Journal of Dermatology最新文献

{"title":"Cutaneous Squamous Cell Carcinoma Arising From Hidradenitis Suppurativa and Epidermal Cyst: Clinical Characteristics, Baseline Neutrophil-To-Lymphocyte Ratio, and Disease-Specific Survival in a Retrospective Cohort","authors":"Yusuke Muto,&nbsp;Taku Fujimura,&nbsp;Airi Kobayashi,&nbsp;Kojiro Segawa,&nbsp;Emi Yamazaki,&nbsp;Ryo Amagai,&nbsp;Erika Tamabuchi,&nbsp;Yumi Kambayashi,&nbsp;Akira Hashimoto,&nbsp;Yoshihide Asano","doi":"10.1111/1346-8138.70433","DOIUrl":"10.1111/1346-8138.70433","url":null,"abstract":"<div>\u0000 \u0000 <p>Cutaneous squamous cell carcinoma (cSCC) may develop in chronic inflammatory settings, but clinicopathological features and outcomes remain poorly defined. To characterize clinical features and disease-specific survival (DSS) of cSCC arising from HS or EC in a single-institution cohort, and to assess baseline neutrophil-to-lymphocyte ratio (NLR) as a readily available inflammatory marker. We retrospectively reviewed 231 patients with cSCC diagnosed at a tertiary academic center between January 2013 and December 2024. After excluding 36 without baseline NLR data, a total of 195 patients were analyzed. Clinical characteristics, tumor staging, HS severity, baseline NLR, and DSS were evaluated. Of 195 evaluable patients, 8 had cSCC arising from hidradenitis suppurativa (HS), 5 from epidermal cysts (EC), 14 from burn scars, and 168 de novo (primary) cSCC. HS/EC-associated cSCC showed significantly higher baseline NLR than others (<i>p</i> = 0.016). In univariate analysis, primary tumor site, clinical T and N stages, baseline NLR, and HS/EC-associated lesion were significantly associated with DSS. Burn scar–associated cSCC was not significantly associated with DSS (<i>p</i> = 0.60). In multivariate analysis, clinical N and T stage (<i>p</i> &lt; 0.05) and HS/EC-associated cSCC (<i>p</i> = 0.020; HR = 4.28, 95% CI, 1.26–14.6) remained independently associated with poorer DSS. In this cohort, cSCC arising from HS or EC was associated with elevated baseline NLR and poorer DSS. These findings suggest that HS/EC-associated cSCC may represent a clinically recognizable high-risk subgroup warranting careful surveillance, while the prognostic role of baseline NLR requires validation in larger studies.</p>\u0000 </div>","PeriodicalId":54848,"journal":{"name":"Journal of Dermatology","volume":"53 10","pages":"1515-1524"},"PeriodicalIF":2.3,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148665430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploratory MRI and Clinical Marker Analysis of Pustulotic Arthro-Osteitis Disease Activity From a Phase 3 Brodalumab Trial","authors":"Taiki Nozaki,&nbsp;Manabu Arai,&nbsp;Junko Ochi,&nbsp;Mona Uchida-Yamada,&nbsp;Masahiro Hashimoto,&nbsp;Mitsuhiro Akiyama,&nbsp;Yuko Kaneko,&nbsp;Yasumasa Kanai,&nbsp;Masahiro Jinzaki","doi":"10.1111/1346-8138.70425","DOIUrl":"10.1111/1346-8138.70425","url":null,"abstract":"<p>Pustulotic arthro-osteitis (PAO) is a clinically important osteoarticular comorbidity affecting approximately 9%–28% of patients with palmoplantar pustulosis (PPP), yet early recognition and standardized activity assessment remain challenging, particularly in routine dermatology practice. This exploratory analysis evaluated patients with PAO to identify potential indicators of disease activity. A magnetic resonance imaging (MRI)-based scoring system for the anterior chest wall (ACW) in patients with PAO was developed. This post hoc analysis used data from the PAO subgroup of patients with PPP enrolled in a previous phase 3 trial. Correlations were assessed between clinical indicators—Ankylosing Spondylitis Disease Activity Score, Assessment of SpondyloArthritis international Society Health Index score, physicians' Numeric Rating Scale-PAO (NRS-PAO) activity score, and patients' NRS-PAO pain score—and