Journal of Rehabilitation Medicine最新文献

{"title":"Do proprioceptive training strategies with dual-task exercises positively influence gait parameters in chronic stroke? A systematic review.","authors":"Michele Vecchio, Rita Chiaramonte, Alessandro De Sire, Enrico Buccheri, Patrizia Finocchiaro, Dalila Scaturro, Giulia Letizia Mauro, Matteo Cioni","doi":"10.2340/jrm.v56.18396","DOIUrl":"10.2340/jrm.v56.18396","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to assess the impact of proprioceptive training strategies with dual-task exercises on gait in people with chronic stroke.</p><p><strong>Study design: </strong>Systematic review.</p><p><strong>Patients: </strong>Chronic stroke.</p><p><strong>Methods: </strong>Searches were conducted in accordance with PRISMA guidelines and PICOS criteria. PubMed, Web of Science, and Scopus databases were systematically searched from November 2020 to February 2022, for eligible clinical trials. Two independent reviewers thoroughly screened potential articles for relevance and assessed the methodology quality. In accordance with the GRADE, PICOS criteria, and Cochrane risk of bias tools, the authors included articles concerning the effectiveness of dual-task in proprioceptive training on gait parameters in people with chronic stroke.</p><p><strong>Results: </strong>Of 3075 identified studies, 11 articles met the inclusion criteria: 7 were randomized clinical trials, 1 was not randomized, and 3 were observational studies. The overall quality of evidence, assessed using the GRADE framework, was high, indicating a high level of confidence in the systematic review's findings. The papers involved 393 stroke patients; 241 underwent dual-task in proprioceptive training, with 152 participants in other stroke rehabilitation; within the dual-task group, 71 engaged in cognitive tasks, and 170 participated in motor tasks. dual-task in proprioceptive training improved gait speed, cadence, stride time, stride length, and step length. The best effects were observed with training 3 times a week for 4 weeks, with each session lasting 30 minutes, on speed, cadence, stride length, and step length.</p><p><strong>Conclusion: </strong>Current evidence suggests that proprioceptive training strategies with dual-task exercises improved walking abilities in people with chronic stroke. Specifically, it enhanced gait speed, a key indicator of clinical severity.</p>","PeriodicalId":54768,"journal":{"name":"Journal of Rehabilitation Medicine","volume":"56 ","pages":"jrm18396"},"PeriodicalIF":2.5,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11337222/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141984038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validity of the Ekblom-Bak Cycle Ergometer Test in Patients with Cardiovascular Disease.","authors":"Magnus Fransplass Storli, Marius Steiro Fimland, Harald Kåre Engan, Jon Arne Sandmæl","doi":"10.2340/jrm.v56.39901","DOIUrl":"10.2340/jrm.v56.39901","url":null,"abstract":"<p><strong>Objective: </strong>To assess the validity of the Ekblom-Bak cycle ergometer test in patients with cardiovascular disease admitted to cardiac rehabilitation.</p><p><strong>Methods: </strong>Estimated peak oxygen consumption from the Ekblom-Bak test was compared with directly measured peak oxygen consumption from a treadmill cardiopulmonary exercise test. Patients completed the cardiopulmonary exercise test first, followed by the Ekblom-Bak test after 24 h rest. Pearson's correlation coefficient (r) was used to establish the correlation between estimated and measured peak oxygen consumption, and Bland-Altman plots with limits of agreement were used to determine the bias between the 2 tests.</p><p><strong>Results: </strong>Twenty-six patients were included in the final analysis. The Ekblom-Bak test significantly overestimated peak oxygen consumption. Agreement between estimated and measured peak oxygen consumption was: bias = 4.3 mL/kg/min (limits of agreement: -4.0-12.6 mL/kg/min).</p><p><strong>Conclusion: </strong>The Ekblom-Bak test overestimated peak oxygen consumption to such an extent that it cannot accurately assess cardiorespiratory fitness in patients with cardiovascular disease. Thus, the cardiopulmonary exercise test remains the test of choice.