Neuroepidemiology最新文献

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Disease Burden of Parkinson's Disease in Asia and Its 34 Countries and Territories from 1990 to 2021: Findings from the Global Burden of Disease Study 2021. 1990年至2021年亚洲及其34个国家和地区帕金森病的疾病负担:2021年全球疾病负担研究结果。
IF 3.2 3区 医学
Neuroepidemiology Pub Date : 2024-11-14 DOI: 10.1159/000542606
Qifan Yang, Xuehui Chang, Shijin Li, Xiao Li, Changyuan Kang, Weiwei Yuan, Guiying Lv
{"title":"Disease Burden of Parkinson's Disease in Asia and Its 34 Countries and Territories from 1990 to 2021: Findings from the Global Burden of Disease Study 2021.","authors":"Qifan Yang, Xuehui Chang, Shijin Li, Xiao Li, Changyuan Kang, Weiwei Yuan, Guiying Lv","doi":"10.1159/000542606","DOIUrl":"10.1159/000542606","url":null,"abstract":"<p><strong>Introduction: </strong>The increasing global population and aging have made Parkinson's disease (PD) a significant public health concern. Comprehensive evaluations of PD burden trends in Asian subregions and countries are lacking. This study investigated PD burden in Asia from 1990 to 2021, categorized by age, sex, and region.</p><p><strong>Methods: </strong>Data from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021 were analyzed to assess the incidence, prevalence, mortality, and disability-adjusted life years (DALYs) across five Asian subregions and 34 countries/territories, using joinpoint regression, decomposition analysis, frontier analysis, and Bayesian models to examine changes, influencing factors, and predict future trends.</p><p><strong>Results: </strong>In 2021, the age-standardized PD incidence and prevalence in Asia were higher than the global average, particularly in East Asia (24.16 and 243.46/100,000, respectively). From 1990 to 2021, the incidence of PD in Asia rose by 198.01%, its prevalence rose by 284.35%, mortality rose by 111.27%, and DALY rose by 144.45%. Males consistently presented a greater PD burden than females did, with a growing sex gap over time. PD burden increased with age, especially among those aged 65 years and older. Population aging was the primary driver of new PD cases, and increasing etiological factors led to more patients. Inequalities in the PD burden have increased between high- and low-income areas, with low-income regions being more affected. By 2036, PD incidence is projected to increase in all subregions except the high-income Asia-Pacific region, with males experiencing a higher rate of increase.</p><p><strong>Conclusion: </strong>The PD burden in Asia has significantly increased over the past three decades, particularly in middle-aged and elderly males, middle- and low-SDI countries, and individuals already suffering from PD. The increasing incidence and aging population necessitate the reallocation of medical resources, improved chronic disease management systems, stronger public health interventions, and sustainable development efforts. Research into etiological factors, pathogenesis, early diagnosis, preventive interventions, and regional management is critical.</p>","PeriodicalId":54730,"journal":{"name":"Neuroepidemiology","volume":" ","pages":"1-33"},"PeriodicalIF":3.2,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142632783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Forecasting the Worldwide Impact of Stroke for Individuals Aged 45 and Above. 预测中风对全球 45 岁及以上人群的影响。
IF 3.2 3区 医学
Neuroepidemiology Pub Date : 2024-11-12 DOI: 10.1159/000542366
Weinv Fan, Qinghua Ma, Qiongfeng Guan, Feng Wang, Hui Li
