Theory in Biosciences最新文献_第4页

Stability of a diffusive-delayed HCV infection model with general cell-to-cell incidence function incorporating immune response and cell proliferation. 扩散性延迟HCV感染模型的稳定性，该模型具有一般的细胞间发生率功能，包括免疫反应和细胞增殖。

IF 1.1 4区生物学

Theory in Biosciences Pub Date : 2023-09-01 DOI: 10.1007/s12064-023-00395-z

Alexis Nangue, Yanick Junior Tchuimeni

{"title":"Stability of a diffusive-delayed HCV infection model with general cell-to-cell incidence function incorporating immune response and cell proliferation.","authors":"Alexis Nangue, Yanick Junior Tchuimeni","doi":"10.1007/s12064-023-00395-z","DOIUrl":"https://doi.org/10.1007/s12064-023-00395-z","url":null,"abstract":"In this work, we analyse the dynamics of a five-dimensional hepatitis C virus infection mathematical model including the spatial mobility of hepatitis C virus particles, the transmission of hepatitis C virus infection by mitosis process of infected hepatocytes with logistic growth, time delays, antibody response and cytotoxic T lymphocyte (CTL) immune response with general incidence functions for both modes of infection transmission, namely virus-to-cell as well as cell-to-cell. Firstly, we prove rigorously the existence, the uniqueness, the positivity and the boundedness of the solution of the initial value and boundary problem associated with the new constructed model. Secondly, we found that the basic reproductive number is the sum of the basic reproduction number determined by cell-free virus infection, determined by cell-to-cell infection and determined by proliferation of infected cells. It is proved the existence of five spatially homogeneous equilibria known as infection-free, immune-free, antibody response, CTL response and antibody and CTL responses. By using the linearization methods, the local stability of the latter is established under some rigorous conditions. Finally, we proved the existence of periodic solutions by highlighting the occurrence of a Hopf bifurcation for a certain threshold value of one delay.","PeriodicalId":54428,"journal":{"name":"Theory in Biosciences","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10039543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Investigation of memory influences on bio-heat responses of skin tissue due to various thermal conditions. 不同热条件下记忆对皮肤组织生物热反应的影响研究。

IF 1.1 4区生物学

Theory in Biosciences Pub Date : 2023-09-01 DOI: 10.1007/s12064-023-00400-5

Rakhi Tiwari, Abhinav Singhal, Rajneesh Kumar, Pappu Kumar, Suniti Ghangas

{"title":"Investigation of memory influences on bio-heat responses of skin tissue due to various thermal conditions.","authors":"Rakhi Tiwari, Abhinav Singhal, Rajneesh Kumar, Pappu Kumar, Suniti Ghangas","doi":"10.1007/s12064-023-00400-5","DOIUrl":"https://doi.org/10.1007/s12064-023-00400-5","url":null,"abstract":"Advancement of new technologies such as laser, focused ultrasound, microwave and radio frequency for thermal therapy of skin tissue has increased numerous challenging situations in medical treatment. In this article, a new meticulous bio-heat transfer model based on memory-dependent derivative with dual-phase-lag has been developed under different thermal conditions such as thermal shock and harmonic-type heating. Laplace transform method is acquired to perceive the analytical consequences. Quantitative results are evaluated for displacement, strain and temperature along with stress distributions in time domain by adopting the technique of inverse Laplace transform. Impacts of the constituents of memory-dependent derivatives-kernel functions along with time-delay parameter are analysed on the studied fields (temperature, displacement, strain and stress) for both thermal conditions separately using computational results. It has been found that the insertion of the memory effect proves itself a unified model, and therefore, this model can better predict temperature field data for thermal treatment processes.","PeriodicalId":54428,"journal":{"name":"Theory in Biosciences","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10039578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The emergence of dynamic networks from many coupled polar oscillators: a paradigm for artificial life. 从许多耦合极性振荡器中产生的动态网络:人工生命的范例。

