David Metsu , Sylvie Caspar-Bauguil , Anne Galinier
{"title":"Carences et excès en micronutriments","authors":"David Metsu , Sylvie Caspar-Bauguil , Anne Galinier","doi":"10.1016/j.nupar.2023.05.002","DOIUrl":"https://doi.org/10.1016/j.nupar.2023.05.002","url":null,"abstract":"<div><p>Health prevention includes an adequate dietary intake of macronutrients (carbohydrates, lipids, proteins) and micronutrients (vitamins, trace elements). Micronutrients play an essential role as co-factors or reducing agents in almost all of the biochemical reactions of cellular metabolism. The objective of this review is to provide an update of knowledge of the metabolism of the main micronutrients such as water-soluble (B1, B6, B9, B12, C) and fat-soluble (A, E, D) vitamins and trace elements (iron, zinc, copper, selenium) with a particular attention to their impact of inflammation. The aim of the review is also to define the status of micronutrients in groups at risk of emerging deficiency (inflammation bowel disease, bariatric surgery, bowel resection, COVID) and to draw out the main messages for putting them into practice. Biomarkers of micronutrient excess are generally less well characterized than those of deficiency, particularly in terms of links to functional or clinical symptoms of toxicity. The prevention of deficiencies in the absence of pathology, is based on a diet varied and balanced that easily covers all needs. Prevention by micronutritional supplements may be justified on a temporary or prolonged basis in particular pathophysiological situations (special diets, drug interactions, pathologies).</p></div>","PeriodicalId":54702,"journal":{"name":"Nutrition Clinique et Metabolisme","volume":"37 3","pages":"Pages 130-148"},"PeriodicalIF":0.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49841982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Emeline Cuvilliez , Jean Claude Desport , Carole Villemonteix , Sandra Guérin , Bastian Coulon , Corentin Varrier , Aurélie Lavaud , Jean Louis Fraysse
{"title":"Étude de l’utilisation de la technique du manger-mains dans les établissements médico-sociaux de la région française de Nouvelle-Aquitaine","authors":"Emeline Cuvilliez , Jean Claude Desport , Carole Villemonteix , Sandra Guérin , Bastian Coulon , Corentin Varrier , Aurélie Lavaud , Jean Louis Fraysse","doi":"10.1016/j.nupar.2023.05.003","DOIUrl":"https://doi.org/10.1016/j.nupar.2023.05.003","url":null,"abstract":"<div><h3>Introduction and objective</h3><p>The finger-food (FF) technique is intended to allow people with neuropsychiatric, visual or motor disabilities to eat by taking food by hand. Data from the use of this technique are scarce. The objective of the study was to specify the modes of use of FF in medico-social establishments in the New-Aquitaine region.</p></div><div><h3>Method</h3><p>A simple secure questionnaire was sent electronically to the 2625 medico-social establishments. Data were collected automatically and answers were presented descriptively.</p></div><div><h3>Results</h3><p>In all, 3% of establishments contacted responded (<em>n</em> <!-->=<!--> <!-->80, 82% from nursing homes, 15% from establishments for disabled adults and 2% from establishments for disabled children). FF concerned 24 establishments and 2% of residents. The presentation of food in FF was in 42% of cases in the form of bites, 30% of toasts and 20% of hydration cubes. The basic materials for FF were scarce. The FF diet was mainly offered at lunch and dinner. The perceived advantages of FF were the maintenance of the residents’ autonomy and pleasure of eating and the fight against undernutrition. On the side of the disadvantages felt, the main ones were the increase in working time, the excessively technical nature of the method and possible hygiene problems.</p></div><div><h3>Conclusion</h3><p>The FF technique seemed to have advantages, but raised problems which could probably be improved, thanks to an increase in the available staff time, the training of professionals, the acquisition of basic materials and the more frequent application of FF during breakfast and snacks. The interest of FF in terms of costs deserved to be explored.