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Time to death after compassionate extubation in medical and neuroscience intensive care units 在内科和神经科学重症监护病房实施体恤性拔管后的死亡时间
IF 2.4 4区 医学
Heart & Lung Pub Date : 2024-10-31 DOI: 10.1016/j.hrtlng.2024.10.005
Elaine Chen MD , Nicholas Kosinski BA , Ramandeep Kaur PhD
{"title":"Time to death after compassionate extubation in medical and neuroscience intensive care units","authors":"Elaine Chen MD ,&nbsp;Nicholas Kosinski BA ,&nbsp;Ramandeep Kaur PhD","doi":"10.1016/j.hrtlng.2024.10.005","DOIUrl":"10.1016/j.hrtlng.2024.10.005","url":null,"abstract":"<div><h3>Background</h3><div>Medical ICU (MICU) and neuroscience ICU (NSICU) populations undergoing compassionate extubation (CE) may have different characteristics that affect post-procedure outcomes.</div></div><div><h3>Objectives</h3><div>To contrast clinical characteristics and evaluate time to death (TTD) following CE in MICU and NSICU populations.</div></div><div><h3>Methods</h3><div>Single-center retrospective cohort study of patients who completed CE in a MICU or NSICU in 2021. Data were obtained by manual chart abstraction. A Mann-Whitney U test was used to compare characteristics between the clinical units.</div></div><div><h3>Results</h3><div>Fifty patients were included in the study, 27 were in the MICU and 23 in the NSICU. Median age was 68 years. Patients in the MICU had a longer LOS before CE than those in the NSICU (10.0 vs. 3.0 days, p=0.001). Patients in the MICU experienced a shorter median TTD after CE than those in the NSICU (25 vs. 195 mins, p=0.004). MICU patients had a higher pre-hospital burden of illness (median CCI 6 vs 3, p=0.003), and a higher degree of organ failure at CE (median SOFA 12 vs 6, p&lt;0.001), with more severe hypoxemia (PaO2/FiO2 ratio of 149 vs 360, p&lt;0.001). Most MICU patients died of infection or cancer, compared with NSICU patients who had intracranial hemorrhage or ischemic stroke.</div></div><div><h3>Conclusion</h3><div>Patients in the NSICU underwent CE after shorter time in the ICU and survived longer afterwards than MICU patients. Patients in the MICU have a higher pre-hospital severity of illness and a higher level of organ failure at the time of CE compared with NSICU patients.</div></div>","PeriodicalId":55064,"journal":{"name":"Heart & Lung","volume":"69 ","pages":"Pages 185-191"},"PeriodicalIF":2.4,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142561378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lived experiences of persons with heart transplantation: A systematic literature review and meta-synthesis 心脏移植患者的生活经历:系统性文献综述和元综合
IF 2.4 4区 医学
Heart & Lung Pub Date : 2024-10-30 DOI: 10.1016/j.hrtlng.2024.10.013
Safae Nour El Hadi RN, MSc , Renzo Zanotti RN, PhD , Matteo Danielis RN, PhD
{"title":"Lived experiences of persons with heart transplantation: A systematic literature review and meta-synthesis","authors":"Safae Nour El Hadi RN, MSc ,&nbsp;Renzo Zanotti RN, PhD ,&nbsp;Matteo Danielis RN, PhD","doi":"10.1016/j.hrtlng.2024.10.013","DOIUrl":"10.1016/j.hrtlng.2024.10.013","url":null,"abstract":"<div><h3>Background</h3><div>Heart transplantation (HT) recipients often report improved quality of life and increased overall happiness, viewing the transplantation as a rebirth and a second chance at life. However, interpretations of normality vary among individuals. Understanding patients' and caregivers’ experiences in depth is crucial to adjust clinical care paths and avoid complications.</div></div><div><h3>Objective</h3><div>To examine the experiences of patients and caregivers after cardiac transplantation.</div></div><div><h3>Methods</h3><div>A systematic search of the literature was performed from January 1, 2013, to September 30, 2023, using the MEDLINE (PubMed), CINHAL (EBSCO), SCOPUS, Web of Science, and Embase (OVID) databases. Full-text, primary qualitative articles written in English, which reported patients’ experiences of daily life after HT, were included.