IF 1.1 4区生物学

Theory in Biosciences Pub Date : 2023-09-01 DOI: 10.1007/s12064-023-00401-4

Alessandro Scirè, Valerio Annovazzi-Lodi

{"title":"The emergence of dynamic networks from many coupled polar oscillators: a paradigm for artificial life.","authors":"Alessandro Scirè, Valerio Annovazzi-Lodi","doi":"10.1007/s12064-023-00401-4","DOIUrl":"https://doi.org/10.1007/s12064-023-00401-4","url":null,"abstract":"This work concerns a many-body deterministic model that displays life-like properties such as emergence, complexity, self-organization, self-regulation, excitability and spontaneous compartmentalization. The model portraits the dynamics of an ensemble of locally coupled polar phase oscillators, moving in a two-dimensional space, that under certain conditions exhibit emergent superstructures. Those superstructures are self-organized dynamic networks, resulting from a synchronization process of many units, over length scales much greater than the interaction range. Such networks compartmentalize the two-dimensional space with no a priori constraints, due to the formation of porous transport walls, and represent a highly complex and novel non-linear behavior. The analysis is numerically carried out as a function of a control parameter showing distinct regimes: static pattern formation, dynamic excitable networks formation, intermittency and chaos. A statistical analysis is drawn to determine the control parameter ranges for the various behaviors to appear. The model and the results shown in this work are expected to contribute to the field of artificial life.","PeriodicalId":54428,"journal":{"name":"Theory in Biosciences","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9977121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Symmetrical distributions of aminoacyl-tRNA synthetases during the evolution of the genetic code. 遗传密码进化过程中氨基酸- trna合成酶的对称分布。

IF 1.1 4区生物学

Theory in Biosciences Pub Date : 2023-09-01 DOI: 10.1007/s12064-023-00394-0

Marco V José, Juan R Bobadilla, Gabriel S Zamudio, Sávio Torres de Farías

引用次数: 0

An epidemic dynamics model with limited isolation capacity. 具有有限隔离能力的流行病动力学模型。

IF 1.1 4区生物学

Theory in Biosciences Pub Date : 2023-09-01 DOI: 10.1007/s12064-023-00399-9

Ishfaq Ahmad, Hiromi Seno

引用次数: 0

Path integral control of a stochastic multi-risk SIR pandemic model. 随机多风险SIR大流行模型的路径积分控制。

IF 1.1 4区生物学

Theory in Biosciences Pub Date : 2023-06-01 DOI: 10.1007/s12064-023-00388-y

Paramahansa Pramanik

引用次数: 3

Stationary distribution and density function analysis of SVIS epidemic model with saturated incidence and vaccination under stochastic environments. 随机环境下具有饱和发病率和疫苗接种的SVIS流行模型的平稳分布和密度函数分析。

IF 1.1 4区生物学

Theory in Biosciences Pub Date : 2023-06-01 DOI: 10.1007/s12064-023-00392-2

Prasenjit Mahato, Sanat Kumar Mahato, Subhashis Das, Partha Karmakar

{"title":"Stationary distribution and density function analysis of SVIS epidemic model with saturated incidence and vaccination under stochastic environments.","authors":"Prasenjit Mahato, Sanat Kumar Mahato, Subhashis Das, Partha Karmakar","doi":"10.1007/s12064-023-00392-2","DOIUrl":"https://doi.org/10.1007/s12064-023-00392-2","url":null,"abstract":"In this article, we study the dynamical properties of susceptible-vaccinated-infected-susceptible (SVIS) epidemic system with saturated incidence rate and vaccination strategies. By constructing the suitable Lyapunov function, we examine the existence and uniqueness of the stochastic system. With the help of Khas'minskii theory, we set up a critical value [Formula: see text] with respect to the basic reproduction number [Formula: see text] of the deterministic system. A unique ergodic stationary distribution is investigated under the condition of [Formula: see text]. In the epidemiological study, the ergodic stationary distribution represents that the disease will persist for long-term behavior. We focus for developing the general three-dimensional Fokker-Planck equation using appropriate solving theories. Around the quasi-endemic equilibrium, the probability density function of the stochastic system is analyzed which is the main theme of our study. Under [Formula: see text], both the existence of ergodic stationary distribution and density function can elicit all the dynamical behavior of the disease persistence. The condition of disease extinction of the system is derived. For supporting theoretical study, we discuss the numerical results and the sensitivities of the biological parameters. Results and conclusions are highlighted.","PeriodicalId":54428,"journal":{"name":"Theory in Biosciences","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10187527/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9520399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hypothesis: functional age and onset of autosomal dominant genetic prion disease. 假设:功能年龄和常染色体显性遗传朊病毒病的发病。