</p></div>","PeriodicalId":54702,"journal":{"name":"Nutrition Clinique et Metabolisme","volume":"37 3","pages":"Pages 155-161"},"PeriodicalIF":0.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49842078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"L’éditorial de la présidente de la SFNCM","authors":"Francisca Joly","doi":"10.1016/j.nupar.2023.08.003","DOIUrl":"https://doi.org/10.1016/j.nupar.2023.08.003","url":null,"abstract":"","PeriodicalId":54702,"journal":{"name":"Nutrition Clinique et Metabolisme","volume":"37 3","pages":"Page 123"},"PeriodicalIF":0.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49904039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Guillaume Ulmann , Claire Cherbuy , Emilie Guerriero , Adam Jirka , Maude Le Gall , Cindy Neuzillet , Aurore Pierson , Didier Quilliot , Manuel Sanchez , Frédéric Valla , Thierry Van Der Linden , Christelle Guillet
{"title":"Modifications des recommandations de la Haute Autorité de santé concernant le diagnostic de la dénutrition : application par les professionnels de la nutrition en pratique clinique","authors":"Guillaume Ulmann , Claire Cherbuy , Emilie Guerriero , Adam Jirka , Maude Le Gall , Cindy Neuzillet , Aurore Pierson , Didier Quilliot , Manuel Sanchez , Frédéric Valla , Thierry Van Der Linden , Christelle Guillet","doi":"10.1016/j.nupar.2023.05.005","DOIUrl":"https://doi.org/10.1016/j.nupar.2023.05.005","url":null,"abstract":"<div><h3>Introduction</h3><p>The new diagnostic criteria of the french health authority (HAS) for undernutrition suggest assessing patients’ muscle strength and/or mass. The methods are less available in practice. Albumin levels are now considered as a criterion for the severity of undernutrition. Our aim was to assess the impact of these changes in recommendations on the practices of professionals involved in screening for and diagnosing undernutrition.</p></div><div><h3>Materials and methods</h3><p>The Scientific Advisory Board of the french speaking society for clinical nutrition and metabolism (SFNCM) used google forms® to conduct an e-mail survey of the society's members.</p></div><div><h3>Results</h3><p>We obtained 363 responses. Eighty-seven percent and 77% of respondents respectively stated that they rarely or never assess muscle mass or strength. A minority of professionals said they were equipped to carry out these assessments (38% had a dynamometer, 23% an impedancemeter). However, even those had access to them did not use them regularly. With regard to albuminemia, almost half of those questioned said they used it to diagnose malnutrition.</p></div><div><h3>Conclusion</h3><p>Few of the professionals responsible for diagnosing undernutrition are able to assess muscle mass and strength, due to a lack of muscle mass and strength due to a lack of access to techniques. The use of albumin levels as a marker of the severity of undernutrition seems ambiguous to some. The training of teams and funding for equipment would therefore seem to be prerequisites for the successful implementation of these recommendations.</p></div>","PeriodicalId":54702,"journal":{"name":"Nutrition Clinique et Metabolisme","volume":"37 3","pages":"Pages 168-175"},"PeriodicalIF":0.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49842077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nicolas Richard , Mathilde Leboutte , Marie-France Vaillant , Xavier Hébuterne , Guillaume Savoye , Rachel Marion-Letellier PhD
{"title":"Quel est le rôle de l’alimentation dans les maladies inflammatoires chroniques de l’intestin ?","authors":"Nicolas Richard , Mathilde Leboutte , Marie-France Vaillant , Xavier Hébuterne , Guillaume Savoye , Rachel Marion-Letellier PhD","doi":"10.1016/j.nupar.2023.02.001","DOIUrl":"https://doi.org/10.1016/j.nupar.2023.02.001","url":null,"abstract":"<div><p>Diet is suspected to play a key role in IBD natural history. IBD patients often believe that diet is associated with symptoms and flares, leading to restrictive diets avoiding dietary components considered as potentially harmful. The risk factors of this restrictive eating disorder are now reported and result from disease activity, from patients’ psychological health and from confusing dietary advice. These