Journal of Antibiotics最新文献_第2页

Resistance to linezolid in Staphylococcus aureus by mutation, modification, and acquisition of genes. 金黄色葡萄球菌通过基因突变、改造和获取对利奈唑胺产生抗药性。

IF 2.1 4区医学

Journal of Antibiotics Pub Date : 2024-10-17 DOI: 10.1038/s41429-024-00778-4

Wenjing Yang, Taoran Chen, Qi Zhou, Jiancheng Xu

{"title":"Resistance to linezolid in Staphylococcus aureus by mutation, modification, and acquisition of genes.","authors":"Wenjing Yang, Taoran Chen, Qi Zhou, Jiancheng Xu","doi":"10.1038/s41429-024-00778-4","DOIUrl":"https://doi.org/10.1038/s41429-024-00778-4","url":null,"abstract":"Linezolid binds to the 50S subunit of the bacterial ribosome, inhibiting bacterial protein synthesis by preventing the formation of the initiation complex. Oxazolidinone antimicrobial drugs represent the last line of defense in treating Staphylococcus aureus infections; thus, resistance to linezolid in S. aureus warrants high priority. This article examines the major mechanisms of resistance to linezolid in S. aureus, which include: mutations in the domain V of 23S rRNA (primarily G2576); chromosomal mutations in the rplC, rplD, and rplV genes (encoding the ribosomal uL3, uL4, and uL22 proteins, respectively); the exogenous acquisition of the methylase encoded by the chloramphenicol-florfenicol resistance (cfr) gene; the endogenous methylation or demethylation of 23S rRNA; the acquisition of optrA and poxtA resistance genes; and the existence of the LmrS multidrug efflux pump. In conclusion, these mechanisms mediate resistance through mutations or modifications to the bacterial target, thereby reducing the affinity of linezolid for the peptidyl transferase center (PTC) binding site or by preventing the binding of linezolid to the PTC through a ribosomal protective effect. The existence of additional, unexplained resistance mechanisms requires further investigation and verification.","PeriodicalId":54884,"journal":{"name":"Journal of Antibiotics","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142481209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploration of vanoxerine analogues as antibacterial agents. 探索作为抗菌剂的 vanoxerine 类似物。

IF 2.1 4区医学

Journal of Antibiotics Pub Date : 2024-10-15 DOI: 10.1038/s41429-024-00781-9

Alexander D H Kingdon, Holly V Adcock, Eleni-Marina Kasimati, Philip Craven, Willem van Schaik, Liam R Cox, Gurdyal S Besra

{"title":"Exploration of vanoxerine analogues as antibacterial agents.","authors":"Alexander D H Kingdon, Holly V Adcock, Eleni-Marina Kasimati, Philip Craven, Willem van Schaik, Liam R Cox, Gurdyal S Besra","doi":"10.1038/s41429-024-00781-9","DOIUrl":"https://doi.org/10.1038/s41429-024-00781-9","url":null,"abstract":"Mycobacterium tuberculosis is a bacterial pathogen, responsible for approximately 1.3 million deaths in 2022 through tuberculosis infections. The complex treatment regimen required to treat tuberculosis and growing rates of drug resistance, necessitates the development of new anti-mycobacterial agents. One approach is to repurpose drugs from other clinical applications. Vanoxerine (GBR 12909) was previously shown to have anti-mycobacterial activity, through dissipating the membrane electric potential and hence, cellular energetics. Several vanoxerine analogues were synthesised in this study, which exhibited a range of activities against mycobacteria and enterococcus. All active analogues had similar impacts on the membrane electric potential and inhibition of ethidium bromide efflux. The most active compound displayed reduced inhibitory activity against the known human target of vanoxerine, the dopamine transporter. This work has identified a promising analogue, which could provide a starting point for further medicinal chemistry and drug development efforts to target mycobacteria.","PeriodicalId":54884,"journal":{"name":"Journal of Antibiotics","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142481208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction: Synthesis and antibacterial action of 3',6'-disubstituted spectinomycins. 更正：3',6'-二取代的光谱霉素的合成和抗菌作用。