MRI indicators, including active lesions such as bone marrow edema extent and intensity, and structural lesions in the ACW, spine, and sacroiliac joints (Spondyloarthritis Research Consortium of Canada [SPARCC] score); the correlations between MRI indicators and plain radiographic indicators were also evaluated. Of 20 included patients (mean age: 56.6 years), the majority were female. MRI examinations detected bone marrow edema in all patients. None of the clinical indicators showed a clear association with MRI indicators. There was no clear association between radiographic indicators and the bone marrow edema extent or intensity scores of lesions in the ACW. The spine SPARCC score was positively correlated with the osteosclerosis score of the ACW (|<i>r</i>| = 0.70; <i>p</i> = 0.0218) and the modified Stoke Ankylosing Spondylitis Spinal Score of the spine (|<i>r</i>| = 0.93; <i>p</i> &lt; 0.001). The MRI-based ACW scoring system may provide a feasible method to standardize disease activity assessment in PAO in clinical practice. Further external validation is warranted, and additional clinical indicators are needed to predict disease activity.</p><p><b>Trial Registration:</b> NCT04061252, UMIN000055398</p>","PeriodicalId":54848,"journal":{"name":"Journal of Dermatology","volume":"53 10","pages":"1448-1456"},"PeriodicalIF":2.3,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1346-8138.70425","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148665505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Topical β-Blocker as a Novel Treatment Option for Periungual Pyogenic Granuloma: A Retrospective Study of Lesion Size Reduction and Pain Improvement","authors":"Yoshinori Watanabe,&nbsp;Minako Ogawa-Tominaga,&nbsp;Michie Katsuta,&nbsp;Itaru Dekio,&nbsp;Akihiko Asahina,&nbsp;Yoshimasa Nobeyama","doi":"10.1111/1346-8138.70399","DOIUrl":"10.1111/1346-8138.70399","url":null,"abstract":"<div>\u0000 \u0000 <p>Periungual pyogenic granuloma (PG) is a benign reactive vascular lesion commonly associated with trauma and/or drug exposure, including anticancer therapies such as epidermal growth factor receptor (EGFR) inhibitors and other targeted agents. These lesions often cause pain, bleeding, and functional impairment, and may lead to interruption or dose reduction of relevant anticancer treatment. However, there remains a need for effective and noninvasive treatment options that can be easily administered in clinical practice. This study aimed to evaluate the clinical effectiveness and safety of topical timolol in patients with periungual PG. A total of 12 patients were treated with topical timolol 0.5% applied twice daily. Clinical outcomes, including lesion size, pain visual analog scale (VAS), and Dermatology Life Quality Index (DLQI), were assessed at baseline, Week 4, and Week 8. Lesion size decreased significantly over time (<i>p</i> = 0.003), with a significant reduction observed at Week 8 compared with baseline (<i>p</i> = 0.002), corresponding to a mean reduction of 60.3% at week 8. Pain VAS significantly improved at both Week 4 (<i>p</i> = 0.043) and Week 8 (<i>p</i> &lt; 0.001), with a mean reduction of 65.5% at Week 8 compared with baseline. DLQI also improved but did not show a statistically significant change. No significant adverse events, including significant changes in blood pressure or heart rate, were observed. In conclusion, the study suggests that topical timolol is a safe and effective treatment for periungual PG, making it a valuable supportive care strategy for patients undergoing anticancer therapy.