restrictive diets are at risk of undernutrition, nutritional deficiencies and of mixed anxiety-depressive disorders. Epidemiological studies have highlighted the role of dietary factors in IBD risk. Mediterranean diets tend to reduce the risk of developing IBD. Conversely, the “Western” diet (high intakes of fat, sugar, salt, animal protein and ultra-processed foods) increases the risk of developing IBD. Experimental studies demonstrate the ability of nutrients to modulate the intestinal inflammatory response by influencing the composition of the intestinal microbiota, the function of the intestinal barrier or various actors of immunity. The level of scientific evidence is currently insufficient to propose an anti-inflammatory diet for IBD patients. Nevertheless, promising avenues of clinical research deserve to be investigated in the future through randomised interventional studies. As recommended by ESPEN statements with a strong consensus, every patient should benefit from dietary follow-up by a health professional as part of a multidisciplinary approach.</p></div>","PeriodicalId":54702,"journal":{"name":"Nutrition Clinique et Metabolisme","volume":"37 3","pages":"Pages 124-129"},"PeriodicalIF":0.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49904040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effects of omega-3 polyunsaturated fatty acids on the levels of pro- and anti-inflammatory cytokines and lipid profile in patients with Parkinson's disease","authors":"Sara Mohammadi , Mirmohsen Sharifi Bonab , Mahdyieh Hamed Behzad , Bahram Pourghassem Gargari","doi":"10.1016/j.nupar.2023.06.001","DOIUrl":"https://doi.org/10.1016/j.nupar.2023.06.001","url":null,"abstract":"<div><h3>Objective</h3><p>Parkinson's disease (PD) is associated with inflammation and lipid profile abnormalities. Considering the effects of omega-3 polyunsaturated fatty acids (ω-3 PUFAs) on inflammation and lipid metabolism, the present study aimed to investigate the effects of ω-3 PUFAs supplementation on the pro- and anti-inflammatory cytokines and lipid profile in PD.</p></div><div><h3>Material and methods</h3><p>In this study, 44 patients with PD were selected and divided into two groups. The intervention group received two capsules of ω-3 PUFAs daily, each capsule containing 120<!--> <!-->mg eicosapentaenoic acid and 180<!--> <span>mg docosahexaenoic acid, and the placebo group received two soft capsules of soybean oil daily for eight weeks. Weight, height, lipid profile (TG, HDL-c, LDL-c, total cholesterol [TC]), and pro- and anti-inflammatory cytokines (IL-6, TNF-α, and IL-10) were assessed at the beginning and at the end of the study.</span></p></div><div><h3>Results</h3><p>Body mass index (<em>P</em> <!-->=<!--> <!-->0.02), weight (<em>P</em> <!-->=<!--> <!-->0.04), HDL-c (<em>P</em> <!-->=<!--> <!-->0.01), LDL-c (<em>P</em> <!-->=<!--> <!-->0.03), and IL-6 (<em>P</em> <!-->=<!--> <span>0.02) levels increased, while TG (</span><em>P</em> <!-->=<!--> <!-->0.01), TNF-α (<em>P</em> <!-->=<!--> <!-->0.01), and IL-10 (<em>P</em> <!-->=<!--> <!-->0.01) decreased significantly in the ω-3 PUFAs group. Between-group comparisons revealed the changes not to be significant after adjustments for baseline values and confounders. Moreover, the changes in TC were not significant in either within- or between-group comparisons.</p></div><div><h3>Conclusion</h3><p>Based on the results of the study, 600<!--> <!-->mg ω-3 PUFAs supplementation for eight weeks has no significant effect on the assessed pro- and anti-inflammatory cytokines and lipid profiles in patients with PD. Further studies with higher doses are needed to better clarify the role of ω-3 PUFAs in the biochemical and clinical outcomes of PD patients.</p></div>","PeriodicalId":54702,"journal":{"name":"Nutrition Clinique et Metabolisme","volume":"37 3","pages":"Pages 181-187"},"PeriodicalIF":0.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49842076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Elizabeth Pérez-Cruz , Irving Horacio Torres-López
