Journal of Biomechanical Engineering-Transactions of the Asme最新文献_第5页

Biomechanical Strain Responses in the Sclera, Choroid, and Retina in Glaucoma Patients After Intraocular Pressure Lowering. 眼压降低后青光眼患者巩膜、脉络膜和视网膜的生物力学应变反应。

IF 1.7 4区医学

Journal of Biomechanical Engineering-Transactions of the Asme Pub Date : 2025-05-01 DOI: 10.1115/1.4068155

Zhuochen Yuan, Cameron A Czerpak, Michael Saheb Kashaf, Harry A Quigley, Thao D Nguyen

{"title":"Biomechanical Strain Responses in the Sclera, Choroid, and Retina in Glaucoma Patients After Intraocular Pressure Lowering.","authors":"Zhuochen Yuan, Cameron A Czerpak, Michael Saheb Kashaf, Harry A Quigley, Thao D Nguyen","doi":"10.1115/1.4068155","DOIUrl":"10.1115/1.4068155","url":null,"abstract":"This study measured the strain response to intraocular pressure (IOP) change in the sclera, choroid, and retina of glaucoma patients whose optic nerve head region was imaged by optical coherence tomography (OCT) before and after IOP-lowering by laser suturelysis following trabeculectomy surgery. The strain response was calculated from digital volume correlation of the prior and after images. The strain response of the sclera, choroid, and retina were compared to those previously published for the anterior lamina cribrosa (ALC). Mean strains were lowest in the retina and highest in the prelaminar neural tissue (PLNT). Maximum principal and maximum shear strains were significantly increased with greater IOP decrease in all five eye regions. Maximum principal and maximum shear strains in the anterior lamina cribrosa and the sclera were significantly related (p = 0.0094). Strain in the radial direction was negative in the ALC and PLNT, but positive in the sclera (p = 0.017). In conclusion, the strain response of the sclera, choroid, and retina is related to the magnitude of IOP change and is smaller than those of the ALC. The strain response of the ALC and sclera are significantly related to each other.","PeriodicalId":54871,"journal":{"name":"Journal of Biomechanical Engineering-Transactions of the Asme","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11977571/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143626693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oversized Total Talar Prosthesis Enhances the Ankle Stability After Total Talus Replacement by Finite Element Analysis. 有限元分析表明，超大尺寸全距骨假体增强了全距骨置换术后踝关节的稳定性。

IF 1.7 4区医学

Journal of Biomechanical Engineering-Transactions of the Asme Pub Date : 2025-05-01 DOI: 10.1115/1.4068008

Hao Li, Haitao Xie, Shujing Kang, Kuixue Xu, Meiming Xie, Haiqiong Xie, Xu Cai, Kai Wei

{"title":"Oversized Total Talar Prosthesis Enhances the Ankle Stability After Total Talus Replacement by Finite Element Analysis.","authors":"Hao Li, Haitao Xie, Shujing Kang, Kuixue Xu, Meiming Xie, Haiqiong Xie, Xu Cai, Kai Wei","doi":"10.1115/1.4068008","DOIUrl":"10.1115/1.4068008","url":null,"abstract":"Total talar replacement (TTR) with an additively manufactured personalized total talar prosthesis (TTP) is an emerging treatment for ankle disorders. However, how to enhance the ankle stability after TTR, which usually raises the ankle instability, has not been explored. This study constructed a set of specific numerical models to investigate the effects of TTR and oversized TTPs on the ankle stability, including inversion, eversion, and anterior stability. The oversized TTPs include TTP-FP1.5 and TTP-FP3 scaled the identical TTP0 by 1.5% and 3.0% along the frontal axis, and TTP-VP1.5 and TTP-VP3 scaled TTP0 by 1.5% and 3.0% along the vertical axis. The numerical results identify that under varus/valgus force, the TTP-FP1.5 and TTP-FP3 produce smaller talar tilt angles compared with that of TTP0, as the inversion and eversion stability are significantly enhanced. Furthermore, TTP-VP1.5 and TTP-VP3 can provide larger contact force to the tibia, providing better anterior stability under anterior drawer force. Additionally, the increased contact force of TTP-VP1.5 and TTP-VP3 with the tibial cartilage enhances the eversion stability. Besides, the increase of TTP size along the vertical axis will weaken the inversion stability under low loads, as this scaling might have compromised the stability of the subtalar joint. The present numerical study systematically investigates the effect of different ways of increasing TTP size on ankle stability after TTP.","PeriodicalId":54871,"journal":{"name":"Journal of Biomechanical Engineering-Transactions of the Asme","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143484772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predicting Milk Flow Behavior in Human Lactating Breast: An Integrated Machine Learning and Computational Fluid Dynamics Approach. 预测人类哺乳乳房的乳汁流动行为：一种集成的机器学习和计算流体动力学方法。

