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Surgically Based Deintensification for Oropharyngeal Cancer: Current Concepts and Future Directions. 口咽癌的外科去强化治疗：目前的概念和未来的方向。
IF 1.4 4区 医学
Otolaryngologic Clinics of North America Pub Date : 2025-10-10 DOI: 10.1016/j.otc.2025.09.001
Michael C Topf, Thomas Kjaergaard, Catherine Po Ling Chan, F Christopher Holsinger
{"title":"Surgically Based Deintensification for Oropharyngeal Cancer: Current Concepts and Future Directions.","authors":"Michael C Topf, Thomas Kjaergaard, Catherine Po Ling Chan, F Christopher Holsinger","doi":"10.1016/j.otc.2025.09.001","DOIUrl":"https://doi.org/10.1016/j.otc.2025.09.001","url":null,"abstract":"<p><p>The paradigm for management of human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (HPV + OPC) has evolved significantly in recent years. Following the interim futility analysis of NRG HN005, which reaffirmed standard-dose cisplatin-based chemoradiation as the standard of care in the nonsurgical setting, this review examines whether surgical approaches now represent the most viable path to treatment deintensification for appropriate patients with HPV + OPC. In this narrative review, we summarize data from key surgical deintensification clinical trials, discuss surgeon credentialing considerations, and review emerging technologies that may further refine patient selection and treatment response assessment.</p>","PeriodicalId":54657,"journal":{"name":"Otolaryngologic Clinics of North America","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145276718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Social Determinants of Health as They Affect Outcomes of Head and Neck Cancer. 影响头颈癌预后的健康社会决定因素
IF 1.4 4区 医学
Otolaryngologic Clinics of North America Pub Date : 2025-10-10 DOI: 10.1016/j.otc.2025.08.011
Evan M Graboyes, Nosayaba Osazuwa-Peters
{"title":"Social Determinants of Health as They Affect Outcomes of Head and Neck Cancer.","authors":"Evan M Graboyes, Nosayaba Osazuwa-Peters","doi":"10.1016/j.otc.2025.08.011","DOIUrl":"https://doi.org/10.1016/j.otc.2025.08.011","url":null,"abstract":"<p><p>Social determinants of health (SDOH) and health-related social risks can be measured in the clinical and research realms through patient self-report, composite neighborhood level measures of disadvantage, and Z-codes. Among patients with head and neck squamous cell carcinoma, differences in SDOH, particularly the domains of economic stability, education access and quality, and health care access, are associated with disparities in oncologic, psychosocial, and quality-of-life outcomes. Research describing the effects of strategies to address adverse SDOH is lacking. The head and neck oncology community is uniquely poised to move from describing disparities in outcomes based on SDOH to addressing them.</p>","PeriodicalId":54657,"journal":{"name":"Otolaryngologic Clinics of North America","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145276789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Innovative Approaches to Head and Neck Cancer Diagnosis. 头颈癌诊断的创新方法。
IF 1.4 4区 医学
Otolaryngologic Clinics of North America Pub Date : 2025-10-07 DOI: 10.1016/j.otc.2025.08.017
Ajith George, Theofano Tikka, David Conway
{"title":"Innovative Approaches to Head and Neck Cancer Diagnosis.","authors":"Ajith George, Theofano Tikka, David Conway","doi":"10.1016/j.otc.2025.08.017","DOIUrl":"https://doi.org/10.1016/j.otc.2025.08.017","url":null,"abstract":"<p><p>Diagnosis, positioned between disease prevention and treatment, is essential for head and neck cancer management. Delays in diagnosis contribute to disease upstaging, leading to more complex treatment with poorer survival and functional outcomes. This article focuses on current and future innovative diagnostic approaches, which vary in maturity and implementation, to promote early diagnosis. These include symptom-based triaging, telemedicine, diagnostic hubs, machine learning, and circulating tumor markers. COVID-19 brought about new diagnostic pathways, many of which remained in place, generating encouraging evidence of pathway efficiency. However, nuanced diagnostic tools for early cancer detection remain far from implementation in a real-world setting.</p>","PeriodicalId":54657,"journal":{"name":"Otolaryngologic Clinics of North America","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145253629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Building Support and Resilience: Finding Balance During Adversity. 建立支持和恢复力：在逆境中找到平衡。
