{"title":"HYPOGLYCÆMIC SHOCK AND THE GRASP-REFLEX: THE EFFECT OF INSULIN SHOCK ON BULBOCAPNINE CATALEPSY IN MONKEYS.","authors":"A Kennedy","doi":"10.1136/jnnp.3.1.27","DOIUrl":"https://doi.org/10.1136/jnnp.3.1.27","url":null,"abstract":"IN a previous communication (Kennedy, 1939) an account has been given of the effects of cardiazol convulsions, such as are used in the treatment of clinical catatonic states, upon the catalepsy-like condition seen in bulbocapnine intoxication in monkeys. A study was made of the effects of convulsions on the grasp-reflex which is invariably present with this state in the bulbocapninized monkey, the intensity of the response being measured by the hanging-time method of Richter (1931). It was shown that the effect of the convulsions was to increase very considerably the cataleptic component of the state produced by bulbocapnine in much the same way as does the inhalation of a high concentration of carbon dioxide (Paterson and Richter, 1932), and that the period during which the grasp-reflex was present was greatly prolonged, though the convulsions alone produced only a transient hanging-response. The purpose of the work to be described was to compare these effects of the induced convulsion with those of hypoglycemic shock. The first object, therefore, was to reproduce in monkeys a condition as nearly as possible resembling therapeutic insulin shock and to determine its effect on motility and upon the grasp-reflex. Having thus standardized the effects of insulin on each animal used, it was then possible to investigate the effects of the hypoglycxmic state on the catalepsy and grasp-reflex phenomena produced by bulbocapnine.","PeriodicalId":54783,"journal":{"name":"Journal of Neurology and Psychiatry","volume":"3 1","pages":"27-36"},"PeriodicalIF":0.0,"publicationDate":"1940-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1136/jnnp.3.1.27","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40109013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"THE EMOTIONAL AND SOMATIC RESPONSE OF SCHIZOPHRENIC PATIENTS AND NORMAL CONTROLS TO ADRENALIN AND DORYL.","authors":"J B Dynes, H Tod","doi":"10.1136/jnnp.3.1.1","DOIUrl":"https://doi.org/10.1136/jnnp.3.1.1","url":null,"abstract":"Number I Page THE EMOTIONAL AND SOMATIC RESPONSE OF SCHIZOPHRENIC PATIENTS AND NORMAL CONTROLS TO ADRENALIN AND DORYL J. B. Dynes and H. Tod 1 THE DISTRIBUTION OF COMMISSURAL FIBRES IN THE CORPUS CALLOSUM IN THE MACAQUE MONKEY S. Sunderland 9 BEHAVIOUR AND MOOD CYCLES APPARENTLY RELATED TO PARATHYROID DEFICIENCY C. P. Richter, W. M. Honeyman, and H. Hunter 19 HYPOGLYCAEMIC SHOCK AND THE GRASP-REFLEX: THE EFFECT OF INSULIN SHOCK ON BULBOCAPNINE CATALEPSY IN MONKEYS A. Kennedy 27 DEGENERATION OF THE PAPILLO-MACULAR BUNDLE IN APES AND ITS SIGNIFICANCE IN HUMAN NEURO-PATHOLOGY H. J. Scherer 37 CRITICAL REVIEW: THE TREATMENT OF MENTAL DISORDERS BY INDUCED CONVULSIONS A. Kennedy 49 EPITOME OF CURRENT JOURNALS 83 BOOK REVIEWS 99","PeriodicalId":54783,"journal":{"name":"Journal of Neurology and Psychiatry","volume":"3 1","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"1940-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1136/jnnp.3.1.1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40109010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"BEHAVIOUR AND MOOD CYCLES APPARENTLY RELATED TO PARATHYROID DEFICIENCY.","authors":"C P Richter, W M Honeyman, H Hunter","doi":"10.1136/jnnp.3.1.19","DOIUrl":"https://doi.org/10.1136/jnnp.3.1.19","url":null,"abstract":"INCREASING interest in the cyclic behaviour of man and animals has been evidenced in recent years, especially in so far as these cyclic changes are related to glandular disturbances. In studies of the spontaneous activity of rats the following cycles have been observed: a 4-5-day cycle associated with ovulation (Wang, 1923) ; a 14-day cycle after section of the pituitary stalk (Richter, 1933) ; a 15-20-day cycle after parathyroidectomy (Richter and Eckert, 1937) ; a 25-35-day cycle after thyroidectomy (Richter, 1933) ; and a 100-day cycle after removal of one ovary and all except a small part of the other ovary (Richter, 1927). Hitherto, in other animals and in humans the only cycles definitely known to depend on endocrine glands were the ovulation