Journal of Hospital Infection最新文献

{"title":"Clinical characteristics and outcome of Candida auris bloodstream infections during an outbreak in a Greek tertiary academic intensive care unit","authors":"E. Paramythiotou , E. Kyriazopoulou , E. Karakike , M. Siopi , F. Frantzeskaki , J. Meletiadis , I. Tsangaris","doi":"10.1016/j.jhin.2025.03.014","DOIUrl":"10.1016/j.jhin.2025.03.014","url":null,"abstract":"","PeriodicalId":54806,"journal":{"name":"Journal of Hospital Infection","volume":"161 ","pages":"Pages 25-27"},"PeriodicalIF":3.9,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144055937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The hidden burden of VRE screening tests in patients colonized with VRE in an acute setting: a retrospective analysis.","authors":"S P Mathew, L Reynolds, S Nally, S Frost, V Boland","doi":"10.1016/j.jhin.2025.04.002","DOIUrl":"10.1016/j.jhin.2025.04.002","url":null,"abstract":"","PeriodicalId":54806,"journal":{"name":"Journal of Hospital Infection","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144046418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors for blood exposure accidents and their reporting in dentistry in The Netherlands","authors":"I.F. Persoon ,&nbsp;A.M. Kaan ,&nbsp;N. Su ,&nbsp;J.J. de Soet ,&nbsp;C.M.C. Volgenant","doi":"10.1016/j.jhin.2025.03.009","DOIUrl":"10.1016/j.jhin.2025.03.009","url":null,"abstract":"<div><h3>Background</h3><div>Oral healthcare practitioners (OHCPs) face risks for blood-borne viruses following blood exposure accidents (BEAs).</div></div><div><h3>Aim</h3><div>This study aimed to investigate occupational BEAs in Dutch oral healthcare clinics, explore BEA risk factors, and identify reasons for non-reporting.</div></div><div><h3>Methods</h3><div>Two questionnaires were distributed: one prospective questionnaire was sent to BEA reporters who contacted a nationally operating reporting centre for occupational BEAs (issued before and after European legislation on recapping), and a retrospective questionnaire was sent to clinics which did not report any BEA in the previous four years. Data were analysed and logistic regression was applied to identify factors associated with BEA occurrence and reporting. This study is reported according to the STROBE-statement.</div></div><div><h3>Findings</h3><div>A total of 516 questionnaires were returned (37.7%), with 445 OHCPs having experienced a BEA, compared with 69 who had not. Most BEAs occurred with anaesthetic needles (43.3%) while cleaning up instruments (51.6%). Recapping remained an important cause after its prohibition (<em>P</em>=0.076). Dentists were less informed on safety protocols (<em>P</em>&lt;0.001) and BEA consequences (<em>P</em>&lt;0.001) compared with non-dentists (oral hygienists and dental assistants). OHCPs with accurate knowledge of BEA protocols were more likely to experience BEAs (OR = 2.9, 95% CI 1.5–5.6, <em>P</em>=0.001) and to report a BEA (OR = 8.0, 95% CI 3.9–16.5, <em>P</em>&lt;0.001) than those without. Dentists had 0.3 times lower odds (95% CI 0.1–0.7, <em>P</em>=0.004) of reporting BEAs than non-dentists.</div></div><div><h3>Conclusions</h3><div>Implementation of guidelines more effectively is crucial to prevent and reduce blood-borne disease transmission. Changing attitudes and behaviours towards recapping and safety-engineered devices is essential, as recapping needles continues to cause many BEAs.</div></div>","PeriodicalId":54806,"journal":{"name":"Journal of Hospital Infection","volume":"160 ","pages":"Pages 26-33"},"PeriodicalIF":3.9,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143923731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of COVID-19 pandemic on the implementation of transmission-based precautions","authors":"K. Yap ,&nbsp;K.Z. Linn ,&nbsp;A.Y. Lim ,&nbsp;X. Huan ,&nbsp;N.B. Han ,&nbsp;L. Sun ,&nbsp;S.H. Tan ,&nbsp;K.C. Thoon ,&nbsp;B.S.P. Ang ,&nbsp;M.L. Ling ,&nbsp;S.K. Pada ,&nbsp;A. Ty ,&nbsp;D. Fisher ,&nbsp;K. Marimuthu","doi":"10.1016/j.jhin.2025.03.010","DOIUrl":"10.1016/j.jhin.2025.03.010","url":null,"abstract":"<div><h3>Background</h3><div>Multidrug-resistant organisms and hospital-acquired infections threaten patient safety. Transmission-based precautions (TBPs) are critical infection prevention and control (IPC) measures but resource intensive. The COVID-19 pandemic disrupted routine IPC practices due to resource diversion for pandemic response, straining systems and compromising TBPs for pathogens of interest (POIs).