Journal of Pediatrics最新文献

{"title":"Pediatric Cataracts as a Presenting Sign of Type 1 Diabetes Mellitus","authors":"Oliver D. Valdivia Camacho BS ,&nbsp;Tara Allison BS ,&nbsp;Lorri B. Wilson MD ,&nbsp;Kellyn Bellsmith MD ,&nbsp;Allison R. Loh MD","doi":"10.1016/j.jpeds.2025.114806","DOIUrl":"10.1016/j.jpeds.2025.114806","url":null,"abstract":"<div><div>We describe three children in whom bilateral cataracts preceded the diagnosis of type 1 diabetes mellitus. This rare sequence of presentation highlights the need to consider diabetes screening in children with idiopathic cataracts, even in the absence of systemic symptoms.</div></div>","PeriodicalId":54774,"journal":{"name":"Journal of Pediatrics","volume":"288 ","pages":"Article 114806"},"PeriodicalIF":3.5,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145058845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"When Disaster Strikes: European Pediatric Societies' Commitment to Children in Crisis through the Montenegro Charter.","authors":"Neboija Kavaric, Joseph Haddad, Massimo Pettoello-Mantovani","doi":"10.1016/j.jpeds.2025.114801","DOIUrl":"10.1016/j.jpeds.2025.114801","url":null,"abstract":"","PeriodicalId":54774,"journal":{"name":"Journal of Pediatrics","volume":" ","pages":"114801"},"PeriodicalIF":3.5,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145024743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Information for Readers","authors":"","doi":"10.1016/S0022-3476(25)00331-2","DOIUrl":"10.1016/S0022-3476(25)00331-2","url":null,"abstract":"","PeriodicalId":54774,"journal":{"name":"Journal of Pediatrics","volume":"285 ","pages":"Article 114790"},"PeriodicalIF":3.5,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144988569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Canadian Paediatric Inpatient Research Network: Development and Early Successes to Advance the Field of Pediatric Hospital Medicine.","authors":"Peter J Gill, Lisa Strifler, Olivier Drouin, Patricia Li, Francine Buchanan, Gita Wahi, Karen L Forbes, Evelyn Constantin, Jimin Lee, Mahmoud Sakran, Keenjal Mistry, Colin Macarthur, Sanjay Mahant","doi":"10.1016/j.jpeds.2025.114795","DOIUrl":"10.1016/j.jpeds.2025.114795","url":null,"abstract":"","PeriodicalId":54774,"journal":{"name":"Journal of Pediatrics","volume":" ","pages":"114795"},"PeriodicalIF":3.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144994429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Qualitative Exploration of Adherence to Methotrexate in Juvenile Idiopathic Arthritis","authors":"Dori Abel MD, MSHP ,&nbsp;Nellie Butler BA ,&nbsp;Anyun Chatterjee MPH ,&nbsp;Samantha Tavlin MA ,&nbsp;Katherine Kellom BA ,&nbsp;Joyce C. Chang MD, MSCE ,&nbsp;Sabrina Gmuca MD, MSCE","doi":"10.1016/j.jpeds.2025.114798","DOIUrl":"10.1016/j.jpeds.2025.114798","url":null,"abstract":"<div><h3>Objective</h3><div>To identify barriers and facilitators of adherence to methotrexate (MTX) in juvenile idiopathic arthritis (JIA).</div></div><div><h3>Study design</h3><div>We conducted a qualitative cross-sectional study employing semistructured interviews of 20 adolescents with JIA with varying levels of MTX adherence, determined by pharmacy dispense data. We used grounded theory to identify common themes, which we organized into barriers and facilitators, subdivided into World Health Organization adherence domains.</div></div><div><h3>Results</h3><div>The sample had equal representation of adherent and nonadherent patients, and of those prescribed oral and injectable MTX. The most common barriers were patient- or medication-related, including anticipatory nausea, anxiety, busy schedules, side effects, and the color, taste, and odor of MTX. Common facilitators included patient-related (reminders, routines, calming techniques, family, autonomy, time since diagnosis) and medication-related factors (autoinjectors, folic acid), as well as some health care system-related (positive clinic experiences), and socioeconomic factors (community medical knowledge).</div></div><div><h3>Conclusions</h3><div>Through interviews with adolescents on MTX for JIA and using the World Health Organization's framework, we gained valuable insight on the most salient barriers and facilitators of MTX adherence. These findings can inform interventions to improve medication adherence and optimize patients' quality of life.