Gastroenterology Report最新文献

{"title":"Technical challenge of EUS-guided pancreatic duct drainage with gastroscopy for pediatric pancreaticojejunostomy stricture.","authors":"Longwei Fang, Zhen Liang, Kun Lian, Senlin Hou, Lichao Zhang","doi":"10.1093/gastro/goae109","DOIUrl":"10.1093/gastro/goae109","url":null,"abstract":"","PeriodicalId":54275,"journal":{"name":"Gastroenterology Report","volume":"13 ","pages":"goae109"},"PeriodicalIF":3.8,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11723821/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142973292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect and application of adiponectin in hepatic fibrosis.","authors":"Taoran Chen, Wenjing Yang, Rongrong Dong, Han Yao, Miao Sun, Jiaxin Wang, Qi Zhou, Jiancheng Xu","doi":"10.1093/gastro/goae108","DOIUrl":"10.1093/gastro/goae108","url":null,"abstract":"<p><p>Hepatic fibrosis, a degenerative liver lesion, significantly contributes to the deterioration and mortality among patients with chronic liver diseases. The condition arises from various factors including toxins, such as alcohol, infections like different types of viral hepatitis, and metabolic diseases. Currently, there are no effective treatments available for liver fibrosis. Recent research has shown that adiponectin (ADPN) exhibits inhibitory effects on hepatic fibrosis. ADPN, an adipocytokine secreted by mature adipocytes, features receptors that are widely distributed across multiple tissues, especially the liver. In the liver, direct effects of ADPN on liver fibrosis include reducing inflammation and regulating hepatic stellate cell proliferation and migration. And its indirect effects include alleviating hepatic endoplasmic reticulum stress and reducing inflammation in hepatic lobules, thereby mitigating hepatic fibrosis. This review aims to elucidate the regulatory role of ADPN in liver fibrosis, explore how ADPN and its receptors alleviate endoplasmic reticulum stress, summarize ADPN detection methods, and discuss its potential as a novel marker and therapeutic agent in combating hepatic fibrosis.</p>","PeriodicalId":54275,"journal":{"name":"Gastroenterology Report","volume":"12 ","pages":"goae108"},"PeriodicalIF":3.8,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11683834/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142907899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uncovering novel therapeutic clues for hypercoagulable active ulcerative colitis: novel findings from old data.","authors":"Zhexuan Yu, Danya Zhao, Yusen Zhang, Kezhan Shen, Shisi Shao, Xiaobo Chen, Jianlong Shu, Guanhua Li","doi":"10.1093/gastro/goae105","DOIUrl":"10.1093/gastro/goae105","url":null,"abstract":"<p><strong>Background: </strong>Hypercoagulability has been shown to act as an important component of ulcerative colitis (UC) pathogenesis and disease activity, and is strongly correlated with the occurrence of venous thromboembolism (VTE). This study aimed at providing novel therapeutic clues for hypercoagulable active UC.</p><p><strong>Methods: </strong>The coagulation score model was developed using VTE cohorts, and the predictive performance of this model was evaluated by coagulation subtypes of UC patients, which were clustered by the unsupervised method. Subsequently, the response of UC of distinct coagulation types, as identified by the coagulation scoring model, to different biological agents was evaluated. Immunoinflammatory cells and molecules that were associated with hypercoagulable active UC were explored by employing gene set variation analysis, single-sample gene set enrichment analysis, univariate logistic regression analysis, and immunohistochemistry.</p><p><strong>Results: </strong>A coagulation scoring model was established, which includes five key coagulation factors (ARHGAP35, CD46, BTK, C1QB, and F2R), and accurately distinguished the coagulation subtypes of UC. When comparing anti-TNF-α agents with other biological agents after determining the model, especially golimumab, it showed more effective treatment for hypercoagulable active UC. CXCL8 has been identified as playing an important role in the tightly interconnected network between the immune-inflammatory system and coagulation system in UC. Immunohistochemical analysis showed that the expression of CXCL8, BTK, C1QB, and F2R was upregulated in active UC.