Journal of Inclusion Phenomena and Macrocyclic Chemistry最新文献_第2页

Supramolecular assembling systems of hemoproteins using chemical modifications 利用化学修饰的血红蛋白的超分子组装系统

IF 2.3 4区化学

Journal of Inclusion Phenomena and Macrocyclic Chemistry Pub Date : 2023-03-18 DOI: 10.1007/s10847-023-01181-6

Koji Oohora

{"title":"Supramolecular assembling systems of hemoproteins using chemical modifications","authors":"Koji Oohora","doi":"10.1007/s10847-023-01181-6","DOIUrl":"10.1007/s10847-023-01181-6","url":null,"abstract":"<div>Inspired by protein assemblies in biological systems, various artificial protein assemblies have been constructed in these decades. Hemoprotein containing porphyrin iron complex, heme, is a unique building block of the artificial protein assemblies due to the structures, physicochemical properties and functions. In the case of hemoprotein containing b-type heme, the heme cofactor is non-covalently bound to the heme-binding site, heme pocket, in the protein matrix. This review summaries our efforts to utilize heme–heme pocket interactions toward supramolecular hemoprotein assembling systems with various structures and/or functions. Simple monomeric hemoprotein, mainly cytochrome b562, was employed as a useful building block and synthetic heme was attached to the cysteine-introduced variant to form a building block showing self-assembling behavior by interprotein heme–heme pocket interactions. The modulations of linker between synthetic heme and protein surface and/or protein modification site contribute to provide various structures such as fiber, ring, branched shape and micelles. Furthermore, hexameric hemoprotein was utilized for another building block with supramolecular approach toward light harvesting system by replacement of heme cofactors with porphyrinoid photosensitizers. A series of artificial hemoprotein assembling systems will contribute to new-type of functional biomaterials.</div>","PeriodicalId":54324,"journal":{"name":"Journal of Inclusion Phenomena and Macrocyclic Chemistry","volume":"103 3-4","pages":"97 - 107"},"PeriodicalIF":2.3,"publicationDate":"2023-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10847-023-01181-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4730504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Colorimetric detection of glutathione by an anionic pyridylazo dye-based Cu2+ complex in the presence of a cationic polyelectrolyte 阴离子吡啶偶氮染料Cu2+络合物在阳离子聚电解质存在下比色法检测谷胱甘肽

IF 2.3 4区化学

Journal of Inclusion Phenomena and Macrocyclic Chemistry Pub Date : 2023-03-17 DOI: 10.1007/s10847-023-01183-4

Mahiro Shimizu, Yoshiaki Koizumi, Shunichi Aikawa, Yasumasa Fukushima

{"title":"Colorimetric detection of glutathione by an anionic pyridylazo dye-based Cu2+ complex in the presence of a cationic polyelectrolyte","authors":"Mahiro Shimizu, Yoshiaki Koizumi, Shunichi Aikawa, Yasumasa Fukushima","doi":"10.1007/s10847-023-01183-4","DOIUrl":"10.1007/s10847-023-01183-4","url":null,"abstract":"<div>The colorimetric sensing system for glutathione (GSH) was constructed by the mixture of three components, an anionic dye 2-(5-bromo-2-pyridylazo)-5-(N-propyl-N-sulfopropylamino)phenol (BrPAPS), a cationic polyelectrolyte poly(diallyldimethylammonium chloride) (PDADMAC), and Cu2+ in an aqueous solution. BrPAPS was complexed with Cu2+ in a 2:1 molar ratio via the electrostatic interaction with PDADMAC (BrPAPS2-Cu2+-PDADMAC). The addition of GSH to the complex caused a hypsochromic shift with a distinct colorimetric response from red to yellow since the regeneration of the original BrPAPS through the interaction between GSH and Cu2+ in a 1:1 stoichiometry. BrPAPS2-Cu2+-PDADMAC allowed the selective recognition of GSH over other amino acids and the detection suffer little interference from them. Hence, BrPAPS2-Cu2+-PDADMAC provides efficient colorimetric sensing of GSH with high selectivity and sensitivity in pure aqueous media.</div>","PeriodicalId":54324,"journal":{"name":"Journal of Inclusion Phenomena and Macrocyclic Chemistry","volume":"103 3-4","pages":"123 - 129"},"PeriodicalIF":2.3,"publicationDate":"2023-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4694253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thermodynamic analysis of methyl orange anion association with α-cyclodextrin using a conductometric approach 甲基橙阴离子与α-环糊精缔合的热力学分析

