Journal of Stroke & Cerebrovascular Diseases最新文献

{"title":"Systematic review and meta-analysis of audits measuring antithrombotic therapy within forty-eight hours for ischemic stroke","authors":"Andy Lim ,&nbsp;Grace Phillips ,&nbsp;Warren Chan ,&nbsp;Shams Albrefkany ,&nbsp;Jeniffer Kim-Blackmore ,&nbsp;Henry Ma ,&nbsp;Thanh Phan","doi":"10.1016/j.jstrokecerebrovasdis.2024.108213","DOIUrl":"10.1016/j.jstrokecerebrovasdis.2024.108213","url":null,"abstract":"<div><h3>Background</h3><div>Meta-analysis of clinical trials supports the use of early antithrombotic medication in ischemic stroke and transient ischemic attack. It is not known whether this therapy is delivered within the 85 % threshold that is acceptable in North America's Get With The Guidelines stroke program.</div></div><div><h3>Aim</h3><div>to investigate the pooled proportion of patients receiving antiplatelet therapy within 48 h of ischemic stroke.</div></div><div><h3>Methods</h3><div>PubMed to November 2022 was searched for studies reporting “stroke”, “audit”, “antithrombotic”, “national” and “registry”. Multilevel random effects meta-analysis was used to cluster studies by country.</div></div><div><h3>Results</h3><div>There were 45 studies describing 1,178,595 patients. The pooled proportion of patients receiving antithrombotic therapy within 48 h was 81.1 %, (95 % CI 74.5, 87.8, <em>p</em> &lt; 0.0001, I²=99.99 %). The high heterogeneity was due to within-country (I²_{Level 3} = 55.4 %) and between-country heterogeneity (I²_{Level 2} = 44.6 %). There was no statistical significance (<em>p</em> = 0.35) between low- to middle- income countries (LMIC) – 81.8 %, (95 % CI 76.1, 87.4, <em>p</em> &lt; 0.01, I²=100 %) and high-income countries (HIC) – 86.8 %, (95 % CI 81.2, 92.3, <em>p</em> &lt; 0.01, I²=99.7 %) nor any difference between contemporary studies (2008 and later) – 86.5 %, (95 % CI 82.3, 90.8, <em>p</em> &lt; 0.01, I²=100 %) – and studies published before 2008 – 69.9 %, (95 % CI 57.4, 82.4, <em>p</em> &lt; 0.01, I²=99.7 %). Sensitivity analysis showed no difference when excluding single centre studies, observations with <em>n</em> &lt; 500, or both. Meta-regression showed proportion of antiplatelet administration at 48 h to increase significantly with subsequent year of publication (β=0.01, 95 % CI 0.00, 0.02, <em>p</em> &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>Our key finding is that the majority of countries do not yet provide early antiplatelet therapy at a level acceptable by Get With The Guidelines hospitals.</div></div>","PeriodicalId":54368,"journal":{"name":"Journal of Stroke & Cerebrovascular Diseases","volume":"34 2","pages":"Article 108213"},"PeriodicalIF":2.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142900377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The prognostic and diagnostic significance of echocardiographic parameters on acute ischemic stroke","authors":"Bo Yang ,&nbsp;Yanni Wu ,&nbsp;Manli Lu ,&nbsp;Yongjun Cao ,&nbsp;Zhigang Miao ,&nbsp;Liuhui Chang ,&nbsp;Hui Li ,&nbsp;Xia Zhang","doi":"10.1016/j.jstrokecerebrovasdis.2024.108220","DOIUrl":"10.1016/j.jstrokecerebrovasdis.2024.108220","url":null,"abstract":"<div><h3>Objective</h3><div>To comprehensively explore the prognostic significance of transthoracic echocardiography (TTE) and three-dimensional speckle-tracking echocardiography (3D STE) parameters in AIS and their role in distinguishing cardioembolic stroke.</div></div><div><h3>Methods</h3><div>301 acute ischemic stroke (AIS) patients were enrolled. TTE and 3D STE were employed to evaluate cardiac function and structure, also left atrial strain. Patients were categorized into two groups based on functional outcome at discharge and 3 months post-stroke, respectively. Models combining variables related to unfavorable outcome were established, and their predictive efficacy was assessed using receiver operating characteristic (ROC) curves. Additionally, AIS patients were stratified into cardioembolic and non-cardioembolic stroke groups. Logistic regression identified predictors for cardioembolic stroke, and ROC curves assessed their diagnostic performance.