IF 1.4 4区 医学
Otolaryngologic Clinics of North America Pub Date : 2025-10-04 DOI: 10.1016/j.otc.2025.08.023
Stephanie A Joe
{"title":"Building Support and Resilience: Finding Balance During Adversity.","authors":"Stephanie A Joe","doi":"10.1016/j.otc.2025.08.023","DOIUrl":"https://doi.org/10.1016/j.otc.2025.08.023","url":null,"abstract":"<p><p>Times of distress and personal setbacks can diminish a person's confidence. Such periods of adversity can disrupt emotional and physical well-being. In these situations, seeking support can feel embarrassing or uncomfortable. Building personal resilience starts with understanding the emotional effects and mental and physical consequences of stress. Resilience is built through seeking peer support, exploring the benefits of coaching, and understanding how to leverage neurobiology to positively influence physical and mental capacities for adaptation and future growth.</p>","PeriodicalId":54657,"journal":{"name":"Otolaryngologic Clinics of North America","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145234029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Strategies for Wellness at Home and Work. 家庭和工作中的健康策略。
IF 1.4 4区 医学
Otolaryngologic Clinics of North America Pub Date : 2025-10-03 DOI: 10.1016/j.otc.2025.08.019
Ilaaf Darrat
{"title":"Strategies for Wellness at Home and Work.","authors":"Ilaaf Darrat","doi":"10.1016/j.otc.2025.08.019","DOIUrl":"https://doi.org/10.1016/j.otc.2025.08.019","url":null,"abstract":"<p><p>This article examines the intricate realities of harmonizing a demanding surgical career with familial responsibilities. It questions the conventional concept of work-life balance, instead presenting it as an evolving set of priorities. Flexible scheduling, proactive planning, effective communication, and dependence on support systems are crucial for managing the dual roles of physician and family member without sacrificing well-being or professional achievement.</p>","PeriodicalId":54657,"journal":{"name":"Otolaryngologic Clinics of North America","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145228687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Precision Radiotherapy for HPV-Associated Oropharyngeal Carcinoma: Evolving Approaches to Dose and Volume De-intensification. hpv相关口咽癌的精确放疗：剂量和体积去强化的新方法。
IF 1.4 4区 医学
Otolaryngologic Clinics of North America Pub Date : 2025-10-03 DOI: 10.1016/j.otc.2025.08.020
Colin Faulkner, Eric Stutheit-Zhao, Jillian Tsai, Nauman Malik
{"title":"Precision Radiotherapy for HPV-Associated Oropharyngeal Carcinoma: Evolving Approaches to Dose and Volume De-intensification.","authors":"Colin Faulkner, Eric Stutheit-Zhao, Jillian Tsai, Nauman Malik","doi":"10.1016/j.otc.2025.08.020","DOIUrl":"https://doi.org/10.1016/j.otc.2025.08.020","url":null,"abstract":"<p><p>This review discusses the current efforts to de-intensify radiotherapy in human papillomavirus -positive oropharyngeal cancer to reduce long-term toxicity without compromising tumor control. It explores strategies, such as reducing dose and volume, selective omission of elective nodal irradiation, and tailoring treatment based on tumor response and patient risk profiles. Emerging evidence from clinical trials supports the safety and efficacy of lower radiation doses and smaller treatment volumes in selected patients. Advanced imaging and precise targeting may allow for smaller margins, further minimizing damage to the surrounding healthy tissue. None of these approaches have yet replaced the current standard of care.</p>","PeriodicalId":54657,"journal":{"name":"Otolaryngologic Clinics of North America","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145228689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mindfulness Skills: Impact on Surgical Well-being and Performance. 正念技能：对外科手术健康和表现的影响。
IF 1.4 4区 医学
Otolaryngologic Clinics of North America Pub Date : 2025-10-03 DOI: 10.1016/j.otc.2025.08.004
