Gastroenterology Report最新文献

{"title":"Perioperative immune-related adverse events in gastric cancer: a new challenge for surgical safety in the era of neoadjuvant immunotherapy.","authors":"Zhouqiao Wu, Jingpu Wang, Ziyu Li, Jiafu Ji","doi":"10.1093/gastro/goag045","DOIUrl":"https://doi.org/10.1093/gastro/goag045","url":null,"abstract":"","PeriodicalId":54275,"journal":{"name":"Gastroenterology Report","volume":"14 ","pages":"goag045"},"PeriodicalIF":4.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13132655/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147823264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metformin for preventing esophageal stricture after circumferential endoscopic submucosal dissection in a canine model.","authors":"Ling Yang, Binbin Xu, Chunwei Fan, Yuju Huang, Li Yu","doi":"10.1093/gastro/goag040","DOIUrl":"https://doi.org/10.1093/gastro/goag040","url":null,"abstract":"<p><strong>Background: </strong>Esophageal stricture frequently occur after extensive endoscopic submucosal dissection (ESD). Effective, safe, and straightforward prevention and treatment methods are lacking. This preclinical animal study evaluated the efficacy of metformin in preventing esophageal stricture following ESD using a dog model.</p><p><strong>Methods: </strong>Ten Beagle dogs were randomly divided into the metformin and control groups. Circumferential esophageal ESD was performed 30-33 cm from the incisors. The metformin group received 100 mg/kg/day metformin from the second postoperative day, while the control group received physiological saline by gavage. After 4 weeks, the Beagles were euthanized, and esophageal tissues were collected for macroscopic and pathological evaluations.</p><p><strong>Results: </strong>Four weeks post-ESD, the modified dysphagia scores in the metformin group were lower than the control [1 (1, 2) vs 3 (3, 4), <i>P </i>= 0.041, Cliff's D = -0.80 (-0.97 to -0.14)]. Macroscopic examination showed that the stricture rate in the metformin group was lower than the control [38.60% (32.50%, 44.30%) vs 53.90% (52.30%, 62.00%), <i>P </i>= 0.056, Cliff's D = -0.76 (-0.97 to 0.09)]. Hematoxylin and eosin staining revealed that the re-epithelialization rate in the metformin group was higher than the control [88.30% (85.60%, 90.10%) vs 20.60% (11.20%, 27.40%), <i>P </i>= 0.008, Cliff's D = 1.00 (0.82-1.00)]. Masson's trichrome staining indicated that the submucosal fibrosis in the metformin group was thin and orderly, with a maximum thickness of 863.00 (786.00, 932.00) μm, whereas the control group exhibited disordered fibrosis with a maximum thickness of 1,275.00 (1,266.00, 1,340.00) μm [<i>P </i>= 0.008, Cliff's D = -1.00 (-1.00 to -0.82)].</p><p><strong>Conclusion: </strong>Metformin effectively promoted esophageal wound re-epithelialization after ESD, reduced submucosal fibrosis, and showed a trend toward alleviating esophageal stricture.</p>","PeriodicalId":54275,"journal":{"name":"Gastroenterology Report","volume":"14 ","pages":"goag040"},"PeriodicalIF":4.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13134663/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147822932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"First-line nanoparticle polymeric micellar paclitaxel with gemcitabine in metastatic pancreatic cancer: a single-arm, prospective, and exploratory study.","authors":"Nan Lyu, Qianqian Wang, Kuirong Jiang, Dong Xu, Yang Wu, Kai Zhang, Jishu Wei, Jianmin Chen, Feng Guo, Zipeng Lu, Bin Xiao, Guosheng Chen, Junli Wu, Wentao Gao, Yuqi Wang, Fufeng Wang, Min Tu","doi":"10.1093/gastro/goag034","DOIUrl":"https://doi.org/10.1093/gastro/goag034","url":null,"abstract":"<p><strong>Background: </strong>Pancreatic cancer is one of the most lethal malignancies, with limited therapeutic options. In this exploratory trial, we aimed to evaluate the efficacy and safety of nanoparticle polymeric micellar paclitaxel (pm-Pac) combined with gemcitabine as first-line treatment for metastatic pancreatic cancer (mPC).</p><p><strong>Methods: </strong>Twenty-one patients with histologically or cytologically confirmed mPC were enrolled in this study. The primary endpoint was progression-free survival (PFS). Meanwhile, the secondary endpoints included the objective response rate (ORR), overall survival, disease control rate (DCR), duration of response (DOR), and safety of combination therapy.