Zeitschrift fur Medizinische Physik最新文献

{"title":"Editorial Board + Consulting Editorial Board","authors":"","doi":"10.1016/S0939-3889(25)00014-5","DOIUrl":"10.1016/S0939-3889(25)00014-5","url":null,"abstract":"","PeriodicalId":54397,"journal":{"name":"Zeitschrift fur Medizinische Physik","volume":"35 1","pages":"Page iii"},"PeriodicalIF":2.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143512609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum to “Evaluation of an anthropomorphic ion chamber and 3D gel dosimetry head phantom at a 0.35 T MR-linac using separate 1.5 T MR-scanners for gel readout” [Z Med. Phys. 32 (2022) 312–325]","authors":"Lukas Nierer , Florian Kamp , Michael Reiner , Stefanie Corradini , Moritz Rabe , Olaf Dietrich , Katia Parodi , Claus Belka , Christopher Kurz , Guillaume Landry","doi":"10.1016/j.zemedi.2024.07.002","DOIUrl":"10.1016/j.zemedi.2024.07.002","url":null,"abstract":"","PeriodicalId":54397,"journal":{"name":"Zeitschrift fur Medizinische Physik","volume":"35 1","pages":"Page 118"},"PeriodicalIF":2.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142127875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum to “Automated parameter selection for accelerated MRI reconstruction via low-rank modeling of local k-space neighborhoods” [Z Med. Phys. 33 (2023) 203–219]","authors":"Efe Ilicak , Emine Ulku Saritas , Tolga Çukur","doi":"10.1016/j.zemedi.2024.07.001","DOIUrl":"10.1016/j.zemedi.2024.07.001","url":null,"abstract":"","PeriodicalId":54397,"journal":{"name":"Zeitschrift fur Medizinische Physik","volume":"35 1","pages":"Page 119"},"PeriodicalIF":2.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142127872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum to “A novel multipurpose device for guided knee motion and loading during dynamic magnetic resonance imaging” [Z Med Phys 32 (2022) 500–513]","authors":"Nicholas M. Brisson , Martin Krämer , Leonie A.N. Krahl , Alexander Schill , Georg N. Duda , Jürgen R. Reichenbach","doi":"10.1016/j.zemedi.2024.07.005","DOIUrl":"10.1016/j.zemedi.2024.07.005","url":null,"abstract":"","PeriodicalId":54397,"journal":{"name":"Zeitschrift fur Medizinische Physik","volume":"35 1","pages":"Page 116"},"PeriodicalIF":2.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142127871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A noise-robust post-processing pipeline for accelerated phase-cycled 23Na Multi-Quantum Coherences MRI","authors":"Christian Licht ,&nbsp;Efe Ilicak ,&nbsp;Fernando E. Boada ,&nbsp;Maxime Guye ,&nbsp;Frank G. Zöllner ,&nbsp;Lothar R. Schad ,&nbsp;Stanislas Rapacchi","doi":"10.1016/j.zemedi.2024.12.004","DOIUrl":"10.1016/j.zemedi.2024.12.004","url":null,"abstract":"<div><h3><strong>Purpose</strong></h3><div>To develop an improved post-processing pipeline for noise-robust accelerated phase-cycled Cartesian Single (SQ) and Triple Quantum (TQ) sodium (²³Na) Magnetic Resonance Imaging (MRI) of in vivo human brain at 7 T.</div></div><div><h3><strong>Theory and Methods</strong></h3><div>Our pipeline aims to tackle the challenges of ²³Na Multi-Quantum Coherences (MQC) MRI including low Signal-to-Noise Ratio (SNR) and time-consuming Radiofrequency (RF) phase-cycling. Our method combines low-rank k-space denoising for SNR enhancement with Dynamic Mode Decomposition (DMD) to robustly separate SQ and TQ signal components. This separation is crucial for computing the TQ/SQ ratio, a key parameter of ²³Na MQC MRI. We validated our pipeline in silico, in vitro and in vivo in healthy volunteers, comparing it with conventional denoising and Fourier transform (FT) methods. Additionally, we assessed its robustness through ablation experiments simulating a corrupted RF phase-cycle step.