</p>","PeriodicalId":54768,"journal":{"name":"Journal of Rehabilitation Medicine","volume":"56 ","pages":"jrm39901"},"PeriodicalIF":2.5,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11334349/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141972318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rehabilitation interventions for neuropathic pain: a systematic review and meta-analysis of randomized controlled trials.","authors":"Emmanuel Bäckryd, Nazdar Ghafouri, Björn Gerdle, Elena Dragioti","doi":"10.2340/jrm.v56.40188","DOIUrl":"10.2340/jrm.v56.40188","url":null,"abstract":"<p><strong>Objective: </strong>Rehabilitation interventions for chronic pain typically include education, cognitive behavioural therapy, and exercise therapy, or a combination of these. A systematic review and meta-analysis of rehabilitation interventions for neuropathic pain was conducted.</p><p><strong>Design: </strong>Randomized controlled trials were identified in PubMed, EMBASE, Cochrane Central Register of Controlled Trials, and PsycINFO databases from inception up to 3 March 2022.</p><p><strong>Subjects/patients: </strong>Adults with chronic (> 3 months) neuropathic pain.</p><p><strong>Methods: </strong>Primary outcomes were pain intensity, pain-related disability, and work participation. Secondary outcomes were quality of life, emotional strain, insomnia, and adverse outcomes, according to VAPAIN guidelines. Analyses were made post-intervention, which was defined as the assessment point immediately following the intervention or at the first-time measurement conducted after the intervention period.</p><p><strong>Results: </strong>In total, 15 studies (total population, n = 764) were incorporated. Most common interventions were cognitive behavioural programmes including acceptance and commitment therapy (n = 4), mindfulness-based interventions (n = 5), and yoga (n  =  2). Psychological interventions reduced both pain intensity (SMD -0.49, 95% CI -0.88 to -0.10) and pain-related disability (SMD -0.51, 95% CI -0.98 to -0.03), whereas other interventions had an effect on pain intensity but not on pain-related disability.</p><p><strong>Conclusion: </strong>Rehabilitation interventions, and psychological interventions in particular, seem to be of value for patients with chronic neuropathic pain.</p>","PeriodicalId":54768,"journal":{"name":"Journal of Rehabilitation Medicine","volume":"56 ","pages":"jrm40188"},"PeriodicalIF":2.5,"publicationDate":"2024-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11318642/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141890975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mapping the costs and socioeconomic characteristics involved in traumatic brain injuries: a scoping review.","authors":"Fanny Crozes, Cyrille Delpierre, Nadège Costa","doi":"10.2340/jrm.v56.18311","DOIUrl":"10.2340/jrm.v56.18311","url":null,"abstract":"<p><strong>Objective: </strong>To identify the articles in the existing literature that analyse healthcare costs according to the socioeconomic position (pre- or post-injury) for traumatic brain injury survivors. Secondary aims were to describe the types of costs and socioeconomic characteristics and to determine whether socioeconomic characteristics affect the risk of traumatic brain injury or whether the consequences of trauma alter living conditions post-injury.</p><p><strong>Methods: </strong>This scoping review followed the methods proposed by Arksey and O'Malley. The literature search was performed in 5 databases.</p><p><strong>Results: </strong>Twenty-two articles were included, published between 1988 and 2023. Only 2 articles (9%) followed the guidelines for economic evaluation of healthcare programmes and 2 articles (9%) evaluated socioeconomic position \"completely\" with 3 main individual measures of socioeconomic characteristics (i.e., education, income, and occupation). The relationship between costs and socioeconomic characteristics could vary in 2 ways in traumatic brain injury: socioeconomic disadvantage was mostly associated with higher healthcare costs, and the cost of healthcare reduced the survivors' living conditions.