Journal of Stroke & Cerebrovascular Diseases最新文献

{"title":"Pre-hospital blood pressure lowering in presumed hyperacute stroke: A systematic review and meta-analysis of randomized controlled trials.","authors":"Ahmed A Ibrahim, Yehya Khlidj, Ahmed Mazen Amin, Mohamed Saad Rakab, AlMothana Manasrah, Abdelrahman Mahmoud, Muhammad Imran, Ahmed Gaber Emara, Mohamed Abuelazm","doi":"10.1016/j.jstrokecerebrovasdis.2024.108158","DOIUrl":"10.1016/j.jstrokecerebrovasdis.2024.108158","url":null,"abstract":"<p><strong>Background: </strong>High blood pressure (BP) is common in acute stroke and a predictor of poor outcomes. Treatment of acute stroke, before a distinction can be made between ischemic and hemorrhagic types, is challenging. We aimed to assess whether patients with presumed acute stroke benefit from pre-hospital BP lowering.</p><p><strong>Methods: </strong>We conducted a comprehensive systematic review and meta-analysis of randomized controlled trials from PubMed, Web of Science, Scopus, and Cochrane searches until June 2024. Dichotomous data were pooled using risk ratio (RR), and continuous data were pooled using mean difference (MD), both with a 95% confidence interval (CI), using (R version 4.3).</p><p><strong>Prospero id: </strong>CRD42024560200.</p><p><strong>Results: </strong>Our analysis included five RCTs encompassing 3,933 patients. There was no difference between early BP control and usual care regarding National Institutes of Health Stroke Scale (NIHSS) after 24 hours (MD: 0.65 with 95% CI [0.01, 1.29], P = 0.05), excellent neurological recovery (Modified Rankin Score (mRS) 0-1) (RR: 1.00 with 95% CI [0.91, 1.11], P= 0.98), functional independence (mRS 0-2) (RR: 1.04 with 95% CI [0.96, 1.13], P= 0.30), and independent Ambulation (mRS 0-3) (RR: 1.01 with 95% CI [0.95, 1.06], P= 0.84). Also, there was no difference between both groups in poor neurological recovery (mRS 4-6) (RR: 0.98 with 95% CI [0.91, 1.07], P= 0.68), all-cause mortality (RR: 1.02 with 95% CI [0.90, 1.15], P= 0.79), and any serious adverse events (RR: 1.04 with 95% CI [0.95, 1.15], P= 0.40). However, early BP control significantly increased the incidence of hypotension (RR: 2.24 with 95% CI [1.14, 4.38], P= 0.02) and headache (RR: 1.51 with 95% CI [1.01, 2.26], P= 0.04).</p><p><strong>Conclusion: </strong>In patients with presumed hyperacute stroke and elevated blood pressure, the rapid initiation of blood pressure reduction in the ambulance very early after symptom onset had no significant benefit regarding functional outcomes in patients with undifferentiated stroke but with an increased incidence of hypotension and headaches.</p>","PeriodicalId":54368,"journal":{"name":"Journal of Stroke & Cerebrovascular Diseases","volume":" ","pages":"108158"},"PeriodicalIF":2.0,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142774137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between leisure-time physical activity and stroke in patients with chronic obstructive pulmonary disease: A population-based study","authors":"Hongping Wang ,&nbsp;Maoliang Tian ,&nbsp;Qun Lai ,&nbsp;Wenqiang Li ,&nbsp;Hao Ding ,&nbsp;Zhiping Deng","doi":"10.1016/j.jstrokecerebrovasdis.2024.108162","DOIUrl":"10.1016/j.jstrokecerebrovasdis.2024.108162","url":null,"abstract":"<div><h3>Background</h3><div>Stroke is the second leading cause of death worldwide. It remains unclear whether chronic obstructive pulmonary disease (COPD) increases the risk of stroke. The purpose of this study was to evaluate the association between COPD and stroke. As physical activity may prevent strokes, we examined whether leisure-time physical activity (LTPA) moderates stroke risk in COPD patients.</div></div><div><h3>Methods</h3><div>13,524 participants from the 2009-2018 National Health and Nutrition Examination Survey (NHANES). We used the Global Physical Activity Questionnaire (GPAQ) questionnaire to obtain self-reported data from LTPA. We used a binary logistic regression model to analyze the association between LTPA, COPD, and stroke risk.</div></div><div><h3>Results</h3><div>The prevalence of COPD in the present study was 5.54%. The risk of stroke in COPD patients is 1.84 times higher than that in those without COPD, with a 95% confidence interval (95%CI) of 1.32,2.56 and <em>P</em> &lt; 0.001. A lower stroke risk was observed in COPD patients who adhered to LTPA than those who did not (OR, 0.50; 95%CI, 0.26, 0.95; <em>P</em> = 0.03). As shown by the restricted cubic spline (RCS), the duration of LTPA in COPD patients was inversely related to the risk of stroke, which decreased as the duration of weekly LTPA increased.