Endocrinologia Y Nutricion最新文献

{"title":"Detección de personas en riesgo de padecer diabetes en farmacias comunitarias de Pontevedra (DEDIPO)","authors":"José Antonio Fornos-Pérez ,&nbsp;N. Floro Andrés-Rodríguez ,&nbsp;J. Carlos Andrés-Iglesias ,&nbsp;Reyes Luna-Cano ,&nbsp;Javier García-Soidán ,&nbsp;Blanca Lorenzo-Veiga ,&nbsp;Rocío Mera-Gallego ,&nbsp;Rosario García-Riestra","doi":"10.1016/j.endonu.2016.06.002","DOIUrl":"https://doi.org/10.1016/j.endonu.2016.06.002","url":null,"abstract":"<div><h3>Objective</h3><p>The aim of this study was to detect people at risk of suffering diabetes or changes in carbohydrate metabolism and to refer them for possible diagnosis to health care centres. The number of diagnoses and costs for the pharmacy were recorded.</p></div><div><h3>Methods</h3><p>A cross-sectional, observational study was conducted in community pharmacies in Pontevedra in September-October of 2014. The Findrisc questionnaire was completed by pharmacy users over 18 years old. If Findrisc score was ≥ 15, capillary blood glucose was measured, and the participant was referred to a physician if the value was ≥110<!--> <!-->mg/dL. The main variables included score in the Findrisc questionnaire, number of diabetes diagnosed, and cost of the service.</p><p>Differences between the groups were calculated using a Chi-squared test, a Student's t test, and/or a Wilcoxon test.</p></div><div><h3>Results</h3><p>This study was conducted in 180 pharmacies on a sample of 4,222 users, including 992 (23.5%) with a high or very high risk of diabetes (F<!--> <!-->≥<!--> <!-->15). In the 1,060 basal capillary blood glucose tests performed, mean glucose level was 110.2 (SD<!--> <!-->=<!--> <!-->20.4)<!--> <!-->mg/dL (56–254). The Galician Health Service sent information about 83 of the 384 (9.1%) subjects referred to a physician: 28 (33.7%) of them were diagnosed with diabetes (3.1% of the sample), and 26 (31.3%) were diagnosed with prediabetes (2.8% of the sample).</p><p>Cost per diagnosed subject was € 184.22 per subject with diabetes and € 96.86 per subject with prediabetes.</p></div><div><h3>Conclusions</h3><p>The proportion of subjects with new diagnosis of diabetes (3.1%) shows the high efficiency of a screening program for hidden diabetics implemented at community pharmacies as the one presented here.</p></div>","PeriodicalId":54323,"journal":{"name":"Endocrinologia Y Nutricion","volume":"63 8","pages":"Pages 387-396"},"PeriodicalIF":0.0,"publicationDate":"2016-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.endonu.2016.06.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72061047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vitamin D status in Egyptian euthyroid multinodular non-toxic goiter patients and its correlation with TSH levels","authors":"Mohamed M. Aboelnaga ,&nbsp;Maha M. Elshafei ,&nbsp;Eman Elsayed","doi":"10.1016/j.endonu.2016.06.005","DOIUrl":"10.1016/j.endonu.2016.06.005","url":null,"abstract":"<div><h3>Background and aim</h3><p>Although the prevalence of MNG is widespread throughout the world, its pathogenesis is poorly understood, and the complex interactions of both genetic predisposition and the individuals’ environment are likely. However, to the best of our knowledge, it remains unknown whether there is a relationship between vitamin D status and prevalence or pathogenesis of euthyroid MNG. Therefore, the goal of the present study was determination of vitamin D status in euthyroid MNG as well as exploration of the correlation between vitamin D status &amp; TSH levels.</p></div><div><h3>Methods</h3><p>A total of 77 patients diagnosed with euthyroid MNG and 50 subjects without goiter were matched according to age, weight and BMI as control group in this case control study.</p></div><div><h3>Results</h3><p>We found that patients with euthyroid MNG had statistically significant lower mean of [25(OH)D] (24.21<!--> <!-->±<!--> <!-->8.68<!--> <!-->ng/mL) in comparison with its mean in control subjects (28.37<!--> <!-->±<!--> <!-->10.91<!--> <!-->ng/mL, <em>P</em> value<!--> <!-->=<!--> <!-->0.019). The 28 sufficient vitamin D MNG patients had statistically significant lower level of TSH than 49 insufficient vitamin D MNG patients. Vitamin D and TSH levels correlate with vitamin D levels in MNG patients in Pearson correlation. Also 25 OH vitamin D was a significant independent predictor for TSH levels among euthyroid MNG patients in regression analysis.