Gastroenterology Report最新文献

{"title":"A novel detachable over-the-scope clip system for the management of esophageal inlet perforation secondary to endoscopic ultrasonography procedures.","authors":"Benhua Wu, Lisheng Wang, Wenbiao Chen","doi":"10.1093/gastro/goaf043","DOIUrl":"10.1093/gastro/goaf043","url":null,"abstract":"","PeriodicalId":54275,"journal":{"name":"Gastroenterology Report","volume":"13 ","pages":"goaf043"},"PeriodicalIF":3.8,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12102062/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144144314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gas in endoscopic full-thickness resection: a potential culprit in combined thoracoabdominal injury?","authors":"Yuewen Li, Xiuyu Zhang, Xuehui Yan, Yuxuan Chen, Shuo Zhang","doi":"10.1093/gastro/goaf038","DOIUrl":"https://doi.org/10.1093/gastro/goaf038","url":null,"abstract":"","PeriodicalId":54275,"journal":{"name":"Gastroenterology Report","volume":"13 ","pages":"goaf038"},"PeriodicalIF":3.8,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12077760/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical features and endoscopic management of sharp wooden object ingestions: a systematic review of 479 cases.","authors":"Kay Chen, Benjamin Chipkin, Alyssa A Grimshaw, Fateh Bazerbachi, Darrick K Li","doi":"10.1093/gastro/goaf035","DOIUrl":"10.1093/gastro/goaf035","url":null,"abstract":"<p><strong>Background and aims: </strong>Ingested sharp objects pose increased risks of adverse events compared with other foreign bodies. We conducted the largest systematic review to date of sharp wooden object ingestions to elucidate patterns in clinical presentation and guide management practices.</p><p><strong>Methods: </strong>Cochrane Library, Google Scholar, Ovid MEDLINE, Ovid Embase, PubMed, Scopus, and Web of Science Core Collection databases were searched for cases of adults who ingested sharp wooden objects. Descriptive statistics were reported for risk factors, clinical presentations, laboratory and imaging findings, adverse events, and treatments.</p><p><strong>Results: </strong>Analysis of 479 cases showed that most patients were unaware of ingestion (74.8%) and toothpicks were the most common ingested item (92.5%). Male sex (70.1%), substance use (9.4%), and edentulousness (6.1%) were risk factors. Common symptoms included abdominal pain (83.7%) and fever (36.7%). Imaging identified the object in 48.1% of cases, with computed tomography being the most sensitive (54.7%). Objects were commonly found in the gastrointestinal tract (79.3%). They were consistently found in the gastrointestinal tract when patients were aware of ingestion or imaging showed an intraluminal/transluminal location. Endoscopy visualized the objects 76.1% of the time, with successful removal in 88.8% of cases; 4.7% of patients required surgery following endoscopic removal. Adverse events included perforation (87.5%) and abscess (33.0%), with a mortality rate of 5.0%.</p><p><strong>Conclusions: </strong>Ingestion of sharp wooden objects presents heterogeneously and can lead to serious complications. Endoscopic removal is safe and effective. We propose a clinical algorithm to guide physicians in diagnosing and managing suspected sharp wooden object ingestion.</p>","PeriodicalId":54275,"journal":{"name":"Gastroenterology Report","volume":"13 ","pages":"goaf035"},"PeriodicalIF":3.8,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12073997/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144058281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term exposure to constant light disrupts intestinal stem cells through sympathoexcitation-induced Wnt5a signaling inhibition.","authors":"Yu-Wan Wang, Qin-Yao Li, Ling-Feng Liu, Xing Tan, Wen Wang, Jia-Cen Sun, Wei-Zhong Wang","doi":"10.1093/gastro/goaf031","DOIUrl":"10.1093/gastro/goaf031","url":null,"abstract":"<p><strong>Background: </strong>Long-term exposure to constant light is becoming a prevalent lifestyle that is associated with irritable bowel syndrome (IBS), a chronic functional gastrointestinal disorder. Intestinal stem cells (ISCs) are an important population of cells that maintain homeostasis and function of intestinal tissues. The purpose of this study was to identify the effects of long-term constant light exposure on gastrointestinal function and the potential mechanisms of sympathetic activity on ISC.