</div></div>","PeriodicalId":54774,"journal":{"name":"Journal of Pediatrics","volume":"288 ","pages":"Article 114798"},"PeriodicalIF":3.5,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144979127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toothless Smiles Are Cute Only in Infants","authors":"Lainie Friedman Ross MD, PhD","doi":"10.1016/j.jpeds.2025.114796","DOIUrl":"10.1016/j.jpeds.2025.114796","url":null,"abstract":"","PeriodicalId":54774,"journal":{"name":"Journal of Pediatrics","volume":"288 ","pages":"Article 114796"},"PeriodicalIF":3.5,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144979147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temporal Trends in Red Blood Cell and Platelet Transfusion Thresholds for Extremely Low Birth Weight Infants","authors":"Ravi M. Patel MD, MSc ,&nbsp;Jeanne E. Hendrickson MD ,&nbsp;Rebecca Birch MPH ,&nbsp;Daniel W. Bougie PhD ,&nbsp;Brian Branchford MD ,&nbsp;Xuxin Chen MD, MS ,&nbsp;Brian Custer PhD, MPH ,&nbsp;Robert A. Desimone MD ,&nbsp;Erika Edwards PhD ,&nbsp;Ruchika Goel MD, MPH ,&nbsp;Jerome Gottschall MD ,&nbsp;Eldad A. Hod MD ,&nbsp;Morvarid Moayeri MD, PhD ,&nbsp;Oliver Karam MD, PhD ,&nbsp;Elizabeth F. Stone MD, PhD ,&nbsp;Naomi L.C. Luban MD ,&nbsp;Cassandra D. Josephson MD ,&nbsp;Martha Sola-Visner MD ,&nbsp;NHLBI Recipient Epidemiology and Donor Evaluation Study-IV-Pediatric (REDS-IV-P)","doi":"10.1016/j.jpeds.2025.114797","DOIUrl":"10.1016/j.jpeds.2025.114797","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate if hematologic thresholds for red blood cell (RBC) and platelet transfusions changed over time following publication of new evidence from randomized trials in a multicenter cohort of extremely low birth weight (ELBW) infants.</div></div><div><h3>Study design</h3><div>We analyzed data from the National Heart Lung and Blood Institute Recipient Epidemiology and Donor Evaluation Study-IV-Pediatrics study from April 2019 through December 2023. We compared pretransfusion hemoglobin and platelet counts closest to each transfusion within 24 hours by year using linear mixed models and used model interaction terms to determine if trends over time differed by postnatal weeks.</div></div><div><h3>Results</h3><div>We evaluated 981 ELBW infants. For trends in RBC transfusion thresholds, 785 infants (80%) received 5182 RBC transfusions, of which 4835 (93%) had a pretransfusion hemoglobin value. Pretransfusion hemoglobin declined over time (<em>P</em> &lt; .0001), with trends differing by postnatal week (interaction <em>P</em> = .005). The greatest year-over-year decline in pretransfusion hemoglobin was in the third postnatal week or later. For platelet transfusions, 221 infants (23%) received 934 platelet transfusions, of which 900 (96%) had a corresponding pretransfusion platelet count. There was no change in pretransfusion platelet count over time (<em>P</em> = .24). These trends did not differ by postnatal week (interaction <em>P</em> = .14), although pretransfusion platelet counts were lower after the first postnatal week (<em>P</em> &lt; .001).</div></div><div><h3>Conclusions</h3><div>In this cohort of US centers, we observed declines in pretransfusion hemoglobin but not pretransfusion platelet counts from 2019 to 2023. These findings suggest evidence from recent RBC and platelet transfusion threshold trials may have been differentially translated into clinical practice for ELBW infants.</div></div>","PeriodicalId":54774,"journal":{"name":"Journal of Pediatrics","volume":"288 ","pages":"Article 114797"},"PeriodicalIF":3.5,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144979169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Dynamic Interaction Between Psychological Health and Sleep Symptoms Following Adolescent Concussion","authors":"Ross Moseley BA ,&nbsp;Patrick M. Carry PhD ,&nbsp;Catherine C. Donahue PhD ,&nbsp;Steven D. Hicks MD, PhD ,&nbsp;Stacey L. Simon PhD ,&nbsp;Julie Wilson MD ,&nbsp;William P. Meehan III MD ,&nbsp;David R. Howell PhD","doi":"10.1016/j.jpeds.2025.114800","DOIUrl":"10.1016/j.jpeds.2025.114800","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate changes in psychological symptoms and sleep quality at 3 clinically relevant milestones following adolescent concussion: while symptomatic, at symptom resolution, and about 2 months after symptom resolution.</div></div><div><h3>Study design</h3><div>We conducted a secondary analysis of a multisite, longitudinal investigation of adolescent concussion recovery. Participants enrolled &lt; 21 days following concussion and completed self-report questionnaires (Patient-Reported Outcomes Measurement Information System [PROMIS] Pediatric Global 25 anxiety and depressive symptom domains and the Pittsburgh Sleep Quality Index [PSQI]) at 3 time points: visit 1 (symptomatic), visit 2 (&lt; 14 days after symptom resolution), and visit 3 (2 months after symptom resolution).