IF 1.7 4区医学

Journal of Biomechanical Engineering-Transactions of the Asme Pub Date : 2025-05-01 DOI: 10.1115/1.4068077

Abdullahi O Olapojoye, Shadi Zaheri, Aria Nostratinia, Fatemeh Hassanipour

{"title":"Predicting Milk Flow Behavior in Human Lactating Breast: An Integrated Machine Learning and Computational Fluid Dynamics Approach.","authors":"Abdullahi O Olapojoye, Shadi Zaheri, Aria Nostratinia, Fatemeh Hassanipour","doi":"10.1115/1.4068077","DOIUrl":"10.1115/1.4068077","url":null,"abstract":"This study develops a comprehensive framework that integrates computational fluid dynamics (CFD) and machine learning (ML) to predict milk flow behavior in lactating breasts. Utilizing CFD and other high-fidelity simulation techniques to tackle fluid flow challenges often entails significant computational resources and time investment. Artificial neural networks (ANNs) offer a promising avenue for grasping complex relationships among high-dimensional variables. This study leverages this potential to introduce an innovative data-driven approach to CFD. The initial step involved using CFD simulations to generate the necessary training and validation datasets. A machine learning pipeline was then crafted to train the ANN. Furthermore, various ANN architectures were explored, and their predictive performance was compared. The design of experiments method was also harnessed to identify the minimum number of simulations needed for precise predictions. This study underscores the synergy between CFD and ML methodologies, designated as ML-CFD. This novel integration enables a neural network to generate CFD-like results, resulting in significant savings in time and computational resources typically required for traditional CFD simulations. The models developed through this ML-CFD approach demonstrate remarkable efficiency and robustness, enabling faster exploration of milk flow behavior in individual lactating breasts compared to conventional CFD solvers.","PeriodicalId":54871,"journal":{"name":"Journal of Biomechanical Engineering-Transactions of the Asme","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143544454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bending Flexibility of Negative Poisson's Ratio Structural Vascular Stent. 负泊松比结构血管支架的弯曲柔韧性。

IF 1.7 4区医学

Journal of Biomechanical Engineering-Transactions of the Asme Pub Date : 2025-05-01 DOI: 10.1115/1.4068156

Mohan Yang, Yao Du, Dongmei Zhu, Xiaozheng Wu, Guoyong Liu

{"title":"Bending Flexibility of Negative Poisson's Ratio Structural Vascular Stent.","authors":"Mohan Yang, Yao Du, Dongmei Zhu, Xiaozheng Wu, Guoyong Liu","doi":"10.1115/1.4068156","DOIUrl":"10.1115/1.4068156","url":null,"abstract":"A negative Poisson's ratio structural vascular stent with arrow-shaped cell is proposed in the paper. In order to improve the bending flexibility of the stent, three shapes of connecting bars, namely, U-shaped, S-shaped, and linear, are designed. The influence of structural parameters of the stent connecting bars on the bending performance of the stent is studied using the finite element method and experimental method. The research results show that compared to S-shaped stents, U-shaped stents have better bending flexibility. In addition, the influence of the parameters of the connection bars of a U-shaped stent on its flexibility is also explored. The longer the length of the U-shaped connection bars, the lower the corresponding bending stiffness and better bending flexibility. The larger the width of the U-shaped connecting bar, the greater the bending stiffness of the stent, and the worse its bending flexibility. And some experiments are conducted using the four points bending method. The deformation of the S-shaped stent and U-shaped stent under bending is very similar, and the bending stiffness of the U-shaped stent is lower than that of the S-shaped bracket, which also verified the correctness of the finite element calculation.","PeriodicalId":54871,"journal":{"name":"Journal of Biomechanical Engineering-Transactions of the Asme","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143626681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Feasible Low-Cost System for Kinematic and Kinetic Analysis of Sit-to-Stand Movement. 一种可行的低成本坐立运动运动学和动力学分析系统。

IF 1.7 4区医学

Journal of Biomechanical Engineering-Transactions of the Asme Pub Date : 2025-04-01 DOI: 10.1115/1.4067981

Daoyuan Wang, Yang Tang, Shengqian Xu, Yichong Wang, Jingtao Yu, Zenghui Gu, Gangmin Ning