</p>\u0000 </div>","PeriodicalId":54848,"journal":{"name":"Journal of Dermatology","volume":"53 10","pages":"1474-1479"},"PeriodicalIF":2.3,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148440600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in γδ T Cells: Cutaneous Biology and Therapeutic Potential for Skin Neoplasms","authors":"Simo Du,&nbsp;Anika Jallorina,&nbsp;Toru Yoshino,&nbsp;Lingyu Bao,&nbsp;Han Bao,&nbsp;Victor Chang,&nbsp;Henry K. Wong,&nbsp;Derek V. Chan,&nbsp;Stephen K. Richardson,&nbsp;Mary F. Lee-Wong","doi":"10.1111/1346-8138.70461","DOIUrl":"10.1111/1346-8138.70461","url":null,"abstract":"<p>γδ T cells represent an increasingly important subset of T lymphocytes in the immune response to cancer and as a platform for novel immunotherapies. The aim of this review is to synthesize recent insights into the biology and advances in therapeutic applications of γδ T cells in cutaneous malignancies, especially melanoma, within a framework of tumor immunology and recent clinical research.</p>","PeriodicalId":54848,"journal":{"name":"Journal of Dermatology","volume":"53 10","pages":"1415-1428"},"PeriodicalIF":2.3,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1346-8138.70461","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148803974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Major Adverse Cardiovascular Event Across Diverse Racial Groups of Psoriasis Patients on Biologic Therapy: A Retrospective Cohort Study","authors":"Chunghwan Ro,&nbsp;Ana Ormaza Vera,&nbsp;Waleed Adawi,&nbsp;Clinton W. Enos","doi":"10.1111/1346-8138.70396","DOIUrl":"10.1111/1346-8138.70396","url":null,"abstract":"<p>Psoriasis is associated with an increased risk of major adverse cardiovascular events (MACE), and biologic therapy may reduce this risk by targeting systemic inflammation. However, limited data exist on whether long term MACE risk differs by biologic class or across racial groups. We conducted a retrospective cohort study to assess the risk of primary MACE in psoriasis patients receiving biological therapies, stratified by biological class, compared with biologic-naïve psoriasis patients. Whether MACE risk among biologic-treated patients varied by race was further examined. After 1:1 propensity score matching, 36 330 biologic-treated patients were compared with 36 330 non-biologic-treated patients. Incident MACE was assessed over 10 years. Class-specific analyses evaluated mutually exclusive biologic exposure groups, including TNF inhibitors (TNFi), IL-17 inhibitors (IL-17i), IL-12/23 inhibitors (IL-12/23i), and IL-23 inhibitors (IL-23i), each compared with an independently matched nonbiologic psoriasis comparator cohort. Race stratified analyses were restricted to biologic-treated patients, with White patients serving as the reference group. Psoriasis patients treated with biologics exhibited a 37% lower hazard of MACE compared with non-biologic users over the 10-year follow-up period [2160 vs. 3294; HR 0.63 (0.60–0.67)]. Class-specific analyses revealed reductions in MACE risk for TNFi [1403 vs. 1844; HR: 0.74 (0.69–0.80)], IL-17i [285 vs. 450; HR: 0.61 (0.53–0.72)], IL-12/23i [280 vs. 374; HR: 0.73 (0.62–0.86)], and IL-23i [238 vs. 363; HR: 0.64 (0.54–0.76)]. Race stratified analyses showed broadly similar MACE risk across racial groups; although, patients identifying as Non-White treated with TNFi did experience a reduced MACE risk compared to White patients [127 vs. 162; HR: 0.79 (0.62–0.99)]. This isolated finding should be interpreted cautiously given multiple race stratified comparisons. Overall, biologic therapy is associated with lower 10-year MACE risk among patients with psoriasis, with findings observed across biologic classes and largely consistent across racial strata.