Merve Ilkiner, Ozgur Ozay

{"title":"Drug release properties of amphoteric HES/p(AETAC-co-IA) hydrogels decorated with gold nanoparticles","authors":"Merve Ilkiner, Ozgur Ozay","doi":"10.1007/s13404-023-00334-2","DOIUrl":"10.1007/s13404-023-00334-2","url":null,"abstract":"<div><p>In this study, amphoteric hydroxyethyl starch/p([2(acryloyloxy)ethyl]trimethylammonium chloride-co-itaconic acid (HES/p(AETAC-co-IA) hydrogels containing both cationic and anionic groups in their structure were synthesized by the redox polymerization method. The synthesized hydrogels were modified with gold nanoparticles, and nanocomposite hydrogels were obtained. The characterizations of the nanocomposite HES/p(AETAC-co-IA)@Au hydrogels prepared for biomedical applications were carried out by SEM, TEM, FT-IR, TGA, and XRD techniques and swelling tests in simulated biological environments. Hydrogels designed as drug carrier cargo materials were loaded with sodium diclofenac (NaDcF) and ibuprofen drugs, and their release properties were studied. The release mechanisms and release kinetics of the two drugs were studied. The release kinetics determined for the drug NaDcF is consistent with the Higuchi model, while the release kinetics determined for ibuprofen is consistent with the first-order model. In addition, the antibacterial and antifungal properties of the hydrogels were tested. It was found that the HES/p(AETAC-co-IA)@Au hydrogel was effective against gram-positive <i>Staphylococcus aureus</i>, gram-negative <i>Pseudomonas aeruginosa</i>, and the fungal species <i>Candida albicans</i>.</p></div>","PeriodicalId":55086,"journal":{"name":"Gold Bulletin","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2023-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41181045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Excited-state gold catalyzed activation of inert C–Cl bonds 激发态金催化惰性C–Cl键的活化

IF 2.2 4区工程技术

Gold Bulletin Pub Date : 2023-09-04 DOI: 10.1007/s13404-023-00332-4

Xiaopeng Wu, Yibin Sun, Chen Mingqi, Yeli Fan

引用次数: 0

Gold nanoparticle-based drug nanocarriers as a targeted drug delivery system platform for cancer therapeutics: a systematic review 基于金纳米粒子的药物纳米载体作为癌症治疗的靶向药物递送系统平台：系统综述

IF 2.2 4区工程技术

Gold Bulletin Pub Date : 2023-08-03 DOI: 10.1007/s13404-023-00331-5

A’liyatur Rosyidah, Supavadee Kerdtoob, Wecka Imam Yudhistyra, Asef Wildan Munfadlila

{"title":"Gold nanoparticle-based drug nanocarriers as a targeted drug delivery system platform for cancer therapeutics: a systematic review","authors":"A’liyatur Rosyidah, Supavadee Kerdtoob, Wecka Imam Yudhistyra, Asef Wildan Munfadlila","doi":"10.1007/s13404-023-00331-5","DOIUrl":"10.1007/s13404-023-00331-5","url":null,"abstract":"<div><p>Cancer was the world’s second major cause of death. Several treatments were available, including chemotherapy, radiotherapy, immunotherapy, and surgery. However, they are restricted due to their risk to normal cells, their ability to destroy the immune system, and conferring increased risk of secondary cancer development. Nanotechnology was extensively researched and used in cancer treatment because nanoparticles could play an essential role in drug delivery. Furthermore, nanoparticle drug delivery systems have been shown to help overcome cancer-related drug resistance. Gold nanoparticles have unique physical, chemical, and biological properties, making them suitable candidates for non-toxic drug carriers. Because of their nanorange size, surface modifications of gold nanoparticles could improve their stability, minimize nanoparticle aggregation, and enhance attachment to anti-cancer agents and target cells, further increasing their ability to penetrate cell membranes and reduce toxicity. This review aims to discuss the current research in targeting drug delivery for anti-cancer agents using gold nanoparticles. By conducting a literature search through the PubMed and Scopus database up to April 2022 using the term gold nanoparticles, targeted drug delivery, chemotherapy, gene therapy, and cancer, this review summarized report on the implementation of gold nanoparticles for targeted drug-delivery systems for cancer therapeutics. The targeting ligands included folic acid, aptamers, hyaluronic acid, glutathione, peptides, and antibodies. According to the findings of studies, implementing gold nanoparticles as nanocarriers significantly improves drug delivery of anti-cancer agents to cancer cells without affecting other untargeted cells. Enhanced cell uptake, increase in drug toxicity, inhibition of tumor growth, and selective drug target are also reported to be the advantages of gold nanoparticle-based targeted drug delivery carriers.</p></div>","PeriodicalId":55086,"journal":{"name":"Gold Bulletin","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2023-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41228896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to: Gold nanoparticles with amyloid-β reduce neurocell cytotoxicity for the treatment and care of Alzheimer’s disease therapy 更正：含有淀粉样蛋白-β的金纳米颗粒可降低阿尔茨海默病治疗和护理中神经细胞的细胞毒性