{"title":"A Feasible Low-Cost System for Kinematic and Kinetic Analysis of Sit-to-Stand Movement.","authors":"Daoyuan Wang, Yang Tang, Shengqian Xu, Yichong Wang, Jingtao Yu, Zenghui Gu, Gangmin Ning","doi":"10.1115/1.4067981","DOIUrl":"10.1115/1.4067981","url":null,"abstract":"The sit-to-stand (STS) movement is a common activity essential for independence and mobility. Traditional methods for assessing STS often involve costly laboratory equipment, limiting their accessibility. This study introduced an economic alternative to the standard motion capture setup. The system presented in this study used an Azure Kinect and a plantar pressure sensor mat to acquire kinematic and kinetic data simultaneously during the STS. The Kinect provided noncontact motion capture, while the pressure sensor array measured ground reaction forces. To address the Kinect's inherent limitations in capturing extremity movements and the sensor array's inability to measure tangential forces, algorithms for the correction of lower limb joints and a multisource fusion model were developed. The accuracy of the proposed system was evaluated against a gold standard Vicon motion capture system. The results indicated that the system delivered estimates comparable to reference values for joint angles (r ranging from 0.85 to 0.99), antero-posterior and vertical ground reaction forces (r ranging from 0.81 to 0.98), joint reaction forces of knee and ankle (r ranging from 0.83 to 0.90), and joint moments of hip and ankle (r ranging from 0.77 to 0.82), suggesting that the proposed system can provide vital kinematic and kinetic data for efficient STS analysis. This study offered an accessible and practical solution for monitoring and assessing mobility in various settings.","PeriodicalId":54871,"journal":{"name":"Journal of Biomechanical Engineering-Transactions of the Asme","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143476918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multiscale Finite Element Modeling of Human Ear for Acoustic Wave Transmission Into Cochlea and Hair Cells Fatigue Failure. 人耳声波传入耳蜗及毛细胞疲劳失效的多尺度有限元模拟。

IF 1.7 4区医学

Journal of Biomechanical Engineering-Transactions of the Asme Pub Date : 2025-04-01 DOI: 10.1115/1.4067577

Yijie Jiang, John J Bradshaw, Roshan Sharma, Rong Z Gan

{"title":"Multiscale Finite Element Modeling of Human Ear for Acoustic Wave Transmission Into Cochlea and Hair Cells Fatigue Failure.","authors":"Yijie Jiang, John J Bradshaw, Roshan Sharma, Rong Z Gan","doi":"10.1115/1.4067577","DOIUrl":"10.1115/1.4067577","url":null,"abstract":"Hearing loss is highly related to acoustic injuries and mechanical damage of ear tissues. The mechanical responses and failures of ear tissues are difficult to measure experimentally, especially cochlear hair cells within the organ of Corti (OC) at microscale. Finite element (FE) modeling has become an important tool for simulating acoustic wave transmission and studying cochlear mechanics. This study harnessed a multiscale FE model to investigate the mechanical behaviors of ear tissues in response to acoustic wave and developed a fatigue mechanical model to describe the outer hair cells (OHCs) failure. A three-dimensional (3D) multiscale FE model consisting of a macroscale model of the ear canal, middle ear, and three-chambered cochlea and a microscale OC model on a representative basilar membrane section, including the hair cells, membranes, and supporting cells, was established. Harmonic acoustic mode was used in the FE model for simulating various acoustic pressures and frequencies. The cochlear basilar membrane and the cochlear pressure induced by acoustic pressures were derived from the macroscale model and used as inputs for microscale OC model. The OC model identified the stress and strain concentrations in the reticular lamina (RL) at the root of stereocilia hair bundles and in the Deiter's cells at the connecting ends with OHCs, indicating the potential mechanical damage sites. OHCs were under cyclic loading and the alternating stress was quantified by the FE model. A fatigue mechanism for OHCs was established based on the modeling results and experimental data. This mechanism would be used for predicting fatigue failure and the resulting hearing loss.","PeriodicalId":54871,"journal":{"name":"Journal of Biomechanical Engineering-Transactions of the Asme","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142959083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluating the Combined Neurotoxicity of Amyloid Beta and Tau Oligomers in Alzheimer's Disease: A Novel Cellular-Level Criterion. 评估β淀粉样蛋白和Tau寡聚物在阿尔茨海默病中的联合神经毒性：一种新的细胞水平标准。

IF 1.7 4区医学

Journal of Biomechanical Engineering-Transactions of the Asme Pub Date : 2025-04-01 DOI: 10.1115/1.4067701

Andrey V Kuznetsov

{"title":"Evaluating the Combined Neurotoxicity of Amyloid Beta and Tau Oligomers in Alzheimer's Disease: A Novel Cellular-Level Criterion.","authors":"Andrey V Kuznetsov","doi":"10.1115/1.4067701","DOIUrl":"10.1115/1.4067701","url":null,"abstract":"A criterion characterizing the combined neurotoxicity of amyloid beta and tau oligomers is suggested. A mathematical model for calculating the value of this criterion during senile plaque and neurofibrillary tangle (NFT) formation is proposed. Computations show that for physiologically relevant parameter values, the value of the criterion increases approximately linearly with time. Once neurofibrillary tangles begin forming in addition to senile plaques, there is an increase in the slope characterizing the rate at which the criterion increases. The critical value of the criterion at which a neuron dies is estimated. Unless the production rates of amyloid beta and tau monomers are very large, computations predict that for the accumulated toxicity to reach the critical value, the neural machinery responsible for the degradation of amyloid beta and tau monomers and aggregates must become dysfunctional. The value of the criterion after 20 years of the aggregation process is strongly influenced by the deposition rates of amyloid beta and tau oligomers into senile plaques and NFTs. This suggests that deposition of amyloid beta and tau oligomers into senile plaques and NFTs may reduce accumulated toxicity by sequestering more toxic oligomeric species into less toxic insoluble aggregates.","PeriodicalId":54871,"journal":{"name":"Journal of Biomechanical Engineering-Transactions of the Asme","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143016696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Toward a Consistent Framework for Describing the Free Vibration Modes of the Brain. 迈向描述大脑自由振动模式的一致框架。