{"title":"Vitamin D status and parathyroid hormone in patients with severe obesity who undergo and not undergo gastric bypass","authors":"Elizabeth Pérez-Cruz , Irving Horacio Torres-López","doi":"10.1016/j.nupar.2023.05.006","DOIUrl":"https://doi.org/10.1016/j.nupar.2023.05.006","url":null,"abstract":"<div><h3>Aim</h3><p>To determine the status of 25(OH)D and parathyroid hormone (PTH) levels in patients with severe obesity who undergo and not undergo gastric bypass (GB); and analyzed their correlation with the degree of obesity and fat mass.</p></div><div><h3>Methods</h3><p>Cross-sectional study in 34 patients, analyzed in two groups: a) patients who not undergo GB and b) patients who did undergo GB. Height, weight, BMI, body composition, % excess weight loss (EWL) and % total weight loss (TWL) were determinate. 25(OH)D level was categorized according to the Endocrine Society criteria.</p></div><div><h3>Results</h3><p>Mean age was of 37.24<!--> <!-->±<!--> <!-->5.83 vs 40.82<!--> <!-->±<!--> <!-->9.03<!--> <!-->years (<em>P</em> <!-->=<!--> <!-->0.021) and BMI of 44.92<!--> <!-->±<!--> <!-->8.63 vs 31.28<!--> <!-->±<!--> <!-->5.60<!--> <!-->kg/m<sup>2</sup> (<em>P</em> <!-->=<!--> <!-->0.001) in patients who did not undergo GB and underwent GB respectively. Patients who underwent GB showed decreased levels of 25(OH)D: 14.04<!--> <!-->±<!--> <!-->10.42<!--> <!-->ng/mL vs patients without surgery 31.95<!--> <!-->±<!--> <!-->31.00<!--> <!-->ng/mL (<em>P</em> <!--><<!--> <!-->0.001). Vitamin D deficiency was identified in 70% patients having GB vs 59% patients without surgery (<em>P</em> <!--><<!--> <!-->0.05). Of all patients with GB, 35% were diagnosed with hyperparathyroidism vs 29% of those without GB (<em>P</em> <!-->=<!--> <!-->0.492). Serum 25(OH)D concentrations were disclosed a significant inverse relationship with the % TWL after surgery, but not with weight, BMI and fat mass.</p></div><div><h3>Conclusions</h3><p>Vitamin D deficiency is prevalent in patients with severe obesity and patients who did undergo GB. The major determinant of low levels of 25(OH)D was % TWL after surgery. Hyperparathyroidism did not indicate vitamin D deficiency.</p></div>","PeriodicalId":54702,"journal":{"name":"Nutrition Clinique et Metabolisme","volume":"37 3","pages":"Pages 176-180"},"PeriodicalIF":0.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49904038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Marianne Fricaudet , Mathilde Di Filippo , Philippe Moulin , Séverine Nony , Marie Anais Peron , Hélène Brignot , Gilles Feron , Cédric Sage , Pierre Poinsot , Rémi Duclaux Loras , Mikael Croyal , Sybil Charriere , Noel Peretti
{"title":"Salivary cholesterol level does not reflect cholesterolemia in children with heterozygous familial hypercholesterolemia","authors":"Marianne Fricaudet , Mathilde Di Filippo , Philippe Moulin , Séverine Nony , Marie Anais Peron , Hélène Brignot , Gilles Feron , Cédric Sage , Pierre Poinsot , Rémi Duclaux Loras , Mikael Croyal , Sybil Charriere , Noel Peretti","doi":"10.1016/j.nupar.2023.04.003","DOIUrl":"https://doi.org/10.1016/j.nupar.2023.04.003","url":null,"abstract":"<div><h3>Objectives</h3><p>Heterozygous familial hypercholesterolemia is a common genetic disease responsible for premature atherosclerosis. Therefore, early diagnosis and treatment are recommended to reduce cardiovascular risk. Usually, the screening is based on high plasma LDL-cholesterol. In children, blood testing is often an obstacle for screening. This study aims to evaluate the relevance of a salivary non-invasive LDL dosage in heterozygous familial hypercholesterolemia in a pediatric population.</p></div><div><h3>Materials and methods</h3><p>Prospective, case control, monocentric study comparaing the salivary cholesterol of 30 heterozygous familial hypercholesterolemia pediatric patients and 30 healthy age-matched controls with two different enzymatic kits (Amplite™ kit - AAT Bioquest® and Total Cholesterol Assay kit - CELL BIOLABS®, Inc).</p></div><div><h3>Results</h3><p>While the median serum total-cholesterol was significantly different in control and heterozygous familial hypercholesterolemia patients as expected, the median salivary cholesterol concentration was similar between the two groups and 1000 times lower than in serum. No correlation was found between salivary and serum cholesterol concentrations.