</p>","PeriodicalId":54848,"journal":{"name":"Journal of Dermatology","volume":"53 10","pages":"1439-1447"},"PeriodicalIF":2.3,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1346-8138.70396","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148595232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CD73 Expression Correlates With Malignant Progression in NF1-Associated Peripheral Nerve Sheath Tumors: Potential Role in Pathological Diagnosis","authors":"Ai Matsuda,&nbsp;Kaori Koga,&nbsp;Mikiko Aoki,&nbsp;Yuichi Yamada,&nbsp;Monji Koga,&nbsp;Masakazu Fujimoto,&nbsp;Makoto Hamasaki,&nbsp;Shinichi Imafuku","doi":"10.1111/1346-8138.70428","DOIUrl":"10.1111/1346-8138.70428","url":null,"abstract":"<div>\u0000 \u0000 <p>This study investigated the association between CD73 expression and malignant progression in NF1-associated peripheral nerve sheath tumors and evaluated its potential as a diagnostic marker. Histopathological differentiation of atypical neurofibromatous neoplasms of uncertain biological potential (ANNUBP) and low-grade malignant peripheral nerve sheath tumors (MPNST) in patients with NF1 remains challenging. Therefore, reliable adjunctive markers are needed to improve diagnostic accuracy. CD73 is an ectoenzyme with ecto-5′-nucleotidase activity. Recent studies have also suggested that CD73 may promote tumor invasion by facilitating extracellular matrix remodeling, independent of immune suppression. To investigate the role of CD73 in NF1-associated tumors, we analyzed CD73 expression in 57 NF1-associated tumors, including 39 benign neurofibromas (NF), 7 ANNUBP, and 11 MPNST, using immunohistochemistry and reverse transcription- quantitative PCR (RT-qPCR) in selected cases. Most tumors arose in the skin or subcutaneous tissue. Among the four histological subtypes of NF, solitary and diffuse types were mostly negative for CD73 expression (19/20 cases), whereas plexiform and mixed types, which are associated with a higher risk of malignant transformation, more frequently exhibited positive expression. Most ANNUBP cases (6/7 cases) demonstrated low or negative CD73 expression, whereas all MPNST cases were positive, with the majority showing high expression (9/11 cases). CD73 expression was significantly higher in MPNST than in solitary and diffuse types of NF and ANNUBP. RT-qPCR analysis consistently demonstrated a stepwise increase in <i>NT5E</i>(CD73) mRNA expression progressing from benign solitary and diffuse types of NF (0.74 ± 0.33) to ANNUBP (2.93 ± 0.57) and MPNST (9.26 ± 4.89). These findings suggest that CD73 expression increases in association with higher tumor grade and malignant progression in NF1-associated peripheral nerve sheath tumors and may serve as a useful adjunctive marker in pathological diagnosis, particularly in cases where distinguishing ANNUBP from MPNST is challenging.</p>\u0000 </div>","PeriodicalId":54848,"journal":{"name":"Journal of Dermatology","volume":"53 10","pages":"1507-1514"},"PeriodicalIF":2.3,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148595234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Vinyl Adhesive Tape Technique With Methylene Blue for Diagnosis of Superficial Fungal Skin Infections","authors":"Thanaphon Anutraungkool,&nbsp;Charoen Choonhakarn,&nbsp;Suteeraporn Chaowattanapanit,&nbsp;Rachot Wongjirattikarn,&nbsp;Narachai Julanon","doi":"10.1111/1346-8138.70420","DOIUrl":"10.1111/1346-8138.70420","url":null,"abstract":"<div>\u0000 \u0000 <p>The Vinyl adhesive tape (VAT) technique with methylene blue (MTB) may be useful as an adjunctive microscopic method for diagnosis of superficial fungal skin infections. A cross-sectional study was conducted between 2022 and 2025 on adults with dermatophytosis, pityriasis versicolor, and cutaneous candidiasis confirmed by skin scraping with potassium hydroxide (KOH). VAT technique with MTB staining was performed at the same lesion. Data on clinical characteristics, hyphal index, and time to microscopic identification were recorded. The primary objective was the positivity rate of VAT technique with MTB in patients with superficial fungal skin infections confirmed by skin scraping and direct microscopy with KOH. Secondary objectives included