IF 1.7 4区医学

Journal of Biomechanical Engineering-Transactions of the Asme Pub Date : 2025-04-01 DOI: 10.1115/1.4067699

Turner Jennings, Rouzbeh Amini, Sinan Müftü

引用次数: 0

Biomechanical Analysis for Enhanced Expulsion-Proof Intervertebral Fusion Device. 增强型防排出椎间融合器的生物力学分析。

IF 1.7 4区医学

Journal of Biomechanical Engineering-Transactions of the Asme Pub Date : 2025-04-01 DOI: 10.1115/1.4067574

Shaolong Tang, Dan Pan, Siyuan Chen, Hengyuan Li, Zhaoming Ye

{"title":"Biomechanical Analysis for Enhanced Expulsion-Proof Intervertebral Fusion Device.","authors":"Shaolong Tang, Dan Pan, Siyuan Chen, Hengyuan Li, Zhaoming Ye","doi":"10.1115/1.4067574","DOIUrl":"10.1115/1.4067574","url":null,"abstract":"This study aimed to compare the sinking and shifting characteristics of an enhanced expulsion-proof intervertebral fusion device (EEIFD) with a traditional transforaminal lumbar interbody fusion device (TTLIFD). Five specimens of each device were selected for analysis. Four mechanical tests-compression, subsidence, expulsion, and torque-were conducted for each cage. Additionally, a blade-cutting torque test was performed on the EEIFD, with load-displacement curves and mechanical values recorded. In static axial compression, static subsidence, and dynamic subsidence tests, the EEIFD demonstrated performance comparable to the TTLIFD. In expulsion testing, the maximum expulsion force for the EEIFD when the blade was rotated out (534.02 ± 21.24 N) was significantly higher than when the blade was not rotated out (476.97 ± 24.45 N) (P = 6.81 × 10-4). Moreover, the maximum expulsion force for the EEIFD with blade rotation (534.02 ± 21.24 N) was significantly higher than that of the TTLIFD (444.01 ± 12.42 N) (P = 9.82 × 10-5). These findings indicated that the EEIFD effectively enhanced expulsion prevention and antisubsidence performance.","PeriodicalId":54871,"journal":{"name":"Journal of Biomechanical Engineering-Transactions of the Asme","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142959065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biomechanical Comparison of Human Walking Locomotion on Solid Ground and Sand. 人类在固体地面和沙子上行走运动的生物力学比较。

IF 1.7 4区医学

Journal of Biomechanical Engineering-Transactions of the Asme Pub Date : 2025-04-01 DOI: 10.1115/1.4067842

Chunchu Zhu, Xunjie Chen, Jingang Yi

{"title":"Biomechanical Comparison of Human Walking Locomotion on Solid Ground and Sand.","authors":"Chunchu Zhu, Xunjie Chen, Jingang Yi","doi":"10.1115/1.4067842","DOIUrl":"10.1115/1.4067842","url":null,"abstract":"Current studies on human locomotion focus mainly on solid ground walking conditions. In this paper, we present a biomechanical comparison of human walking locomotion on solid ground and sand. A novel dataset containing three-dimensional motion and biomechanical data from 20 able-bodied adults for walking locomotion on solid ground and sand is collected. We present the data collection methods and report the sensor data along with the kinematic and kinetic profiles of joint biomechanics. The results reveal significant gait adaptations to the yielding terrain (i.e., sand), such as increased stance duration, reduced push-off force, and altered joint angles and moments. Specifically, the knee angle during the gait cycle on sand shows a delayed peak flexion and an increased overall magnitude, highlighting an adaptation to maintain stability on yielding terrain. These adjustments, including changes in joint timing and energy conservation mechanisms, provide insights into the motion control strategies humans adopt to navigate on yielding terrains. The dataset, containing synchronized ground reaction forces (GRFs) and kinematic data, offers a valuable resource for further exploration in foot-terrain interactions and human walking assistive devices development on yielding terrains.","PeriodicalId":54871,"journal":{"name":"Journal of Biomechanical Engineering-Transactions of the Asme","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143384140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0