</div></div><div><h3>Results</h3><div>We found that a decrease in early diastolic peak velocity of the mitral valve (E value) was independently associated with adverse outcomes at both discharge (<em>P</em> = 0.014, OR = 0.126, 95% CI 0.024-0.657) and 3 months post-stroke in AIS patients (<em>P</em> = 0.004, OR = 0.054, 95% CI 0.007-0.403). Adding E value significantly improved predictive ability for adverse outcome at discharge and 3 months post-onset (0.807 vs. 0.794; 0.834 vs. 0.815). Moreover, left atrial diameter (LAD) [area under the curve (AUC) = 0.705] was the most valuable TTE parameter, and left atrial reservoir circumferential strain (LASr-c) (AUC = 0.766) was the most valuable STE parameter, even among all echocardiographic parameters for prediction of cardioembolic stroke.</div></div><div><h3>Conclusions</h3><div>This study indicates reduced E value was associated with unfavorable outcome at discharge and 3 months post-onset of AIS patients. LAD, especially LASr-c exhibited optimal diagnostic performance on cardioembolic stroke.</div></div>","PeriodicalId":54368,"journal":{"name":"Journal of Stroke & Cerebrovascular Diseases","volume":"34 2","pages":"Article 108220"},"PeriodicalIF":2.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142928769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causal association of inflammation with ischemic stroke and its subtypes: a bidirectional Mendelian randomization study","authors":"FangFang Qian ,&nbsp;XiaoHui Du ,&nbsp;YouHua He","doi":"10.1016/j.jstrokecerebrovasdis.2024.108190","DOIUrl":"10.1016/j.jstrokecerebrovasdis.2024.108190","url":null,"abstract":"<div><h3>Background</h3><div>Emerging evidence underscores a bidirectional relationship between ischemic stroke (IS) and inflammation, yet the causality of this association remains uncertain. We conducted a two-sample bidirectional Mendelian randomization (MR) study aimed at investigating the causal links between inflammation and IS.</div></div><div><h3>Methods</h3><div>Single nucleotide polymorphism from genome-wide association studies of 112 inflammatory cytokines and IS were chosen as instrumental variables. We evaluated the causal effects of inflammatory factors on IS outcomes and examined the mediating effects of risk factors for IS. Additionally, reverse MR analysis was conducted to determine whether the occurrence of IS influenced levels of inflammatory cytokines. Causal associations were assessed using inverse variance weighting, complemented by sensitivity analyses incorporating weighted median and MR-Egger methods.</div></div><div><h3>Results</h3><div>We found associations between genetically predicted plasma levels of 25 inflammatory factors and IS along with its subtypes. MR supports smoking, body mass index, atrial fibrillation, coronary artery disease, heart failure, systolic blood pressure, diastolic blood pressure and type 2 diabetes as risk factors for IS. Notably, coronary artery disease and heart failure seemed to mediate the RANTES, HGF, IL-5 associations with IS. In addition, reverse MR analysis suggested a causal relationship between IS and its subtypes and 19 inflammatory factors.</div></div><div><h3>Conclusion</h3><div>In summary, inflammation was suggestively causally associated with the risk of IS, and inflammatory cytokines had downstream effect on IS. Future studies should explore whether inflammatory factors found to have significant associations with IS risk could be manipulated to reduce IS risk, and the neuroinflammatory mechanisms after IS.</div></div>","PeriodicalId":54368,"journal":{"name":"Journal of Stroke & Cerebrovascular Diseases","volume":"34 2","pages":"Article 108190"},"PeriodicalIF":2.