</p></div><div><h3>Conclusions</h3><p>Patients with euthyroid MNG have lower levels of vitamin D and TSH levels correlate with vitamin D levels in euthyroid MNG patients. In addition, 25 OH vitamin D was a significant independent predictor for TSH levels among euthyroid MNG patients. We recommend hypovitaminosis D evaluation and correction in patients with MNG.</p></div>","PeriodicalId":54323,"journal":{"name":"Endocrinologia Y Nutricion","volume":"63 8","pages":"Pages 380-386"},"PeriodicalIF":0.0,"publicationDate":"2016-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.endonu.2016.06.005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34329078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comentarios sobre «Hipoglucemia desapercibida en personas con diabetes tipo 1»","authors":"Florentino Carral San Laureano,&nbsp;María del Carmen Ayala Ortega,&nbsp;Antonia Piñero Zaldivar,&nbsp;Coral Expósito","doi":"10.1016/j.endonu.2016.05.005","DOIUrl":"https://doi.org/10.1016/j.endonu.2016.05.005","url":null,"abstract":"","PeriodicalId":54323,"journal":{"name":"Endocrinologia Y Nutricion","volume":"63 8","pages":"Page 435"},"PeriodicalIF":0.0,"publicationDate":"2016-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.endonu.2016.05.005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72061482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Apoplejía hipofisaria como forma de presentación de un tumor teratoide/rabdoide atípico en el adulto","authors":"Laura Larrán-Escandón ,&nbsp;Isabel Mateo-Gavira ,&nbsp;Francisco Javier Vilchez-López ,&nbsp;Efraim Gómez Cárdenas ,&nbsp;Manuel Aguilar Diosdado","doi":"10.1016/j.endonu.2016.05.004","DOIUrl":"https://doi.org/10.1016/j.endonu.2016.05.004","url":null,"abstract":"","PeriodicalId":54323,"journal":{"name":"Endocrinologia Y Nutricion","volume":"63 7","pages":"Pages 364-365"},"PeriodicalIF":0.0,"publicationDate":"2016-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.endonu.2016.05.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72062111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Situación clínica de una cohorte de pacientes con diabetes tipo 1 más de 2 décadas después del inicio. Resultados de un programa específico de seguimiento en una unidad de referencia","authors":"Antonio J. Amor ,&nbsp;Maria Cabrer ,&nbsp;Marga Giménez ,&nbsp;Irene Vinagre ,&nbsp;Emilio Ortega ,&nbsp;Ignacio Conget","doi":"10.1016/j.endonu.2016.03.008","DOIUrl":"https://doi.org/10.1016/j.endonu.2016.03.008","url":null,"abstract":"<div><h3>Background and objective</h3><p>The clinical course of type 1 diabetes mellitus (T1DM) has changed in recent decades. The aim of our study was to assess the long-term (&gt; 20 years) clinical status of a patient cohort with T1DM under a specific treatment and follow-up program.</p></div><div><h3>Patients and methods</h3><p>A single center, observational, cross-sectional study was conducted of a patient cohort diagnosed with T1DM in the 1986-1994 period at our tertiary university hospital. Clinical characteristics, metabolic parameters, and occurrence of chronic complications and comorbidities after &gt; 20 years of follow-up were collected. All subjects entered our specific program for patients with newly-diagnosed T1D and were followed up using the same clinical protocol. Data are shown as mean (standard deviation) or as number of patients and percentage. The appropriate test was used to compare quantitative and qualitative data. A <em>P</em> value &lt;0.05 was considered statistically significant.</p></div><div><h3>Results</h3><p>A total of 279 patients were recorded, of whom 153 (53.6% women; mean age 46.6<!--> <!-->±<!--> <!-->8.6 years; age at onset 23.3<!--> <!-->±<!--> <!-->8.8 years; disease duration, 23.3<!--> <!-->±<!--> <!-->2.6 years) continued to attend our diabetes unit at the time of the analysis. Of these patients, 24.8% were administered continuous subcutaneous insulin infusion (CSII). Mean HbA1c in the past 5 years and in the last year were7.8<!--> <!-->±<!--> <!-->0.9% and 7.7<!--> <!-->±<!--> <!-->1.1% respectively (7.3<!--> <!-->±<!--> <!-->1.5% in those given CSII). Smoking was reported by 19.6% of patients, while 15.7% had high blood pressure and 37.9% dyslipidemia. Diabetic retinopathy was diagnosed in 20.4%, and 11.3% of the total cohort had nephropathy. Only 1.3% of our patients had a history of CVD.</p></div><div><h3>Conclusions</h3><p>Data collected from a cohort of patients with T1DM for more than 2 decades regularly followed up with a specific program in a tertiary university hospital suggest a remarkably low prevalence of diabetic complications.