{"title":"Forecasting the Worldwide Impact of Stroke for Individuals Aged 45 and Above.","authors":"Weinv Fan, Qinghua Ma, Qiongfeng Guan, Feng Wang, Hui Li","doi":"10.1159/000542366","DOIUrl":"10.1159/000542366","url":null,"abstract":"<p><strong>Background: </strong>We aimed to assess the global impact of stroke in people aged 45 years and older between 1990 and 2030, focusing on morbidity, mortality, and disability-adjusted life years (DALYs).</p><p><strong>Methods: </strong>Generalized additive models were used to project disease burden from 2020 to 2030. Additionally, the association between sociodemographic index (SDI) and stroke burden was investigated, and regional differences were assessed by Mann-Whitney U test.</p><p><strong>Results: </strong>The overall age-standardized stroke incidence rate (ASIR) among adults aged 45 years and older is projected to increase from 2020 to 2030, with an estimated annual percentage change (EAPC) of 1.29. Conversely, the age-standardized death rate (ASDR) in EAPC is expected to decrease by -1.48, and the age-standardized DALY in EAPC is expected to decrease by -1.66. By 2030, men are expected to have higher ASIR (181.81) and ASDR (87.31) than women (ASIR: 151.85, ASDR: 65.20). Regional differences are large. East Asia is expected to have the highest ASIR in 2030 (265.55). Age estimates show that older age groups, particularly those aged 75-79, are at higher risk of stroke. In addition, there is a significant inverse relationship between SDI and stroke severity, with areas with higher SDI tending to have lower morbidity, mortality, and DALYs.</p><p><strong>Conclusion: </strong>From 1990 to 2030, ASIR is expected to upgrade, especially in East Asia and regions with lower SDI. Men will bear a greater burden than women.</p>","PeriodicalId":54730,"journal":{"name":"Neuroepidemiology","volume":" ","pages":"1-13"},"PeriodicalIF":3.2,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142632785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analysis of Stroke Burden in China from 1990 to 2021 and Projections for the Next Decade. 1990 至 2021 年中国脑卒中负担分析及未来十年预测。
IF 3.2 3区 医学
Neuroepidemiology Pub Date : 2024-11-07 DOI: 10.1159/000542487
Xingzhu Li, Tianyu Jin, Chen Bai, Xianna Wang, Haojie Zhang, Tong Zhang
{"title":"Analysis of Stroke Burden in China from 1990 to 2021 and Projections for the Next Decade.","authors":"Xingzhu Li, Tianyu Jin, Chen Bai, Xianna Wang, Haojie Zhang, Tong Zhang","doi":"10.1159/000542487","DOIUrl":"10.1159/000542487","url":null,"abstract":"<p><strong>Introduction: </strong>This study aimed to describe the temporal trends of stroke burden in different age and sex groups in China from 1990 to 2021, including incidence, prevalence, mortality, and disability-adjusted life years (DALYs), and to compare these data with global figures.</p><p><strong>Methods: </strong>Using data from the Global Burden of Disease database from 1990 to 2021, we analyzed changes in stroke burden in China and globally. The average annual percentage change (AAPC) was calculated using Joinpoint software to reflect trends. Stroke burden differences across various age groups and sexes were compared, and the ARIMA model was utilized for future projections.</p><p><strong>Results: </strong>Between 1990 and 2021, the age-standardized incidence rate (ASIR) of stroke in China decreased from 226.938 to 204.753 per 100,000, while the global ASIR decreased from 180.973 to 141.553 per 100,000. The age-standardized prevalence rate (ASPR) in China increased from 1,167.425 to 1,301.42 per 100,000, whereas the global ASPR decreased from 1,201.111 to 1,099.31 per 100,000. The age-standardized mortality rate (ASMR) in China fell from 242.18 to 138.029 per 100,000, while the global ASMR decreased from 144.313 to 87.454 per 100,000. China's age-standardized DALY rate (ASDR) declined from 4,834.791 to 2,648.025 per 100,000, whereas the global ASDR decreased from 3,078.952 to 1,886.196 per 100,000. The AAPCs for ASIR, ASPR, ASMR, and ASDR in China were -0.370%, 0.326%, -1.793%, and -1.933%, respectively, compared to -0.291%, -0.807%, -1.601%, and -1.570% globally from 1990 to 2021. Age and sex significantly influenced the stroke burden, with higher incidence and mortality rates in males than in females. Projections for the next decade indicate that stroke incidence in China will remain stable, with an expected rise in ASPR, and declines in ASMR and ASDR. Globally, ASIR is expected to decline, while ASPR will rise, and ASMR and ASDR will continue to decrease.