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142830832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"“Mechanical thrombectomy beyond 6 hours for acute ischemic strokes due to M2 occlusions”","authors":"Maria Pereira Coutinho ,&nbsp;Sofia Galego ,&nbsp;Marta Alves ,&nbsp;Ana Papoila ,&nbsp;Isabel Fragata ,&nbsp;Ana Paiva Nunes","doi":"10.1016/j.jstrokecerebrovasdis.2024.108219","DOIUrl":"10.1016/j.jstrokecerebrovasdis.2024.108219","url":null,"abstract":"<div><h3>Background</h3><div>The time frame for mechanical thrombectomy (MT) in acute ischemic stroke (AIS) is enlarging. Guidelines recommend MT until 6 h of symptom onset in M2 segment occlusions (grade IIB). In practice, it is frequently performed later.</div></div><div><h3>Aims</h3><div>To assess the functional prognosis of AIS patients subjected to M2 segment's MT beyond 6 h, compared to standard intervention.</div></div><div><h3>Methods</h3><div>Retrospective cohort study including all consecutive AIS patients subjected to MT of M2 occlusions between 1st January 2018 and 31st December 2020 in St Joseph's Local Health Unit, Lisbon, Portugal. Allocation to standard or extended groups was done according to the symptom-to-puncture time, whether within or beyond 6 h after symptom onset, respectively. The primary outcome was the modified Rankin Scale (mRS) at three months. Secondary outcomes were symptomatic intracranial hemorrhage (sICH) at 24 h and three-month mortality.</div></div><div><h3>Results</h3><div>We included 155 patients, 51.0 % men, median age 76.0 years (P₂₅:69.0;P₇₅:86.0), baseline mRS “0-2” in 84.5 %, mean NIHSS 13.6(6.5). Initial Computed Tomography showed early ischemic changes in 27.1 %. Most patients belonged to the standard group (71.0 %). Groups had similar baseline features. The standard group underwent more frequent (68.2 % vs 44.4 %, <em>p</em> = 0.006) and earlier (2 h02 min, 3 h02 min, <em>p</em> &lt; 0.001) fibrinolysis. Symptom-to-puncture times were 7 h13 min (extended) and 4h01 min (standard), <em>p</em> &lt; 0.001. Outcomes were similar between groups (three months’ mRS [<em>p</em> = 0.578]; sICH [<em>p</em> = 0.720]; three-month mortality [<em>p</em> = 0.422]).</div></div><div><h3>Conclusions</h3><div>Our study suggests similar outcomes in M2 occlusions performing MT before and beyond 6 h of symptom onset, consistent with previous studies. Patients might benefit from widening inclusion criteria for MT in AIS.</div></div>","PeriodicalId":54368,"journal":{"name":"Journal of Stroke & Cerebrovascular Diseases","volume":"34 2","pages":"Article 108219"},"PeriodicalIF":2.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142907918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the association between the TyG-WHtR index and the incidence of stroke in the obese population: based on NHANES data from 1998 to 2018","authors":"Liyan Fu ,&nbsp;Qingxuan Xing ,&nbsp;Xiaoqian Wang ,&nbsp;Yaoyao Chen ,&nbsp;Jingjing Kong ,&nbsp;Jin Li ,&nbsp;Baohong Yue","doi":"10.1016/j.jstrokecerebrovasdis.2024.108209","DOIUrl":"10.1016/j.jstrokecerebrovasdis.2024.108209","url":null,"abstract":"<div><h3>Background</h3><div>The TyG index is an emerging low-cost and efficient indicator that is significantly associated with stroke. Multiple studies have confirmed the impact of the TyG index on cerebrovascular diseases. However, the role of indices combining TyG with different obesity factors, such as triglyceride glucose-waist-height ratio (TyG-WHtR) on stroke risk in obese individuals remains unclear. This study utilizes data from the National Health and Nutrition Examination Survey database between 1998 and 2018 to explore the relationship between stroke and the TyG-WHtR index in obese individuals.</div></div><div><h3>Methods</h3><div>This cross-sectional study analyzed data from 5767 obese individuals from the NHANES database between 1998 and 2018. Univariate and multivariate logistic regression analyses were used to study the association between TyG-WHtR and stroke, utilizing continuous variables or categorizing variables based on quartiles. Propensity score matching (PSM) and subgroup analysis stratifying characteristics of TyG-WHtR and stroke were further conducted to study their relationship. Additionally, restricted cubic spline (RCS) analysis was performed to examine the linear relationship between TyG-WHtR and stroke.