</div></div><div><h3>Results</h3><div>The search yielded 5,114 articles; 13 articles that fully met the inclusion criteria were selected for extraction and synthesis. The inductive approach led to the identification of 28 codes, which were then grouped into seven categories and three themes: 1) Undergoing an emotionally charged journey, 2) Balancing personal health and social dynamics, and 3) Fostering existential reflection.</div></div><div><h3>Conclusions</h3><div>This review underscores the importance of further research and the development of a standardized assessment framework for post-HT patients, emphasizing the need to consider not just clinical factors but also psychological and personal aspects to improve outcomes and quality of life. Additionally, the review identified a lack of comprehensive information about the experiences of caregivers, highlighting the need for further studies to better understand and support their roles in the post-transplant journey.</div></div>","PeriodicalId":55064,"journal":{"name":"Heart & Lung","volume":"69 ","pages":"Pages 174-184"},"PeriodicalIF":2.4,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142555008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of day of admission on patients admitted with complete heart block: Analyzing the weekend effect 入院日期对完全性心脏传导阻滞患者的影响:分析周末效应
IF 2.4 4区 医学
Heart & Lung Pub Date : 2024-10-30 DOI: 10.1016/j.hrtlng.2024.10.007
Nahush Roop Bansal , Abdulmajeed Alharbi , Shahnaz Rehman , Ragheb Assaly
{"title":"Impact of day of admission on patients admitted with complete heart block: Analyzing the weekend effect","authors":"Nahush Roop Bansal ,&nbsp;Abdulmajeed Alharbi ,&nbsp;Shahnaz Rehman ,&nbsp;Ragheb Assaly","doi":"10.1016/j.hrtlng.2024.10.007","DOIUrl":"10.1016/j.hrtlng.2024.10.007","url":null,"abstract":"<div><h3>Background</h3><div>Complete heart block (CHB) is a conduction disorder that can be fatal if not treated promptly. Admission on a week or weekend day may influence the outcomes of cardiac emergencies, such as CHB.</div></div><div><h3>Objectives</h3><div>The purpose of this study was to determine the effects of weekday vs. weekend admissions in terms of CHB outcomes.</div></div><div><h3>Methods</h3><div>A retrospective cohort study was conducted using the National Inpatient Sample database to study the outcomes of adult patients admitted with complete heart block. Outcomes were compared between the patients admitted on weekends (midnight Friday to midnight Sunday) and weekdays.</div></div><div><h3>Results</h3><div>Thirty-four thousand three hundred ninety-five patients were included, of which 7350 (21.37 %) were admitted on weekends. Mean age for included patients was 75.69 years, with 43.23 % females. Compared to those admitted on weekdays, participants admitted on weekends had similar mortality (aOR 0.73; 95 % CI 0.46–1.16), longer length of stay (mean increase 0.74 days; <em>P</em> &lt; 0.01) and higher hospital charges (mean increase $10,540.82; <em>P</em> &lt; 0.01). Weekend admissions were associated with higher rates of cardiac arrest (adjusted OR 1.40; 95 % CI 1.07–1.84; <em>P</em> = 0.02) and higher rates of cardiogenic shock (adjusted OR 1.40; 95 % CI 1.07–1.83; <em>P</em> = 0.01) and similar rates of permanent pacemaker implantation (adjusted OR 0.88; 95 % CI 0.77–1.01; <em>P</em> = 0.06), but had longer delay to permanent pacemaker (mean increase 0.46 days; <em>P</em> &lt; 0.01).</div></div><div><h3>Conclusion</h3><div>Hospital and administrative-level strategies are needed to address the differences between the weekend and weekday CHB admissions.</div></div>","PeriodicalId":55064,"journal":{"name":"Heart & Lung","volume":"69 ","pages":"Pages 168-173"},"PeriodicalIF":2.4,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142549029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Co-morbidities and Disparities in Heart Failure Care, How Are We Doing? 心力衰竭护理中的共病和差异,我们做得如何?