and menstrual cycles. In humans with pathological disturbances we know of several other cycles, but we have no knowledge regarding their origin (1) the morning-evening variations in mood seen particularly in depressions (2) a 2-day cycle of alternating good and bad days of behaviour and sleep found in manic-depressive patients (Richter, 1938) ; (3) a 4-6-day cycle manifested in sleep (Richter, 1934) ; and (4) a 9-11-day cycle manifested in attacks of gastric pain (Levine and Richter, 1935). A cycle of approximately 40 days' duration associated with parathyroid deficiency has now been observed in a parathyroidectomized monkey, and a cycle of about the same length of time has been observed in a patient with a parathyroid deficiency.","PeriodicalId":54783,"journal":{"name":"Journal of Neurology and Psychiatry","volume":"3 1","pages":"19-26"},"PeriodicalIF":0.0,"publicationDate":"1940-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1136/jnnp.3.1.19","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40109012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"DEGENERATION OF THE PAPILLO-MACULAR BUNDLE IN APES AND ITS SIGNIFICANCE IN HUMAN NEURO-PATHOLOGY.","authors":"H J Scherer","doi":"10.1136/jnnp.3.1.37","DOIUrl":"https://doi.org/10.1136/jnnp.3.1.37","url":null,"abstract":"Introduction ROTHMANN (1906), Schroder (1908), and Schob (1931), published the early work on spontaneous lesions of the peripheral optic pathways in isolated cases of apes who died of a diffuse degenerative process in the white matter of the centrum ovale and (or) the spinal cord. These authors gave contradictory descriptions of the lesions in the optic pathways. Scherer (1932), who first recognized the pathological identity of this spontaneous disease in apes with that known in the human as \" sub-acute combined degeneration \" (Scherer, 1937) described these optic lesions in more detail. He emphasized their comparative frequency in this condition, and compared them to the rare optic nerve degenerations reported in human subacute combined degeneration. During recent systematic researches on the peripheral optic pathways in monkeys dying from a variety of causes, degenerative lesions in the optic nerves, chiasma, and tracts were found in a surprisingly high percentage of the animals, without degenerative changes elsewhere in the nervous system. Also, in these animals, the keepers had not noticed any visual disturbance during life. The purpose of this paper is first to describe the frequency, exact localization, and histological characteristics of these lesions, and to discuss the possible pathogenesis. Secondly, to compare these lesions with corresponding changes occurring in man and also with those in monkeys affected by definite degenerative changes in other parts of the nervous system (subacute combined degeneration).","PeriodicalId":54783,"journal":{"name":"Journal of Neurology and Psychiatry","volume":"3 1","pages":"37-48"},"PeriodicalIF":0.0,"publicationDate":"1940-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1136/jnnp.3.1.37","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40109014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A CRITICAL REVIEW: THE TREATMENT OF MENTAL DISORDERS BY INDUCED CONVULSIONS.","authors":"A Kennedy","doi":"10.1136/jnnp.3.1.49","DOIUrl":"https://doi.org/10.1136/jnnp.3.1.49","url":null,"abstract":"","PeriodicalId":54783,"journal":{"name":"Journal of Neurology and Psychiatry","volume":"3 1","pages":"49-82"},"PeriodicalIF":0.0,"publicationDate":"1940-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1136/jnnp.3.1.49","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40109015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"EPITOME OF CURRENT JOURNALS","authors":"Acta Psychiatrica, ET Neurologica","doi":"10.1136/jnnp.3.1.83","DOIUrl":"https://doi.org/10.1136/jnnp.3.1.83","url":null,"abstract":"*The Cerebral Vasomotor-Regulation. S. Christiansen, M. Fog, and T. Vangaard. 413. Cerebral Vasomotor Regulation.