</div></div><div><h3><strong>Results</strong></h3><div>Our denoising algorithm doubled SNR compared to non-denoised images and enhanced SNR by up to 29% compared to Wavelet denoising. The low-rank approach produced high-quality images even at later echo times, allowing reduced signal averaging. DMD effectively separated the SQ and TQ signals, even with missing RF phase cycle steps, resulting in superior Structural Similarity (SSIM) of <span><math><mrow><mn>0.89</mn><mo>±</mo><mn>0.024</mn></mrow></math></span> and lower Root Mean Squared Error (RMSE) of <span><math><mrow><mn>0.055</mn><mo>±</mo><mn>0.008</mn></mrow></math></span> compared to conventional FT methods (SSIM=<span><math><mrow><mn>0.71</mn><mo>±</mo><mn>0.061</mn></mrow></math></span>, RMSE=<span><math><mrow><mn>0.144</mn><mo>±</mo><mn>0.036</mn></mrow></math></span>). This pipeline enabled high-quality 8x8x15mm³ in vivo ²³Na MQC MRI, with a reduction in acquisition time from 48 to 10 min at 7 T.</div></div><div><h3><strong>Conclusion</strong></h3><div>The proposed pipeline improves robustness in ²³Na MQC MRI by exploiting low-rank properties to denoise signals and DMD to effectively separate SQ and TQ signals. This approach ensures high-quality MR images of both SQ and TQ components, even in accelerated and incomplete RF phase-cycling cases.</div></div>","PeriodicalId":54397,"journal":{"name":"Zeitschrift fur Medizinische Physik","volume":"35 1","pages":"Pages 98-108"},"PeriodicalIF":2.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143026272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Compartment-specific 129Xe HyperCEST z spectroscopy and chemical shift imaging of cucurbit[6]uril in spontaneously breathing rats","authors":"Agilo Luitger Kern ,&nbsp;Marcel Gutberlet ,&nbsp;Regina Rumpel ,&nbsp;Inga Bruesch ,&nbsp;Jens M. Hohlfeld ,&nbsp;Frank Wacker ,&nbsp;Bennet Hensen","doi":"10.1016/j.zemedi.2023.08.005","DOIUrl":"10.1016/j.zemedi.2023.08.005","url":null,"abstract":"<div><div>¹²⁹Xe hyperpolarized gas chemical exchange saturation transfer (HyperCEST) MRI has been suggested as molecular imaging modality but translation to in vivo imaging has been slow, likely due to difficulties of synthesizing suitable molecules. Cucurbit[6]uril–either in readily available non-functionalized or potentially in functionalized form–may, combined with ¹²⁹Xe HyperCEST MRI, prove useful as a switchable ¹²⁹Xe MR contrast agent but the likely differential properties of contrast generation in individual chemical compartments as well as the influence of ¹²⁹Xe signal drifts encountered in vivo on HyperCEST MRI are unknown. Here, HyperCEST z spectroscopy and chemical shift imaging with compartment-specific analysis are performed in a total of 10 rats using cucurbit[6]uril injected i.v. and under a protocol employing spontaneous respiration. Differences in intensity of the HyperCEST effect between chemical compartments and anatomical regions are investigated. Strategies to mitigate influence of signal instabilities associated with drifts in physiological parameters are developed. It is shown that presence of cucurbit[6]uril can be readily detected under spontaneous ¹²⁹Xe inhalation mostly in aqueous tissues further away from the lung. Differences of effect intensity in individual regions and compartments must be considered in HyperCEST data interpretation. In particular, there seems to be almost no effect in lipids. ¹²⁹Xe HyperCEST MR measurements utilizing spontaneous respiration protocols and extended measurement times are feasible. HyperCEST MRI of non-functionalized cucurbit[6]uril may create contrast between anatomical structures in vivo.</div></div>","PeriodicalId":54397,"journal":{"name":"Zeitschrift fur Medizinische Physik","volume":"35 1","pages":"Pages 33-45"},"PeriodicalIF":2.