IF 2.4 4区 医学
Heart & Lung Pub Date : 2024-10-29 DOI: 10.1016/j.hrtlng.2024.10.002
Linda Ordway MS, NP
{"title":"Co-morbidities and Disparities in Heart Failure Care, How Are We Doing?","authors":"Linda Ordway MS, NP","doi":"10.1016/j.hrtlng.2024.10.002","DOIUrl":"10.1016/j.hrtlng.2024.10.002","url":null,"abstract":"","PeriodicalId":55064,"journal":{"name":"Heart & Lung","volume":"69 ","pages":"Page A1"},"PeriodicalIF":2.4,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142549028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
LUDT-ADHF trial: Lung ultrasound-guided diuretic therapy for hospitalized patients with acute decompensated heart failure: An open-label clinical trial LUDT-ADHF 试验:针对急性失代偿性心力衰竭住院患者的肺部超声引导下利尿疗法:一项开放标签临床试验。
IF 2.4 4区 医学
Heart & Lung Pub Date : 2024-10-21 DOI: 10.1016/j.hrtlng.2024.10.001
Masoud Kashoob MD , Salim Al-Busaidi MD , Juhaina Salim Al-Maqbali MSc , Amira Al-Badi MD , Aya Aalhamad MD , Zubaida Al Falahi MD , Aisha Al Huraizi MD , Hatem Al Farhan MD , Khalfan Al Zeedy MD , Abdul Hakeem Al Hashim MD , Mohammed H Al-Ghailani MD , Muhammad Shoaib FRACP , Haitham El Bingawi MD , Abdullah M. Al Alawi FACP,FRACP
{"title":"LUDT-ADHF trial: Lung ultrasound-guided diuretic therapy for hospitalized patients with acute decompensated heart failure: An open-label clinical trial","authors":"Masoud Kashoob MD ,&nbsp;Salim Al-Busaidi MD ,&nbsp;Juhaina Salim Al-Maqbali MSc ,&nbsp;Amira Al-Badi MD ,&nbsp;Aya Aalhamad MD ,&nbsp;Zubaida Al Falahi MD ,&nbsp;Aisha Al Huraizi MD ,&nbsp;Hatem Al Farhan MD ,&nbsp;Khalfan Al Zeedy MD ,&nbsp;Abdul Hakeem Al Hashim MD ,&nbsp;Mohammed H Al-Ghailani MD ,&nbsp;Muhammad Shoaib FRACP ,&nbsp;Haitham El Bingawi MD ,&nbsp;Abdullah M. Al Alawi FACP,FRACP","doi":"10.1016/j.hrtlng.2024.10.001","DOIUrl":"10.1016/j.hrtlng.2024.10.001","url":null,"abstract":"<div><div><strong>Background</strong> Acute Decompensated Heart Failure (ADHF) constitutes a major reason for hospital admissions and significantly contributes to increased morbidity and mortality. Limited research indicates that lung ultrasound (LUS) may enhance the care for patients with ADHF.</div><div><strong>Objective</strong>s The purpose of this study was to evaluate the impact of LUS-guided diuretic therapy on reducing length of hospital stay (LOS) and 90-day readmissions among patients with ADHF.</div><div><strong>Methods</strong> This open-label, non-randomized clinical trial included patients with ADHF managed with diuretics based on LUS findings of B-lines and pleural effusion (LUS group) compared to those receiving standard care (control group). The primary outcome was LOS during the index admission, and secondary outcomes included 90-day ADHF readmissions, all-cause readmissions, and safety parameters like acute kidney injury, hypokalemia, and hypotension.</div><div><strong>Results</strong> The study included a total of 77 patients, segregated into two groups: control and LUS. The median age of the patients was 68 years, with women slightly outnumbering men (53.25%, n=41). The most prevalent comorbidities were hypertension (88.31%, n=68), diabetes mellitus (59.74%, n=46), and chronic kidney disease (66.23%, n=51). The LUS group had a shorter LOS, though not statistically significant (4 vs five days, p= 0.175). Patients in the LUS group had significantly fewer 90-day ADHF readmissions compared to the control group (10.53% vs. 35.9%; p&lt;0.01). Survival analysis demonstrated that the LUS group had a longer time to 90-day ADHF readmissions, with a hazard ratio (HR) of 0.24 (95% CI: 0.08–0.75, p=0.014). For 90-day all-cause readmissions, the LUS group also showed a longer time to readmission compared to controls, with an HR of 0.45 (95% CI: 0.200–1.005, p=0.046). For other safety measures, there was no significant difference in the incidence of adverse events, including acute kidney injury, hypokalaemia, or hypotension, between the LUS and control groups.</div><div><strong>Conclusion</strong> LUS might reduce in-hospital mortality and readmissions among adults with acute decompensated HF. However, further double-blinded randomized clinical trials are needed to confirm these preliminary results.</div></div>","PeriodicalId":55064,"journal":{"name":"Heart & Lung","volume":"69 ","pages":"Pages 155-162"},"PeriodicalIF":2.4,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142513274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gender and age predict advanced heart failure in gene-negative patients with hypertrophic cardiomyopathy 性别和年龄可预测肥厚型心肌病基因阴性患者的晚期心力衰竭。
