Endocrinologia Y Nutricion最新文献

{"title":"Severe systemic type 1 pseudohypoaldosteronism: 5 years of evolution","authors":"Maria Miguel Gomes , Sofia Martins , Olinda Marques , Nicole da Silva , Ana Antunes","doi":"10.1016/j.endonu.2016.08.002","DOIUrl":"https://doi.org/10.1016/j.endonu.2016.08.002","url":null,"abstract":"","PeriodicalId":54323,"journal":{"name":"Endocrinologia Y Nutricion","volume":"63 9","pages":"Pages 502-505"},"PeriodicalIF":0.0,"publicationDate":"2016-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.endonu.2016.08.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72106832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"El abordaje de la inmunoterapia específica de las enfermedades autoinmunes a través de la nanomedicina","authors":"Joan Verdaguer","doi":"10.1016/j.endonu.2016.05.003","DOIUrl":"https://doi.org/10.1016/j.endonu.2016.05.003","url":null,"abstract":"","PeriodicalId":54323,"journal":{"name":"Endocrinologia Y Nutricion","volume":"63 9","pages":"Pages 437-439"},"PeriodicalIF":0.0,"publicationDate":"2016-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.endonu.2016.05.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72069823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pathogenesis of thyroid autoimmune disease: the role of cellular mechanisms","authors":"Ana Maria Ramos-Leví,&nbsp;Mónica Marazuela","doi":"10.1016/j.endonu.2016.04.003","DOIUrl":"10.1016/j.endonu.2016.04.003","url":null,"abstract":"<div><p>Hashimoto's thyroiditis (HT) and Graves’ disease (GD) are two very common organ-specific autoimmune diseases which are characterized by circulating antibodies and lymphocyte infiltration. Although humoral and cellular mechanisms have been classically considered separately in the pathogenesis of autoimmune thyroid diseases (AITD), recent research suggests a close reciprocal relationship between these two immune pathways. Several B- and T-cell activation pathways through antigen-presenting cells (APCs) and cytokine production lead to specific differentiation of T helper (Th) and T regulatory (Treg) cells. This review will focus on the cellular mechanisms involved in the pathogenesis of AITD. Specifically, it will provide reasons for discarding the traditional simplistic dichotomous view of the T helper type 1 and 2 pathways (Th1/Th2) and will focus on the role of the recently characterized T cells, Treg and Th17 lymphocytes, as well as B lymphocytes and APCs, especially dendritic cells (DCs).</p></div>","PeriodicalId":54323,"journal":{"name":"Endocrinologia Y Nutricion","volume":"63 8","pages":"Pages 421-429"},"PeriodicalIF":0.0,"publicationDate":"2016-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.endonu.2016.04.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34525746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Falso hipertiroidismo franco por interferencia en inmunoanálisis","authors":"Olga Simó-Guerrero ,&nbsp;Gabriel Giménez-Pérez ,&nbsp;Assumpta Recasens-Gracia ,&nbsp;Carme Villà-Blasco ,&nbsp;Ignasi Castells-Fusté","doi":"10.1016/j.endonu.2016.05.001","DOIUrl":"https://doi.org/10.1016/j.endonu.2016.05.001","url":null,"abstract":"","PeriodicalId":54323,"journal":{"name":"Endocrinologia Y Nutricion","volume":"63 8","pages":"Pages 431-432"},"PeriodicalIF":0.0,"publicationDate":"2016-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.endonu.2016.05.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72061487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of lanreotide in combination with cabergoline or pegvisomant in patients with acromegaly in the clinical practice: The ACROCOMB study","authors":"Manuel Puig-Domingo ,&nbsp;Alfonso Soto ,&nbsp;Eva Venegas ,&nbsp;Ricardo Vilchez ,&nbsp;Concepción Blanco ,&nbsp;Fernando Cordido ,&nbsp;Tomás Lucas ,&nbsp;Mónica Marazuela ,&nbsp;Rosa Casany ,&nbsp;Guillem Cuatrecasas ,&nbsp;Carmen Fajardo ,&nbsp;María Ángeles Gálvez ,&nbsp;Silvia Maraver ,&nbsp;Tomás Martín ,&nbsp;Enrique Romero ,&nbsp;Miguel Paja ,&nbsp;Antonio Picó ,&nbsp;Ignacio Bernabeu ,&nbsp;Eugenia Resmini ,&nbsp;on behalf of the ACROCOMB study group","doi":"10.1016/j.endonu.2016.05.010","DOIUrl":"10.1016/j.endonu.2016.05.010","url":null,"abstract":"<div><h3>Purpose</h3><p>To describe real-world use of lanreotide combination therapy for acromegaly.