identifying factors associated with positive results and comparing time to microscopic identification. Among 208 participants (mean [SD] age, 50.87 [19.36] years; 44% female), the overall positivity rate of VAT technique with MTB was 89.4% (186/208), with positivity rates of 83.3% (105/126) for dermatophytosis, 100% (41/41) for pityriasis versicolor, and 97.6% (40/41) for cutaneous candidiasis. In dermatophytosis, factors significantly associated with positive MTB results included onset of presentation equal or less than a week (adjusted OR 5.26, <i>p</i> = 0.023) and high hyphal index (adjusted OR 8.24, <i>p</i> = 0.002). For dermatophytosis, KOH microscopy yielded a shorter time to identification, whereas for pityriasis versicolor, the VAT technique with MTB was faster. Among KOH-confirmed cases, the VAT technique with MTB showed the highest positivity rate in pityriasis versicolor, followed by cutaneous candidiasis, whereas the positivity rate was lower in dermatophytosis.</p>\u0000 </div>","PeriodicalId":54848,"journal":{"name":"Journal of Dermatology","volume":"53 10","pages":"1498-1506"},"PeriodicalIF":2.3,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148581889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pre-Referral Provisional Diagnoses and Final Diagnostic Subtypes of Pemphigus at a Regional Tertiary Dermatology Center in Japan: A Single-Center Retrospective Study","authors":"Shohei Kitayama,&nbsp;Teruhiko Makino,&nbsp;Tadamichi Shimizu","doi":"10.1111/1346-8138.70407","DOIUrl":"10.1111/1346-8138.70407","url":null,"abstract":"<div>\u0000 \u0000 <p>Pemphigus comprises autoimmune blistering diseases with heterogeneous clinical presentations, but pre-referral provisional diagnoses in regional tertiary dermatology practice have been less well characterized. We retrospectively reviewed 35 consecutive patients diagnosed with pemphigus at Toyama University Hospital, a regional tertiary dermatology center in Japan, between January 2011 and May 2026. Final diagnoses were established using clinical, histopathological, immunopathological, and serological findings. We extracted referral characteristics, pre-referral provisional diagnoses, final diagnoses, disease severity, and dates of symptom onset and referral visit from medical records. The median age was 69 years, and 20 patients (57.1%) were female. Final diagnoses were pemphigus vulgaris in 15 patients (42.9%), pemphigus foliaceus in 10 (28.6%), paraneoplastic pemphigus in 3 (8.6%), intercellular IgG/IgA dermatosis in 3 (8.6%), pemphigus herpetiformis in 2 (5.7%), pemphigus vegetans in 1 (2.9%), and unclassified pemphigus in 1 (2.9%). Only 10 patients (28.6%) had pemphigus recorded as the pre-referral diagnosis; other pre-referral diagnoses included impetigo, Behçet's disease, refractory stomatitis, dermatitis/eczema, pemphigoid, and drug eruption. Exploratory cosinor analysis suggested possible annual variation in the interval from symptom onset to referral visit, with longer intervals around winter and shorter intervals around summer. By mapping pre-referral diagnoses to final pemphigus diagnoses, this study highlights heterogeneity in diagnostic subtypes and referral pathways through which pemphigus reaches regional tertiary dermatology care.</p>\u0000 </div>","PeriodicalId":54848,"journal":{"name":"Journal of Dermatology","volume":"53 10","pages":"1532-1536"},"PeriodicalIF":2.3,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148475185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Infrared Thermography as a Clinical Clue to Eccrine Angiomatous Hamartoma in a Child","authors":"Ming-Ying Wu,&nbsp;Kuniaki Ohara","doi":"10.1111/1346-8138.70436","DOIUrl":"10.1111/1346-8138.70436","url":null,"abstract":"<div>\u0000 \u0000 <p>Eccrine angiomatous hamartoma is an uncommon benign cutaneous hamartoma characterized by proliferation