</p><p><strong>Conclusion: </strong>From 1990 to 2021, the incidence, mortality, and DALYs of stroke in China have decreased, while the prevalence has increased. Stroke burden is age-related, with higher prevalence in older adults and higher mortality in the elderly. Males are more susceptible to stroke and have a higher risk of death. Over the next decade, stroke prevalence in China is expected to rise, posing challenges due to population aging, even as mortality and disability rates decline. Sustained public health efforts will be necessary.</p>","PeriodicalId":54730,"journal":{"name":"Neuroepidemiology","volume":" ","pages":"1-12"},"PeriodicalIF":3.2,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142606204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Stroke Is Not an Accident: An Integrative Review on the Use of the Term Cerebrovascular Accident. 中风不是意外:关于使用 "脑血管意外 "一词的综合评述》。
IF 3.2 3区 医学
Neuroepidemiology Pub Date : 2024-10-28 DOI: 10.1159/000542301
Catherine Burns, Ailie Sanders, Lauren M Sanders, Lachlan L Dalli, Valery Feigin, Dominique A Cadilhac, Geoffrey Donnan, Bo Norrving, Muideen T Olaiya, Balakrishnan Nair, Nathan Henry, Monique F Kilkenny
{"title":"Stroke Is Not an Accident: An Integrative Review on the Use of the Term Cerebrovascular Accident.","authors":"Catherine Burns, Ailie Sanders, Lauren M Sanders, Lachlan L Dalli, Valery Feigin, Dominique A Cadilhac, Geoffrey Donnan, Bo Norrving, Muideen T Olaiya, Balakrishnan Nair, Nathan Henry, Monique F Kilkenny","doi":"10.1159/000542301","DOIUrl":"10.1159/000542301","url":null,"abstract":"<p><strong>Background: </strong>Cerebrovascular accident (CVA) is an outdated term for describing stroke as it implies stroke is an accident. We conducted an integrative review to examine the use of CVA in terms of (1) frequency in major medical journals over time; (2) associated publication characteristics (e.g., number of authors, senior author country, topic); and (3) frequency in medical records.</p><p><strong>Methods: </strong>We searched Google Scholar for publications in leading neurology and vascular journals (Quartile 1) across two 5-year periods (1998-2002 and 2018-2022) using the terms \"cerebrovascular accident\" or \"CVA.\" Two reviewers independently reviewed full-text publications and recorded the frequency of CVA use. Rates of use (per 1,000 articles/year) were calculated for each journal and time period. Associations of publication characteristics with CVA use were determined using multivariable logistic regression models. In addition, admission and discharge forms in the Auckland Regional Community Stroke Study (ARCOS V) were audited for frequency of use of the term CVA.</p><p><strong>Results: </strong>Of the 1,643 publications retrieved, 1,539 were reviewed in full. Of these, CVA was used ≥1 time in 676 publications, and ≥2 times in 276 publications (129 in 1998-2002; 147 in 2018-2022). The terms CVA and stroke both appeared in 57% of publications where CVA was used ≥2 times in 1998-2002, compared to 65% in 2018-2022. Majority of publications were on the topic of stroke (22% in 1998-2002; 20% in 2018-2022). There were no associations between publication characteristics and the use of CVA. The highest rate of CVA use in 2018-2022 was in Circulation, which had increased over time from 1.3 uses per 1,000 publications in 1998-2002 to 1.8 uses per 1,000 publications in 2018-2022. The largest reduction in the use of CVA was in Neuroepidemiology (2.0 uses per 1,000 publications in 1998-2002 to 0 uses in 2018-2022). The term CVA was identified in 0.2% (17/7,808) of stroke admission and discharge forms audited.