</p><p><strong>Conclusion: </strong>This work highlights the need for a detailed and methodologically sound assessment of the relationship between socioeconomic characteristics and the costs associated with trauma. Modelling the care pathways of traumatic brain injury would make it possible to identify populations at risk of poor recovery or deterioration following a TBI, and to develop specific care pathways. The aim is to build more appropriate, effective, and equitable care programmes.</p>","PeriodicalId":54768,"journal":{"name":"Journal of Rehabilitation Medicine","volume":"56 ","pages":"jrm18311"},"PeriodicalIF":2.5,"publicationDate":"2024-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11318505/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141890973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiple sclerosis and spasticity: the role of anaesthetic nerve blocks on rectus femoris muscle. When should stiff knee be treated with botulinum toxin?","authors":"Alessio Baricich, Marco Battaglia, Margherita B Borg, Alberto Loro, Paola Morlino, Lucia Cosenza, Michele Bertoni, Alessandro Picelli, Andrea Santamato, Thierry Deltombe","doi":"10.2340/jrm.v56.40437","DOIUrl":"10.2340/jrm.v56.40437","url":null,"abstract":"<p><strong>Objective: </strong>To compare the effect of rectus femoris diagnostic motor nerve blocks (DNB) with anaesthetics and rectus femoris muscle botulinum toxin (BoNT-A) injection in multiple sclerosis patients with unilateral stiff-knee gait.</p><p><strong>Design: </strong>Prospective observational study Subjects/Patients: Multiple sclerosis patients in stable condition.</p><p><strong>Methods: </strong>Patients underwent evaluation before and 1 hour after the anaesthetic block, and 1 month after the botulinum injection. Assessment included a 10-m walking test, a 6-minute walking test, a timed-up-and-go (TUG) test, and a Baseline Expanded Disability Status Scale (EDSS). Post-DNB and post-BoNT-A satisfaction was measured with the global assessment of efficacy scale.</p><p><strong>Results: </strong>Fourteen patients with unilateral stiff-knee gait due to multiple sclerosis underwent a DNB, among whom 13 received botulinum injections in the rectus femoris muscle after a satisfying test result. Positive post-DNB results correlated with significant functional improvements after BoNT-A. Higher EDSS and longer time from diagnosis correlated with poorer post-DNB and post-BoNT-A absolute outcomes.</p><p><strong>Conclusion: </strong>DNB showed predictive value for BoNT-A outcomes, especially in the case of worse functional status. It effectively predicted endurance and walking speed improvement, while TUG showed greater improvement after botulinum. In cases of uncertain therapeutic benefit, nerve blocks may provide a valuable diagnostic support, particularly in patients with lower functional status.</p>","PeriodicalId":54768,"journal":{"name":"Journal of Rehabilitation Medicine","volume":"56 ","pages":"jrm40437"},"PeriodicalIF":2.5,"publicationDate":"2024-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11318643/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141890974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of neck-specific exercises with and without internet support on cervical range of motion and neck muscle endurance in chronic whiplash-associated disorders: analysis of functional outcomes of a randomized controlled trial.","authors":"Gunnel Peterson, Emma Nilsing Strid, Margaretha Jönsson, Jesper Hävermark, Anneli Peolsson","doi":"10.2340/jrm.v56.34785","DOIUrl":"10.2340/jrm.v56.34785","url":null,"abstract":"<p><strong>Objective: </strong>To compare the effects of a neck-specific exercise programme with internet support and 4 physiotherapist sessions (NSEIT) and the same neck-specific exercises supervised by a physiotherapist (NSE) on neck muscle endurance and cervical range of motion.</p><p><strong>Design: </strong>Randomized controlled trial.</p><p><strong>Patients: </strong>A total of 140 participants with chronic whiplash-associated disorders grade II or grade III were randomly assigned to the NSEIT or NSE groups.