</div></div><div><h3>Aim</h3><div>To investigate the impact of the COVID-19 pandemic on the implementation of pathogen-specific TBPs in five Singapore acute hospitals before and during the COVID-19 pandemic from August 2020 to August 2021.</div></div><div><h3>Methods</h3><div>The primary outcome measure was the proportion of patients on appropriate pathogen-specific TBPs. The variables between the two cycles were compared to assess the impact of COVID-19 on the implementation of pathogen-specific IPC measures.</div></div><div><h3>Findings</h3><div>A total of 8601 patient records were reviewed (4132 in Cycle 1 and 4469 in Cycle 2). Appropriate TBP implementation decreased by 39% during Cycle 2 compared to Cycle 1 (odds ratio (OR): 0.61; 95% confidence interval (CI): 0.50–0.73; <em>P</em> &lt; 0.01). Staff unawareness of POIs emerged as the most common factor contributing to inappropriate TBP placement across both cycles. Notably, patients with meticillin-resistant <em>Staphylococcus aureus</em> only experienced a significant decrease in appropriate TBP during Cycle 2 (OR: 0.56; 95% CI: 0.44–0.71; <em>P</em> &lt; 0.01). Interestingly, hospitals with higher pre-pandemic TBP adherence rates maintained better compliance during the pandemic.</div></div><div><h3>Conclusion</h3><div>The COVID-19 pandemic adversely affected the implementation of appropriate TBPs in Singapore acute care hospitals. This study highlights the need for proactive appropriate TBP maintainance during public health emergencies.</div></div>","PeriodicalId":54806,"journal":{"name":"Journal of Hospital Infection","volume":"162 ","pages":"Pages 76-83"},"PeriodicalIF":3.9,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143804882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing healthcare workforce management: the economic impact of in-house molecular testing during the COVID-19 pandemic.","authors":"P T Coutinho, É J Manchesski, P D Batista, V U Palma, J P F Fortti, G M Faleiro, L da S Almeida, M Reche, A C Pasqualotto","doi":"10.1016/j.jhin.2025.04.001","DOIUrl":"10.1016/j.jhin.2025.04.001","url":null,"abstract":"","PeriodicalId":54806,"journal":{"name":"Journal of Hospital Infection","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143804883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Why is the pathogen positivity rate so high even after chlorhexidine-alcohol disinfection?","authors":"Y Xiao, C Tan, J Zou, S Chen, B Tian, A Wu, C Li","doi":"10.1016/j.jhin.2025.01.018","DOIUrl":"10.1016/j.jhin.2025.01.018","url":null,"abstract":"","PeriodicalId":54806,"journal":{"name":"Journal of Hospital Infection","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143797145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are particle counts better than microbiological sampling to assess air supply cleanliness in operating theatres?","authors":"A. Bak ,&nbsp;P. Hoffman ,&nbsp;C. Mackintosh ,&nbsp;H. Humphreys","doi":"10.1016/j.jhin.2025.03.012","DOIUrl":"10.1016/j.jhin.2025.03.012","url":null,"abstract":"","PeriodicalId":54806,"journal":{"name":"Journal of Hospital Infection","volume":"160 ","pages":"Pages 128-130"},"PeriodicalIF":3.9,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143797098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term within-household sharing of ESBL-producing E. coli carrying bla_CTX-M-147 that converted to bla_CTX-M-14.","authors":"H Aardema, S Rosema, M A Fliss, L Gard, A J M Lokate, C L E Hazenberg, A Voss, E Bathoorn","doi":"10.1016/j.jhin.2025.03.008","DOIUrl":"10.1016/j.jhin.2025.03.008","url":null,"abstract":"","PeriodicalId":54806,"journal":{"name":"Journal of Hospital Infection","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143797101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health economic burden of refractory and recurrent Clostridioides difficile infection in the inpatient setting of the German healthcare system – the IBIS Study","authors":"S.M. Wingen-Heimann ,&nbsp;A. Ullah ,&nbsp;M.R. Cruz Aguilar ,&nbsp;S.K. Gräfe ,&nbsp;J. Conrad ,&nbsp;K. Giesbrecht ,&nbsp;K.-P. Hunfeld ,&nbsp;C. Lübbert ,&nbsp;S. Pützfeld ,&nbsp;P.A. Reuken ,&nbsp;M. Schmitz-Rode ,&nbsp;E. Schalk ,&nbsp;T. Schmidt-Wilcke ,&nbsp;S. Schmiedel ,&nbsp;P. Solbach ,&nbsp;M.J.G.T. Vehreschild","doi":"10.1016/j.jhin.2025.03.011","DOIUrl":"10.1016/j.jhin.2025.03.011","url":null,"abstract":"<div><h3>Background</h3><div><em>Clostridioides difficile</em> infections (CDIs) remain a prevalent and costly healthcare challenge, particularly affecting elderly, comorbid patients. Evidence on the health economic burden of CDI in Germany, particularly in refractory and recurrent patients is limited.