</p></div><div><h3>Patients and methods</h3><p>ACROCOMB is a retrospective observational Spanish study of patients with active acromegaly treated with lanreotide combination therapy between 2006 and 2011. 108 patients treated at 44 Spanish Endocrinology Departments were analyzed separately: 61 patients received lanreotide/cabergoline (cabergoline cohort) and 47 lanreotide/pegvisomant (pegvisomant cohort).</p></div><div><h3>Results</h3><p>Patient median age was 50.8 years in the cabergoline cohort and 42.7 years in the pegvisomant cohort. Prior medical treatments were somatostatin analogue (SSA) monotherapy (40 [66%] patients) or dopamine agonists (7 [11%] patients) in the cabergoline cohort and SSA (29 [62%] patients) or pegvisomant monotherapy (16 [34%] patients) in the pegvisomant cohort. Across both cohorts 12 patients were previously untreated, and prior therapy was unknown/missing in 4 patients. Median duration of combined treatment was 1.6 years (0.1–6) and 2.1 years (0.4–6.3) in the cabergoline and pegvisomant cohorts, respectively. At baseline, median insulin growth factor (IGF)-I values were 149% upper limit of normal (ULN) (15–505%) in the cabergoline cohort and 156% ULN (15–534%) in the pegvisomant cohort, and decreased to 104% ULN (13–557%) <em>p</em> <!-->&lt;<!--> <!-->0.001 and 86% ULN (23–345%) <em>p</em> <!-->&lt;<!--> <!-->0.0001, respectively, at end of study (EOS). Normal age-adjusted values of IGF-I were obtained in 48% of lanreotide/cabergoline-treated patients and 70% of lanreotide/pegvisomant-treated patients at EOS. There were no significant changes in hepatic, cardiac or glycaemic parameters in either cohort.</p></div><div><h3>Conclusion</h3><p>In clinical practice lanreotide treatment combinations are useful options for patients with acromegaly when monotherapy is insufficient; particularly, the combination of lanreotide and pegvisomant in patients not controlled with either SSA or pegvisomant alone has high efficacy and is well-tolerated.</p></div>","PeriodicalId":54323,"journal":{"name":"Endocrinologia Y Nutricion","volume":"63 8","pages":"Pages 397-408"},"PeriodicalIF":0.0,"publicationDate":"2016-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.endonu.2016.05.010","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34755486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cetoacidosis diabética asociada a tratamiento con canagliflozina","authors":"Marta Diéguez-Felechosa,&nbsp;Lorena Suárez-Gutiérrez","doi":"10.1016/j.endonu.2016.05.008","DOIUrl":"https://doi.org/10.1016/j.endonu.2016.05.008","url":null,"abstract":"","PeriodicalId":54323,"journal":{"name":"Endocrinologia Y Nutricion","volume":"63 8","pages":"Pages 430-431"},"PeriodicalIF":0.0,"publicationDate":"2016-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.endonu.2016.05.008","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72061481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resultados perinatales entre macrosomas hijos de madre diabética y macrosomas hijos de madre no diabética","authors":"Jose Maria Lloreda-García,&nbsp;Sandra Sevilla-Denia,&nbsp;Alba Rodríguez-Sánchez,&nbsp;Pablo Muñoz-Martínez,&nbsp;Marta Díaz-Ruiz","doi":"10.1016/j.endonu.2016.04.010","DOIUrl":"https://doi.org/10.1016/j.endonu.2016.04.010","url":null,"abstract":"<div><h3>Objective</h3><p>To assess the incidence and perinatal complications of macrosomic infants born to diabetic and non-diabetic mothers.</p></div><div><h3>Patients and methods</h3><p>A six-year retrospective study of newborns at our hospital. A total of 996 macrosomic newborns were found. Maternal characteristics, mode of delivery, and perinatal outcomes were studied.</p></div><div><h3>Results</h3><p>Of 18005 newborns, 996 were macrosomic infants (5.53%). Of these, 103 (10.3%) were born to diabetic mothers. Diabetic mothers had higher parity (1.89 vs. 1.35; <em>P</em>&lt;0.000), cesarean section rate (52.4 vs. 31.1%; <em>P</em>&lt;0.05), and resuscitation rate (5.8 vs. 1.8%; <em>P</em>&lt;0.006; RR: 2.9; 95% <span>CI:</span> 1.42-5.9), and greater need for hospitalization (19.4 vs. 9.6%; p&lt;0.002; RR: 2; 95% CI: 1.3-3.2) and intensive care (5.8 vs. 0.7%; <em>P</em>&lt;0.000; RR: 5.3; 95% CI: 2.8-10) mostly for hypoglycemia (7.8 vs. 1%; <em>P</em>&lt;0.000; RR: 5; 95% CI: 2.8-8.3), jaundice (8.7 vs. 2.1%; <em>P</em>&lt;0.000; RR: 3.1; 95% CI: 1.9-5.9), respiratory distress (4.9 vs. 1.3%; <em>P</em>&lt;0.009; RR: 2.9; 95% CI: 1.4-6.7), and asphyxia (2.9 vs. 0.4%; <em>P</em>&lt;0.005; RR: 4.3; 95% CI: 1.8-11.1). No differences were found in birth trauma.