</p><p><strong>Results: </strong>The median PFS was 7.4 months (95% confidence interval [CI]: 5.4-9.4 months). The ORR and DCR were 52.4% (95% CI: 29.1%-75.7%) and 95.2% (95% CI: 85.3%-100%), respectively. Amongst patients who achieved partial response, the median DOR was 4.8 months (95% CI: 1.5-8.1 months). No treatment-related deaths were reported. Grade 3-4 adverse events (AEs) occurred in 81.0% of patients, with increased γ-glutamyltransferase levels (38.1%), neutropenia (33.3%), and leukocytopenia (28.6%) being the most frequent AEs. Low SERPINB3 and SERPINB4 expression was correlated with prolonged PFS, accompanied by the significant downregulation of gene sets involved in DNA replication, nonsense-mediated mRNA decay, and protein translation in long-PFS tumours. Tumour immune microenvironment analysis revealed that patients with short PFS had increased levels of common lymphoid progenitors and decreased populations of mature B and T lymphocytes.</p><p><strong>Conclusions: </strong>The combination of pm-Pac and gemcitabine as first-line therapy for mPC exhibited favourable tolerability and clinical efficacy. However, larger randomized-controlled trials are needed to validate these preliminary findings.</p><p><strong>Trial registration: </strong>www.chictr.org.cn, ChiCTR2300078861.</p>","PeriodicalId":54275,"journal":{"name":"Gastroenterology Report","volume":"14 ","pages":"goag034"},"PeriodicalIF":4.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13132657/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147823521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Natural history, clinical associations, and management issues of idiopathic sclerosing mesenteritis: a prospective cohort study.","authors":"Christina Liava, Danai Chourmouzi, Emmanouil Sinakos, Georgia Gioula, Evangelos Akriviadis","doi":"10.1093/gastro/goag035","DOIUrl":"https://doi.org/10.1093/gastro/goag035","url":null,"abstract":"","PeriodicalId":54275,"journal":{"name":"Gastroenterology Report","volume":"14 ","pages":"goag035"},"PeriodicalIF":4.2,"publicationDate":"2026-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13109999/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147789158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multisystem toxicity and non-cirrhotic portal hypertension linked to arsenic exposure from a traditional herbal preparation.","authors":"You Deng, Guanhua Zhang, Weijia Duan, Xinyan Zhao","doi":"10.1093/gastro/goag036","DOIUrl":"https://doi.org/10.1093/gastro/goag036","url":null,"abstract":"","PeriodicalId":54275,"journal":{"name":"Gastroenterology Report","volume":"14 ","pages":"goag036"},"PeriodicalIF":4.2,"publicationDate":"2026-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13109998/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147789161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Partial splenic infarction after endoscopic hemostasis: a case report.","authors":"Qing Li, Xiaocun Xing, Jiahuan Liu, Xue Xiao","doi":"10.1093/gastro/goag029","DOIUrl":"https://doi.org/10.1093/gastro/goag029","url":null,"abstract":"","PeriodicalId":54275,"journal":{"name":"Gastroenterology Report","volume":"14 ","pages":"goag029"},"PeriodicalIF":4.2,"publicationDate":"2026-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13105837/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147789238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endoscopic therapy for multifocal early esophageal cancer complicated by esophageal varices: a case report.","authors":"Yanbin Wei, Zinan Zhang, Jiafei Peng, Fuliang He, Lixue Xu, Xin Yao, Peng Li, Jie Xing","doi":"10.1093/gastro/goag038","DOIUrl":"https://doi.org/10.1093/gastro/goag038","url":null,"abstract":"","PeriodicalId":54275,"journal":{"name":"Gastroenterology Report","volume":"14 ","pages":"goag038"},"PeriodicalIF":4.2,"publicationDate":"2026-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13099638/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147789227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Type 1 autoimmune pancreatitis presenting with exophytic pancreatic mass formation and ascites: a case report.","authors":"Yusuke Kitera, Junichi Kaneko, Shioto Suzuki, Daijiro Suzuki, Kohei Nishizawa, Yuichi Hirano, Shinya Ikeda, Takuya Otsu, Masaki Takinami, Yurimi Takahashi, Yuzo Sasada, Kazuhito Kawata, Satoshi Tamura","doi":"10.1093/gastro/goag030","DOIUrl":"https://doi.org/10.1093/gastro/goag030","url":null,"abstract":"","PeriodicalId":54275,"journal":{"name":"Gastroenterology Report","volume":"14 ","pages":"goag030"},"PeriodicalIF":4.2,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13094541/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147789250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of long-term outcomes between endoscopic submucosal dissection and esophagectomy for superficial esophageal squamous cell carcinoma.","authors":"Byeong Yun Ahn, Quanxin Zheng, Soo-Jeong Cho, Sang Gyun Kim, Chang Hyun Kang, Hyunsoo Chung","doi":"10.1093/gastro/goag032","DOIUrl":"https://doi.org/10.1093/gastro/goag032","url":null,"abstract":"<p><strong>Background: </strong>Endoscopic submucosal dissection (ESD) is increasingly being performed as a less invasive alternative to esophagectomy for superficial esophageal squamous cell carcinoma (SESCC); however, comparative long-term outcome data, especially for non-curative resection (non-CR) cases and elderly patients, remain limited. This study aimed to compare the clinical outcomes of ESD and esophagectomy using a propensity score (PS)-matched cohort.