of eccrine and vascular components. It usually presents at birth or in childhood as a solitary extremity lesion and may be associated with pain, tenderness, hypertrichosis, or hyperhidrosis. We report a 6-year-old boy with a recurrent warm, hyperhidrotic subcutaneous tumor on the lateral aspect of the right ankle. The lesion had previously been excised under the clinical impression of hemangioma and was reported as angiolipoma, but later recurred and enlarged. Clinical examination showed a flesh-colored 5 × 4.5 cm tumor with clear surface secretion. Qualitative infrared thermography demonstrated focal surface warmth over the lesion. Histopathology showed well-circumscribed unencapsulated dermal and subcutaneous nodules composed of proliferating eccrine glands, vascular channels, mucinous stroma, mature fat, dilated sweat ducts, and large vessels with organizing thrombus, confirming eccrine angiomatous hamartoma. In this case, infrared thermography converted clinically perceived warmth into a visible, non-contact surface map that may help localize symptomatic surface involvement when planning conservative excision. Histopathology remains essential for diagnosis.</p>\u0000 </div>","PeriodicalId":54848,"journal":{"name":"Journal of Dermatology","volume":"53 10","pages":"1552-1554"},"PeriodicalIF":2.3,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148803981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk Factors for Cutaneous Immune-Related Adverse Events in the Japanese Population: A Retrospective Single-Center Cohort Study","authors":"Tomoya Watanabe,&nbsp;Kohei Yamakawa,&nbsp;Miyu Kobayashi,&nbsp;Yusuke Saigusa,&nbsp;Yukie Yamaguchi","doi":"10.1111/1346-8138.70370","DOIUrl":"10.1111/1346-8138.70370","url":null,"abstract":"<p>Immune checkpoint inhibitor (ICI)-driven alterations in the immune system can induce immune-related adverse events (irAEs). Cutaneous irAEs are notable for being the most common and for their early onset; however, the risk factors underlying their development and severity remain unclear. In this study, we retrospectively analyzed 1224 Japanese patients treated with at least one ICI at Yokohama City University Hospital between 2014 and 2024 and identified the risk factors for cutaneous irAEs using multivariable logistic regression analysis. Overall, 145 cutaneous irAEs were identified in 134 patients (10.9%), of which 18 (1.5%) developed grade 4 cutaneous irAEs. Statistical analysis revealed that anti-programmed cell death protein 1 (anti-PD-1) and anti-cytotoxic T-lymphocyte associated protein-4 (anti-CTLA-4) combination therapy was significantly associated with the risk of developing cutaneous irAEs compared with anti-PD-1 (odds ratio [OR] = 3.21; 95% confidence interval [CI], 1.85–5.54; <i>p</i> &lt; 0.001) or anti-PD ligand 1 (OR = 4.53; 95% CI, 2.06–10.34; <i>p</i> &lt; 0.001) monotherapy. A higher baseline eosinophil count (OR = 1.27; 95% CI, 1.06–1.55; <i>p</i> = 0.013) and melanoma (OR = 2.11; 95% CI, 1.17–3.72; <i>p</i> = 0.011) were associated with an increased risk of cutaneous irAEs. Furthermore, female sex (OR = 4.13; 95% CI, 1.36–13.11; <i>p</i> = 0.012) and high baseline monocyte count (OR = 6.68; 95% CI, 1.87–27.61; <i>p</i> = 0.003) were risk factors for grade 4 cutaneous irAEs. These results indicated that anti-PD-1 and anti-CTLA-4 combination therapy, high eosinophil counts, and melanoma were associated with a higher risk of developing cutaneous irAEs, whereas female sex and high monocyte counts were risk factors for severe cutaneous irAEs.</p>","PeriodicalId":54848,"journal":{"name":"Journal of Dermatology","volume":"53 9","pages":"1245-1260"},"PeriodicalIF":2.3,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1346-8138.70370","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148378864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}