</p><p><strong>Methods: </strong>Outcomes were changes in active cervical range of motion, cranio-cervical flexion test, neck muscle endurance, and neck pain, at 3- and 15-month follow-ups.</p><p><strong>Results: </strong>There were no significant differences between the NSEIT and NSE groups. There was a significant group-by-time inter-action effect in active cervical range of motion flexion/extension where the NSEIT group improved to 3-month follow-up, but the NSE group did not. Both groups were significantly improved over time in all other outcomes (p < 0.001) at 3- and 15-month follow-ups, with effect size between 0.64 and 1.35 in active cervical range of motion, cranio-cervical flexion test, dorsal neck muscle endurance, and neck pain, and effect size between 0.22 and 0.42 in ventral neck muscle endurance.</p><p><strong>Conclusion: </strong>Both NSE and NSEIT led to improved neck function. Depending on the patients' needs, either NSE or NSEIT could be used as treatment for patients with chronic whiplash-associated disorders.</p>","PeriodicalId":54768,"journal":{"name":"Journal of Rehabilitation Medicine","volume":"56 ","pages":"jrm34785"},"PeriodicalIF":2.5,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11301840/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141789872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Commentary on \"Effects of upper limb vibratory stimulation training on motor symptoms in Parkinson's disease: an observational study\".","authors":"Mebanpynjop Dohtdong, Shanika Sharma, Varun Kalia","doi":"10.2340/jrm.v56.40920","DOIUrl":"10.2340/jrm.v56.40920","url":null,"abstract":"","PeriodicalId":54768,"journal":{"name":"Journal of Rehabilitation Medicine","volume":"56 ","pages":"jrm40920"},"PeriodicalIF":2.5,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11302131/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141789871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of moderate-intensity aerobic exercise on cognitive function in individuals with stroke-induced mild cognitive impairment: a randomized controlled pilot study.","authors":"Yuanling Huang, Haining Ou, Weijian Zhao, Qiang Lin, Yajing Xue, Rui Xia, Zhouchun Tan, Xiaofang Zhao, Lifang Xiong, Zeqin Yan, Zubin Zheng, Junbin Wen","doi":"10.2340/jrm.v56.33001","DOIUrl":"10.2340/jrm.v56.33001","url":null,"abstract":"<p><strong>Objective: </strong>To assess the impact of moderate-intensity aerobic exercise on working memory in stroke-induced mild cognitive impairment (MCI).</p><p><strong>Design: </strong>Randomized, double-blind controlled study.</p><p><strong>Subjects and methods: </strong>Twenty MCI patients from the Fifth Affiliated Hospital of Guangzhou Medical University (December 2021 to February 2023), aged 34-79, 2-12 months post-stroke, were divided into an experimental group (EG) and a control group (CG), each with 10 participants. The EG underwent standard rehabilitation plus 40 minutes of aerobic exercise, while the CG received only standard therapy, 5 times weekly for 2 weeks. Working memory was tested using the n-back task, and overall cognitive function was measured with the MOCA and MMSE Scales before and after the intervention.</p><p><strong>Results: </strong>The EG showed higher 3-back correctness (71.80 ± 14.53 vs 56.50 ± 13.66), MOCA scores (27.30 ± 1.57 vs 24.00 ± 3.13), and improved visuospatial/executive (4.60 ± 0.52 vs 3.30 ± 1.06) and delayed recall (4.30 ± 0.82 vs 3.00 ± 1.56) on the MOCA scale compared with the CG.</p><p><strong>Conclusion: </strong>Moderate-intensity aerobic exercise may enhance working memory, visuospatial/executive, and delayed recall functions in stroke-induced MCI patients.</p>","PeriodicalId":54768,"journal":{"name":"Journal of Rehabilitation Medicine","volume":"56 ","pages":"jrm33001"},"PeriodicalIF":2.5,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11247515/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141494325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health-related quality of life and participation after inpatient rehabilitation of sepsis survivors with severe sequelae: a cohort study.","authors":"Ulf Bodechtel, Thea Koch, Lars Heubner, Peter Spieth, Ines Rößler, Jan Mehrholz","doi":"10.2340/jrm.v56.18670","DOIUrl":"10.2340/jrm.v56.18670","url":null,"abstract":"<p><strong>Objective: </strong>To describe health-related quality of life and participation after rehabilitation of severely affected sepsis survivors.