</p><p><strong>Methods: </strong>Rats housed in a 24 h constant light chamber for 4 weeks were used as the constant light exposure animal model. Hematoxylin-eosin staining and immunohistochemical examination were used to determine the pathological changes of the intestine. Propranolol (<i>ARs</i> inhibitor; 40 mg/kg/day), metoprolol (<i>ADRβ1</i> inhibitor; 50 mg/kg/day), and Box5 (<i>Wnt5a</i> inhibitor; 2 μg/day) were used to examine the effect of sympathoexcitation and Wnt signaling pathway on constant light-induced gastrointestinal disorders.</p><p><strong>Results: </strong>We found that 4 weeks of constant light exposure in rats resulted in a decrease in the number of ISC and an increase in sympathetic activity. Intestinal β1-adrenoceptor expression and reactive oxygen species (ROS) were significantly increased, but <i>Wnt5a</i> expression decreased in the continuous light-exposed rats. Similarly, we found that administration of the β1-adrenoceptor antagonist metoprolol for 4 weeks attenuated the effects of continuous light exposure on the intestine, which was rescued by the reintroduction of <i>Wnt5a</i>.</p><p><strong>Conclusion: </strong>Taken together, these data indicate that sympathoexcitation is critical for disruption of ISC under constant light exposure, suggesting that targeting β1-adrenoceptor/oxidative stress/<i>Wnt5a</i> axis may be a potential strategy for ISC disruption induced by prolonged sustained light exposure, providing a new direction for IBS treatment.</p>","PeriodicalId":54275,"journal":{"name":"Gastroenterology Report","volume":"13 ","pages":"goaf031"},"PeriodicalIF":3.8,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12116419/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144175647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Liver cirrhosis in metabolic dysfunction-associated steatohepatitis.","authors":"Donghyun Ko, Do Han Kim, Pojsakorn Danpanichkul, Masahito Nakano, Chitchai Rattananukrom, Karn Wijarnpreecha, Cheng Han Ng, Mark D Muthiah","doi":"10.1093/gastro/goaf037","DOIUrl":"https://doi.org/10.1093/gastro/goaf037","url":null,"abstract":"<p><p>In the present narrative review, we have summarized the current evidence on the natural progression of metabolic dysfunction-associated steatohepatitis (MASH) cirrhosis observed through the placebo arm in clinical trials and observational studies. The outcomes scrutinized throughout our review were histology-related changes, non-invasive fibrosis markers, indicators of decompensation, end-stage hepatic complications, and mortality reported during the different clinical trials. Given the short duration of clinical trials, observational studies were included to obtain better insight into the long-term progression and prognosis of MASH cirrhosis. Lastly, new updates about MASH cirrhosis treatments were listed, and the results of these randomized clinical trials were described to enhance our understanding of our current standing in the treatment of MASH cirrhosis.</p>","PeriodicalId":54275,"journal":{"name":"Gastroenterology Report","volume":"13 ","pages":"goaf037"},"PeriodicalIF":3.8,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12065432/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144005644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endoscopic ultrasound-guided rendezvous technique with dual endoscopic technique rescue the difficult cannulation after Billroth type II gastrectomy.","authors":"Jiao Tian, Yaoting Li, Yankun Hou, Tingting Yu, Lichao Zhang, Guoying Wang, Senlin Hou","doi":"10.1093/gastro/goaf036","DOIUrl":"https://doi.org/10.1093/gastro/goaf036","url":null,"abstract":"","PeriodicalId":54275,"journal":{"name":"Gastroenterology Report","volume":"13 ","pages":"goaf036"},"PeriodicalIF":3.8,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12043204/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144040817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of chewing gum combined with WeChat-enhanced instruction on bowel preparation in constipated patients: a randomized-controlled trial.","authors":"Cong Gao, Deli Zou, Weiyi Wang, Yingchao Li, Jie Han, Dongshuai Su, Xingshun Qi","doi":"10.1093/gastro/goaf034","DOIUrl":"https://doi.org/10.1093/gastro/goaf034","url":null,"abstract":"<p><strong>Background and aims: </strong>Constipated patients have higher risk of poor bowel preparation and suffer from dysfunction of the intestinal motor. Chewing gum can stimulate gut motility and enhanced instructions can improve the quality of bowel preparation. The objective of this study was to investigate whether chewing gum combined with WeChat-enhanced instruction can increase the quality of bowel preparation in constipated patients.</p><p><strong>Methods: </strong>This was a single-center, endoscopist-blinded, randomized-controlled trial. Patients were assigned (1:1) to the chewing gum and WeChat-enhanced instruction (CGW) group and the control group. Patients in both groups received 3 L of polyethylene glycol (PEG) before colonoscopy. Patients in the CGW group were asked to chew one piece of gum for 20 min after drinking each 1 L of PEG and received enhanced instruction via WeChat the day before colonoscopy. The quality of the bowel preparation (primary outcome), adenoma and/or polyp detection rate (ADR/PDR), number of polyps and/or adenomas, procedure time, and adverse events were compared.</p><p><strong>Results: </strong>A total of 115 patients were finally analysed, including 60 in the CGW group and 55 in the control group. The proportion of adequate bowel preparation and the Boston Bowel Preparation Scale score were not statistically different between the two groups (76.7% vs 70.9%; 6.80 ± 1.42 vs 6.40 ± 1.78; both <i>P </i>><i> </i>0.05). There was no significant difference in the ADR/PDR and number of polyps and/or adenomas (both <i>P </i>><i> </i>0.05). However, there was a significantly higher incidence of nausea in the CGW group than in the control group (33.3% vs 16.4%, <i>P </i>=<i> </i>0.036).</p><p><strong>Conclusions: </strong>Chewing gum combined with WeChat-enhanced instruction does not improve the quality of bowel preparation for colonoscopy in constipated patients but does increase the incidence of nausea.</p>","PeriodicalId":54275,"journal":{"name":"Gastroenterology Report","volume":"13 ","pages":"goaf034"},"PeriodicalIF":3.8,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12036959/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144058286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endoscopic gas leak in diverted colon mimics perforation.","authors":"Julia L Beilis, Bo Shen","doi":"10.1093/gastro/goaf033","DOIUrl":"https://doi.org/10.1093/gastro/goaf033","url":null,"abstract":"","PeriodicalId":54275,"journal":{"name":"Gastroenterology Report","volume":"13 ","pages":"goaf033"},"PeriodicalIF":3.8,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12022212/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144026773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TRUB1 is a novel biomarker for promoting malignancy in colorectal cancer via NFκB signaling.","authors":"Yingzhao Wang, Yonghuang Tan, Tianhao Zhang, Zhaoliang Wang, Jingru Gong, Zhenshuang Du, Yong Mei, Jinping Ma","doi":"10.1093/gastro/goaf027","DOIUrl":"https://doi.org/10.1093/gastro/goaf027","url":null,"abstract":"<p><strong>Background: </strong>Colorectal cancer (CRC) is one of the most aggressive malignancies of the digestive tract, characterized by aberrant post-transcriptional RNA modifications, including pseudouridine (Ψ). TruB pseudouridine synthase family member 1 (TRUB1) is a key pseudouridine synthase but its role in CRC progression remains unclear.