</div></div><div><h3>Conclusion</h3><div>COPD is positively associated with stroke risk. LTPA reduces the risk of stroke in patients with COPD, suggesting that it may be a promising measure for preventing stroke in this population.</div></div>","PeriodicalId":54368,"journal":{"name":"Journal of Stroke & Cerebrovascular Diseases","volume":"34 1","pages":"Article 108162"},"PeriodicalIF":2.0,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142746998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aphasia profiles and trajectories in acute ischemic stroke: An observational study","authors":"Olivier Bill ,&nbsp;Laurent Lievens ,&nbsp;Dimitris Lambrou ,&nbsp;Ashraf Eskandari ,&nbsp;Valerie Beaud ,&nbsp;Patrik Michel","doi":"10.1016/j.jstrokecerebrovasdis.2024.108142","DOIUrl":"10.1016/j.jstrokecerebrovasdis.2024.108142","url":null,"abstract":"<div><h3>Background</h3><div>In acute ischemic stroke (AIS), neuropsychological deficits and their long-term impact are insufficiently studied. We studied pure aphasic AIS patients, their short-term aphasiological course, predictors of persisting aphasia, and their outcome.</div></div><div><h3>Methods</h3><div>In the ASTRAL Registry, we assessed all pure aphasic AIS patients from 2003-2019, and reviewed their neuropsychological examination performed after 3-10 days. We identified factors associated with persistent significant aphasia in the subacute phase, and predictors of unfavourable functional outcome at 3 months (mRS≥ 2), using multivariate analyses (MVA).</div></div><div><h3>Results</h3><div>Among 4513 consecutive AISs, 131 (2.9 %) had pure aphasia at admission. Eighty-one had a good quality neuropsychological examination and were analysed further (median age 76.3yrs; 44.4 % female; 6.2 % left-handed; 27.2 % treated by acute revascularization). Of these, 28.4 % still had significant aphasia in the subacute phase. Persistent aphasia was independently associated with cardioembolic (OR 13.6, 95 %CI 2.6-70.8) or atheromatous (OR 16.0, 95 %CI 1.9-132.1) stroke mechanisms, and with an executive function deficit on neuropsychological examination (OR 10.5, 95 %CI 2.0-54.4). At 3 months, female gender (OR 4.2, 95 %CI 1.2-15.3) and significant aphasia in the subacute phase (OR 12.0, 95 %CI 3.3-43.6) predicted an mRS≥2.</div></div><div><h3>Conclusion</h3><div>Pure aphasia was present in 2.9 % of all AIS patients and resolved in three-quarters in the subacute phase. Persistent aphasia was associated with embolic stroke mechanisms and concomitant executive function impairment, and poor 3 months outcome, with female gender and enduring subacute aphasia. These data may help with prognostication, management and rehabilitation planning.</div></div><div><h3>Key message</h3><div>Pure aphasic ischemic stroke is rare and most recover spontaneously within days, and persistent subacute aphasia is associated with defined embolic stroke mechanisms, and concomitant executive dysfunction. Unfavourable functional outcome at 3 months is present in women and if there is persistent subacute aphasia.</div></div>","PeriodicalId":54368,"journal":{"name":"Journal of Stroke & Cerebrovascular Diseases","volume":"34 1","pages":"Article 108142"},"PeriodicalIF":2.0,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142751660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and efficacy of argatroban combined with antiplatelet therapy for acute mild-to-moderate ischemic stroke with large artery atherosclerosis","authors":"Jia Yan ,&nbsp;Shuai Yu ,&nbsp;Hongxuan Feng ,&nbsp;Huimin Zhao ,&nbsp;Xiaofeng Dong ,&nbsp;Qinrong Xu ,&nbsp;Guoli Xu ,&nbsp;Qingzhang Cheng ,&nbsp;Xin Tan ,&nbsp;Qian Gui ,&nbsp;Guanhui Wu","doi":"10.1016/j.jstrokecerebrovasdis.2024.108151","DOIUrl":"10.1016/j.jstrokecerebrovasdis.2024.108151","url":null,"abstract":"<div><h3>Background and Purpose</h3><div>Patients with stroke due to large artery atherosclerosis are at risk of early progression and recurrence. The efficacy and safety of argatroban in stroke patients who did not receive reperfusion therapy, and which patients may benefit from it, are uncertain.