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Recurrent Squamous Cell Carcinoma of the Head & Neck: Novel Approaches to Re-Irradiation. 头颈部复发性鳞状细胞癌：再照射的新方法。
IF 1.4 4区 医学
Otolaryngologic Clinics of North America Pub Date : 2025-09-29 DOI: 10.1016/j.otc.2025.08.010
Dwight E Heron, Matthew C Ward, Sue S Yom, Carl R Peterson, Sharon A Spencer, Michelle Echevarria
{"title":"Recurrent Squamous Cell Carcinoma of the Head & Neck: Novel Approaches to Re-Irradiation.","authors":"Dwight E Heron, Matthew C Ward, Sue S Yom, Carl R Peterson, Sharon A Spencer, Michelle Echevarria","doi":"10.1016/j.otc.2025.08.010","DOIUrl":"https://doi.org/10.1016/j.otc.2025.08.010","url":null,"abstract":"<p><p>Recurrent squamous cell carcinoma of the head and neck remains a formidable clinical challenge. This article provides detailed current and novel reirradiation strategies, including integration of systemic, targeted, and immunotherapeutic approaches, including highlighting ongoing clinical trials.</p>","PeriodicalId":54657,"journal":{"name":"Otolaryngologic Clinics of North America","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145202109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Optimal Adjuvant Therapy of Head and Neck Squamous Cancer After Primary Surgical Resection. 头颈部鳞癌原发手术切除后的最佳辅助治疗。
IF 1.4 4区 医学
Otolaryngologic Clinics of North America Pub Date : 2025-09-23 DOI: 10.1016/j.otc.2025.08.018
Robin J D Prestwich, Armando De Virgilio
{"title":"Optimal Adjuvant Therapy of Head and Neck Squamous Cancer After Primary Surgical Resection.","authors":"Robin J D Prestwich, Armando De Virgilio","doi":"10.1016/j.otc.2025.08.018","DOIUrl":"https://doi.org/10.1016/j.otc.2025.08.018","url":null,"abstract":"<p><p>Optimal selection of patients for adjuvant therapy following primary surgery for head and neck squamous cancer is challenging. Decision-making depends on a range of patient and disease factors including the presence or otherwise of a host of pathologic risk factors. Postoperative radiotherapy is the standard of care for advanced disease and has a role for early-stage disease in the presence of multiple risk factors. Concurrent chemotherapy improves outcomes for high-risk pathology having extranodal extension and/or very close/positive margins, and in these patients, immunotherapy in the perioperative period is associated with better locoregional control. Adjuvant therapy has significant toxicity.</p>","PeriodicalId":54657,"journal":{"name":"Otolaryngologic Clinics of North America","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145139398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nasopharyngeal Cancer Screening: Methods, Target Populations, and Next Steps. 鼻咽癌筛查：方法、目标人群和下一步
IF 1.4 4区 医学
Otolaryngologic Clinics of North America Pub Date : 2025-09-22 DOI: 10.1016/j.otc.2025.08.006
Wai Kei Jacky Lam, Guannan Kang, Kwan Chee Allen Chan
{"title":"Nasopharyngeal Cancer Screening: Methods, Target Populations, and Next Steps.","authors":"Wai Kei Jacky Lam, Guannan Kang, Kwan Chee Allen Chan","doi":"10.1016/j.otc.2025.08.006","DOIUrl":"https://doi.org/10.1016/j.otc.2025.08.006","url":null,"abstract":"<p><p>This article reviews current strategies for nasopharyngeal carcinoma (NPC) screening, emphasizing the importance of early detection to improve outcomes. It highlights plasma Epstein-Barr virus (EBV) DNA testing, including advances in molecular profiling by next-generation sequencing that enhances specificity. The role of EBV antibody assays, particularly novel markers like anti-BNLF2b, is discussed for risk stratification and mortality reduction. In addition, emerging biomarkers, genetic variants, and noninvasive methods, such as transoral brushing, are explored to optimize early diagnosis. Overall, integrating these approaches holds promise for more effective, targeted NPC screening in high-risk populations, ultimately reducing mortality and improving patient quality of life.</p>","PeriodicalId":54657,"journal":{"name":"Otolaryngologic Clinics of North America","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145132785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
State of the Art Multimodality Management of Laryngeal and Hypopharyngeal Cancers that Optimizes Survival and Function. 优化生存和功能的喉癌和下咽癌多模式管理的最新进展。
IF 1.4 4区 医学
Otolaryngologic Clinics of North America Pub Date : 2025-09-22 DOI: 10.1016/j.otc.2025.08.015
Amar Rajgor, Vinita Takiar, David Hamilton
