Journal of Dermatology最新文献

{"title":"Maximum Standard Uptake Value of Pre-Therapeutic 18F-Fluorodeoxyglucose Positron Emission Tomography Predicts Outcomes in Indolent Adult T-Cell Leukemia/Lymphoma Patients With Cutaneous Involvement","authors":"Kyoko Nogami,&nbsp;Yotaro Nishikawa,&nbsp;Kosuke Mochida,&nbsp;Tamasa Terada,&nbsp;Minako Azuma,&nbsp;Michikazu Nakai,&nbsp;Masahiro Amano","doi":"10.1111/1346-8138.17867","DOIUrl":"10.1111/1346-8138.17867","url":null,"abstract":"<p>The prognostic utility of 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) in adult T-cell leukemia/lymphoma (ATLL) remains unclear, particularly in patients with indolent subtypes and cutaneous involvement. This study aimed to evaluate the usefulness of FDG-PET in predicting clinical outcomes in patients with indolent ATLL presenting with skin lesions. We retrospectively reviewed indolent ATLL with cutaneous involvement who underwent ¹⁸F-fluorodeoxyglucose positron emission tomography at our institute for initial disease staging between April 2007 and March 2022. The data obtained were compared with the findings of cutaneous involvement in ATLL. The effect of maximum standardized uptake value on progression-free survival was analyzed using the Kaplan–Meier method. Patients were divided into groups based on whether their maximum standardized uptake value was above or below the overall mean maximum standardized uptake value (2.18), and progression-free survival was compared between the groups. Forty-three patients with indolent ATLL were included. We divided the cutaneous involvement of ATLL into six subtypes according to a previously reported classification of eruption types: patch, plaque, multipapular, nodulotumoral, erythrodermic, and purpuric. A total of 18 of 43 patients (41.9%) had ¹⁸F-fluorodeoxyglucose-positive cutaneous lesions. However, 25 patients showed no ¹⁸F-fluorodeoxyglucose uptake in cutaneous lesions. There was a significant difference in the mean maximum standardized uptake value between the nodulotumoral and multipapular (<i>p</i> = 0.036), nodulotumoral and patch (<i>p</i> = 0.036). There was a statistically significant difference in progression-free survival between the maximum standardized uptake value ≥ 2.18 and &lt; 2.18 groups (<i>p</i> = 0.020). These findings indicate that the maximum standardized uptake value in cutaneous lesions could determine the prognostic association of ATLL with cutaneous lesions. Careful follow-up is required for patients with a higher maximum standardized uptake value for cutaneous lesions.</p>","PeriodicalId":54848,"journal":{"name":"Journal of Dermatology","volume":"52 10","pages":"1519-1526"},"PeriodicalIF":2.7,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1346-8138.17867","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144791153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biophysical and Ultrasonographic Findings of Cutaneous Macular Amyloidosis Lesions in Comparison With Uninvolved Skin","authors":"Aurif Nassiri Kashani,&nbsp;Taraneh Yazdanparast,&nbsp;Fatemeh Amiri,&nbsp;Mansour Nassiri Kashani,&nbsp;Alireza Firooz,&nbsp;Mehdi Gheisari","doi":"10.1111/1346-8138.17824","DOIUrl":"10.1111/1346-8138.17824","url":null,"abstract":"<div>\u0000 \u0000 <p>Macular amyloidosis (MA) is a primary localized cutaneous amyloidosis (PLCA), characterized by amyloid deposition in the papillary dermis. The goal of this study was to compare biophysical characteristics in MA lesions with uninvolved skin. Stratum corneum (SC) hydration, transepidermal water loss (TEWL), surface friction, pH, sebum, melanin, erythema, temperature, elasticity parameters (R0, R2, and R5), thickness, and echo-density of epidermis and dermis were measured on the active MA lesions in 22 patients and compared with the healthy area adjacent to the lesion as control. Paired <i>t-</i>test was used for statistical analyses, and a <i>p</i> &lt; 0.05 was considered significant. SC hydration, skin friction were significantly lower, whereas TEWL, pH, erythema index, melanin content, and the thickness of epidermis were significantly higher in MA lesions. There was no significant difference in other biophysical and ultrasonographic parameters between MA and normal skin. MA lesions are characterized by specific changes in ultrasonographic and biophysical parameters, compatible with their histological features. These charachteristics are likely to be useful in the early and noninvasive detection of cutaneous MA in the future.