</div></div><div><h3>Methods</h3><div>We conducted a cohort study to assess whether argatroban given within 72 hours of symptom onset, combined with antiplatelet therapy, improved neurological outcomes of patients with acute mild to moderate ischemic stroke in China. Patients were divided into the combined treatment group and the control group. Inverse probability of treatment weighting was used to balance baseline covariates. The primary efficacy outcome is the proportion of mRS score 0-2 at 90 days. The secondary efficacy outcomes included END proportion, change in NIHSS score from the baseline to day 7, recurrent cardiovascular events, and cardiovascular death. The safety outcomes were hemorrhagic transformation (HT) of infarction and organ hemorrhage at 7 days.</div></div><div><h3>Results</h3><div>Compared with the control group, a higher proportion of mRS (0-2) at 90 days was found in patients in the combined treatment group (85.3% vs 74.5%, p=0.042). There was no significant difference in the safety outcomes between the two groups. Exploratory subgroup analysis showed positive associations with argatroban combined therapy and good prognosis in NIHSS score ≥5 and age ≥70 subgroups.</div></div><div><h3>Conclusions</h3><div>Our study suggested that argatroban can improve neurological outcomes for mild to moderate LAA patients but not increase the risk of bleeding.</div></div>","PeriodicalId":54368,"journal":{"name":"Journal of Stroke & Cerebrovascular Diseases","volume":"34 1","pages":"Article 108151"},"PeriodicalIF":2.0,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142755910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exergames for rehabilitation in stroke survivors: Umbrella review of meta-analyses","authors":"Carla Sílvia Fernandes ,&nbsp;Bruno Magalhães ,&nbsp;Filipe Gonçalves ,&nbsp;Andreia Lima ,&nbsp;Mafalda Silva ,&nbsp;Maria Teresa Moreira ,&nbsp;Célia Santos ,&nbsp;Salomé Ferreira","doi":"10.1016/j.jstrokecerebrovasdis.2024.108161","DOIUrl":"10.1016/j.jstrokecerebrovasdis.2024.108161","url":null,"abstract":"<div><h3>Background</h3><div>It is essential to explore alternative methods to motivate stroke survivors throughout their lengthy rehabilitation journey. Exergames have emerged as promising tools for rehabilitating this demographic.</div></div><div><h3>Objective</h3><div>We aimed to synthesize the combined evidence from meta-analyses that assessed the effects of exergames in the rehabilitation of stroke survivors.</div></div><div><h3>Methods</h3><div>The umbrella review was conducted utilizing several databases, including MEDLINE® (Medical Literature Analysis and Retrieval System Online), CINAHL® (Cumulative Index to Nursing and Allied Health Literature), the Psychology and Behavioral Sciences Collection, SPORTDiscus®, and Scopus®. It included studies published until December 2023 without any restrictions based on publication date.</div></div><div><h3>Results</h3><div>The analysis included 11 meta-analyses involving approximately 9,615 patients, reflecting a growing adoption of exergames in post-stroke rehabilitation since 2015, focusing on using Nintendo Wii. The analyzed studies varied widely in intervention duration (from 1 to 16 weeks) and were applied across different phases of post-stroke rehabilitation, from the acute to the chronic phase. Significant improvements were observed in balance and upper limb functionality, although there was notable methodological heterogeneity and variability in the results.</div></div><div><h3>Conclusions</h3><div>This study highlights the value of exergames in the rehabilitation of stroke survivors and recommends future research that adopts rigorous methodological designs with clearly specified intervention stages. It underscores the importance of additional qualitative studies to explore the perspectives of patients and healthcare professionals regarding exergames, aiming to refine rehabilitation strategies and enhance the clinical benefits achieved.