</p><p><strong>Conclusions: </strong>Anti-TNF-α agents have significant therapeutic effects on hypercoagulable active UC, and the strong association between CXCL8, hypercoagulation, and disease activity provides a novel therapeutic insight into hypercoagulable active UC.</p>","PeriodicalId":54275,"journal":{"name":"Gastroenterology Report","volume":"12 ","pages":"goae105"},"PeriodicalIF":3.8,"publicationDate":"2024-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11681937/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142903846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Amino acid-based enteral nutrition is effective for pediatric Crohn's disease: a multicenter prospective study.","authors":"","doi":"10.1093/gastro/goae107","DOIUrl":"https://doi.org/10.1093/gastro/goae107","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1093/gastro/goad072.].</p>","PeriodicalId":54275,"journal":{"name":"Gastroenterology Report","volume":"12 ","pages":"goae107"},"PeriodicalIF":3.8,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11669312/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142900112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current status of serum metabolites biomarkers for polyps and colorectal cancer: a systematic review.","authors":"Maryam Fatimah Abu Bakar, Azmawati Mohammed Nawi, Siok Fong Chin, Suzana Makpol","doi":"10.1093/gastro/goae106","DOIUrl":"10.1093/gastro/goae106","url":null,"abstract":"<p><strong>Background: </strong>Early detection of colorectal cancer (CRC) is crucial to enhance the disease treatment and prognosis of patients. Colonoscopy remains the gold standard for CRC detection; however, it requires trained personnel with expensive tools. Currently, serum metabolites have been discovered to be used to discriminate patients with polyps and CRC. This study aimed to identify the most commonly detected predictive serum metabolites for polyps and CRC.</p><p><strong>Methods: </strong>A systematic search of the Web of Science, PubMed, and Cochrane Library databases was conducted using PRISMA guidelines. Ten studies investigating serum metabolite biomarkers of CRC and polyps using different analytical platforms and study populations were included. QUADOMICS tool was used to analyse the quality of the included studies. All reported metabolites were then enriched into the pathways using MetaboAnalyst 5.0.</p><p><strong>Results: </strong>We found that several potential signature metabolites overlapped between studies, including tyrosine, lysine, cystine, arabinose, and lactate for CRC and lactate and glutamate for polyps. The most affected pathways related to CRC were the urea cycle, glutathione metabolism, purine metabolism, glutamate metabolism, and ammonia recycling. In contrast, those affected in the polyps were the urea cycle, glutamate metabolism, glutathione metabolism, arginine and proline metabolism, and carnitine synthesis.</p><p><strong>Conclusions: </strong>This review has found commonly detected serum metabolites for polyps and CRC with huge potential to be used in clinical settings. However, the differences between altered pathways in polyps and CRC, other external factors, and their effects on the regulation level, sensitivity, and specificity of each identified metabolite remained unclear, which could benefit from a further extensive cohort study and well-defined analysis equipment.