IF 2.2 4区工程技术

Gold Bulletin Pub Date : 2023-07-24 DOI: 10.1007/s13404-023-00330-6

Qing Hong, Xinchun Jin, Chenheng Zhou, Jiahui Shao

引用次数: 0

Gold nanoparticles with amyloid-β reduce neurocell cytotoxicity for the treatment and care of Alzheimer’s disease therapy 具有淀粉样蛋白-β的金纳米粒子降低神经细胞的细胞毒性，用于阿尔茨海默病的治疗和护理

IF 2.2 4区工程技术

Gold Bulletin Pub Date : 2023-07-02 DOI: 10.1007/s13404-023-00327-1

Qing Hong, Xinchun Jin, Chenheng Zhou, Jiahui Shao

{"title":"Gold nanoparticles with amyloid-β reduce neurocell cytotoxicity for the treatment and care of Alzheimer’s disease therapy","authors":"Qing Hong, Xinchun Jin, Chenheng Zhou, Jiahui Shao","doi":"10.1007/s13404-023-00327-1","DOIUrl":"10.1007/s13404-023-00327-1","url":null,"abstract":"<div><p>Protein oligomerization contributes to Alzheimer’s disease development (AD). A nanoparticle that can speed up the oligomerization of proteins is generally considered harmful. Gold nanoparticles (AuNPs) have been reported to be making headway in biological platforms, but they may also have the capacity to stimulate protein oligomerization. Our goal herein was to investigate the neurotoxicity and oligomerization of amyloid-β-1-42 (Aβ<sub>1-42</sub>) in the presence of AuNPs. The precipitation approach was used to create AuNPs, which were then analyzed using transmission electron microscopy (TEM), ThT, Congo red, and CD spectroscopy. The results demonstrated that the 50-nm-sized fabricated AuNPs guided acceleration in Aβ<sub>1-42</sub>. In addition, cytotoxicity studies on PC 12 cells showed that Aβ<sub>1-42</sub> with AuNPs were less toxic than untreated oligomers Aβ<sub>1-42</sub> in terms of inducing cell death, oxidative apoptosis, stress, and membrane leakage. In conclusion, our investigation sheds light on how AuNPs stimulate the development of cytotoxic oligomers by binding to proteins in Alzheimer’s disease.</p></div>","PeriodicalId":55086,"journal":{"name":"Gold Bulletin","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2023-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41229102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electrochemical sensing based on Au particle@SiO2@CQDs nanocomposites 基于Au的电化学传感particle@SiO2@CQDs纳米复合材料

IF 2.2 4区工程技术

Gold Bulletin Pub Date : 2023-06-29 DOI: 10.1007/s13404-023-00329-z

Huiqin Li, Lihua Wu, Hui Lei, Cui Deng, Fan Huang, Lijun Ren, Hongge Zhang, Weiwei Zhao, Qian Zhao

{"title":"Electrochemical sensing based on Au particle@SiO2@CQDs nanocomposites","authors":"Huiqin Li, Lihua Wu, Hui Lei, Cui Deng, Fan Huang, Lijun Ren, Hongge Zhang, Weiwei Zhao, Qian Zhao","doi":"10.1007/s13404-023-00329-z","DOIUrl":"10.1007/s13404-023-00329-z","url":null,"abstract":"<div><p>In this study, carbon quantum dots (CQDs) were first synthesized using a hydrothermal method, and then, Au@SiO<sub>2</sub> core-shell nanomaterials were synthesized using layer-by-layer assembly. CQDs were adsorbed on the surface of Au@SiO<sub>2</sub> nanoparticles through self-assembly to form Au@SiO<sub>2</sub>/CQDs nanocomposite materials. Transmission electron microscopy and X-ray diffraction were used to characterize the size, shape, element composition, and structure of nanocomposites; ultraviolet-visible absorption spectroscopy and fluorescence spectroscopy were used to analyze the optical properties of nanocomposites. The results show that Au@SiO<sub>2</sub>/CQD nanomaterials have a core-shell structure with good morphology and exhibit excellent luminescence characteristics. The electrochemical performance of nanocomposites was characterized using electrochemical means, and a hydrogen peroxide sensor was constructed for the sensitive detection of hydrogen peroxide, thus realizing the rapid and sensitive detection of hydrogen peroxide at levels as low as 0.2 mM. The electrode GCE modified with Au@SiO<sub>2</sub>/CQDs exhibits good selectivity and stability in the detection of hydrogen peroxide.</p></div>","PeriodicalId":55086,"journal":{"name":"Gold Bulletin","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2023-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41229479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Detection of Pseudomonas aeruginosa and Acinetobacter baumannii genomic DNA using gold nanoprobes 金纳米探针检测铜绿假单胞菌和鲍曼不动杆菌基因组DNA