</p><p><strong>Methods: </strong>Public databases and CRC cell lines were analysed to assess TRUB1 expression in CRC. Receiver-operating characteristic (ROC) curve analysis and survival analysis were performed to evaluate the diagnostic and prognostic significance of TRUB1. The impact of TRUB1 on tumor proliferation and Ψ modification was examined in TRUB1-knock-down HCT116 cell lines. Mechanistically, RNA sequencing of control and TRUB1-knock-down HCT116 cells was conducted to identify potential pathways, which were validated by using real-time polymerase chain reaction (PCR), Western blot, and immunofluorescence assays.</p><p><strong>Results: </strong>TRUB1 was significantly upregulated in CRC tumor tissues and cell lines. ROC analysis showed that TRUB1 had strong diagnostic potential and its overexpression was associated with poorer overall survival in CRC patients. In TRUB1-knock-down HCT116 cells, apoptosis increased and tumor growth slowed in nude mice, with a corresponding increase in apoptosis-related proteins and decreased Ψ modification. Mechanistically, RNA sequencing indicated that tumor necrosis factor α signaling via the nuclear factor kappa B (NFκB) pathway was activated in TRUB1-knock-down HCT116 cells. Further analysis identified Baculoviral inhibitor of apoptosis proteins repeat-containing 3 (BIRC3) as a potential downstream target gene that was regulated by TRUB1 in the NFκB pathway.</p><p><strong>Conclusions: </strong>TRUB1 serves as a potential biomarker for CRC diagnosis and prognosis, and it can inhibit apoptosis in CRC cells via BIRC3-mediated NFκB signaling.</p>","PeriodicalId":54275,"journal":{"name":"Gastroenterology Report","volume":"13 ","pages":"goaf027"},"PeriodicalIF":3.8,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12011359/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144009666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intestinal decompression and drainage in preventing post-endoscopic submucosal dissection electrocoagulation syndrome in colorectal ESD: a prospective study.","authors":"Yunpeng Dong, Jiao Liu, Wen Jia, Meng Zhang, Xuezhu Wang, Meiling Lin, Zhuo Yang","doi":"10.1093/gastro/goaf020","DOIUrl":"https://doi.org/10.1093/gastro/goaf020","url":null,"abstract":"<p><strong>Background and aims: </strong>This study explored the efficacy of a prophylactic intestinal decompression tube in reducing the incidence of post-endoscopic submucosal dissection electrocoagulation syndrome (PECS).</p><p><strong>Methods: </strong>A total of 157 eligible patients with colorectal mucosal lesions scheduled for endoscopic submucosal dissection (ESD) were prospectively recruited; after drop out 11 patients, 146 patients were randomly assigned to an experimental group (group 1, <i>n </i>=<i> </i>73) or control group (group 2, <i>n </i>=<i> </i>73). Patients in the experimental group underwent placement of an intestinal decompression drainage tube after ESD, while the control group received no additional treatment after ESD. The primary outcome was the incidence of PECS. Secondary outcomes included the incidence of postoperative complications, time to removal of the intestinal decompression tube, the degree of abdominal pain as measured by the visual analog scale (VAS), and the participants' self-rated comfort level with the intestinal decompression tube.</p><p><strong>Results: </strong>A total of 146 patients (<i>n </i>=<i> </i>73 per group) were finally analyzed between July 2022 and February 2023. All tumors were successfully resected en bloc. A significant difference in the incidence of PECS was found between group 1 and group 2 (5.5% vs 16.4%; <i>P </i>=<i> </i>0.034). Precisely, 61.6% of patients felt painless for intestinal decompression tube, and no severe or unbearable pain was reported.</p><p><strong>Conclusions: </strong>The placement of intestinal decompression drainage tube could reduce the incidence of PECS after colorectal ESD, which might play a preventive role in the occurrence of PECS.</p>","PeriodicalId":54275,"journal":{"name":"Gastroenterology Report","volume":"13 ","pages":"goaf020"},"PeriodicalIF":3.8,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12000527/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144059867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}