</p></div><div><h3>Conclusions</h3><p>Macrosomic infants born to diabetic mothers have an increased risk of hospital admission in the neonatal period for hypoglycemia, jaundice, respiratory distress, and asphyxia, and a greater need of intensive care. Obstetric trauma rates were similar in both groups.</p></div>","PeriodicalId":54323,"journal":{"name":"Endocrinologia Y Nutricion","volume":"63 8","pages":"Pages 409-413"},"PeriodicalIF":0.0,"publicationDate":"2016-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.endonu.2016.04.010","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72061498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Esteatohepatitis no alcohólica y diabetes","authors":"Juan Caballeria ,&nbsp;Llorenç Caballeria","doi":"10.1016/j.endonu.2016.06.001","DOIUrl":"https://doi.org/10.1016/j.endonu.2016.06.001","url":null,"abstract":"","PeriodicalId":54323,"journal":{"name":"Endocrinologia Y Nutricion","volume":"63 8","pages":"Pages 377-379"},"PeriodicalIF":0.0,"publicationDate":"2016-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.endonu.2016.06.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72061499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impacto económico y satisfacción de la implantación de una consulta de alta resolución de patología nodular tiroidea en Endocrinología","authors":"Gonzalo Díaz-Soto,&nbsp;Beatriz Torres,&nbsp;Juan Jose López Gómez,&nbsp;Emilia Gómez Hoyos,&nbsp;Aurelia Villar,&nbsp;Enrique Romero,&nbsp;Daniel A. de Luis","doi":"10.1016/j.endonu.2016.04.005","DOIUrl":"https://doi.org/10.1016/j.endonu.2016.04.005","url":null,"abstract":"<div><h3>Background and objective</h3><p>No conclusive data exist on the value of a high resolution thyroid nodule clinic for management of nodular thyroid disease. The aim of this study was to evaluate the economic impact of and user satisfaction with a high resolution thyroid nodule clinic (HRTNC) in coordination with primary care.</p></div><div><h3>Patients and method</h3><p>A prospective, observational, descriptive study was conducted to analyze data from 3,726 patients (mean age 61<!--> <!-->±<!--> <!-->12 years; 85% women) evaluated at an HRTNC during 2014 and 2015. Demographic data (sex and age), number of ultrasound examinations and fine needle aspiration cytologies (FNAC), referral center and consultation type were assessed.</p></div><div><h3>Results</h3><p>In 2014 and 2015, 3,726 neck ultrasound examinations and 926 FNACs (3.8% rated as non-diagnostic) were performed. Among the 1,227 patients evaluated for the first time, 21.5% did not require a second endocrine appointment, which resulted in mean estimated savings of 14,354.55 euros. Of all patients, 41.1% were referred from primary care, 33.4% from endocrinology, and 26.5% from other specialties. As compared to 2013, the number of thyroid ultrasound examinations requested decreased by 65.3% and 59.7% in 2014 and 2015 respectively, with mean estimated savings of 137,563.92 euros. Mean user satisfaction assessed was 4.0 points (95% confidence interval, 3.7-4.3) on a 5-point scale.</p></div><div><h3>Conclusions</h3><p>HRTNCs at endocrinology departments, coordinated with primary care, are a viable, cost-effective alternative with a positive user perception.</p></div>","PeriodicalId":54323,"journal":{"name":"Endocrinologia Y Nutricion","volume":"63 8","pages":"Pages 414-420"},"PeriodicalIF":0.0,"publicationDate":"2016-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.endonu.2016.04.005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72061489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acidosis por D-lactato: una causa inusual de acidosis metabólica","authors":"Alejandra Planas-Vilaseca,&nbsp;Fernando Guerrero-Pérez,&nbsp;Agustina P. Marengo,&nbsp;Rafael Lopez-Urdiales,&nbsp;Núria Virgili-Casas","doi":"10.1016/j.endonu.2016.04.007","DOIUrl":"https://doi.org/10.1016/j.endonu.2016.04.007","url":null,"abstract":"","PeriodicalId":54323,"journal":{"name":"Endocrinologia Y Nutricion","volume":"63 8","pages":"Pages 433-434"},"PeriodicalIF":0.0,"publicationDate":"2016-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.endonu.2016.04.007","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72061488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}