</div></div><div><h3>Results</h3><div>We followed 72 participants (median age = 15.5, interquartile range: 14-17; 46% female; 79% sport-related concussion). Prevalence of poor sleep quality (PSQI &gt; 4) was high at each visit (78% at visit 1, 57% at visit 2, and 41% at visit 3). There was significant (<em>P</em> &lt; .0001) improvement in PROMIS anxiety/depression and PSQI between visits 1 and 2. PSQI was positively correlated with PROMIS anxiety (<em>P</em> = .0003) and depression (<em>P</em> = .0050). Correlations between PSQI and depression (<em>P</em> = .1103) and anxiety (<em>P</em> = .5276) domain scores did not differ significantly across the study visits. A subset of patients (22.2%) developed clinically relevant anxiety/depression symptoms at visit 3 despite reporting none at visit 2.</div></div><div><h3>Conclusions</h3><div>Poor sleep quality was highly prevalent and associated with worse psychological health symptoms. Incorporating routine assessments of sleep and psychological health, during and after recovery, may help clinicians provide interventions and reduce risk of psychological symptoms after concussion.</div></div>","PeriodicalId":54774,"journal":{"name":"Journal of Pediatrics","volume":"288 ","pages":"Article 114800"},"PeriodicalIF":3.5,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144979181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to The Impact of Being Born Preterm or Small for Gestational Age on Early Vascular Aging in Adolescents [J Pediatr 201 (2018) 49-54.e1]","authors":"Katharina Stock ,&nbsp;Anna Schmid ,&nbsp;Elke Griesmaier ,&nbsp;Nina Gande ,&nbsp;Christoph Hochmayr ,&nbsp;Michael Knoflach ,&nbsp;Ursula Kiechl-Kohlendorfer ,&nbsp;Early Vascular Aging (EVA) Study Group: Early Vascular Aging (EVA) Study Group,&nbsp;Benoit Bernar ,&nbsp;Bernhard Winder ,&nbsp;Carmen Reiter ,&nbsp;Christina Burger ,&nbsp;Julia Klingenschmid ,&nbsp;Julia Marxer ,&nbsp;Mandy Asare ,&nbsp;Manuela Bock-Bartl ,&nbsp;Martina Kothmayer ,&nbsp;Maximilian Bohl ,&nbsp;Maximilian Pircher ,&nbsp;Ralf Geiger ,&nbsp;Stefan Julia Kiechl","doi":"10.1016/j.jpeds.2025.114758","DOIUrl":"10.1016/j.jpeds.2025.114758","url":null,"abstract":"","PeriodicalId":54774,"journal":{"name":"Journal of Pediatrics","volume":"286 ","pages":"Article 114758"},"PeriodicalIF":3.5,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144979097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Course and Outcomes of Invasive Haemophilus influenzae Infections among Children at Two Hospitals in Alaska","authors":"Victoria A. Balta PhD, MPH ,&nbsp;Bionca Davis MN, MPH ,&nbsp;Carolynn K. DeByle BS ,&nbsp;Christine Desnoyers MBA, BA ,&nbsp;Marah Gotcsik MD ,&nbsp;Benjamin Westley MD, FAAP, FACP, FIDSA ,&nbsp;Marc Fischer MD, MPH ,&nbsp;Jonathan Steinberg RN, MPH","doi":"10.1016/j.jpeds.2025.114799","DOIUrl":"10.1016/j.jpeds.2025.114799","url":null,"abstract":"<div><h3>Objective</h3><div>Our objective was to compare the clinical course of invasive <em>Haemophilus influenzae</em> disease by type among children at 2 hospitals in Alaska.</div></div><div><h3>Study design</h3><div>We performed a retrospective review of invasive <em>H. influenzae</em> cases among Alaska children aged &lt;10 years who received care at the Alaska Native Medical Center in Anchorage or the Yukon-Kuskokwim Delta Regional Hospital in Bethel, Alaska, during 2013-2019. Clinical and demographic data were obtained by medical record review. Categorical variables were compared with Fisher's exact test.</div></div><div><h3>Results</h3><div>We identified 62 invasive <em>H. influenzae</em> infections, including 45 (73%) type a (Hia), 8 (13%) type b (Hib), 7 (11%) nontypeable (NTHi), and 2 (3%) type f (Hif). All children were Alaska Native. Overall, 43 (69%) cases occurred in previously healthy children with no underlying medical conditions. Nineteen (31%) children required intensive care and 13 (21%) died or still had clinical sequelae at 1 year postinfection. All deaths (n = 6) and long-term sequelae (n = 7) occurred in children with Hia or Hib meningitis. Children with NTHi were more likely to require respiratory support compared with children with Hia, Hib, or Hif (6/7, 86% vs 15/55, 27%) (<em>P</em> &lt; .01).</div></div><div><h3>Conclusions</h3><div>We identified severe disease among Alaska Native children with invasive Hia, Hib, Hif, and NTHi infections. Hia and Hib caused more meningitis-associated fatalities, and NTHi caused more respiratory complications. Characterizing trends in invasive <em>H. influenzae</em> illness will help direct public health strategies, including the development and use of novel vaccines.</div></div>","PeriodicalId":54774,"journal":{"name":"Journal of Pediatrics","volume":"288 ","pages":"Article 114799"},"PeriodicalIF":3.5,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144979138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}