</div></div>","PeriodicalId":54368,"journal":{"name":"Journal of Stroke & Cerebrovascular Diseases","volume":"34 1","pages":"Article 108161"},"PeriodicalIF":2.0,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142751875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor regarding “Hybrid clinical-radiomics model based on fully automatic segmentation for predicting the early expansion of spontaneous intracerebral hemorrhage: A multi-center study”","authors":"Donglei Wang BD ,&nbsp;Zhiwei Li BD ,&nbsp;Xiaopeng Lu MD","doi":"10.1016/j.jstrokecerebrovasdis.2024.108160","DOIUrl":"10.1016/j.jstrokecerebrovasdis.2024.108160","url":null,"abstract":"","PeriodicalId":54368,"journal":{"name":"Journal of Stroke & Cerebrovascular Diseases","volume":"34 1","pages":"Article 108160"},"PeriodicalIF":2.0,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142751892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and efficacy of Neuroform Atlas stent-assisted coiling for the treatment of distal intracranial aneurysms: A single-center experience","authors":"Xiaoting Chang ,&nbsp;Mingyang Fei ,&nbsp;Baozhi Feng ,&nbsp;Tong Ren ,&nbsp;Wei Shang","doi":"10.1016/j.jstrokecerebrovasdis.2024.108156","DOIUrl":"10.1016/j.jstrokecerebrovasdis.2024.108156","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the effectiveness, safety, and efficacy of Atlas stents in the treatment of distal intracranial aneurysms (IAs).</div></div><div><h3>Methods</h3><div>We retrospectively analyzed patients with IAs who underwent stent-assisted coiling (SAC) from January 2018 to January 2022 and divided them into two groups: distal IAs treated with Atlas SAC and wide-necked aneurysms in other locations treated with SAC. The clinical data, imaging data, and postoperative follow-up data for the two groups of patients during hospitalization were collected.</div></div><div><h3>Results</h3><div>Fifteen patients were included in the distal IA group, and 332 patients were included in the non-distal IA group. The baseline data for the two groups of patients were compared, and significant differences in aneurysm locations, whether the aneurysm had ruptured, and the width of the aneurysm neck were found between the two groups. In the distal IA group, all stents were successfully placed and released during the operation. No aneurysm rupture occurred during the operation. Immediate postoperative digital subtraction angiography (DSA) showed complete embolization of the aneurysm in 10 patients. Ischemic complications occurred perioperatively in two patients. The postoperative follow-up showed a poor prognosis (modified Rankin scale (mRs) &gt; 2) in three patients and aneurysm recurrence in one patient. No significant differences in the treatment effect, surgical complications, or follow-up results were found between the two groups.</div></div><div><h3>Conclusion</h3><div>In this series, the use of Atlas SAC for the treatment of distal IAs was not associated with higher complication rates, and shows satisfactory long-term occlusion rates and follow-up results.</div></div>","PeriodicalId":54368,"journal":{"name":"Journal of Stroke & Cerebrovascular Diseases","volume":"34 1","pages":"Article 108156"},"PeriodicalIF":2.0,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142741202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in utilization and impact of hospital procedural volume on mortality after endovascular thrombectomy for acute ischemic stroke","authors":"Zafar Ali MD ,&nbsp;Sayyeda Aleena Mufarrih MD ,&nbsp;Amjad Ali ,&nbsp;Michael G. Abraham MD ,&nbsp;Gokul Ramani MD ,&nbsp;Kamal Gupta MD","doi":"10.1016/j.jstrokecerebrovasdis.2024.108133","DOIUrl":"10.1016/j.jstrokecerebrovasdis.2024.108133","url":null,"abstract":"<div><h3>Objectives</h3><div>Endovascular thrombectomy (EVT) has become an established treatment for eligible acute ischemic stroke (AIS) patients, but data on mortality trends and the association between procedural volume and outcomes in the United States is limited.</div></div><div><h3>Materials and Methods</h3><div>This retrospective study analyzed data from the Nationwide Readmissions Database (NRD) to investigate trends in EVT utilization, outcomes, and the relationship between hospital procedural volume and inpatient mortality for AIS admissions between 2016-2020. Patients undergoing EVT were identified using ICD-10 procedure codes. Hospitals were categorized into quintiles based on EVT volumes, and mortality rates compared across quintiles. Multivariable regression identified predictors of mortality.