IF 2.1 4区医学

Journal of Antibiotics Pub Date : 2024-10-11 DOI: 10.1038/s41429-024-00777-5

Suresh Dharuman, Gregory A Phelps, Christine M Dunn, Laura A Wilt, Patricia A Murphy, Robin B Lee, Hannah E Snoke, Petra Selchow, Klara Haldimann, Erik C Böttger, Sven N Hobbie, Peter Sander, Richard E Lee

引用次数: 0

Drimane sesquiterpene esters produced by Aspergillus insuetus BF-1613 as inhibitors of sterol O-acyltransferase 胰曲霉 BF-1613 产生的作为甾醇 O-酰基转移酶抑制剂的 Drimane 倍半萜酯。

IF 2.1 4区医学

Journal of Antibiotics Pub Date : 2024-10-10 DOI: 10.1038/s41429-024-00774-8

Elyza Aiman Azizah Nur, Keisuke Kobayashi, Rio Tejima, Yosuke Katada, Hiroshi Tomoda, Taichi Ohshiro

引用次数: 0

Streptomyces albidocamelliae sp. nov., an endophytic actinomycete isolated from the leaves of Camellia oleifera Streptomyces albidocamelliae sp.

IF 2.1 4区医学

Journal of Antibiotics Pub Date : 2024-10-03 DOI: 10.1038/s41429-024-00776-6

Pei-Lan Long, Jia-Xing Liu, Yan Xiao, Ping Mo, Jian Gao

{"title":"Streptomyces albidocamelliae sp. nov., an endophytic actinomycete isolated from the leaves of Camellia oleifera","authors":"Pei-Lan Long, Jia-Xing Liu, Yan Xiao, Ping Mo, Jian Gao","doi":"10.1038/s41429-024-00776-6","DOIUrl":"10.1038/s41429-024-00776-6","url":null,"abstract":"A novel actinobacterium strain, HUAS 14-6T, was isolated from the healthy leaves of Camellia oleifera collected from Changde City, Hunan Province, China. Strain HUAS 14-6T produced tight spiral spore chains consisting of oval or spherical spores with a smooth surface. 16S rRNA gene sequence analysis revealed that strain HUAS 14-6T belonged to the genus Streptomyces and shared highest similarity to Streptomyces bungoensis DSM 41781T (99.72%). Phylogenetic analysis based on 16S rRNA gene sequences indicated strain HUAS 14-6T was in a clade with S. bungoensis DSM 41781T. However, the ANIm and dDDH between strain HUAS 14-6T and S. bungoensis DSM 41781T were 88.16% and 31.2%, respectively, far less than the species-level thresholds. Phylogenetic trees based on the five housekeeping genes (atpD, gyrB, recA, rpoB and trpB) showed that strain HUAS 14-6T formed a separate branch, indicating that this strain could belong to a potential new species. Pairwise MLSA distances between strain HUAS 14-6T and all type strains exhibiting 16S rRNA gene sequence similarities of ≥98.7% to it were much higher than the maximum range of 0.014 recommended for delineating a new Streptomyces species. Based on polyphasic taxonomic study, HUAS 14-6T represents a novel species within the genus Streptomyces for which the name Streptomyces albidocamelliae sp. nov. is proposed. The type strain is HUAS 14-6T (=MCCC 1K08365T=JCM 35920T).","PeriodicalId":54884,"journal":{"name":"Journal of Antibiotics","volume":"77 12","pages":"786-793"},"PeriodicalIF":2.1,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41429-024-00776-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142373601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Winners of the 2022 JA Ōmura Awards for excellence 2022 年 JA Ōmura 优秀奖获奖者。

IF 2.1 4区医学

Journal of Antibiotics Pub Date : 2024-10-01 DOI: 10.1038/s41429-024-00767-7

Richard E. Lee, Minoru Yoshida

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Phenotypic changes and gene expression profiles of Vibrio parahaemolyticus in response to low concentrations of ampicillin 副溶血性弧菌对低浓度氨苄西林的表型变化和基因表达谱。