</p>\u0000 </div>","PeriodicalId":54848,"journal":{"name":"Journal of Dermatology","volume":"52 9","pages":"1411-1417"},"PeriodicalIF":2.7,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144791152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationships Between Secukinumab Concentrations, Disease Activity, and IL-17A Levels in Psoriasis: A Cross-Sectional Observational Study","authors":"Kouzhu Zhu,&nbsp;Zhou Lu,&nbsp;Lei Cao,&nbsp;Panyu Wu,&nbsp;Yuanbo Huang,&nbsp;Shuo Meng,&nbsp;Yan Wang,&nbsp;Lei Wang","doi":"10.1111/1346-8138.17893","DOIUrl":"10.1111/1346-8138.17893","url":null,"abstract":"<div>\u0000 \u0000 <p>Secukinumab has been approved for the treatment of psoriasis. Off-label high-dose regimens have been used for certain patients. Therapeutic drug monitoring can assist in adjusting treatment plans. This study aimed to determine the therapeutic threshold of secukinumab and evaluate the influence of patient characteristics on secukinumab concentrations in patients with psoriasis. Patients with psoriasis (<i>n</i> = 36) treated with secukinumab during the maintenance therapy were enrolled in this cross-sectional study. Disease activity was determined using the psoriasis area and severity index (PASI) score, with an optimal response (OR) defined as ≤ 2. Secukinumab trough concentrations were measured using an in-house developed sandwich ELISA method. The median secukinumab concentrations in patients with OR were significantly higher than in those without (35.08 vs. 25.94 μg/mL, <i>p &lt;</i> 0.05). Secukinumab levels greater than 35.43 μg/mL were associated with OR (sensitivity of 50.00%, specificity of 89.89%, AUC = 0.70 and <i>p &lt;</i> 0.05). Multivariate logistic regression showed that secukinumab concentrations were significantly associated with OR (odds ratio: 1.02; 95% CI: 1.01–1.12; <i>p</i> = 0.04). Linear mixed-effects analysis indicated that an increase in body weight and a decrease in albumin were associated with a decrease in secukinumab concentrations. IL-17A levels showed no correlation with PASI score or secukinumab concentrations. Secukinumab concentrations over 35.43 μg/mL were associated with OR in patients with psoriasis. When determining the treatment dose, attention may be paid to patients with higher body weight and lower albumin levels in order to prevent underdosing.</p>\u0000 </div>","PeriodicalId":54848,"journal":{"name":"Journal of Dermatology","volume":"52 10","pages":"1570-1575"},"PeriodicalIF":2.7,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144786320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immune Checkpoint Inhibitor-Induced IgA Vasculitis With Abundant IgA Anti-Endothelial Cell Antibodies","authors":"Eori Noda,&nbsp;Mariko Ogawa-Momohara,&nbsp;Satoshi Kamiya,&nbsp;Norika Akashi,&nbsp;Yuta Yamashita,&nbsp;Haruka Koizumi,&nbsp;Takuya Takeichi,&nbsp;Yoshinao Muro,&nbsp;Masashi Akiyama","doi":"10.1111/1346-8138.17895","DOIUrl":"10.1111/1346-8138.17895","url":null,"abstract":"","PeriodicalId":54848,"journal":{"name":"Journal of Dermatology","volume":"52 10","pages":"e938-e939"},"PeriodicalIF":2.7,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144786319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case of Granular C3 Dermatosis With Methemoglobinemia After Administration of Dapsone","authors":"Shiori Azuma,&nbsp;Yutaka Inaba,&nbsp;Chiharu Tateishi,&nbsp;Takashi Hashimoto,&nbsp;Masatoshi Jinnin","doi":"10.1111/1346-8138.17887","DOIUrl":"10.1111/1346-8138.17887","url":null,"abstract":"","PeriodicalId":54848,"journal":{"name":"Journal of Dermatology","volume":"52 10","pages":"e931-e932"},"PeriodicalIF":2.7,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144786318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frontal Fibrosing Alopecia Colocalized With Vitiligo","authors":"Moyuka Wada-Irimada,&nbsp;Takehiro Takahashi,&nbsp;Kengo Kinjo,&nbsp;Mana Sekine,&nbsp;Ryo Amagai,&nbsp;Naokazu Hatchome,&nbsp;Yoshihide Asano","doi":"10.1111/1346-8138.17891","DOIUrl":"10.1111/1346-8138.17891","url":null,"abstract":"","PeriodicalId":54848,"journal":{"name":"Journal of Dermatology","volume":"52 10","pages":"e936-e937"},"PeriodicalIF":2.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144762915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary Cutaneous Peripheral T-Cell Lymphoma, Not Otherwise Specified With a T-Follicular Helper Phenotype Treated by Rituximab and Low-Dose Prednisolone: A Case Report","authors":"Yuka Nakayama,&nbsp;Eiji Kiyohara,&nbsp;Satoshi Nojima,&nbsp;Manabu Fujimoto","doi":"10.1111/1346-8138.17890","DOIUrl":"10.1111/1346-8138.17890","url":null,"abstract":"","PeriodicalId":54848,"journal":{"name":"Journal of Dermatology","volume":"52 10","pages":"e933-e935"},"PeriodicalIF":2.