IF 2.3 4区化学

Journal of Inclusion Phenomena and Macrocyclic Chemistry Pub Date : 2023-02-20 DOI: 10.1007/s10847-023-01180-7

Sa’ib J. Khouri, Abdelmnim M. Altwaiq

{"title":"Thermodynamic analysis of methyl orange anion association with α-cyclodextrin using a conductometric approach","authors":"Sa’ib J. Khouri, Abdelmnim M. Altwaiq","doi":"10.1007/s10847-023-01180-7","DOIUrl":"10.1007/s10847-023-01180-7","url":null,"abstract":"<div>The electrical conductivities of aqueous solutions of the azo dye methyl orange (sodium salt) were measured at 25.0 °C in the concentration range between 2.103 × 10–4 and 9.255 × 10–4 mol L−1. Molar conductivity values fit the Debye–Hückel–Wager equation for a symmetric electrolyte. The estimated value of the molar conductivity of the sodium salt of methyl orange at infinite dilution is found to be 77.93 ± 0.38 S cm2 mol−1. The calculated ionic conductivity at infinite dilution of the anion of methyl orange is 27.82 S cm2 mol−1. Using the same methodology, a thermodynamic analysis of the association between methyl orange anion and α-cyclodextrin was conducted at 20.0, 25.0, 32.0, and 40.0 °C. The measured molar conductivities decreased as the mole ratio of α-cyclodextrin to methyl orange went below 3. The conductivity measurements were analysed using a model 1:1 stoichiometry at the four different temperatures. The values of the thermodynamic quantities ∆H° and ∆S° for the inclusion process were calculated by using Van’t Hoff plot, their values are − 27.35 kJ mol−1 and − 9.70 J K−1 mol−1 respectively. For this case of the studied inclusion process this inclusion was disfavored through entropy change and favored through enthalpy change.</div>","PeriodicalId":54324,"journal":{"name":"Journal of Inclusion Phenomena and Macrocyclic Chemistry","volume":"103 1-2","pages":"89 - 95"},"PeriodicalIF":2.3,"publicationDate":"2023-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4791078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trihalide-included (I2, Br2 and IBrCl−) bambus[6]urils in halogenation and iodine-catalysed reactions 含三卤化物(I2, Br2和IBrCl−)的竹[6]尾尾在卤化和碘催化反应中的作用

IF 2.3 4区化学

Journal of Inclusion Phenomena and Macrocyclic Chemistry Pub Date : 2023-02-13 DOI: 10.1007/s10847-023-01179-0

Renato Salviato Cicolani, Antonio Gustavo Sampaio de Oliveira-Filho, Ana Paula de Lima Batista, Grégoire Jean-François Demets

引用次数: 0

Solubilities and metal extraction behaviors for calix[4]arene acetic-acid derivatives in various organic solvents 杯[4]芳烃乙酸衍生物在各种有机溶剂中的溶解度及金属萃取行为

IF 2.3 4区化学

Journal of Inclusion Phenomena and Macrocyclic Chemistry Pub Date : 2023-01-30 DOI: 10.1007/s10847-023-01178-1

Tatsuya Oshima, Tatsuya Ishibashi, Keisuke Ohto

{"title":"Solubilities and metal extraction behaviors for calix[4]arene acetic-acid derivatives in various organic solvents","authors":"Tatsuya Oshima, Tatsuya Ishibashi, Keisuke Ohto","doi":"10.1007/s10847-023-01178-1","DOIUrl":"10.1007/s10847-023-01178-1","url":null,"abstract":"<div>Calixarene derivatives exhibit excellent extractability and selectivity for metal ions based on their chelating and size-discriminating effects; however, their poor solubility in aliphatic hydrocarbons, which are used as solvents in industrial processes, hinders their practical use. In this study, the relationship between solubility of calix[4]arene acetic-acid derivatives in various organic solvents and Hansen solubility parameters of the solvents was investigated. The center coordinates of the Hansen solubility sphere of the p-tert-octylcalix[4]arene acetic-acid derivative (tOct[4]CH2COOH), as determined from its solubility in 50 different solvents, are δD = 17.24, δP = 4.73, δH = 4.45, which indicate that this extractant is less polar than p-tert-butylcalix[4]arene acetic-acid derivative. The solubilities of tOct[4]CH2COOH in diethylene glycol dibutyl ether (DBC) and 2-nonanone (2-NON) were 92.6 mM and 91.1 mM, respectively. DBC and 2-NON are relatively preferable as solvents from the viewpoint of physical properties (low viscosity, relatively low water solubility, and high flash point). Extractability of Pb(II) using tOct[4]CH2COOH dissolved in various solvents was compared. Extraction in DBC proceeded at much higher pH than that in other solvents. Extraction of various metals in 2-NON proceeded at higher pH than that in chloroform. The order of metal selectivity of tOct[4]CH2COOH in 2-NON was similar to that in chloroform. The extraction reaction for Pb(II) using tOct[4]CH2COOH was determined by slope analysis. These results suggest that 2-NON can be an alternative to chlorinated solvents for use of tOct[4]CH2COOH as a metal extractant.</div>","PeriodicalId":54324,"journal":{"name":"Journal of Inclusion Phenomena and Macrocyclic Chemistry","volume":"103 1-2","pages":"71 - 79"},"PeriodicalIF":2.3,"publicationDate":"2023-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10847-023-01178-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"5148320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New macrocycles based on pyrazole-tetrazole subunit: synthesis, characterization and their complexing properties toward heavy metal cations 基于吡唑-四唑亚基的新型大环:合成、表征及其对重金属阳离子的络合性能