</p><p><strong>Conclusion: </strong>We found evidence of changes in the use of CVA in the scientific literature over the past two decades. Editors, authors, and clinicians should avoid the use of the term CVA as it perpetuates the use of an ambiguous and inappropriate term.</p>","PeriodicalId":54730,"journal":{"name":"Neuroepidemiology","volume":" ","pages":"1-9"},"PeriodicalIF":3.2,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142523708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Global, Regional, and National Burden of Brain and Central Nervous System Cancers for Males from 1990 to 2021 and Its Predicted Level in the Next 25 Years. 1990 年至 2021 年全球、地区和国家的男性脑癌和中枢神经系统癌症负担及其未来 25 年的预测水平。
IF 3.2 3区 医学
Neuroepidemiology Pub Date : 2024-10-24 DOI: 10.1159/000541917
Aierpati Maimaiti, Maidina Tuersun, Xixian Wang, Maimaitili Mijiti, Hao Wu, Chunyu Cong, Zengliang Wang, Yongxin Wang
{"title":"Global, Regional, and National Burden of Brain and Central Nervous System Cancers for Males from 1990 to 2021 and Its Predicted Level in the Next 25 Years.","authors":"Aierpati Maimaiti, Maidina Tuersun, Xixian Wang, Maimaitili Mijiti, Hao Wu, Chunyu Cong, Zengliang Wang, Yongxin Wang","doi":"10.1159/000541917","DOIUrl":"10.1159/000541917","url":null,"abstract":"<p><strong>Background: </strong>A study of the global burden of cerebral and central nervous system (CNS) cancers from the Global Burden of Diseases (GBD) indicates that these cancers significantly contribute to morbidity and mortality internationally. To fully understand the global impact of CNS cancer, expanded research efforts are essential. We analyzed the temporal trend of the disease burden from 1990 to 2021 and made projections for the expected burden from 2020 through 2044.</p><p><strong>Methods: </strong>We tapped into GBD 2021 Study data to evaluate CNS cancer incidence and trends among males. Prevalence was assessed with DisMod-MR, trends via cluster analysis, and estimated annual percentage change (EAPC) calculated via linear regression. Forecasts for 2022-2044 used APC and BAPC models, with a p value <0.05 considered significant. Analyses relied on R software 4.0.2.</p><p><strong>Results: </strong>In 2021, males experienced between 148,118 and 232,469 new brain and CNS cancer cases, indicating increased global burden from 1990 to 2021. An observed link between the prevalence's EAPCs and Human Development Indices (HDIs) suggests higher incidence in more developed regions. Projections using the APC model suggest rising numbers of cases and losses in disability-adjusted life years (DALYs) from 2020 to 2044, while age-standardized rates are expected to decrease overall.</p><p><strong>Conclusions: </strong>In summary, a higher Socio-Demographic Index (SDI) correlates with better outcomes for CNS cancer due to early medical interventions in regions with strong healthcare systems. This demonstrates the need for equitable healthcare policies that focus on improving diagnostic capabilities and professional training to enhance survival rates universally.</p>","PeriodicalId":54730,"journal":{"name":"Neuroepidemiology","volume":" ","pages":"1-20"},"PeriodicalIF":3.2,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142513156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Influence of Birth Weight, Socio-Economic Status, and Adult Health on Brain Volumes during Ageing. 出生体重、社会经济地位和成人健康对衰老过程中脑容量的影响。
IF 3.2 3区 医学
Neuroepidemiology Pub Date : 2024-10-14 DOI: 10.1159/000541918
Christopher J McNeil, Tina Habota, Anca-Larisa Sandu, Gordon Waiter, Heather Whalley, Alison D Murray