</div></div><div><h3>Results</h3><div>A total of 5767 participants were included in the statistical analysis, comprising 227 stroke patients and 5540 non-stroke participants. Multivariable logistic regression analysis revealed a positive association between TyG-WHtR and stroke both before and after matching (<em>P</em> &lt; 0.001), with statistically significant differences. Subgroup analysis indicated a statistically significant difference among non-Hispanic white individuals, and RCS analysis showed a non-linear relationship between TyG-WHtR and stroke before matching, but a linear relationship after matching.</div></div><div><h3>Conclusion</h3><div>In obese individuals, a higher TyG-WHtR index is positively associated with stroke risk.</div></div>","PeriodicalId":54368,"journal":{"name":"Journal of Stroke & Cerebrovascular Diseases","volume":"34 2","pages":"Article 108209"},"PeriodicalIF":2.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142878447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic study of intracranial branch atheromatous disease in the blood-supplying areas of the lenticulostriate and paramedian pontine arteries","authors":"Yang Liu ,&nbsp;Lihua Wang ,&nbsp;Kuang Fu ,&nbsp;Xiaotong Kong ,&nbsp;Wenhui Guo ,&nbsp;Ning Wang ,&nbsp;Xuesong Sun ,&nbsp;Hanlu Cai ,&nbsp;Yan Yu ,&nbsp;Zhaobo Zhang ,&nbsp;Xingbang Zou ,&nbsp;Ying Cao ,&nbsp;Doudou Luo ,&nbsp;Peifang Liu","doi":"10.1016/j.jstrokecerebrovasdis.2024.108210","DOIUrl":"10.1016/j.jstrokecerebrovasdis.2024.108210","url":null,"abstract":"<div><h3>Introduction</h3><div>Branch atheromatous disease (BAD) is prone to early neurological deterioration (END), leading to a poor prognosis. The most common arteries causing END are the lenticulostriate arteries (LSA) and the paramedian pontine arteries (PPA). To gain insight into the characteristics of symptomatic plaques and their association with poor prognosis in patients with BAD, we conducted a prospective study using high-resolution magnetic resonance imaging (HRMRI).</div></div><div><h3>Methods</h3><div>A total of 75 patients with BAD in the vascular range of LSA or PPA were recruited for this study. The vascular and plaque features of the carrier middle cerebral artery (MCA) and basilar artery (BA) were evaluated through the application of HRMRI, and the local cerebral blood flow (CBF) of the lesion was assessed through pseudo-continuous arterial spin-labeling (pCASL), and the number and location of cerebral microbleeds (CMBs) were documented by susceptibility-weighted imaging (SWI). Univariable and multivariable logistic regression analyses were performed to analyze the factors that affected the prognosis.</div></div><div><h3>Results</h3><div>A poor prognosis was observed in 24 patients (32%) with BAD. A total of 28 patients (37%) developed END. Multifactorial analysis showed statistically significant differences in the dorsal plaque of BA (OR: 19.15, 95% CI 1.72–385.37, <em>p</em>=0.028), male (OR: 26.22, 95% CI 3.18–406.31, <em>p</em>=0.007), and NIHSS at 7 days of onset (OR: 2.24, 95% CI 1.4–4.45, <em>p</em>=0.004).</div></div><div><h3>Conclusions</h3><div>In patients with BAD in LSA and PPA areas, the dorsal plaque of BA, male, and NIHSS at 7 days of onset were independent risk factors for poor prognosis.</div></div>","PeriodicalId":54368,"journal":{"name":"Journal of Stroke & Cerebrovascular Diseases","volume":"34 2","pages":"Article 108210"},"PeriodicalIF":2.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142878450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endovascular thrombectomy for acute ischemic stroke with primary occlusion of the anterior cerebral artery: A meta-analysis","authors":"Shovan Bhatia BS ,&nbsp;Sirisha T. Nouduri BS ,&nbsp;Akshay Sankar BS ,&nbsp;Michael R. Kann BE ,&nbsp;Angela Hardi MS ,&nbsp;Joseph S. Hudson MD ,&nbsp;Alhamza R. Al-Bayati MD ,&nbsp;Raul G. Nogueira ,&nbsp;Michael J. Lang MD ,&nbsp;Bradley A. Gross MD","doi":"10.1016/j.jstrokecerebrovasdis.2024.108208","DOIUrl":"10.1016/j.jstrokecerebrovasdis.2024.108208","url":null,"abstract":"<div><h3>Background</h3><div>Anterior cerebral artery (ACA) occlusions account for up to 4 % of all acute ischemic strokes and may lead to debilitating outcomes. While endovascular thrombectomy (EVT) is a well-established treatment for large vessel occlusions, its efficacy and safety for primary ACA occlusions remains unclear. This systematic review and meta-analysis aims to address this gap by evaluating the clinical outcomes, safety, and efficacy of EVT in the treatment for primary ACA occlusions.