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10136802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reducing electromagnetic interference in MR thermometry: A comparison of setup configurations for MR-guided microwave ablations","authors":"Simon Schröer ,&nbsp;Daniel Düx ,&nbsp;Josef Joaquin Löning Caballero ,&nbsp;Julian Glandorf ,&nbsp;Thomas Gerlach ,&nbsp;Dominik Horstmann ,&nbsp;Othmar Belker ,&nbsp;Moritz Gutt ,&nbsp;Frank Wacker ,&nbsp;Oliver Speck ,&nbsp;Bennet Hensen ,&nbsp;Marcel Gutberlet","doi":"10.1016/j.zemedi.2024.07.004","DOIUrl":"10.1016/j.zemedi.2024.07.004","url":null,"abstract":"&lt;div&gt;&lt;div&gt;Magnetic Resonance (MR) thermometry is used for the monitoring of MR-guided microwave ablations (MWA), and for the intraoperative evaluation of ablation regions. Nevertheless, the accuracy of temperature mapping may be compromised by electromagnetic interference emanating from the microwave (MW) generator. This study evaluated different setups for improving magnetic resonance imaging (MRI) during MWA with a modified MW generator.&lt;/div&gt;&lt;div&gt;MWA was performed in 15 gel phantoms comparing three setups: The MW generator was placed outside the MR scanner room, either connected to the MW applicator using a penetration panel with a radiofrequency (RF) filter and a 7 m coaxial cable (Setup 1), or through a waveguide using a 5 m coaxial cable (Setup 2). Setup 3 employed the MW generator within the MR scan room, connected by a 5 m coaxial cable. The coaxial cables in setups 2 and 3 were modified with custom shielding to reduce interference. The setups during ablation (active setup) were compared to a reference setup without the presence of the MW system. Thermometry and thermal dose maps (CEM43 model) were compared for the three configurations. Primary endpoints for assessment were signal-to-noise ratio (SNR), temperature precision, Sørensen-Dice-Coefficient (DSC), and RF-noise spectra.&lt;/div&gt;&lt;div&gt;Setup 3 showed highly significant electromagnetic interference during ablation with a SNR decrease by −60.4%±13.5% (&lt;span&gt;&lt;math&gt;&lt;mrow&gt;&lt;mi&gt;p&lt;/mi&gt;&lt;mo&gt;&lt;&lt;/mo&gt;&lt;mn&gt;0.001&lt;/mn&gt;&lt;/mrow&gt;&lt;/math&gt;&lt;/span&gt;) compared to reference imaging. For setup 1 and setup 2 no significant decrease in SNR was measured with differences of −2.9%±9.8% (&lt;span&gt;&lt;math&gt;&lt;mrow&gt;&lt;mi&gt;p&lt;/mi&gt;&lt;mo&gt;=&lt;/mo&gt;&lt;mn&gt;0.6&lt;/mn&gt;&lt;/mrow&gt;&lt;/math&gt;&lt;/span&gt;) and −1.5%±12.8% (&lt;span&gt;&lt;math&gt;&lt;mrow&gt;&lt;mi&gt;p&lt;/mi&gt;&lt;mo&gt;=&lt;/mo&gt;&lt;mn&gt;0.8&lt;/mn&gt;&lt;/mrow&gt;&lt;/math&gt;&lt;/span&gt;), respectively. SNR differences were significant between active setups 1 and 3 with −51.2%±16.1% (&lt;span&gt;&lt;math&gt;&lt;mrow&gt;&lt;mi&gt;p&lt;/mi&gt;&lt;mo&gt;&lt;&lt;/mo&gt;&lt;mn&gt;0.001&lt;/mn&gt;&lt;/mrow&gt;&lt;/math&gt;&lt;/span&gt;) and between active setups 2 and 3 with −59.0%±15.5% (&lt;span&gt;&lt;math&gt;&lt;mrow&gt;&lt;mi&gt;p&lt;/mi&gt;&lt;mo&gt;&lt;&lt;/mo&gt;&lt;mn&gt;0.001&lt;/mn&gt;&lt;/mrow&gt;&lt;/math&gt;&lt;/span&gt;) but not significant between active setups 1 and 2 with 19.0%±13.7% (&lt;span&gt;&lt;math&gt;&lt;mrow&gt;&lt;mi&gt;p&lt;/mi&gt;&lt;mo&gt;=&lt;/mo&gt;&lt;mn&gt;0.09&lt;/mn&gt;&lt;/mrow&gt;&lt;/math&gt;&lt;/span&gt;). Furthermore, no significant differences were seen in temperature precision or DSCs between all setups, ranging from 0.33 °C ± 0.04 °C (Setup 1) to 0.38 °C ± 0.06 °C (Setup 3) (&lt;span&gt;&lt;math&gt;&lt;mrow&gt;&lt;mi&gt;p&lt;/mi&gt;&lt;mo&gt;=&lt;/mo&gt;&lt;mn&gt;0.6&lt;/mn&gt;&lt;/mrow&gt;&lt;/math&gt;&lt;/span&gt;) and from 87.0%±1.6% (Setup 3) to 88.1%±1.6% (Setup 2) (&lt;span&gt;&lt;math&gt;&lt;mrow&gt;&lt;mi&gt;p&lt;/mi&gt;&lt;mo&gt;=&lt;/mo&gt;&lt;mn&gt;0.58&lt;/mn&gt;&lt;/mrow&gt;&lt;/math&gt;&lt;/span&gt;), respectively.&lt;/div&gt;&lt;div&gt;Both setups (1 and 2) with the MW generator outside the MR scanner room were beneficial to reduce electromagnetic interference during MWA. Moreover, provided that a shielded cable is utilized in setups 2 and 3, all configurations displayed negligible differences in temperature precision and DSCs, indicating that the location of the MW gener","PeriodicalId":54397,"journal":{"name":"Zeitschrift fur Medizinische Physik","volume":"35 1","pages":"Pages 59-68"},"PeriodicalIF":2.