IF 2.3 4区化学

Journal of Inclusion Phenomena and Macrocyclic Chemistry Pub Date : 2023-01-18 DOI: 10.1007/s10847-023-01177-2

Mounir Cherfi, Tarik Harit, Fouad Malek

引用次数: 1

Synthesis of multi-hybrid hemicucurbiturils 多杂化半脲类化合物的合成

IF 2.3 4区化学

Journal of Inclusion Phenomena and Macrocyclic Chemistry Pub Date : 2023-01-17 DOI: 10.1007/s10847-022-01176-9

Xiaoting Yuan, Qingkai Zeng, Li Wang, Yuting You, Xingbao Cen, Qianjun Zhang, Qingmei Ge, Hang Cong, Mao Liu

引用次数: 0

Retention of a plethora of essential oils and aromas in deep eutectic solvent:water:cyclodextrin mixtures 在深共晶溶剂:水:环糊精混合物中保留过多的精油和香气

IF 2.3 4区化学

Journal of Inclusion Phenomena and Macrocyclic Chemistry Pub Date : 2022-12-29 DOI: 10.1007/s10847-022-01174-x

Lamia Nakhle, Miriana Kfoury, Hélène Greige-Gerges, David Landy

{"title":"Retention of a plethora of essential oils and aromas in deep eutectic solvent:water:cyclodextrin mixtures","authors":"Lamia Nakhle, Miriana Kfoury, Hélène Greige-Gerges, David Landy","doi":"10.1007/s10847-022-01174-x","DOIUrl":"10.1007/s10847-022-01174-x","url":null,"abstract":"<div>Essential oils (EOs) and aromas have long been used in the perfume, cosmetic, pharmaceutical and food industries. Yet, aside their poor solubility and instability, their high volatility limits their application. Their encapsulation in cyclodextrins (CDs) or their solvation in deep eutectic solvents (DESs) are two efficient strategies to resolve such problems. Thus, the present study aims to investigate the retention ability of the combination of DESs and CDs towards a wide variety of EOs and aromas. Thus, the capacity of formulations combining choline chloride:urea (ChCl:U) DES, CDs and water to retain and decrease the volatility of twenty EOs and twenty-one aromas was examined. Also, the formation constants (Kf) of CD/aroma inclusion complexes in this new non-conventional medium were determined. Results showed that ChCl:U DES:water 70:30 wt% mixed with 10 wt% CD had an efficient ability to retain all the studied EOs and aromas. Also, the addition of CDs in this mixture was shown to be advantageous in improving the efficiency of the formulation even if lower complexation ability towards the aromas was observed compared to water. Altogether, the obtained results will encourage the use of DES:water:CD mixtures for the incorporation of EOs and aromas in different preparations.</div>","PeriodicalId":54324,"journal":{"name":"Journal of Inclusion Phenomena and Macrocyclic Chemistry","volume":"103 1-2","pages":"35 - 44"},"PeriodicalIF":2.3,"publicationDate":"2022-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"5112756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Binding behavior and in vitro cytotoxicity of inclusion complexes between aminopterin and cucurbit[7]uril 氨基蝶呤与葫芦包合物的结合行为及体外细胞毒性研究[7]

IF 2.3 4区化学

Journal of Inclusion Phenomena and Macrocyclic Chemistry Pub Date : 2022-12-25 DOI: 10.1007/s10847-022-01175-w