IF 2.4 4区 医学
Heart & Lung Pub Date : 2024-10-21 DOI: 10.1016/j.hrtlng.2024.10.006
Fangfang Ji , Xueshou Yu , Wenxu Sheng , Wenxiu Zhang , Ying Wei , Xiaobin Ji , Zhengyi Shan , Lin Qi
{"title":"Gender and age predict advanced heart failure in gene-negative patients with hypertrophic cardiomyopathy","authors":"Fangfang Ji ,&nbsp;Xueshou Yu ,&nbsp;Wenxu Sheng ,&nbsp;Wenxiu Zhang ,&nbsp;Ying Wei ,&nbsp;Xiaobin Ji ,&nbsp;Zhengyi Shan ,&nbsp;Lin Qi","doi":"10.1016/j.hrtlng.2024.10.006","DOIUrl":"10.1016/j.hrtlng.2024.10.006","url":null,"abstract":"<div><h3>Background</h3><div>Patients with hypertrophic cardiomyopathy (HCM) may develop concomitant advanced heart failure (HF). However, there is limited data on the clinical outcomes of HCM patients without sarcomere gene mutations who have advanced HF.</div></div><div><h3>Objectives</h3><div>To identify prognostic factors for advanced HF in gene-negative patients within a large HCM cohort.</div></div><div><h3>Methods</h3><div>A total of 1529 unrelated patients with HCM were enrolled between 1999 and 2018, and followed throughout the study period. All patients underwent genotyping through whole exome or panel sequencing. From this cohort, 735 patients without mutations were studied. We assessed the effects of family history, clinical findings, and echocardiographic parameters on the development of advanced HF. Multivariable Cox proportional hazards regression analysis was conducted to identify risk factors associated with advanced HF.</div></div><div><h3>Results</h3><div>Of the 735 gene-negative patients studied, the mean age was 52.5±13.2 years, 69.5% were male, and the mean follow-up duration was 3.2±2.3 years. During this period, 97 patients (13.2%) developed advanced HF. Using multivariable analysis, we identified significant risk factors for advanced HF: female gender (adjusted hazard ratio [HR] 2.499, 95% confidence interval [CI] 1.531–4.081, P&lt;0.001) and older age at enrollment (adjusted HR 1.298, 95% CI 1.00–1.682, P=0.049). These findings suggest that female patients and those enrolled at an older age are at a higher risk for developing advanced HF.</div></div><div><h3>Conclusion</h3><div>Female gender and older age may predict a higher risk of advanced HF in gene-negative patients with HCM. Early detection and proactive treatment are crucial for managing and preventing complications in these patients.</div></div>","PeriodicalId":55064,"journal":{"name":"Heart & Lung","volume":"69 ","pages":"Pages 163-167"},"PeriodicalIF":2.4,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142513273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Changes in Treg cells and cytokines in the peripheral blood of patients with coronary artery disease combined with type 2 diabetes mellitus 冠心病合并 2 型糖尿病患者外周血中 Treg 细胞和细胞因子的变化。
IF 2.4 4区 医学
Heart & Lung Pub Date : 2024-10-18 DOI: 10.1016/j.hrtlng.2024.10.004
Runqi Liu , Jinghui Bao , Ying Tang , Danyan Xu , Li Shen , Huali Qin