</p></div><div><h3>Conclusion</h3><p>Although cholesterol is detectable in saliva, our study suggests that the low salivary cholesterol concentrations result mostly from variable gingival bleeding, precluding any reliable use for Heterozygous Familial Hypercholesterolemia screening in children.</p></div>","PeriodicalId":54702,"journal":{"name":"Nutrition Clinique et Metabolisme","volume":"37 3","pages":"Pages 162-167"},"PeriodicalIF":0.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49841980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"L’utilisation du logiciel DENUM et la politique nutritionnelle ont permis l’amélioration de la détection des patients dénutris de 80 % (séjours > 2 nuits) en 5 mois et une valorisation financière dans un service d’orthopédie en région Occitanie","authors":"V. Attalin , R. Foliwe , A. Avignon","doi":"10.1016/j.nupar.2023.03.074","DOIUrl":"https://doi.org/10.1016/j.nupar.2023.03.074","url":null,"abstract":"<div><h3>Introduction et but de l’étude</h3><p>La dénutrition touche une personne sur 3 en institution, avec des conséquences médicoéconomiques considérables. Dans les services de soins, le temps diététique est généralement insuffisant pour effectuer une prise en charge optimale de l’ensemble des patients. C’est notamment le cas dans les services de chirurgie orthopédique alors que la dénutrition peut fortement grever le pronostic des patients opérés. Au-delà d’un déficit de prise en charge, cela se traduit également par un faible renseignement de la dénutrition dans le codage PMSI et donc un défaut de valorisation des séjours. Il est ainsi crucial de prioriser les patients les plus à risque de dénutrition pour optimiser le temps diététique. Les outils numériques se sont développés au cours des dernières années et certaines applications permettent aux soignants d’optimiser le diagnostic et la prise en charge nutritionnelle. Ces outils, dès à présents intégrés aux soins, sont néanmoins consommateurs de temps pour les soignants.</p></div><div><h3>Matériel et méthodes</h3><p>La clinique Saint Jean Sud de France s’est dotée de l’application « DENUM » qui permet au patient de remplir lui-même ses données nutritionnelles et de faire le lien avec l’équipe diététique de l’établissement. Suite au remplissage par le patient, l’équipe diététique reçoit, le cas échéant, une alerte et priorise les patients dans sa journée. Le diagnostic nutritionnel est optimisé à iso-ressource (sans augmenter le nombre d’ETP ou le temps diététique). L’application ne réalise aucun diagnostic, elle ne se substitue pas aux prescriptions médicales de consultation diététique dans le service ni aux pratiques habituelles de la prise en charge diététique au sein d’un service hospitalier. Elle constitue donc une aide au diagnostic et à la prise en charge. Nous avons évalué de façon rétrospective l’amélioration de la cotation de la dénutrition dans ce secteur de soin.</p></div><div><h3>Résultats et analyses statistiques</h3><p>Entre mars et juin 2022, les patients du Service d’orthopédie de la Clinique Saint Jean (Occitanie) ont reçu avant chaque séjour un sms avec un lien pour remplir les données sur <span>www.denum.fr</span><svg><path></path></svg>. Pendant la période d’observation, 890 patients ont renseigné le questionnaire DENUM. Parmi ceux-ci, 324 ont été évalués par la plateforme en situation de risque nutritionnel, soit 36,4 %. Cent huit d’entre eux, soit 12,1 %, étaient hospitalisés pour un séjour de plus de 2 nuits, avec une valorisation PMSI attendue. Comparée aux mois précédents, la politique nutritionnelle instaurée dans la clinique a permis de faire passer le taux de détection de la dénutrition chez les patients hospitalisés (hors ambulatoire) de 3,13 % à 5,7 % (+2,5 %), soit 80 % d’augmentation. En extrapolant sur les données de la littérature, la valorisation de la prise en charge de la dénutrition sur les séjours de plus de 2 nuits peut être attendue à 6343,75 € sur 5","PeriodicalId":54702,"journal":{"name":"Nutrition Clinique et Metabolisme","volume":"37 2","pages":"Page e42"},"PeriodicalIF":0.6,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49880336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}