IF 1.1 4区生物学

Theory in Biosciences Pub Date : 2023-06-01 DOI: 10.1007/s12064-023-00389-x

Michael Bordonaro

引用次数: 0

A biological and a mathematical model of SLE treated by mesenchymal stem cells covering all the stages of the disease. 间充质干细胞治疗SLE的生物学和数学模型，涵盖疾病的所有阶段。

IF 1.1 4区生物学

Theory in Biosciences Pub Date : 2023-06-01 DOI: 10.1007/s12064-023-00390-4

Ali Yazdani, Fariba Bahrami, Arash Pourgholaminejad, Reza Moghadasali

{"title":"A biological and a mathematical model of SLE treated by mesenchymal stem cells covering all the stages of the disease.","authors":"Ali Yazdani, Fariba Bahrami, Arash Pourgholaminejad, Reza Moghadasali","doi":"10.1007/s12064-023-00390-4","DOIUrl":"https://doi.org/10.1007/s12064-023-00390-4","url":null,"abstract":"In this study, we proposed a biological model explaining the progress of autoimmune activation along different stages of systemic lupus erythematosus (SLE). For any upcoming stage of SLE, any new component is introduced, when it is added to the model. Particularly, the interaction of mesenchymal stem cells, with the components of the model, is specified in a way that both the inflammatory and anti-inflammatory functions of these cells would be covered. The biological model is then recapitulated to a model with less complexity that explains the main features of the problem. Later, a 7th-order mathematical model for SLE is proposed, based on this simplified model. Finally, the range of validity of the proposed mathematical model was assessed. For this purpose, we simulated the model and analyzed the simulation results in case of some known behaviors of the disease, such as tolerance breach, the appearance of systemic inflammation, development of clinical signs, and occurrence of flares and improvements. The model was able to reproduce these events, qualitatively.","PeriodicalId":54428,"journal":{"name":"Theory in Biosciences","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9525132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A computational investigation of cis-gene regulation in evolution. 进化中顺式基因调控的计算研究。

IF 1.1 4区生物学

Theory in Biosciences Pub Date : 2023-06-01 DOI: 10.1007/s12064-023-00391-3

Mohammed Mahmud, Mulugeta Bekele, Narayan Behera

{"title":"A computational investigation of cis-gene regulation in evolution.","authors":"Mohammed Mahmud, Mulugeta Bekele, Narayan Behera","doi":"10.1007/s12064-023-00391-3","DOIUrl":"https://doi.org/10.1007/s12064-023-00391-3","url":null,"abstract":"In biological processes involving gene networks, genes regulate other genes that determine the phenotypic traits. Gene regulation plays an important role in evolutionary dynamics. In a genetic algorithm, a trans-gene regulatory mechanism was shown to speed up adaptation and evolution. Here, we examine the effect of cis-gene regulation on an adaptive system. The model is haploid. A chromosome is partitioned into regulatory loci and structural loci. The regulatory genes regulate the expression and functioning of structural genes via the cis-elements in a probabilistic manner. In the simulation, the change in the allele frequency, the mean population fitness and the efficiency of phenotypic selection are monitored. Cis-gene regulation increases adaption and accelerates the evolutionary process in comparison with the case involving absence of gene regulation. Some special features of the simulation results are as follows. A low ratio of regulatory loci and structural loci gives higher adaptation for fixed total number of loci. Plasticity is advantageous beyond a threshold value. Adaptation is better for large number of total loci when the ratio of regulatory loci to structural loci is one. However, it reaches a saturation beyond which the increase in the total loci is not advantageous. Efficiency of the phenotypic selection is higher for larger value of the initial plasticity.","PeriodicalId":54428,"journal":{"name":"Theory in Biosciences","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9874536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0