{"title":"Changes in Treg cells and cytokines in the peripheral blood of patients with coronary artery disease combined with type 2 diabetes mellitus","authors":"Runqi Liu ,&nbsp;Jinghui Bao ,&nbsp;Ying Tang ,&nbsp;Danyan Xu ,&nbsp;Li Shen ,&nbsp;Huali Qin","doi":"10.1016/j.hrtlng.2024.10.004","DOIUrl":"10.1016/j.hrtlng.2024.10.004","url":null,"abstract":"<div><h3>Background</h3><div>Patients with coronary artery disease (CAD) combined with type 2 diabetes mellitus (T2DM) develop serious atherosclerotic and diffuse lesions. Inadequate numbers and the dysfunction of CD4<sup>+</sup>CD25<sup>+</sup>Foxp3<sup>+</sup>regulatory T lymphocytes (Treg cells) are common mechanisms underlying the immunopathological damage in CAD and T2DM.</div></div><div><h3>Objectives</h3><div>We aimed to explore Treg cell changes in patients with CAD complicated with T2DM and to investigate the association between Treg cells and the severity of CAD.</div></div><div><h3>Methods</h3><div>A total of 257 participants were included in the study, divided into a healthy control group (HC, <em>n</em> = 63), CAD group (<em>n</em> = 106), and CAD complicated with T2DM group (CAD+T2DM, <em>n</em> = 88). Flow cytometry detected Treg cell levels, and serum IL-10, IL-6, and ELISA detected TGF-β.</div></div><div><h3>Results</h3><div>The sample for this study consisted of 170 males and 87 females, with 88 (34.24 %) participants having diabetes and 169 (65.76 %) without diabetes. The proportion of circulating Treg cells was lower in the CAD and CAD+T2DM groups than in the HC group, and it was lower in the CAD+T2DM group than in the CAD group. The plasma levels of IL-10 and TGF-β were lower in the CAD than in the HC group, and the levels in the CAD+T2DM group were significantly lower than those in the CAD group. However, the plasma IL-6 level changed in the opposite direction. Gensini's score was negatively correlated with Treg cells (<em>R</em> = - 0.57, <em>P</em> &lt; .05). Subgroup analyses and interaction analyses showed that the association of Treg with the Gensini score was robust.</div></div><div><h3>Conclusion</h3><div>The level of Treg cells was an independent protective factor for patients with CAD and T2DM and was negatively correlated with the Gensini score. Therefore, Treg cells may be used as therapeutic targets for CAD with T2DM patients.</div></div>","PeriodicalId":55064,"journal":{"name":"Heart & Lung","volume":"69 ","pages":"Pages 147-154"},"PeriodicalIF":2.4,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142481334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of depressive symptoms and engagement in physical activity with event-free survival in patients with heart failure 心力衰竭患者的抑郁症状和体育锻炼与无事件生存期的关系
IF 2.4 4区 医学
Heart & Lung Pub Date : 2024-10-17 DOI: 10.1016/j.hrtlng.2024.10.003
Geunyeong Cha PhD (c), MSN, RN , Misook L. Chung PhD, RN , JungHee Kang PhD, RN , Chin-Yen Lin PhD, RN , Martha J. Biddle PhD, RN , Jia-Rong Wu PhD, RN , Terry A. Lennie PhD, RN , Ashmita Thapa BSN, RN , Debra K. Moser PhD, RN
{"title":"Association of depressive symptoms and engagement in physical activity with event-free survival in patients with heart failure","authors":"Geunyeong Cha PhD (c), MSN, RN ,&nbsp;Misook L. Chung PhD, RN ,&nbsp;JungHee Kang PhD, RN ,&nbsp;Chin-Yen Lin PhD, RN ,&nbsp;Martha J. Biddle PhD, RN ,&nbsp;Jia-Rong Wu PhD, RN ,&nbsp;Terry A. Lennie PhD, RN ,&nbsp;Ashmita Thapa BSN, RN ,&nbsp;Debra K. Moser PhD, RN","doi":"10.1016/j.hrtlng.2024.10.003","DOIUrl":"10.1016/j.hrtlng.2024.10.003","url":null,"abstract":"<div><h3>Background</h3><div>Heart failure (HF) subtype, depressive symptoms, and physical inactivity independently contribute to survival outcomes, but the effect of the interaction of these variables on survival outcomes remains unknown.</div></div><div><h3>Objectives</h3><div>We aimed to determine whether depressive symptoms and engagement in physical activity differentially interact to predict the combined endpoint of all-cause death or rehospitalization among patients with HF and reduced (HFrEF) or preserved ejection fraction (HFpEF).</div></div><div><h3>Methods</h3><div>This study was a secondary analysis. The sample was categorized by the presence or absence of depressive symptoms, and engagement or non-engagement in physical activity. Cox proportional hazard modeling was used to predict the combined endpoint of all-cause death or rehospitalization.