</p></div>","PeriodicalId":54323,"journal":{"name":"Endocrinologia Y Nutricion","volume":"63 7","pages":"Pages 339-344"},"PeriodicalIF":0.0,"publicationDate":"2016-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.endonu.2016.03.008","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72062115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Asociación entre la razón triglicéridos/colesterol HDL y ateromatosis carotídea en mujeres posmenopáusicas de mediana edad","authors":"Walter Masson,&nbsp;Daniel Siniawski,&nbsp;Martín Lobo,&nbsp;Graciela Molinero,&nbsp;Melina Huerín","doi":"10.1016/j.endonu.2016.04.004","DOIUrl":"https://doi.org/10.1016/j.endonu.2016.04.004","url":null,"abstract":"<div><h3>Background and objective</h3><p>The triglyceride/HDL cholesterol ratio, as a surrogate marker of insulin resistance, may be associated to presence of subclinical carotid atherosclerosis in postmenopausal women. The aim of this study was to explore this association.</p></div><div><h3>Patients and methods</h3><p>Women (last menstrual period<!--> <!-->≥<!--> <!-->2 years) in primary prevention up to 65 years of age were recruited. Association between the triglyceride/HDL cholesterol (HDL-C) ratio and presence of carotid plaque, assessed by ultrasonography, was analyzed. ROC analysis was performed, determining the precision of this ratio to detect carotid plaque.</p></div><div><h3>Results</h3><p>A total of 332 women (age 57<!--> <!-->±<!--> <!-->5 years) were recruited. Triglyceride/HDL-C ratio was 2.35<!--> <!-->±<!--> <!-->1.6. Prevalence of carotid plaque was 29%. Women with carotid plaque had higher triglyceride/HDL-C ratios (3.33<!--> <!-->±<!--> <!-->1.96 vs. 2.1<!--> <!-->±<!--> <!-->1.2, <em>P</em> <!-->&lt;<!--> <!-->.001) than women with no carotid plaque. A positive relationship was seen between quintiles of this ratio and prevalence of carotid plaque (p<!--> <!-->&lt;<!--> <!-->.001). Regardless of other risk factors, women with higher triglyceride/HDL-C ratios were more likely to have carotid plaque (odds ratio 1.47, 95% confidence interval 1.20-1.79, <em>P</em> <!-->&lt;<!--> <!-->.001). The area under the curve of the triglyceride/HDL-C ratio to detect carotid plaque was .71 (95% confidence interval .65 to .76), and the optimal cut-off point was 2.04.</p></div><div><h3>Conclusions</h3><p>In postmenopausal women in primary prevention, insulin resistance, estimated from the triglyceride/HDL-C ratio, was independently associated to a greater probability of carotid plaque. A value of such ratio greater than 2 may be used for assessing cardiovascular risk in this particular group of women.</p></div>","PeriodicalId":54323,"journal":{"name":"Endocrinologia Y Nutricion","volume":"63 7","pages":"Pages 327-332"},"PeriodicalIF":0.0,"publicationDate":"2016-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.endonu.2016.04.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72062118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiología de la acromegalia en Ecuador","authors":"Enrique López Gavilanez ,&nbsp;Kempis Guerrero Franco ,&nbsp;Narcisa Solórzano Zambrano ,&nbsp;Manuel Navarro Chávez ,&nbsp;Camilo López Estrella ,&nbsp;Luis Vaca Burbano ,&nbsp;Eduardo Marriott Díaz","doi":"10.1016/j.endonu.2016.03.009","DOIUrl":"https://doi.org/10.1016/j.endonu.2016.03.009","url":null,"abstract":"<div><h3>Objectives</h3><p>To assess the epidemiology of acromegaly in the city of Guayaquil, Ecuador, and to compare our results to those reported in the literature.</p></div><div><h3>Patients, material and methods</h3><p>An analysis was made of retrospective and prospective data from all patients with acromegaly attending endocrinology clinics at the 4 main hospitals of the public health network of Guayaquil from January 2000 to December 2014. Age at diagnosis, estimated delay in diagnosis, imaging studies of pituitary gland, basal growth hormone (GH) level, GH after an oral glucose tolerance test (OGTT-GH), and serum levels of insulin-like growth factor 1 (IGF-1) were recorded. Incidence and prevalence of the disease were estimated using information from the 2010 census of population and housing.</p></div><div><h3>Results</h3><p>Forty-eight cases were recorded in the study period in 17 males (35.4%) and 31 females (64.5%); M/F ratio<!--> <!-->=<!--> <!-->1.8:1. Mean age at diagnosis was 47.3<!--> <!-->±<!--> <!-->16.8 years (range 18-86). Delay in diagnosis was 7.3<!--> <!-->±<!--> <!-->6.3 years (range 1-30). Mean age at diagnosis was 47.9<!--> <!-->±<!--> <!-->18.2 years in males and 46.3<!--> <!-->±<!--> <!-->15.8 years in females. Delay in diagnosis was 10.2<!--> <!-->±<!