{"title":"The Influence of Birth Weight, Socio-Economic Status, and Adult Health on Brain Volumes during Ageing.","authors":"Christopher J McNeil, Tina Habota, Anca-Larisa Sandu, Gordon Waiter, Heather Whalley, Alison D Murray","doi":"10.1159/000541918","DOIUrl":"10.1159/000541918","url":null,"abstract":"<p><strong>Introduction: </strong>Greater late-life brain volumes are associated with resilience against dementia. We examined relationships between birth weight, lifelong socio-economic status, and health with late-life brain volumes. We hypothesised that early life factors directly affect late-life brain volumes.</p><p><strong>Methods: </strong>Adults aged 59-67 y underwent MRI and brain volumes were measured. Birth weight and lifelong health, and socio-economic status were quantified and the principal components of each extracted. Relationships were examined using regression and structural equation analysis.</p><p><strong>Results: </strong>Birth weight (β = 0.095, p = 0.017) and childhood socio-economic status (β = 0.091, p = 0.033, n = 280) were directly associated with brain volume. Childhood socio-economic status was further associated with grey matter volume (β = 0.04, p = 0.047). Adult health was linked to increased brain volume (β = 0.15, p = 0.003).</p><p><strong>Conclusion: </strong>Birth weight and childhood socio-economic status are associated with whole and regional brain volume through direct mechanisms. Optimal fetal development, reduced childhood poverty, and good adult health could reduce brain atrophy and delay dementia onset in late-life.</p>","PeriodicalId":54730,"journal":{"name":"Neuroepidemiology","volume":" ","pages":"1-9"},"PeriodicalIF":3.2,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142481196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Direct Medical Cost of Essential Tremor. 本质性震颤的直接医疗成本。
IF 3.2 3区 医学
Neuroepidemiology Pub Date : 2024-10-11 DOI: 10.1159/000541968
Kandice A Kapinos, Elan D Louis
{"title":"The Direct Medical Cost of Essential Tremor.","authors":"Kandice A Kapinos, Elan D Louis","doi":"10.1159/000541968","DOIUrl":"10.1159/000541968","url":null,"abstract":"<p><strong>Objectives: </strong>The aim of the study was to determine the direct medical cost of illness from essential tremor (ET) from a patient perspective.</p><p><strong>Methods: </strong>Secondary data from the Optum's de-identified Clinformatics® Data Mart Database from 2018-2019 were used to assess medical resource utilization and costs. Propensity score matching was used to match patients aged 40+ to statistically similar controls. Generalized linear models were used to estimate average, adjusted total costs of care per year, by healthcare setting, and provider specialty.</p><p><strong>Results: </strong>The final sample included 41,200 patients with at least one ET claim and 36,871 matched patients. Overall, ET patients aged 40+ had about USD 28,217 in direct medical costs per year, which was about USD 1,601 more than matched comparisons (p < 0.001). This was driven by greater number of outpatient visits overall and with specialists. Extrapolating the estimates from our study and pairing them with published age-specific disease prevalence statistics for ET, we calculated an annual cost for direct medical care of ET patients aged 40+ to be about USD 9.4 billion.</p><p><strong>Conclusion: </strong>The estimated direct medical costs among adults aged 40+ with an ET diagnosis aggregated to the population level are nontrivial.</p>","PeriodicalId":54730,"journal":{"name":"Neuroepidemiology","volume":" ","pages":"1-7"},"PeriodicalIF":3.2,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142481195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevalence, Incidence, and Mortality of Myasthenia Gravis and Myasthenic Syndromes: A Systematic Review. 重症肌无力和肌无力综合征的患病率、发病率和死亡率:系统综述。
IF 3.2 3区 医学
Neuroepidemiology Pub Date : 2024-10-09 DOI: 10.1159/000539577
Francesco Sciancalepore, Niccolò Lombardi, Giulia Valdiserra, Marco Bonaso, Emiliano Cappello, Giulia Hyeraci, Giada Crescioli, Maria Grazia Celani, Teresa Anna Cantisani, Paola Brunori, Simona Vecchi, Ilaria Bacigalupo, Nicoletta Locuratolo, Eleonora Lacorte, Nicola Vanacore, Ursula Kirchmayer