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141918507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantification of regional CMRO2 in human brain using dynamic 17O-MRI at 3T","authors":"Hao Song ,&nbsp;Johannes Fisher ,&nbsp;Ali Caglar Özen ,&nbsp;Burak Akin ,&nbsp;Stefan Schumann ,&nbsp;Michael Bock","doi":"10.1016/j.zemedi.2023.07.004","DOIUrl":"10.1016/j.zemedi.2023.07.004","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the feasibility of cerebral metabolic rate of oxygen consumption (CMRO₂) measurements with MRI at 3 Tesla in different brain regions.</div></div><div><h3>Methods</h3><div>CMRO₂ represents a key indicator of the physiological state of brain tissue. Dynamic ¹⁷O-MRI with inhalation of isotopically enriched ¹⁷O gas has been used to quantify global CMRO₂ in brain white (WM) and gray matter (GM). However, global CMRO₂ can only reflect the overall oxygen metabolism of the brain and cannot provide enough information on local tissue oxygen metabolism. To investigate the feasibility of determination of regional CMRO₂ at a clinical 3 T MRI system, CMRO₂ values in frontal, parietal and occipital WM and GM were determined in 5 healthy volunteers and compared to evaluate the regional differences of oxygen metabolism in WM and GM. Additionally, regional CMRO₂ values were determined in deep brain structures including thalamus, dorsal striatum, caudate nucleus and insula cortex and in the cerebella, and compared with literature values from ¹⁵O-PET studies.</div></div><div><h3>Results</h3><div>In cortical GM the determined CMRO₂ values were in good agreement with the literature, whereas values in WM were about 32–48% higher than literature values. Regional analysis revealed a significantly higher CMRO₂ in the occipital GM compared to the frontal and parietal GM. By contrast, no significant difference of CMRO₂ was observed across the WM. In addition, CMRO₂ in deep brain structures was lower compared to literature values and in the cerebella a good hemispheric symmetry of the tissue oxygen metabolism was found.</div></div><div><h3>Conclusion</h3><div>Dynamic ¹⁷O-MRI enables direct, non-invasive determination of regional CMRO₂ in brain structures in healthy volunteers at 3T.</div></div>","PeriodicalId":54397,"journal":{"name":"Zeitschrift fur Medizinische Physik","volume":"35 1","pages":"Pages 46-58"},"PeriodicalIF":2.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10320518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum to “Investigation of biases in convolutional neural networks for semantic segmentation using performance sensitivity analysis” [Z Med Phys 32 (2022) 346–360]","authors":"Daniel Güllmar ,&nbsp;Nina Jacobsen ,&nbsp;Andreas Deistung ,&nbsp;Dagmar Timmann ,&nbsp;Stefan Ropele ,&nbsp;Jürgen R. Reichenbach","doi":"10.1016/j.zemedi.2024.07.007","DOIUrl":"10.1016/j.zemedi.2024.07.007","url":null,"abstract":"","PeriodicalId":54397,"journal":{"name":"Zeitschrift fur Medizinische Physik","volume":"35 1","pages":"Page 114"},"PeriodicalIF":2.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142127877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum to “Multiple direction needle-path planning and inverse dose optimization for robotic low-dose rate brachytherapy” [Z Med Phys 32 (2022) 173–187]","authors":"Philipp Aumüller ,&nbsp;Andreas Rothfuss ,&nbsp;Martin Polednik ,&nbsp;Yasser Abo-Madyan ,&nbsp;Michael Ehmann ,&nbsp;Frank A. Giordano ,&nbsp;Sven Clausen","doi":"10.1016/j.zemedi.2024.07.009","DOIUrl":"10.1016/j.zemedi.2024.07.009","url":null,"abstract":"","PeriodicalId":54397,"journal":{"name":"Zeitschrift fur Medizinische Physik","volume":"35 1","pages":"Page 112"},"PeriodicalIF":2.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142127878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}