Juan Chang, Ke Wang, Jue Chen, Yinxia Chang

{"title":"Binding behavior and in vitro cytotoxicity of inclusion complexes between aminopterin and cucurbit[7]uril","authors":"Juan Chang, Ke Wang, Jue Chen, Yinxia Chang","doi":"10.1007/s10847-022-01175-w","DOIUrl":"10.1007/s10847-022-01175-w","url":null,"abstract":"<div>Aminopterin (AMT) is a kind of universal antineoplastic drugs, but it has severe toxic and side effects, leaving it rarely used in clinic. Herein, we found that cucurbit[7]uril (CB[7]) and AMT can form stable inclusion complexes, and the formation of CB[7]-AMT 2:1 supramolecular inclusion complex was confirmed by UV-visible absorption spectra, fluorescence spectra, 1H NMR, and molecular modeling calculations in aqueous solution. Binding stability constants (Ks) were determined by UV-visible and fluorescence spectra method, with 3.88 × 1010 L2 mol–2 and 5.24 × 1010 L2 mol–2, respectively. The binding energy was calculated to be 102.6 kcal mol–1 for the CB[7]-AMT complex. And then, through a series of cell experiments of CCK8 assay, DAPI staining and hoechst33342/PI double staining, we fully proved that the CB[7]-AMT complex can reduce the toxicity of AMT to normal cells such as hepatocyte line LO2, and improve its anticancer effect on cancer cells overexpressing spermine, typically like human colon cancer cell line HCT116. It confirmed that the CB[7]-AMT complex had the effect of reducing toxicity and increasing efficiency. These results indicated that CB[7]-AMT inclusion complex might be a promising novel formulation of AMT for its clinical development.</div>","PeriodicalId":54324,"journal":{"name":"Journal of Inclusion Phenomena and Macrocyclic Chemistry","volume":"103 1-2","pages":"45 - 55"},"PeriodicalIF":2.3,"publicationDate":"2022-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4959416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Synthesis of p-methoxybenzaldehyde/β-cyclodextrin inclusion complex and studies of its release properties in polylactic acid film 对甲氧基苯甲醛/β-环糊精包合物的合成及其在聚乳酸膜中的释放性能研究

IF 2.3 4区化学

Journal of Inclusion Phenomena and Macrocyclic Chemistry Pub Date : 2022-11-30 DOI: 10.1007/s10847-022-01173-y

Jing Xu, Lixin Lu, Liao Pan

{"title":"Synthesis of p-methoxybenzaldehyde/β-cyclodextrin inclusion complex and studies of its release properties in polylactic acid film","authors":"Jing Xu, Lixin Lu, Liao Pan","doi":"10.1007/s10847-022-01173-y","DOIUrl":"10.1007/s10847-022-01173-y","url":null,"abstract":"<div>Nowadays, due to the rapid development of the times, the study of green controlled release active packaging film has become an integral part of food packaging industry. In order to prepare eco-friendly food green packaging with sustainable release of active ingredients, this study used saturated aqueous solution method to prepare p-methoxybenzaldehyde/β-cyclodextrin inclusion complex, and analyzed the effects of three single factors, namely inclusion temperature, mixing time and inclusion ratio, on the entrapment efficiency and loading capacity. It is found that when the inclusion temperature was 50 °C, mixing time was 4 h and inclusion ratio was 10:1, the entrapment efficiency was 75.18%, the loading capacity could reach 7.52%. Meanwhile, the molecular docking method was used to study molecular interactions, indicating that p-methoxybenzaldehyde can form stable inclusion complexes with β-cyclodextrin. Polylactic acid (PLA) was then used as the base fluid to prepare a p-methoxybenzaldehyde releasable film, which was protected by β-cyclodextrin resulting in a significantly lower release rate than that of added p-methoxybenzaldehyde directly to the film. The inclusion complex was only physical mixing and did not react with PLA, and the inclusion of β-cyclodextrin allowed for effective control of the continuous release of p-methoxybenzaldehyde from the film.<h3>Graphical abstract</h3>\u0000 <figure><div><div><div><picture><source><img></source></picture></div></div></div></figure>\u0000 </div>","PeriodicalId":54324,"journal":{"name":"Journal of Inclusion Phenomena and Macrocyclic Chemistry","volume":"103 1-2","pages":"21 - 34"},"PeriodicalIF":2.3,"publicationDate":"2022-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"5165225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1