</p><p><strong>Methods: </strong>Patients with SESCC who underwent ESD or esophagectomy at a tertiary referral center between 2011 and 2021 were retrospectively reviewed. In the PS-matched cohort, overall survival (OS), disease-specific survival (DSS), recurrence-free survival (RFS), additional treatments, and adverse events were compared. Subgroup analyses were conducted for non-CR cases and elderly patients (≥70 years).</p><p><strong>Results: </strong>Among the 63 PS-matched pairs, OS, DSS, and RFS were comparable between the ESD and esophagectomy groups. The 5-year OS, DSS, and RFS rates were 89.9% versus 79.2%, 95.7% versus 94.4%, and 90.6% versus 89.1%, respectively. The ESD group had significantly fewer adverse events (47.6% vs 68.3%, <i>P </i>< 0.05) and a shorter median hospital stay (1.0 vs 10.0 days, <i>P </i>< 0.001) than the esophagectomy group. Survival outcomes were also similar in the non-CR and elderly subgroups.</p><p><strong>Conclusions: </strong>ESD is a safe and effective alternative to esophagectomy for SESCC, including in non-CR and elderly patients. Given the limitations of preprocedural depth assessment and the high risk of complications associated with esophagectomy, staging ESD for SESCC may represent a reasonable treatment option, particularly for elderly or high-risk patients.</p>","PeriodicalId":54275,"journal":{"name":"Gastroenterology Report","volume":"14 ","pages":"goag032"},"PeriodicalIF":4.2,"publicationDate":"2026-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13092296/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147730728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrated endoscopy: a new method for improving the diagnostic accuracy of <i>Helicobacter pylori</i> infection status.","authors":"Dong Yang, Nan Zhang, Ke Tao, Meng Li, Hong Xu","doi":"10.1093/gastro/goag027","DOIUrl":"10.1093/gastro/goag027","url":null,"abstract":"<p><strong>Aim: </strong>We proposed an integrated endoscopic strategy and compared it with conventional methods to assess whether it improves the diagnostic accuracy of <i>Helicobacter pylori</i> infection status.</p><p><strong>Methods: </strong>A retrospective cohort (between 1 August 2022 and 30 April 2024; <i>n</i> = 163) was used to compare white light endoscopy (WLE) and magnifying endoscopy (ME) and to prespecify the integrated endoscopy (IE) algorithm. IE first uses ME to grade the proportion of fundic crypt openings and then applies WLE features to classify <i>H. pylori</i> status. A prospective cohort (between 1 May 2024 and 30 December 2024; <i>n</i> = 221) applied the locked IE algorithm and compared its performance with WLE and ME. The primary outcome was overall diagnostic accuracy; secondary outcomes were accuracy for each infection status category.</p><p><strong>Results: </strong>In the retrospective cohort, IE achieved higher overall accuracy than WLE and ME (79.8% vs 69.9% and 71.8%, respectively), with improved accuracy for negative (85.4%) and eradicated status (72.5%). ME was more accurate than WLE for negative (82.9% vs 61.0%) and eradicated status (62.7% vs 52.9%), whereas WLE was more accurate for positive status (87.3% vs 71.8%). In the prospective cohort, IE again showed the highest overall accuracy (86.4% vs 70.6% for WLE and 72.9% for ME), with higher accuracy for negative (90.7%) and eradicated status (92.4%), while WLE maintained higher accuracy for positive status (89.8% vs 78.4% for IE).</p><p><strong>Conclusion: </strong>IE that combines ME-based fundic crypt opening assessment with WLE features may improve endoscopic classification of overall, negative, and eradicated <i>H. pylori</i> infection status compared with WLE or ME alone. These findings support IE as a promising diagnostic approach that warrants further multicenter confirmation. (ClinicalTrials.gov, NCT06397066.).</p>","PeriodicalId":54275,"journal":{"name":"Gastroenterology Report","volume":"14 ","pages":"goag027"},"PeriodicalIF":4.2,"publicationDate":"2026-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13033319/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147582531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}