Surgically Based Deintensification for Oropharyngeal Cancer: Current Concepts and Future Directions.

IF 1.4 4区医学 Q3 OTORHINOLARYNGOLOGY

Otolaryngologic Clinics of North America Pub Date : 2025-10-10 DOI:10.1016/j.otc.2025.09.001

Michael C Topf, Thomas Kjaergaard, Catherine Po Ling Chan, F Christopher Holsinger

引用次数: 0

Abstract

The paradigm for management of human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (HPV + OPC) has evolved significantly in recent years. Following the interim futility analysis of NRG HN005, which reaffirmed standard-dose cisplatin-based chemoradiation as the standard of care in the nonsurgical setting, this review examines whether surgical approaches now represent the most viable path to treatment deintensification for appropriate patients with HPV + OPC. In this narrative review, we summarize data from key surgical deintensification clinical trials, discuss surgeon credentialing considerations, and review emerging technologies that may further refine patient selection and treatment response assessment.

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口咽癌的外科去强化治疗：目前的概念和未来的方向。

近年来，人乳头瘤病毒（HPV）相关口咽鳞状细胞癌（HPV + OPC）的治疗模式发生了重大变化。NRG HN005的中期有效性分析再次确认了标准剂量顺铂为基础的放化疗作为非手术治疗的标准，本综述探讨了手术方法是否代表了适合HPV + OPC患者治疗去强化的最可行途径。在这篇叙述性综述中，我们总结了来自关键手术去强化临床试验的数据，讨论了外科医生的资质考虑，并回顾了可能进一步完善患者选择和治疗反应评估的新兴技术。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Otolaryngologic Clinics of North America 医学-耳鼻喉科学

CiteScore

3.00

自引率

0.00%

发文量

152

审稿时长

6-12 weeks

期刊介绍： Otolaryngologic Clinics of North America updates you on the latest trends in patient management; keeps you up to date on the newest advances; and provides a sound basis for choosing treatment options. Each issue focuses on a single topic in otolaryngology and is presented under the direction of an experienced guest editor.