</p><p><strong>Design: </strong>Cohort study.</p><p><strong>Subjects/patients: </strong>Patients with severe sequelae after sepsis treated in a multidisciplinary rehabilitation pathway were included.</p><p><strong>Methods: </strong>Patient characteristics at the time of diagnosis, and the outcome 3 months after discharge from rehabilitation are described. At that time, health-related quality of life, social participation, and the rate of living at home were measured.</p><p><strong>Results: </strong>Of the 498 patients enrolled, 100 severely impaired patients were transferred for a multidisciplinary rehabilitation approach. Fifty-five of them were followed up at 3 months. Descriptive and inference statistics showed that 69% were living at home with or without care. Health-related quality of life and participation scores were 0.64 ± 0.32 for the EQ-5D utility index and 54.98 ± 24.97 for the Reintegration of Normal Living Index. A multivariate regression model explaining health-related quality of life at 3 months included age, lower limb strength, and walking ability during rehabilitation (r2 = 0.5511). Participation at 3 months was explained by age, body mass index, lower limb strength, and duration of tracheal intubation (r2 = 0.6229).</p><p><strong>Conclusion: </strong>Patients who have experienced serious sepsis with severe sequelae can achieve a moderate level of quality of life and participation within a multidisciplinary pathway.</p>","PeriodicalId":54768,"journal":{"name":"Journal of Rehabilitation Medicine","volume":"56 ","pages":"jrm18670"},"PeriodicalIF":2.5,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11247512/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141494324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Post-polio syndrome - somatosensory dysfunction and its relation to pain: a pilot study with quantitative sensory testing.","authors":"Daniel Dahlgren, Kristian Borg, Eva Melin","doi":"10.2340/jrm.v56.26192","DOIUrl":"10.2340/jrm.v56.26192","url":null,"abstract":"<p><strong>Objective: </strong>To explore and characterize somatosensory dysfunction in patients with post-polio syndrome and chronic pain, by conducting examinations with Quantitative Sensory Testing.</p><p><strong>Design: </strong>A cross-sectional, descriptive, pilot study conducted during 1 month.</p><p><strong>Subjects/patients: </strong>Six patients with previously established post-polio syndrome and related chronic pain.</p><p><strong>Methods: </strong>All subjects underwent a neurological examination including neuromuscular function, bedside sensory testing, a thorough pain anamnesis, and pain drawing. Screening for neuropathic pain was done with 2 questionnaires. A comprehensive Quantitative Sensory Testing battery was conducted with z-score transformation of obtained data, enabling comparison with published reference values and the creation of sensory profiles, as well as comparison between the study site (more polio affected extremity) and internal control site (less affected extremity) for each patient.</p><p><strong>Results: </strong>Derived sensory profiles showed signs of increased prevalence of sensory aberrations compared with reference values, especially Mechanical Pain Thresholds, with significant deviation from reference data in 5 out of 6 patients. No obvious differences in sensory functions were seen between study sites and internal control sites.</p><p><strong>Conclusion: </strong>Post-polio syndrome may be correlated with a mechanical hyperalgesia/allodynia and might be correlated to a somatosensory dysfunction. With lack of evident side-to-side differences, the possibility of a generalized dysfunction in the somatosensory system might be considered.</p>","PeriodicalId":54768,"journal":{"name":"Journal of Rehabilitation Medicine","volume":"56 ","pages":"jrm26192"},"PeriodicalIF":2.5,"publicationDate":"2024-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11218677/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141447642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}