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144762916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reduction in Dressing Change Burden in Patients With Epidermolysis Bullosa—Impact of Oleogel-S10","authors":"Anna L. Bruckner,&nbsp;Dédée Murrell,&nbsp;Lara Wine Lee,&nbsp;Eli Sprecher,&nbsp;Dimitra Kiritsi,&nbsp;Laura Maher,&nbsp;Sandra Löwe,&nbsp;Maryanne Donovan,&nbsp;Johannes S. Kern,&nbsp;the EASE investigators","doi":"10.1111/1346-8138.17884","DOIUrl":"https://doi.org/10.1111/1346-8138.17884","url":null,"abstract":"<p>Epidermolysis bullosa (EB) is a severe genetic disorder marked by skin fragility and blistering from minimal trauma. Management relies on frequent and painful dressing changes. The EASE study (NCT03068780), the largest to date in EB, previously demonstrated accelerated wound healing and reduced wound burden for Oleogel-S10 (birch triterpenes) versus control gel. This post hoc analysis focused on dressing change frequency and related time and cost savings among patients with daily dressing changes at baseline (Oleogel-S10 <i>n</i> = 47, control gel <i>n</i> = 53). By Day 90, 35.6% of Oleogel-S10 patients required fewer daily changes versus 10.6% in the control group (<i>p</i> = 0.005). Weekly dressing changes reduced by 1.36 ± 0.24 with Oleogel-S10 compared to 0.41 ± 0.23 for control (difference −0.95 ± 0.33; <i>p</i> = 0.005). This translated to almost three fewer dressing changes every 2 weeks for Oleogel-S10 versus nearly one change for the control gel. The estimated time saved per week was 10.7 h with Oleogel-S10 (6.4 h patient, 4.3 h caregiver) versus 4.0 h with control (2.4 h patient, 1.6 h caregiver). Estimated dressing costs reduced by 59%, from $63.4 k to $25.9 k per patient over 27 months. Oleogel-S10 significantly reduced dressing frequency and time burden, with potential to ease the intensive demands of EB wound care.</p>","PeriodicalId":54848,"journal":{"name":"Journal of Dermatology","volume":"52 9","pages":"1447-1451"},"PeriodicalIF":2.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1346-8138.17884","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144998985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful Treatment of Clear Cell Sarcoma Using Radiotherapy and Immune Checkpoint Inhibitors","authors":"Kenya Tokai,&nbsp;Akira Kaneko,&nbsp;Daichi Miyagi,&nbsp;Shuichi Shimada,&nbsp;Ikko Kajihara,&nbsp;Katsunari Makino,&nbsp;Satoshi Fukushima","doi":"10.1111/1346-8138.17882","DOIUrl":"10.1111/1346-8138.17882","url":null,"abstract":"","PeriodicalId":54848,"journal":{"name":"Journal of Dermatology","volume":"52 10","pages":"e927-e928"},"PeriodicalIF":2.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144762917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Retrospective Study of Diffuse Plexiform Neurofibroma With Surgical Intervention in Neurofibromatosis 1","authors":"Monji Koga,&nbsp;Akiko Yoshinaga,&nbsp;Yuko Ehara,&nbsp;Itaru Tsuge,&nbsp;Yuichi Yoshida,&nbsp;Satoshi Takagi,&nbsp;Shinichi Imafuku","doi":"10.1111/1346-8138.17888","DOIUrl":"https://doi.org/10.1111/1346-8138.17888","url":null,"abstract":"<div>\u0000 \u0000 <p>Diffuse plexiform neurofibroma (DPN) is a subtype of plexiform neurofibroma that primarily develops on a large pigmented macule. These tumors often exhibit substantial growth and carry a risk of malignant transformation. Consequently, DPN can significantly impact the quality of life and prognosis in patients with neurofibromatosis 1, underscoring the critical need for effective therapeutic options. MEK inhibitors, such as Mirdametinib and Selumetinib, have recently become available for symptomatic, unresectable pediatric PN. However, surgical resection remains the only viable treatment for adult patients in Japan. Nevertheless, a consensus on the optimal timing and necessity of surgical intervention has not been established. This multicenter retrospective study analyzed 95 cases of DPN, including 46 who underwent surgical treatment. The most common age at the time of surgery was in the third decade of life, and 71.7% of them were female. Tumors were most commonly located in the trunk (42.1%), and 40% of them were less than 10 cm in size and associated with pain. Complete excision was achieved in 24.1% of the resected tumors. In terms of postoperative adverse events, significant hemorrhage was observed in 4 cases (8.6%), and 2 cases (4.3%) resulted in neurological deficits. These findings suggest that surgical intervention is undertaken for smaller, painful tumors located in anatomically accessible regions. As DPN grows in size, surgical resection becomes challenging, highlighting the importance of considering early intervention while curative resection remains feasible.</p>\u0000 </div>","PeriodicalId":54848,"journal":{"name":"Journal of Dermatology","volume":"52 10","pages":"1589-1592"},"PeriodicalIF":2.7,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145297618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}