</div></div><div><h3>Methods</h3><div>The IBIS study was a non-interventional retrospective and prospective study conducted from August 2017 to September 2020 in 10 German hospitals to assess the health economic burden of inpatient CDI treatment. It categorized CDI episodes into initial, refractory and recurrent, following the current ESCMID guidelines. A micro-costing approach from the societal perspective was applied, considering personnel, material, and infrastructure costs for treatment on different types of hospital wards, targeted antibiotic CDI therapies, and productivity losses due to illness-related disability.</div></div><div><h3>Findings</h3><div>Mean total costs per patient were €13,607 (95% CI: €12,124–€15,171) for the initial, €19,953 (95% CI: €16,839–€23,377) refractory and €22,671 (95% CI: €16,088–€30,474; <em>P</em>&lt;0.001) for the recurrence group. Treatment on a general ward was the most important cost driver. Mean hospital length of stay in the initial, refractory group and recurrence group was 30 (95% CI: 27–33) vs 41 (95% CI: 35–46) vs 47 days (95% CI: 37–57; <em>P</em>&lt;0.001), respectively. Patients with initial, refractory and recurrent CDI required 11 (95% CI: 10–1), 15 (95% CI: 13–16) and 24 days (95% CI: 22–27; <em>P</em>&lt;0.001) of targeted antibiotic therapy for CDI.</div></div><div><h3>Conclusion</h3><div>The IBIS study contributes valuable insights to the health economic burden of refractory and recurrent CDI in the German inpatient setting and underlines the importance of effective first-line treatment to improve treatment outcomes and reduce overall costs related to CDI.</div></div>","PeriodicalId":54806,"journal":{"name":"Journal of Hospital Infection","volume":"160 ","pages":"Pages 19-25"},"PeriodicalIF":3.9,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143797099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality indicators for appropriate inpatient antibiotic use: results from two national surveys in Italy, 2016–2022","authors":"C. Vicentini ,&nbsp;A. Russotto ,&nbsp;R. Bussolino ,&nbsp;M. Castagnotto ,&nbsp;C. Gastaldo ,&nbsp;S. Bazzolo ,&nbsp;D. Gamba ,&nbsp;S. Corcione ,&nbsp;F.G. De Rosa ,&nbsp;F. D'Ancona ,&nbsp;C.M. Zotti ,&nbsp;Italian PPS network","doi":"10.1016/j.jhin.2025.03.007","DOIUrl":"10.1016/j.jhin.2025.03.007","url":null,"abstract":"<div><h3>Background</h3><div>To address its high antimicrobial resistance (AMR) and antibiotic consumption rates, Italy introduced a national action plan to contrast AMR (PNCAR) in 2017.</div></div><div><h3>Aim</h3><div>To investigate trends in antibiotic use, prescribing practices, and AMR rates in Italy through indicators of appropriate antibiotic use.</div></div><div><h3>Methods</h3><div>Two point prevalence surveys (PPSs), according to The European Centre for Disease Prevention and Control (ECDC) methods and definitions, were conducted in 2016 and 2022. Indicators of appropriate antibiotic use were defined and measured. Antibiotic use prevalence and AMR rates for specific pathogen–drug combinations were calculated. To account for potential confounding factors, a propensity score matching approach was applied to compare the results of the two PPS editions using prevalence rate ratio (PRR).</div></div><div><h3>Results</h3><div>Overall, 28,991 patients from 140 hospitals and 60,403 patients from 325 hospitals were included in 2016 and 2022, respectively. Patient characteristics remained stable, but patients were increasingly exposed to invasive procedures. The overall prevalence of antibiotic use decreased from 43.51 to 41.52 (PRR 0.95, 95% confidence interval, CI 0.94–0.97, <em>P</em>&lt;0.001). Improvements in some prescribing practices were identified: the proportion of surgical prophylaxis lasting &gt;1 day decreased from 55.99% to 52.15%, (PRR 0.94, 95% CI 0.90–0.98, <em>P</em>&lt;0.001) and the proportion of culture-guided hospital infection treatments increased from 33.68% to 48.57% (PRR 1.30, 95% CI 1.22–1.38, <em>P</em>&lt;0.05). Conversely, a significant rise in the proportion of last line/broad-spectrum agents was recorded for most indications.</div></div><div><h3>Conclusion</h3><div>This study provided a mapping of prescribing activity at national level, and defined measurable quality indicators, through which strengths and areas for improvement in prescribing practices were identified.</div></div>","PeriodicalId":54806,"journal":{"name":"Journal of Hospital Infection","volume":"160 ","pages":"Pages 34-44"},"PeriodicalIF":3.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143782089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}