Gold nanoparticle-based drug nanocarriers as a targeted drug delivery system platform for cancer therapeutics: a systematic review

IF 2.2 4区 工程技术 Q2 Chemistry
A’liyatur Rosyidah, Supavadee Kerdtoob, Wecka Imam Yudhistyra, Asef Wildan Munfadlila
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引用次数: 0

Abstract

Cancer was the world’s second major cause of death. Several treatments were available, including chemotherapy, radiotherapy, immunotherapy, and surgery. However, they are restricted due to their risk to normal cells, their ability to destroy the immune system, and conferring increased risk of secondary cancer development. Nanotechnology was extensively researched and used in cancer treatment because nanoparticles could play an essential role in drug delivery. Furthermore, nanoparticle drug delivery systems have been shown to help overcome cancer-related drug resistance. Gold nanoparticles have unique physical, chemical, and biological properties, making them suitable candidates for non-toxic drug carriers. Because of their nanorange size, surface modifications of gold nanoparticles could improve their stability, minimize nanoparticle aggregation, and enhance attachment to anti-cancer agents and target cells, further increasing their ability to penetrate cell membranes and reduce toxicity. This review aims to discuss the current research in targeting drug delivery for anti-cancer agents using gold nanoparticles. By conducting a literature search through the PubMed and Scopus database up to April 2022 using the term gold nanoparticles, targeted drug delivery, chemotherapy, gene therapy, and cancer, this review summarized report on the implementation of gold nanoparticles for targeted drug-delivery systems for cancer therapeutics. The targeting ligands included folic acid, aptamers, hyaluronic acid, glutathione, peptides, and antibodies. According to the findings of studies, implementing gold nanoparticles as nanocarriers significantly improves drug delivery of anti-cancer agents to cancer cells without affecting other untargeted cells. Enhanced cell uptake, increase in drug toxicity, inhibition of tumor growth, and selective drug target are also reported to be the advantages of gold nanoparticle-based targeted drug delivery carriers.

Abstract Image

基于金纳米粒子的药物纳米载体作为癌症治疗的靶向药物递送系统平台:系统综述
癌症是世界第二大死亡原因。有几种治疗方法,包括化疗、放疗、免疫疗法和手术。然而,由于它们对正常细胞的风险、破坏免疫系统的能力以及增加继发癌症发展的风险,它们受到限制。纳米技术在癌症治疗中得到了广泛的研究和应用,因为纳米颗粒可以在药物递送中发挥重要作用。此外,纳米粒子药物递送系统已被证明有助于克服癌症相关的耐药性。金纳米粒子具有独特的物理、化学和生物特性,是无毒药物载体的合适候选者。由于其纳米范围的大小,金纳米颗粒的表面修饰可以提高其稳定性,最大限度地减少纳米颗粒的聚集,并增强对抗癌剂和靶细胞的附着,进一步提高其穿透细胞膜的能力并降低毒性。本文旨在探讨利用金纳米粒子靶向给药抗癌药物的研究现状。截至2022年4月,通过使用金纳米粒子、靶向药物递送、化疗、基因治疗和癌症等术语对PubMed和Scopus数据库进行文献检索,本综述总结了金纳米粒子用于癌症治疗靶向药物递送系统的实施报告。靶向配体包括叶酸、适体、透明质酸、谷胱甘肽、肽和抗体。根据研究结果,在不影响其他非靶向细胞的情况下,将金纳米粒子作为纳米载体显著改善抗癌剂向癌症细胞的药物递送。据报道,增强细胞摄取、增加药物毒性、抑制肿瘤生长和选择性药物靶向也是基于金纳米粒子的靶向药物递送载体的优点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Gold Bulletin
Gold Bulletin 工程技术-材料科学:综合
CiteScore
3.30
自引率
4.50%
发文量
0
审稿时长
3 months
期刊介绍: Gold Bulletin is the premier international peer reviewed journal on the latest science, technology and applications of gold. It includes papers on the latest research advances, state-of-the-art reviews, conference reports, book reviews and highlights of patents and scientific literature. Gold Bulletin does not publish manuscripts covering the snthesis of Gold nanoparticles in the presence of plant extracts or other nature-derived extracts. Gold Bulletin has been published over 40 years as a multidisciplinary journal read by chemists, physicists, engineers, metallurgists, materials scientists, biotechnologists, surface scientists, and nanotechnologists amongst others, both within industry and academia. Gold Bulletin is published in Association with the World Gold Council.
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