</div></div><div><h3>Results</h3><div>Of 2,535,777 AIS admissions, 90,110 (3.6 %) underwent EVT (median age of 70 and 50 % female in both groups). EVT utilization increased from 2.8 % in 2016 to 3.9 % in 2020 (p &lt; 0.001). Patients receiving EVT had higher prevalence of atrial fibrillation and coronary artery disease but lower rates of hyperlipidemia and tobacco use. Inpatient mortality was higher with EVT (13 % vs 4 %, p &lt; 0.001) but declined from 16 % in 2016-2017 to 12 % in 2020 (p &lt; 0.001). Hemiparalysis and atrial fibrillation were associated with higher EVT likelihood. Mortality decreased with higher hospital EVT volume. After adjustment, higher procedural centers were associated with lower mortality.</div></div><div><h3>Conclusion</h3><div>EVT utilization for AIS increased nationally from 2016-2020 while associated mortality declined. Higher hospital procedural volumes were associated with lower mortality.</div></div>","PeriodicalId":54368,"journal":{"name":"Journal of Stroke & Cerebrovascular Diseases","volume":"34 1","pages":"Article 108133"},"PeriodicalIF":2.0,"publicationDate":"2024-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142711880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence and characterization of late onset movement disorders following thrombolysis or thrombectomy for acute ischemic stroke: A retrospective cohort study","authors":"Wenzheng Yu MD,&nbsp;Aya Shnawa MD,&nbsp;Jeffrey Swarz MD,&nbsp;Ambreen Zaidi BA,&nbsp;Lester Y. Leung MD, MSc","doi":"10.1016/j.jstrokecerebrovasdis.2024.108155","DOIUrl":"10.1016/j.jstrokecerebrovasdis.2024.108155","url":null,"abstract":"","PeriodicalId":54368,"journal":{"name":"Journal of Stroke & Cerebrovascular Diseases","volume":"34 1","pages":"Article 108155"},"PeriodicalIF":2.0,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142696199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contextual and clinical factors as explainers of stroke severity, residual motor impairments, and functional independence during hospitalization","authors":"Kênia Kiefer Parreiras de Menezes PT, Ph.D. ,&nbsp;Aline Alvim Scianni PT, Ph.D. ,&nbsp;Patrick Roberto Avelino PT, Ph.D. ,&nbsp;Iza Faria-Fortini OT, Ph.D. ,&nbsp;Valdisson Sebastião Bastos PT ,&nbsp;Christina Danielli Coelho de Morais Faria PT, Ph.D.","doi":"10.1016/j.jstrokecerebrovasdis.2024.108154","DOIUrl":"10.1016/j.jstrokecerebrovasdis.2024.108154","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate if contextual and clinical factors would explain stroke severity, residual motor impairments, and functional independence in people with stroke during hospitalization.</div></div><div><h3>Materials and methods</h3><div>This cross-sectional study retrieved data from medical records between January 2014 to December 2021. Explanatory independent variables were contextual (sex, age, marital status, occupation, and local of residence) and clinical (stroke type, length of hospital stay, and cognitive function) factors. Stroke severity (National Institutes of Health Stroke Scale), residual motor impairments (Fugl-Meyer scale), and functional independence (Functional Independence Measure) were the dependent variables. Stepwise multiple linear regression analysis was used (α=5%).</div></div><div><h3>Results</h3><div>Data from 1.606 individuals (64±15 years old) were retrieved. Cognitive function was the strongest explainer of all models, as follows: severity (23%;<em>p</em>&lt;0.001), residual motor impairment (16%;<em>p</em>&lt;0.001), and functional independence (32%;<em>p</em>&lt;0.001). Length of hospital stays was the second explainer, adding from 7% to 8% to the models, while stroke type was the third explainer, adding 1% to all models. Finally, age was the last explainer of the two models, adding 1% to the severity and functional independence model.</div></div><div><h3>Conclusion</h3><div>The clinical variables explained more the dependent variables (all three were included in the models), than contextual variables (only age was included). Lower cognitive function, a clinical variable that is quick and easy to evaluate, best explained worse severity, residual motor impairments, and functional independence in people with stroke during hospitalization. Although higher length of hospital stays, hemorrhagic stroke, and older age added little to the explained variance, they should not be underlooked.</div></div>","PeriodicalId":54368,"journal":{"name":"Journal of Stroke & Cerebrovascular Diseases","volume":"34 1","pages":"Article 108154"},"PeriodicalIF":2.0,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142693971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}