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Metal Ions in Biological Systems最新文献

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Gold complexes in the treatment of rheumatoid arthritis. 金配合物治疗类风湿性关节炎。
Metal Ions in Biological Systems Pub Date : 2004-01-01 DOI: 10.1201/9780203913703.ch9
L. Messori, G. Marcon
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引用次数: 79
Radiometallo-labeled peptides in tumor diagnosis and therapy. 放射性金属标记肽在肿瘤诊断和治疗中的应用。
Metal Ions in Biological Systems Pub Date : 2004-01-01
Mihaela Ginj, Helmut R Maecke
{"title":"Radiometallo-labeled peptides in tumor diagnosis and therapy.","authors":"Mihaela Ginj,&nbsp;Helmut R Maecke","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Radiometallo-labeled analogs of somatostatin have shown great benefit in the in vivo localization and targeted radiotherapy of human tumors. The progress and innovation in this clinical application came from the change in strategy, leaving the most widely used radiohalogens for a coordination chemistry approach. The use of chelators appended to the biologically active peptide which convey high thermodynamic and kinetic stability to the radiopeptides did not only improve the pharmacokinetics and pharmacodynamics of the molecules, but surprisingly the biological potency as well. The most urgent problem to be solved in the field is to improve the kidney clearance of the radiopeptides. The kidney turned out to be the dose limiting organ in this type of targeted radiotherapy. Coordination chemical strategies have already paved the way to a successful clinical application; it is most likely that chelator modification will further help to improve the renal handling of radiometallo-peptides.</p>","PeriodicalId":54739,"journal":{"name":"Metal Ions in Biological Systems","volume":"42 ","pages":"109-42"},"PeriodicalIF":0.0,"publicationDate":"2004-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24573220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cisplatin and related anticancer drugs: recent advances and insights. 顺铂及相关抗癌药物:最新进展和见解。
Metal Ions in Biological Systems Pub Date : 2004-01-01
Katie R Barnes, Stephen J Lippard
{"title":"Cisplatin and related anticancer drugs: recent advances and insights.","authors":"Katie R Barnes,&nbsp;Stephen J Lippard","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":54739,"journal":{"name":"Metal Ions in Biological Systems","volume":"42 ","pages":"143-77"},"PeriodicalIF":0.0,"publicationDate":"2004-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24573221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Polynuclear platinum drugs. 多核铂类药物。
Metal Ions in Biological Systems Pub Date : 2004-01-01
Nicholas Farrell
{"title":"Polynuclear platinum drugs.","authors":"Nicholas Farrell","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":54739,"journal":{"name":"Metal Ions in Biological Systems","volume":"42 ","pages":"251-96"},"PeriodicalIF":0.0,"publicationDate":"2004-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24573224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Copper and zinc complexes as antiinflammatory drugs. 铜锌配合物作为抗炎药物。
Metal Ions in Biological Systems Pub Date : 2004-01-01
Carolyn T Dillon, Trevor W Hambley, Brendan J Kennedy, Peter A Lay, Jane E Weder, Qingdi Zhou
{"title":"Copper and zinc complexes as antiinflammatory drugs.","authors":"Carolyn T Dillon,&nbsp;Trevor W Hambley,&nbsp;Brendan J Kennedy,&nbsp;Peter A Lay,&nbsp;Jane E Weder,&nbsp;Qingdi Zhou","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":54739,"journal":{"name":"Metal Ions in Biological Systems","volume":"41 ","pages":"253-77"},"PeriodicalIF":0.0,"publicationDate":"2004-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24573238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Radiolanthanides in nuclear medicine. 核医学中的放射性元素。
Metal Ions in Biological Systems Pub Date : 2004-01-01
Frank Rösch, Eva Forssell-Aronsson
{"title":"Radiolanthanides in nuclear medicine.","authors":"Frank Rösch,&nbsp;Eva Forssell-Aronsson","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":54739,"journal":{"name":"Metal Ions in Biological Systems","volume":"42 ","pages":"77-108"},"PeriodicalIF":0.0,"publicationDate":"2004-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24573219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Calcium status and supplementation. 钙的状况和补充。
Metal Ions in Biological Systems Pub Date : 2004-01-01
Lasse Larsson, Per Magnusson
{"title":"Calcium status and supplementation.","authors":"Lasse Larsson,&nbsp;Per Magnusson","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":54739,"journal":{"name":"Metal Ions in Biological Systems","volume":"41 ","pages":"71-102"},"PeriodicalIF":0.0,"publicationDate":"2004-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24573233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The use and role of zinc and its compounds in wound healing. 锌及其化合物在伤口愈合中的使用和作用。
Metal Ions in Biological Systems Pub Date : 2004-01-01
Paul W Jones, David R Williams
{"title":"The use and role of zinc and its compounds in wound healing.","authors":"Paul W Jones,&nbsp;David R Williams","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":54739,"journal":{"name":"Metal Ions in Biological Systems","volume":"41 ","pages":"139-83"},"PeriodicalIF":0.0,"publicationDate":"2004-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24573235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gold complexes as antitumor agents. 金配合物作为抗肿瘤剂。
Metal Ions in Biological Systems Pub Date : 2004-01-01
Luigi Messori, Giordana Marcon
{"title":"Gold complexes as antitumor agents.","authors":"Luigi Messori,&nbsp;Giordana Marcon","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":54739,"journal":{"name":"Metal Ions in Biological Systems","volume":"42 ","pages":"385-424"},"PeriodicalIF":0.0,"publicationDate":"2004-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24573228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metal ion dependent antibiotics in chemotherapy. 化疗中金属离子依赖性抗生素。
Metal Ions in Biological Systems Pub Date : 2004-01-01
David H Petering, Chuanwu Xia, William E Antholine
{"title":"Metal ion dependent antibiotics in chemotherapy.","authors":"David H Petering,&nbsp;Chuanwu Xia,&nbsp;William E Antholine","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":54739,"journal":{"name":"Metal Ions in Biological Systems","volume":"42 ","pages":"463-97"},"PeriodicalIF":0.0,"publicationDate":"2004-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24573230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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