</div></div><div><h3>Methods</h3><div>Following PRISMA guidelines, five databases were queried from database inception until April 2024 for studies describing the use of EVT for acute ischemic primary ACA occlusions. Following abstract, title, and full text-screening, data on patient demographics, clinical presentation, procedural details, and surgical outcomes were extracted from included articles. Primary outcomes were successful reperfusion (modified-Treatment in Cerebral Infarction (mTICI) score 2b-3), and favorable functional outcomes (3-month modified Rankin Scale (mRS) scores 0-2). Secondary outcomes included 3-month mortality rates and procedural complication rates. Meta-analysis was performed using a random-effects model, with heterogeneity assessed by the Higgins index (I²&gt;50 %).</div></div><div><h3>Results</h3><div>Ten studies met eligibility criteria, encompassing a total of 265 patients with complete clinical and outcome data. Across the pooled meta-analysis, the rate of successful reperfusion (mTICI ≥ 2b) was 0.78 (95 % CI: 0.67-0.86) and the rate of 3-month mRS score 0-2 was 0.41 (95 % CI: 0.33-0.51). Pooled meta-analysis of secondary outcomes analysis revealed a 3-month mortality rate of 0.20 (95 % CI: 0.15-0.26), while the rate of symptomatic intracerebral hemorrhage was 0.04 (95 % CI: 0.02-0.08).</div></div><div><h3>Conclusion</h3><div>Our findings demonstrate that while successful reperfusion can be achieved with low complication rates, primary ACA occlusions treated with EVT are associated with high morbidity and mortality.</div></div>","PeriodicalId":54368,"journal":{"name":"Journal of Stroke & Cerebrovascular Diseases","volume":"34 2","pages":"Article 108208"},"PeriodicalIF":2.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142886322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Admission red blood cell distribution width as a prognostic biomarker of stroke-associated pneumonia and mortality in acute ischemic stroke patients treated with thrombolysis","authors":"Sarawut Krongsut ,&nbsp;Nat Na-Ek ,&nbsp;Nop Khongthon","doi":"10.1016/j.jstrokecerebrovasdis.2025.108254","DOIUrl":"10.1016/j.jstrokecerebrovasdis.2025.108254","url":null,"abstract":"<div><h3>Background</h3><div>Red blood cell distribution width (RDW) is an inflammatory marker potentially linked to stroke-associated pneumonia (SAP). This study assessed RDW's role in predicting SAP, mortality, and poor outcomes in acute ischemic stroke (AIS) patients treated with thrombolysis.</div></div><div><h3>Methods</h3><div>A retrospective analysis (2015–2022) of AIS patients treated with thrombolysis examined admission RDW levels. Outcomes included SAP, in-hospital (IHM) and 3-month mortality, and poor functional outcomes. Associations were analyzed using multivariable logistic regression, with predictive performance assessed via area under a receiver operating characteristic curve (AuROC), net reclassification index (NRI), and integrated discrimination improvement (IDI) metrics.</div></div><div><h3>Results</h3><div>Of 345 patients, 70 (20.3 %) developed SAP. A 1-SD increase in RDW was associated with SAP (adjusted odds ratio [aOR]: 1.73; 95 % CI: 1.27–2.35), IHM (aOR: 2.14; 95 % CI: 1.43–3.21), and 3-month mortality (aOR: 1.74; 95 % CI: 1.19–2.56). The association was stronger in non-diabetics and those under 65. Although RDW did not improve the AuROC for SAP or mortality predictions, it significantly improved the NRI and IDI (<em>p</em> &lt; 0.05).