-A method for the determination of the cerebral Origin of Cerebral H.emorrhages. control of the peripheral circulation in Cerebral hxemorrhages were produced man is described. In two cases with experimentally by raising the blood pressure localized cortical lesions the cerebral control artificially following toxic or embolic of the circulation in the hands was affected. injury to the vessels. The rise in blood (B. McA.)","PeriodicalId":54783,"journal":{"name":"Journal of Neurology and Psychiatry","volume":"3 1","pages":"83 - 99"},"PeriodicalIF":0.0,"publicationDate":"1940-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1136/jnnp.3.1.83","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63907780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"EPITOME OF CURRENT JOURNALS","authors":"","doi":"10.1136/jnnp.2.4.361","DOIUrl":"https://doi.org/10.1136/jnnp.2.4.361","url":null,"abstract":"The Electroencephalograms of Psychotic Patients. P. A. Davis and H. Davis. 1,007. Cerebral Cortical Calcification simulating Pick's Disease. E. Kahn, E. G. Lion, and H. M. Zimmerman. 1,027. Effects of Vitamin B5 Shock in Schizophrenia. L. H. Chase. 1,035. Course and Prognosis in Schizophrenia. W. Malamud and N. Render. 1,039. Treatment of the Total Organism in Schizophrenic Patients. W. Corwin and J. W. Thompson. 1,059. The Effects of Insulin Hypoglycemia on the Blood Pressure Response in Oxygen Deficiency in Man. S. H. Kraines and E. Gelhorn. 1,067. A Public Health Approach to the Problem of Convulsive Disorders. B. T. McGhie and C. R. Myers. 1,077. A Study of Prolonged Coma following Insulin Shock. D. Lester. 1,083. Radiologic Gastrointestinal Studies in Epilepsy. L. J. Robinson. 1,095. Administrative Conditions and Problems of the California Mental Hospitals. H. Lutgens. 1,103.","PeriodicalId":54783,"journal":{"name":"Journal of Neurology and Psychiatry","volume":"2 1","pages":"361 - 377"},"PeriodicalIF":0.0,"publicationDate":"1939-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1136/jnnp.2.4.361","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63905736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
W H McMenemey, C Worster-Drought, J Flind, H G Williams
{"title":"FAMILIAL PRESENILE DEMENTIA: REPORT OF CASE WITH CLINICAL AND PATHOLOGICAL FEATURES OF ALZHEIMER'S DISEASE.","authors":"W H McMenemey, C Worster-Drought, J Flind, H G Williams","doi":"10.1136/jnnp.2.4.293","DOIUrl":"https://doi.org/10.1136/jnnp.2.4.293","url":null,"abstract":"","PeriodicalId":54783,"journal":{"name":"Journal of Neurology and Psychiatry","volume":"2 4","pages":"293-302"},"PeriodicalIF":0.0,"publicationDate":"1939-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1136/jnnp.2.4.293","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40109005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"ARHINENCEPHALY.","authors":"R M Stewart","doi":"10.1136/jnnp.2.4.303","DOIUrl":"https://doi.org/10.1136/jnnp.2.4.303","url":null,"abstract":"No human brain has yet been described in which all the structures which are believed to be subservient to the sense of smell have been absent, and consequently the designation \" arhinencephaly \" is misleading in that it suggests complete absence of a functional unit. In the majority of recorded cases the maldevelopment present has been either a partial or a complete absence of the olfactory bulbs and parts of the hippocampal formation with its association and commissural systems. In this limited sense the term \" arhinencephaly\" may perhaps be sanctioned on the grounds that it affords a concise and convenient title for a condition which otherwise would be difficult to define within the compass of a few words.","PeriodicalId":54783,"journal":{"name":"Journal of Neurology and Psychiatry","volume":"2 4","pages":"303-12"},"PeriodicalIF":0.0,"publicationDate":"1939-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1136/jnnp.2.4.303","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40109006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A CRITICAL REVIEW: VITAMIN B DEFICIENCY AND NERVOUS DISEASE.","authors":"C D Aring, T D Spies","doi":"10.1136/jnnp.2.4.335","DOIUrl":"https://doi.org/10.1136/jnnp.2.4.335","url":null,"abstract":"","PeriodicalId":54783,"journal":{"name":"Journal of Neurology and Psychiatry","volume":"2 4","pages":"335-60"},"PeriodicalIF":0.0,"publicationDate":"1939-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1136/jnnp.2.4.335","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40109009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}