IF 2.2 4区工程技术

Gold Bulletin Pub Date : 2023-04-24 DOI: 10.1007/s13404-023-00326-2

Marjan Bagherinajafabad, Hassan Bardania, Elham Moazamian, Seyed Sajjad Khoramrooz

{"title":"Detection of Pseudomonas aeruginosa and Acinetobacter baumannii genomic DNA using gold nanoprobes","authors":"Marjan Bagherinajafabad, Hassan Bardania, Elham Moazamian, Seyed Sajjad Khoramrooz","doi":"10.1007/s13404-023-00326-2","DOIUrl":"10.1007/s13404-023-00326-2","url":null,"abstract":"<div><p>Conventional techniques for microbial detection are time-consuming, expensive, and unsuitable. The use of nanoparticles is a valuable technique for the detection of bacterial as well as viral DNA. Gold nanoparticles (gold NPs) have been used as a promising detector for rapid and low-cost identification of microbes with high sensitivity. In this study, gold nanoparticles-probes were used to identify <i>Pseudomonas aeruginosa</i> and <i>Acinetobacter baumannii</i> genomic DNA. Thiol-functionalized probes were attached to gold NPs. Hybridization of the probe with the amplified product of Oprl and glta genes resulted in accumulation of gold nanoparticles in a cross-linked manner, caused a color change of the reaction mixture, which indicated the presence of <i>Pseudomonas aeruginosa</i> and <i>Acinetobacter baumannii</i> in the sample. To study the sensitivity, the polymerase chain reaction product with different bacteria was used, and results were compared. The gold nanoparticle-based colorimetric assay can be used as a direct and rapid method with high sensitivity for specific identification of these pathogens in clinical and food samples.</p></div>","PeriodicalId":55086,"journal":{"name":"Gold Bulletin","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2023-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s13404-023-00326-2.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41229333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Energy transfer in gold photocatalysis 金光催化中的能量转移

IF 2.2 4区工程技术

Gold Bulletin Pub Date : 2022-08-09 DOI: 10.1007/s13404-022-00321-z

Siyu Xia, Jin Xie

引用次数: 7

Post-synthesis heating, a key step to tune the LPR band of gold nanorods covered with CTAB or embedded in a silica shell 合成后加热，这是调整被CTAB覆盖或嵌入硅壳的金纳米棒的LPR带的关键步骤

IF 2.2 4区工程技术

Gold Bulletin Pub Date : 2022-08-08 DOI: 10.1007/s13404-022-00320-0

Angela Candreva, Francesco Parisi, Giuseppe Di Maio, Francesca Scarpelli, Iolinda Aiello, Nicolas Godbert, Massimo La Deda

{"title":"Post-synthesis heating, a key step to tune the LPR band of gold nanorods covered with CTAB or embedded in a silica shell","authors":"Angela Candreva, Francesco Parisi, Giuseppe Di Maio, Francesca Scarpelli, Iolinda Aiello, Nicolas Godbert, Massimo La Deda","doi":"10.1007/s13404-022-00320-0","DOIUrl":"10.1007/s13404-022-00320-0","url":null,"abstract":"<div><p>The transitioning of nanotechnology from laboratory to industrial-scale manufacturing poses various challenges in nanoparticle realization. From this perspective, beside the conventional synthetic procedure, based on the seed-mediated growth approach, a reshaping thermal strategy has been investigated to improve the control on gold nanorods aspect ratio, with the aim to point out a potential and encouraging way to better manage the scalability and reproducibility of nanoparticles. For this purpose, nanorods covered with CTAB and nanorods enclosed within a silica shell of tuned thickness have been synthesized and submitted to a post-thermal treatment at various temperatures, up to 300 °C for CTAB recovered gold nanorods (AuNR@CTAB), and up to 500 °C for silica-shell embedded gold nanorods (AuNR@SiO<sub>2</sub>). For AuNR@CTAB, through accurate temperature control, the longitudinal plasmonic band can be moved very close to the transversal one upon slight reduction of their length. Instead, for AuNR@SiO<sub>2</sub>, owing to the fully inorganic shell, a higher temperature of treatment can be reached leading to the possibility of reshaping the nanorods into spheres without the observation of any by-products.</p></div>","PeriodicalId":55086,"journal":{"name":"Gold Bulletin","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2022-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s13404-022-00320-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4326383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Enantioselective redox gold catalysis 对映选择性氧化还原金催化

IF 2.2 4区工程技术

Gold Bulletin Pub Date : 2022-08-04 DOI: 10.1007/s13404-022-00317-9

Chetan C. Chintawar, Nitin T. Patil

引用次数: 4