{"title":"State of the Art Multimodality Management of Laryngeal and Hypopharyngeal Cancers that Optimizes Survival and Function.","authors":"Amar Rajgor, Vinita Takiar, David Hamilton","doi":"10.1016/j.otc.2025.08.015","DOIUrl":"https://doi.org/10.1016/j.otc.2025.08.015","url":null,"abstract":"<p><p>Laryngeal and hypopharyngeal cancers present complex challenges, with treatments often impairing essential functions such as speech and swallowing. This review explores multimodal management strategies that optimize both oncological control and post-treatment quality of life. Surgical innovations, including transoral approaches, conservation laryngectomy, and microvascular reconstruction, are evaluated alongside non-surgical modalities such as chemotherapy and targeted radiation techniques. Emphasis is placed on function-centered care, early rehabilitation, and the importance of shared decision making. A multidisciplinary, individualized approach is critical for achieving survival while preserving voice, swallowing, and airway function.</p>","PeriodicalId":54657,"journal":{"name":"Otolaryngologic Clinics of North America","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145132764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nutrition for Otolaryngologists. 耳鼻喉科医生的营养。
IF 1.4 4区 医学
Otolaryngologic Clinics of North America Pub Date : 2025-09-22 DOI: 10.1016/j.otc.2025.08.001
Karen Pitman, Taylor Martin
{"title":"Nutrition for Otolaryngologists.","authors":"Karen Pitman, Taylor Martin","doi":"10.1016/j.otc.2025.08.001","DOIUrl":"https://doi.org/10.1016/j.otc.2025.08.001","url":null,"abstract":"<p><p>Optimal nutrition underpins peak performance. Dietary preferences are personal, and any dietary pattern can support health and endurance. The key principles are food choices that support metabolic health, maintain calorie balance and hydration, provide adequate macro and micronutrients, and limit ultra-processed foods.</p>","PeriodicalId":54657,"journal":{"name":"Otolaryngologic Clinics of North America","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145132796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ergonomics. 人体工程学。
IF 1.4 4区 医学
Otolaryngologic Clinics of North America Pub Date : 2025-09-20 DOI: 10.1016/j.otc.2025.08.012
Eric Formeister, Marissa Pentico, Sydney C Butts
{"title":"Ergonomics.","authors":"Eric Formeister, Marissa Pentico, Sydney C Butts","doi":"10.1016/j.otc.2025.08.012","DOIUrl":"https://doi.org/10.1016/j.otc.2025.08.012","url":null,"abstract":"<p><p>This review provides an evidence-based overview of ergonomics in otolaryngology-head and neck surgery, with guidance for optimizing positioning during in-office and operative procedures. Herein, we summarize recent findings highlighting the prevalence of musculoskeletal (MSK) pain among Otolaryngology, Head and Neck (OHN) surgeons and outline validated ergonomic risk assessment tools. Strategies for equipment and posture optimization are organized by visualization modality-open, endoscopic/exoscopic, microscopic, and robotic. We conclude with effective interventions to prevent and manage MSK disorders in the surgical workforce.</p>","PeriodicalId":54657,"journal":{"name":"Otolaryngologic Clinics of North America","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145114817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Head and Neck Cancer Screening: Current Status in Oral Cavity and Oropharyngeal Carcinomas. 头颈癌筛查：口腔和口咽癌的现状。
IF 1.4 4区 医学
Otolaryngologic Clinics of North America Pub Date : 2025-09-16 DOI: 10.1016/j.otc.2025.08.005
Hugh A J Kim, Kristina Dahlstrom, Erich M Sturgis, Andrew Day, Antoine Eskander
{"title":"Head and Neck Cancer Screening: Current Status in Oral Cavity and Oropharyngeal Carcinomas.","authors":"Hugh A J Kim, Kristina Dahlstrom, Erich M Sturgis, Andrew Day, Antoine Eskander","doi":"10.1016/j.otc.2025.08.005","DOIUrl":"https://doi.org/10.1016/j.otc.2025.08.005","url":null,"abstract":"<p><p>A good cancer screening program utilizes accurate, cost-effective methods targeted at a high-risk population to enable effective interventions in treatment and prevention. The US Preventative Services Task Force does not recommend oral cavity or oropharyngeal cancer (OPC) screening in asymptomatic adults by primary care physicians. South and Southeast Asians may represent a targetable population for oral cavity screening examinations given their proportionally higher prevalence of tobacco chewing. Otolaryngologists must support human papillomavirus (HPV) vaccination. A potential screening paradigm for HPV-related OPC may involve screening high-risk subjects using biofluid-based biomarkers, comprehensive head and neck and anogenital examination, and imaging.</p>","PeriodicalId":54657,"journal":{"name":"Otolaryngologic Clinics of North America","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145082392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Functional and Survivorship Considerations after Treatment of Primary and Recurrent Head and Neck Cancer. 原发性和复发性头颈癌治疗后的功能和生存考虑。