</div></div><div><h3>Results</h3><div>A total of 1002 patients with HF were included (mean age 64.3 ± 12.7 years; 637 males [64 %]; 844 White [84 %]). Among them, 35.3 % did not engage in physical activity, while 64.7 % engaged in any level of physical activity, and 29.7 % had depressive symptoms. In both subtypes, depressive symptoms were associated with the highest risk of all-cause death or rehospitalization. Among patients with HFrEF, those with depressive symptoms who did not engage in physical activity were associated with a 136 % higher risk of the combined endpoint, while among those with HFpEF, depressive symptoms and engagement in physical activity were associated with a 78 % higher risk.</div></div><div><h3>Conclusions</h3><div>Depressive symptoms and lack of physical activity predicted the combined endpoint of all-cause death or rehospitalization among patients with HFrEF, while depressive symptoms alone were the strongest predictor among patients with HFpEF.</div></div>","PeriodicalId":55064,"journal":{"name":"Heart & Lung","volume":"69 ","pages":"Pages 138-146"},"PeriodicalIF":2.4,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142445876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparative analysis of survival rate and quality of life in axial-flow pump left ventricular assist devices (LVADs) 轴流泵左心室辅助装置(LVAD)存活率和生活质量的比较分析
IF 2.4 4区 医学
Heart & Lung Pub Date : 2024-10-15 DOI: 10.1016/j.hrtlng.2024.09.012
Amin Khorshid Savar , Hongrui Wang, Nuo Chen, Yunzhang Cheng
{"title":"Comparative analysis of survival rate and quality of life in axial-flow pump left ventricular assist devices (LVADs)","authors":"Amin Khorshid Savar ,&nbsp;Hongrui Wang,&nbsp;Nuo Chen,&nbsp;Yunzhang Cheng","doi":"10.1016/j.hrtlng.2024.09.012","DOIUrl":"10.1016/j.hrtlng.2024.09.012","url":null,"abstract":"<div><h3>Background</h3><div>The rising heart failure rates globally show the pressing demand for treatment progress, especially in Left Ventricular Assist Devices (LVADs). Axial-flow pump LVADs are gaining notice for their small size, few moving parts, and potential for miniaturization, providing a vital option for heart transplants during donor shortages.</div></div><div><h3>Objectives</h3><div>Despite several studies on LVADs, there is a notable lack of research specifically comparing axial-flow pumps with similar technology. This gap hinders the identification of the most optimal technology to guide development efforts and meet patient needs. This study aims to comprehensively compare the most commonly used axial-flow pumps and provide a detailed analysis focusing on survival rates and quality of life parameters.</div></div><div><h3>Methods</h3><div>As a developer of axial-flow pumps (LVADs), our group conducted a systematic review of the current axial-flow pump LVADs. We analyzed studies comparing these devices, focusing on key metrics such as survival rates and quality of life.</div></div><div><h3>Results</h3><div>The HeartMate 2 and Jarvik 2000 show superior survival rates (up to 86.9 % at 6 months, 96.3 % at 3 years) and (6-month survival 67 %-91 %) respectively, compared to the other axial flow pumps LVAD. The results underscore the importance of choosing the optimal device and informing the direction of future developments.</div></div><div><h3>Conclusion</h3><div>In this paper, we aim to inform future studies to enhance their effectiveness and advance the overall performance of these devices, ultimately benefiting patients and developers. This review furnishes evidence-based recommendations for the most appropriate axial-flow pumps based on survival rates and quality of life parameters.</div></div>","PeriodicalId":55064,"journal":{"name":"Heart & Lung","volume":"69 ","pages":"Pages 127-137"},"PeriodicalIF":2.4,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142433397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Board of Directors 董事会
IF 2.4 4区 医学
Heart & Lung Pub Date : 2024-10-10 DOI: 10.1016/S0147-9563(24)00176-6
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