IF 2.1 4区医学

Journal of Antibiotics Pub Date : 2024-09-25 DOI: 10.1038/s41429-024-00772-w

Xi Luo, Miaomiao Zhang, Yiquan Zhang, Xue Li, Renfei Lu

{"title":"Phenotypic changes and gene expression profiles of Vibrio parahaemolyticus in response to low concentrations of ampicillin","authors":"Xi Luo, Miaomiao Zhang, Yiquan Zhang, Xue Li, Renfei Lu","doi":"10.1038/s41429-024-00772-w","DOIUrl":"10.1038/s41429-024-00772-w","url":null,"abstract":"Vibrio parahaemolyticus is a leading cause of seafood-associated gastroenteritis and possesses intrinsic resistance to ampicillin. While ampicillin can trigger transcriptional responses of global genes, the behavioral and molecular changes that occur in V. parahaemolyticus when exposed to ampicillin are not fully understood. In this work, we investigated the effects of low concentrations of ampicillin on the physiology and gene expression of V. parahaemolyticus by combining phenotypic assays and RNA sequencing (RNA-seq) analysis. Our results showed that the growth of V. parahaemolyticus were notably delayed, and both motility and c-di-GMP production were significantly inhibited in the response to low concentrations of ampicillin stress. In contrast, biofilm formation by V. parahaemolyticus was enhanced by exposure to low concentrations of ampicillin. However, low concentrations of ampicillin had no effect on the cytotoxicity or adherence activity of V. parahaemolyticus. The RNA-seq data revealed that a low concentration of ampicillin significantly affected the expression levels of 676 genes, including those involved in antibiotic resistance, virulence, biofilm formation, and regulation. This work contributes to our understanding of how V. parahaemolyticus alters its behavior and gene expression in response to ampicillin exposure.","PeriodicalId":54884,"journal":{"name":"Journal of Antibiotics","volume":"77 12","pages":"823-836"},"PeriodicalIF":2.1,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41429-024-00772-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142332573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aldgamycins Q1 and Q2, two novel 16-membered macrolides from the rare actinomycete Saccharothrix sp. 16Sb2-4 来自稀有放线菌 Saccharothrix sp. 16Sb2-4 的两种新型 16 元大环内酯--Aldgamycins Q1 和 Q2。

IF 2.1 4区医学

Journal of Antibiotics Pub Date : 2024-09-25 DOI: 10.1038/s41429-024-00775-7

Keke Luo, Qin Yang, Yuyu Liu, Chenghang Sun, Shaowei Liu

引用次数: 0

The influence of marine fungal meroterpenoid meroantarctine A toward HaCaT keratinocytes infected with Staphylococcus aureus 海洋真菌美仑塔辛 A 对受金黄色葡萄球菌感染的 HaCaT 角质细胞的影响

IF 2.1 4区医学

Journal of Antibiotics Pub Date : 2024-09-10 DOI: 10.1038/s41429-024-00771-x

Ekaterina A. Chingizova, Artur R. Chingizov, Ekaterina S. Menchinskaya, Evgeny A. Pislyagin, Aleksandra S. Kuzmich, Elena V. Leshchenko, Gleb V. Borkunov, Irina V. Guzhova, Dmitry L. Aminin, Ekaterina A. Yurchenko

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Cytosporones Y and Z, new antifungal polyketides produced by the fungal strain Trichoderma sp. FKI-6626 由真菌菌株毛霉 FKI-6626 产生的新型抗真菌多酮--细胞孢子内酯 Y 和 Z。

IF 2.1 4区医学

Journal of Antibiotics Pub Date : 2024-09-06 DOI: 10.1038/s41429-024-00765-9

Haruki Azami, Yoshihiro Watanabe, Hiroki Kojima, Yurika Yoshida, Sayaka Ban, Kenichi Nonaka, Takashi Yaguchi, Masato Iwatsuki

引用次数: 0