IF 1.4 4区 医学
Otolaryngologic Clinics of North America Pub Date : 2025-09-16 DOI: 10.1016/j.otc.2025.08.013
Grainne Brady, Sarah Stephen, Heather Starmer
{"title":"Functional and Survivorship Considerations after Treatment of Primary and Recurrent Head and Neck Cancer.","authors":"Grainne Brady, Sarah Stephen, Heather Starmer","doi":"10.1016/j.otc.2025.08.013","DOIUrl":"https://doi.org/10.1016/j.otc.2025.08.013","url":null,"abstract":"<p><p>The number of head and neck cancer (HNC) survivors is increasing and with this comes an increasing cohort of patients with ongoing, complex and potentially unmet survivorship needs. Quality-of-life (QoL) in HNC survivorship is increasingly understood to be a very important consideration in the care of patients treated for HNC before, during and in the longer term after treatment. This article highlights the importance of engaging a multidisciplinary team (MDT) for survivorship needs. It is critical for the entire MDT to understand the primary drivers of QoL in survivorship to develop and apply appropriate interventions.</p>","PeriodicalId":54657,"journal":{"name":"Otolaryngologic Clinics of North America","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145082405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Expert Patients and Their Contribution to Head and Neck Cancer Service Delivery, Education, Governance and Research. 专家患者及其对头颈癌服务提供、教育、治理和研究的贡献。
IF 1.4 4区 医学
Otolaryngologic Clinics of North America Pub Date : 2025-09-16 DOI: 10.1016/j.otc.2025.08.007
Michael Thick, Val Bryant
{"title":"Expert Patients and Their Contribution to Head and Neck Cancer Service Delivery, Education, Governance and Research.","authors":"Michael Thick, Val Bryant","doi":"10.1016/j.otc.2025.08.007","DOIUrl":"https://doi.org/10.1016/j.otc.2025.08.007","url":null,"abstract":"<p><p>Both authors are survivors of head and neck cancer, with a combined lived experience of more than 20 years. In the years following their treatment, they have supported fellow patients through their own cancer journeys and have contributed to the work of several regional and national stakeholder organizations. They offer a unique perspective-rooted in lived experience-on what truly constitutes patient-centered care, and how patients can meaningfully contribute. This article presents their reflections on cancer care from the patient's viewpoint and outlines practical ways in which patients can play an active, valuable role in both clinical practice and research.</p>","PeriodicalId":54657,"journal":{"name":"Otolaryngologic Clinics of North America","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145082369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Role of Faith in Wellness (for Otolaryngologists). 信仰在健康中的作用（适用于耳鼻喉科医生）。
IF 1.4 4区 医学
Otolaryngologic Clinics of North America Pub Date : 2025-09-15 DOI: 10.1016/j.otc.2025.08.002
Brian B Burkey
{"title":"The Role of Faith in Wellness (for Otolaryngologists).","authors":"Brian B Burkey","doi":"10.1016/j.otc.2025.08.002","DOIUrl":"https://doi.org/10.1016/j.otc.2025.08.002","url":null,"abstract":"<p><p>The association between faith and health or healing was viewed warily by skeptics and scientists over much of the latter half of the 20th century; however, the last 25 years has seen a plethora of research supporting a strong link between faith and improved health outcomes. This is so accepted that much research is now focused instead on the underlying processes creating this link. This should not be so surprising given the long philosophic tradition of the human being a duality of body and soul, and the importance of faith acknowledged by the early leaders in modern medicine.</p>","PeriodicalId":54657,"journal":{"name":"Otolaryngologic Clinics of North America","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145076125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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