--> <!-->7.9 and 5.7<!--> <!-->±<!--> <!-->3.9 years in males and females, respectively. Prevalence of acromegaly is 18.7 cases per million inhabitants, and incidence of acromegaly 1.3 cases per million people per year.</p></div><div><h3>Conclusions</h3><p>Acromegaly predominates in females, and is diagnosed in the fourth decade with a delay of approximately 8 years, usually even longer in males. Incidence and prevalence are lower than reported in international series. The disease is underdiagnosed and underreported in Ecuador.</p></div>","PeriodicalId":54323,"journal":{"name":"Endocrinologia Y Nutricion","volume":"63 7","pages":"Pages 333-338"},"PeriodicalIF":0.0,"publicationDate":"2016-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.endonu.2016.03.009","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72062116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comentarios a «Hipercarotinemia tras cirugía bariátrica»","authors":"Sonsoles Gutiérrez Medina,&nbsp;Paloma Iglesias Bolaños,&nbsp;Amalia Paniagua Ruíz,&nbsp;María Blanca Martínez-Barbeíto","doi":"10.1016/j.endonu.2016.05.006","DOIUrl":"https://doi.org/10.1016/j.endonu.2016.05.006","url":null,"abstract":"","PeriodicalId":54323,"journal":{"name":"Endocrinologia Y Nutricion","volume":"63 7","pages":"Page 375"},"PeriodicalIF":0.0,"publicationDate":"2016-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.endonu.2016.05.006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72062113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diabetes knowledge among Greek Type 2 Diabetes Mellitus patients","authors":"Dimitrios Poulimeneas ,&nbsp;Maria G. Grammatikopoulou ,&nbsp;Vasiliki Bougioukli ,&nbsp;Parthena Iosifidou ,&nbsp;Maria F. Vasiloglou ,&nbsp;Maria-Assimina Gerama ,&nbsp;Dimitrios Mitsos ,&nbsp;Ioanna Chrysanthakopoulou ,&nbsp;Maria Tsigga ,&nbsp;Kyriakos Kazakos","doi":"10.1016/j.endonu.2016.04.008","DOIUrl":"10.1016/j.endonu.2016.04.008","url":null,"abstract":"<div><h3>Background &amp; objective</h3><p>Diabetes knowledge has been shown to improve glycemic control and associate with several demographic parameters. In Greece, a country with high obesity rates, disease knowledge has never been evaluated in diabetic patients. This cross sectional study aimed to assess diabetes knowledge and its associations between social and demographic parameters, among Greek type 2 diabetes mellitus (T2DM) patients.</p></div><div><h3>Methods</h3><p>One hundred fifty nine patients with T2DM were recruited from an urban and a rural clinic in Greece. Diabetes knowledge was assessed with the Brief Diabetes Knowledge Test (DKT). Basic anthropometry was performed. Data regarding glycemic control and sociodemographic characteristics were collected from the patients’ medical files.</p></div><div><h3>Results</h3><p>Greek T2DM patients demonstrated poor disease knowledge (mean DKT score 8.3<!--> <!-->±<!--> <!-->2.2/14.0 and mean DKT as a percent of correct answers 59.6<!--> <!-->±<!--> <!-->15.8%). No differences were observed between sex, place of residence, or glycemic control, among subjects. Patients with higher education demonstrated greater diabetes knowledge. Simple obesity with concurrent central obesity or suboptimal glycemic control decreased diabetes knowledge among participants. Additionally, waist circumference was inversely correlated to diabetes knowledge.</p></div><div><h3>Conclusions</h3><p>Based on the DKT, Greek patients exhibit poor diabetes knowledge. This study provides evidence for the need for better diabetes education in order to ameliorate disease outcome.</p></div>","PeriodicalId":54323,"journal":{"name":"Endocrinologia Y Nutricion","volume":"63 7","pages":"Pages 320-326"},"PeriodicalIF":0.0,"publicationDate":"2016-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.endonu.2016.04.008","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34551700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estruma ovárico maligno y cáncer papilar de tiroides sincrónicos","authors":"Pablo Fernández Catalina,&nbsp;Antonia Rego Iraeta,&nbsp;Mónica Lorenzo Solar,&nbsp;Paula Sánchez Sobrino","doi":"10.1016/j.endonu.2016.05.002","DOIUrl":"https://doi.org/10.1016/j.endonu.2016.05.002","url":null,"abstract":"","PeriodicalId":54323,"journal":{"name":"Endocrinologia Y Nutricion","volume":"63 7","pages":"Pages 366-367"},"PeriodicalIF":0.0,"publicationDate":"2016-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.endonu.2016.05.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72062110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}