Veronica F Sullins, Paul Adam Gonzales, Michael Malotte, Carter C Lebares
{"title":"Mindfulness Skills: Impact on Surgical Well-being and Performance.","authors":"Veronica F Sullins, Paul Adam Gonzales, Michael Malotte, Carter C Lebares","doi":"10.1016/j.otc.2025.08.004","DOIUrl":"https://doi.org/10.1016/j.otc.2025.08.004","url":null,"abstract":"<p><p>Cognitive training is essential for optimal performance in high-stakes fields like surgery. Research shows that mindfulness-based interventions can help surgeons achieve cognitive clarity, emotional regulation, and technical excellence, benefiting patients, teams, and health care systems. For these interventions to be effective, they must be culturally accepted, integrated at multiple levels, and tailored to specific specialties. Despite challenges, context-sensitive strategies and consistent daily practice can make mindfulness a core asset rather than just a wellness tool. Adopting mindfulness can help surgery reduce burnout, build resilience, improve performance, and strengthen the human connection central to surgical care.</p>","PeriodicalId":54657,"journal":{"name":"Otolaryngologic Clinics of North America","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145228692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Novel Treatment Approaches in Recurrent/Metastatic Squamous Head and Neck Cancer. 复发/转移性鳞状头颈部癌的新治疗方法。
IF 1.4 4区 医学
Otolaryngologic Clinics of North America Pub Date : 2025-10-03 DOI: 10.1016/j.otc.2025.08.009
Sandra Llop, Pablo Jiménez-Labaig, Ilaria Micheletto, Nabil F Saba, Ben O'Leary
{"title":"Novel Treatment Approaches in Recurrent/Metastatic Squamous Head and Neck Cancer.","authors":"Sandra Llop, Pablo Jiménez-Labaig, Ilaria Micheletto, Nabil F Saba, Ben O'Leary","doi":"10.1016/j.otc.2025.08.009","DOIUrl":"https://doi.org/10.1016/j.otc.2025.08.009","url":null,"abstract":"<p><p>The prognosis of recurrent/metastatic head and neck squamous cell carcinoma (HNSCC) remains poor, with most patients presenting with primary or acquired resistance to immune checkpoint inhibitors (ICIs). Upon progression on ICIs, the only standard of care treatment options are chemotherapy ± cetuximab combinations with high toxicity rates and limited efficacy, underscoring the urgent need for more effective and tolerable therapeutic strategies. This review explores the landscape of rapidly evolving novel treatment approaches in recurrent/metastatic HNSCC, including ICI combinations, therapeutic vaccines, injectable drugs, bispecific antibodies, antibody-drug conjugates, multitargeted kinase inhibitors and new targeted therapy agents.</p>","PeriodicalId":54657,"journal":{"name":"Otolaryngologic Clinics of North America","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145228662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Contemporary Management of Frontal Sinus Fractures 额窦骨折的当代治疗。
IF 1.4 4区 医学
Otolaryngologic Clinics of North America Pub Date : 2025-10-01 DOI: 10.1016/j.otc.2025.03.007
Tsung-Yen Hsieh MD , Mary Roz Timbang MD , E. Bradley Strong MD
{"title":"Contemporary Management of Frontal Sinus Fractures","authors":"Tsung-Yen Hsieh MD ,&nbsp;Mary Roz Timbang MD ,&nbsp;E. Bradley Strong MD","doi":"10.1016/j.otc.2025.03.007","DOIUrl":"10.1016/j.otc.2025.03.007","url":null,"abstract":"","PeriodicalId":54657,"journal":{"name":"Otolaryngologic Clinics of North America","volume":"58 5","pages":"Pages 819-830"},"PeriodicalIF":1.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144053938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Functional and Cosmetic Brow Lift 功能性和美容性提眉术。
IF 1.4 4区 医学
Otolaryngologic Clinics of North America Pub Date : 2025-10-01 DOI: 10.1016/j.otc.2025.04.003
Bailey R. Minehart MD , Jose E. Barrera MD
{"title":"The Functional and Cosmetic Brow Lift","authors":"Bailey R. Minehart MD ,&nbsp;Jose E. Barrera MD","doi":"10.1016/j.otc.2025.04.003","DOIUrl":"10.1016/j.otc.2025.04.003","url":null,"abstract":"","PeriodicalId":54657,"journal":{"name":"Otolaryngologic Clinics of North America","volume":"58 5","pages":"Pages 831-844"},"PeriodicalIF":1.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144555871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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