{"title":"Prevalence, Incidence, and Mortality of Myasthenia Gravis and Myasthenic Syndromes: A Systematic Review.","authors":"Francesco Sciancalepore, Niccolò Lombardi, Giulia Valdiserra, Marco Bonaso, Emiliano Cappello, Giulia Hyeraci, Giada Crescioli, Maria Grazia Celani, Teresa Anna Cantisani, Paola Brunori, Simona Vecchi, Ilaria Bacigalupo, Nicoletta Locuratolo, Eleonora Lacorte, Nicola Vanacore, Ursula Kirchmayer","doi":"10.1159/000539577","DOIUrl":"10.1159/000539577","url":null,"abstract":"<p><strong>Introduction: </strong>No systematic reviews were published in the last years investigating epidemiological data, involving myasthenia gravis (MG) and related myasthenic syndromes. This systematic review aimed to estimate the prevalence, incidence, and mortality of all MG types and myasthenic syndromes worldwide.</p><p><strong>Methods: </strong>All literature published up to February 2024 was retrieved by searching the databases \"Medline,\" \"Embase,\" \"ISI Web of Science\" and \"CINAHL\" using the following search terms: (epidemiolog* OR frequency OR prevalence OR incidence OR mortality) AND (myasth* OR \"anti-acetylcholine receptor antibody\" OR \"AChR\" OR \"MuSK\" OR \"anti-muscle specific kinase antibody\" OR \"LRP4\" OR \"seronegative MG\").</p><p><strong>Results: </strong>A total of 94 studies, performed between 1952 and 2022, were included. Prevalence of MG ranged from 20 to 475 cases per million, with a mean prevalence of 173.3 (95% confidence interval [CI]: 129.7-215.5) cases per million and a median prevalence of 129.6 cases per million. Incidence rates ranged from 2.3 to 61.3 cases per million person-years, with a mean incidence of 15.7 (95% CI: 11.5-19.9) and a median of 13.3 cases. Mortality rates showed a mean of 1.4 (95% CI: 0.8-2.1) cases per million person-years. Acetylcholine receptor (AChR)-MG was the clinical subtype more frequent in terms of prevalence and incidence.</p><p><strong>Discussion: </strong>The prevalence and incidence of MG have significantly increased over the last years worldwide, probably due to the improvement of epidemiological methodologies and current advances in diagnosis. However, we observed a significant variation in frequencies of MG between and within countries because of methodological biases and complex heterogeneity of the disease characterized by several phenotypes and different clinical responses.</p>","PeriodicalId":54730,"journal":{"name":"Neuroepidemiology","volume":" ","pages":"1-14"},"PeriodicalIF":3.2,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142395361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Strength of Association between Coronavirus Disease 2019 and Neurological Disorders in Children: A Case-Control Study. 2019 年冠状病毒疾病与儿童神经系统疾病之间的关联强度:病例对照研究
IF 5.7 3区 医学
Neuroepidemiology Pub Date : 2024-09-12 DOI: 10.1159/000541303
Utcharee Intusoma,Wisarut Srisintorn,Titaporn Thamcharoenvipas,Kemmapon Chumchuen
{"title":"Strength of Association between Coronavirus Disease 2019 and Neurological Disorders in Children: A Case-Control Study.","authors":"Utcharee Intusoma,Wisarut Srisintorn,Titaporn Thamcharoenvipas,Kemmapon Chumchuen","doi":"10.1159/000541303","DOIUrl":"https://doi.org/10.1159/000541303","url":null,"abstract":"Evidence suggests potential neurological complications of Coronavirus Disease 2019 (COVID-19), particularly in adults. While case series have hinted at associations between COVID-19 and neurological disorders (NDs) in children, the extent of this link remains unclear. This study investigates temporal trends in NDs during the pandemic and assesses their potential association with COVID-19 infection in children. We analyzed national Thai hospitalization data (2017-2022) for children under 18 with specific NDs (acute transverse myelitis, central nervous system demyelination, neuromyelitis optica, optic neuritis, polyneuropathy, stroke). An interrupted time series analysis was employed to identify changes in the incidence trends of NDs following the declaration of the COVID-19 pandemic. A matched