</div></div><div><h3>Conclusions</h3><div>RDW is independently associated with increased risk of SAP, IHM, and 3-month mortality in AIS patients treated with thrombolysis, suggesting its potential as a prognostic marker.</div></div>","PeriodicalId":54368,"journal":{"name":"Journal of Stroke & Cerebrovascular Diseases","volume":"34 4","pages":"Article 108254"},"PeriodicalIF":2.0,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143082088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The health-related quality of life among stroke survivors with post-COVID conditions living in the United States","authors":"Seyyed Sina Hejazian ,&nbsp;Ajith Vemuri ,&nbsp;Alireza Vafaei Sadr ,&nbsp;Shima Shahjouei ,&nbsp;Sasan Bahrami ,&nbsp;Vida Abedi ,&nbsp;Ramin Zand","doi":"10.1016/j.jstrokecerebrovasdis.2025.108246","DOIUrl":"10.1016/j.jstrokecerebrovasdis.2025.108246","url":null,"abstract":"<div><h3>Background and aim</h3><div>It is widely recognized that a considerable number of COVID-19 survivors continue to experience post-COVID conditions (PCCs). Given that stroke survivors face a heightened risk of PCCs compared to the general population, our objective was to assess the impact of PCCs on the health-related quality of life (HRQL) among stroke survivors in the United States.</div></div><div><h3>Method</h3><div>We used the Behavioral Risk Factor Surveillance System data 2022. Respondents with a history of COVID-19 infection and stroke were selected and classified based on whether they experienced PCCs. Finally, the HRQL-related items, including self-reported general health (SRGH), the number of days with compromised mental and physical health, and the daily efficiency, were compared between the two groups.</div></div><div><h3>Results</h3><div>Overall, 3988 respondents (42.8 % aged above 64 years old, 45.8 % men) were enrolled. Compared to stroke survivors without PCCs, those with PCCs had significantly worse SRGH and a higher number of days with compromised mental and physical health. However, although multivariate regression analysis supported the adverse impact of PCCs on the SRGH of stroke survivors, the results were not statistically significant (aOR = 1.32,CI95 %:[0.98-1.78],p = 0.070). Fatigue and dyspnea emerged as the most significantly associated symptoms with impaired SRGH. Additionally, lower education and annual household income level, smoking, lack of physical activity, and comorbidities including diabetes, heart, and pulmonary disease were associated with a higher prevalence of unfavorable SRGH among stroke survivors with PCCs.</div></div><div><h3>Conclusion</h3><div>Our study highlights that PCCs might be associated with worse SRGH. Lower education, income, and physical activity, smoking, and comorbidities were associated with a higher rate of unfavorable SRGH among stroke survivors with PCCs.</div></div>","PeriodicalId":54368,"journal":{"name":"Journal of Stroke & Cerebrovascular Diseases","volume":"34 4","pages":"Article 108246"},"PeriodicalIF":2.0,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143076311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Door-to-Needle Time Trends After Transition to Tenecteplase: A Multicenter Texas Stroke Registry” [Journal of Stroke and Cerebrovascular Diseases 33 (2024) 107774]","authors":"Nathaniel Rodriguez ,&nbsp;Sidarrth Prasad ,&nbsp;DaiWai M. Olson ,&nbsp;Sujani Bandela ,&nbsp;Gretchel Gealogo Brown ,&nbsp;Yoon Kwon ,&nbsp;Mehari Gebreyohanns ,&nbsp;Erica M. Jones ,&nbsp;Nneka L. Ifejika ,&nbsp;Suzanne Stone ,&nbsp;Jane A. Anderson ,&nbsp;Sean I. Savitz ,&nbsp;Salvador Cruz-Flores ,&nbsp;Steven J. Warach ,&nbsp;Mark P. Goldberg ,&nbsp;Lee A. Birnbaum","doi":"10.1016/j.jstrokecerebrovasdis.2025.108250","DOIUrl":"10.1016/j.jstrokecerebrovasdis.2025.108250","url":null,"abstract":"","PeriodicalId":54368,"journal":{"name":"Journal of Stroke & Cerebrovascular Diseases","volume":"34 4","pages":"Article 108250"},"PeriodicalIF":2.0,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143069732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}