case-control analysis was conducted using data specific to the Thai COVID-19 outbreak period. This analysis aimed to estimate the association between recent/concurrent COVID-19 infection and NDs in children. A propensity score matching on age group, sex, and month of admission was performed before conducting logistic regression. From 2017-2022, 1,721 children admitted with NDs (2,474 admissions), with a male predominance (55%) and average age of 10.6 years. Significant slope change was observed in optical neuritis trends coinciding with the third COVID-19 wave. The case-control analysis included 468 cases and 2,340 controls. Children with NDs had a significantly higher prevalence of recent/concurrent COVID-19 (matched odds ratio: 1.95, 95% confidence interval: 1.21-3.16). Subgroup analysis revealed an association between stroke and recent/concurrent COVID-19 (matched odds ratio: 3.05, 95% confidence interval: 1.3-7.16). Thus, this study suggests an association between recent/concurrent COVID-19 and NDs, especially pediatric stroke.","PeriodicalId":54730,"journal":{"name":"Neuroepidemiology","volume":"71 1","pages":"1-16"},"PeriodicalIF":5.7,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142255698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Low sun exposure is associated with both progressive-onset and relapse-onset multiple sclerosis risk: a case-control study. 少晒太阳与进展期发病和复发期发病的多发性硬化症风险有关:一项病例对照研究。
IF 5.7 3区 医学
Neuroepidemiology Pub Date : 2024-09-11 DOI: 10.1159/000540921
Ying Li,Alice Saul,Bruce Taylor,Anne-Louise Ponsonby,Steve Simpson-Yap,Leigh Blizzard,Simon Broadley,Jeannette Lechner-Scott,,Ingrid van der Mei
{"title":"Low sun exposure is associated with both progressive-onset and relapse-onset multiple sclerosis risk: a case-control study.","authors":"Ying Li,Alice Saul,Bruce Taylor,Anne-Louise Ponsonby,Steve Simpson-Yap,Leigh Blizzard,Simon Broadley,Jeannette Lechner-Scott,,Ingrid van der Mei","doi":"10.1159/000540921","DOIUrl":"https://doi.org/10.1159/000540921","url":null,"abstract":"BACKGROUNDSun exposure has consistently been associated with Multiple Sclerosis (MS) onset, but case samples are predominantly relapse-onset MS (ROMS), and risk estimates have rarely been reported separately for ROMS and progressive-onset MS (POMS). We aimed to determine whether sun exposure prior to disease onset was associated with POMS, and whether the effect differed between POMS and ROMS.METHODSThis nationwide case-control study included 153 POMS cases, 204 incident ROMS cases, and 558 community controls with data from two separate datasets: the PPMS Study (2015-2019) and the Ausimmune Study (2003-2006). Information on time spent in the sun before first MS symptom, skin phenotype, sun protection behavior was collected. Satellite data on ambient ultraviolet radiation (UVR) was used to calculate cumulative UVR dose. Unconditional logistic regression was used with adjustment for covariates.RESULTSThere were consistent dose-response associations, with higher levels of UVR exposure associated with a reduced risk of POMS, both for leisure-time and occupational UVR from age 6 to symptom onset. Associations were overall stronger for POMS than ROMS. For example, cumulative leisure-time UVR dose (per 100 kJ/m2 increment) was associated with POMS (aOR 0.93, 95% CI 0.91-0.95) and the association was slightly weaker for ROMS (aOR 0.96, 95% CI 0.94-0.99) for age 6 to symptom onset (test for interaction p&lt;0.001).CONCLUSIONSLow levels of sun exposure, throughout the whole life span, are associated with increased risk of POMS and ROMS onset. The sun effects are usually stronger for POMS than ROMS.","PeriodicalId":54730,"journal":{"name":"Neuroepidemiology","volume":"40 1","pages":"1-15"},"PeriodicalIF":5.7,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142222974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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