</p>","PeriodicalId":54275,"journal":{"name":"Gastroenterology Report","volume":"12 ","pages":"goae106"},"PeriodicalIF":3.8,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11646065/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142829977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"¹⁸F-FAPI-42 PET/CT enhances the diagnostic efficacy for peritoneal metastasis of colorectal cancer and guides treatment decisions: an original retrospective study.","authors":"Xuneng Zhang, Rongqin Zhang, Qingyang Zheng, Zichuan He, Bing Lan, Yun Zhong, Zhichao Huang, Wei Fan, Hui Wang, Keli Yang, Zhanwen Zhang, Huaiming Wang","doi":"10.1093/gastro/goae104","DOIUrl":"10.1093/gastro/goae104","url":null,"abstract":"<p><strong>Background: </strong>Colorectal cancer is the third-most common type of cancer. When peritoneal metastasis (PM) develops, diagnosing metastatic lesions is difficult and the prognosis is poor. This study aimed to compare the value of fluorine-18 fibroblast activation protein-specific inhibitor (¹⁸F-FAPI-42) and fluorine-18 fluorodeoxyglucose (¹⁸F-FDG) positron emission tomography/computed tomography (PET/CT) for detecting PM of colorectal cancer and to guide clinical decision-making.</p><p><strong>Methods: </strong>Forty-eight patients with PM who underwent both ¹⁸F-FAPI-42 and ¹⁸F-FDG PET/CT examinations were studied. The maximum standardized uptake value (SUV max), tumor-to-background ratios (TBRs) and peritoneal cancer index (PCI) of the PM were compared between the two imaging techniques. The intraclass correlation coefficient (ICC) was used to compare the consistency between the PET/CT PCI score and the intraoperative PCI. A receiver-operating characteristic curve was used to predict the accuracy of CC-0 cytoreduction (complete cytoreduction with no visible disease).</p><p><strong>Results: </strong>The sensitivity and accuracy of ¹⁸F-FAPI-42 PET/CT for detecting PM were higher than those of ¹⁸F-FDG PET/CT (82.1% vs 61.1%, <i>P </i><<i> </i>0.01; 84.6% vs 74.5%, <i>P </i><<i> </i>0.01). The median SUV max and TBR of PM was greater in ¹⁸F-FAPI-42 than in ¹⁸F-FDG PET/CT [4.8 (1.9-20.1) vs 4.7 (1.0-11.0), <i>P </i>=<i> </i>0.02; 4.3 (1.4-14.6) vs 2.9 (0.6-8.0), <i>P </i><<i> </i>0.01, respectively]. The median PCI of PM based on ¹⁸F-FAPI-42 PET/CT was greater than that based on ¹⁸F-FDG PET/CT (15 vs 9, <i>P </i><<i> </i>0.01). The ICC for ¹⁸F-FAPI-42 PCI was greater than that for ¹⁸F-FDG PCI (0.915 vs 0.724, <i>P </i><<i> </i>0.01). The cut-off values of the PCI of the PM for ¹⁸F-FAPI-42 and ¹⁸F-FDG PET/CT to predict CC-0 were <18 and <10, with areas under the curve of 0.80 and 0.79, respectively.</p><p><strong>Conclusions: </strong>¹⁸F-FAPI-42 PET/CT has superior diagnostic efficacy for PM, particularly in the right upper epigastrium and small intestine. The PCI score of ¹⁸F-FAPI-42 PET/CT is very close to the intraoperative PCI score and has a high value for predicting CC-0. The individualized management of PM based on the ¹⁸F-FAPI-42 PET/CT PCI score is pivotal.</p>","PeriodicalId":54275,"journal":{"name":"Gastroenterology Report","volume":"12 ","pages":"goae104"},"PeriodicalIF":3.8,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11646066/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142830904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The benefit of surgery during systematic therapy for gastrointestinal stromal tumor liver metastasis: a SEER-based retrospective study.","authors":"Bozhi Hu, Yingjiang Ye, Zhidong Gao","doi":"10.1093/gastro/goae095","DOIUrl":"10.1093/gastro/goae095","url":null,"abstract":"<p><strong>Background: </strong>The liver is the most common site of gastrointestinal stromal tumor (GIST) metastasis. Most patients who develop metastases gradually develop multiline drug resistance during long-term systematic treatment. We aimed to evaluate the benefit of surgery during the systematic treatment of GIST liver metastases.</p><p><strong>Methods: </strong>Data on GISTs with liver metastasis were retrieved from the Surveillance, Epidemiology, and End Results database. This study included 607 patients, of whom 380 patients were treated with chemotherapy alone (Chemo group) and 227 patients underwent surgery in addition to chemotherapy (Chemo&Surg group). The primary outcomes were cancer-specific survival (CSS) and overall survival (OS). Propensity score matching (PSM) was performed to balance the baseline factors.</p><p><strong>Results: </strong>According to the multivariate analysis, surgery benefitted both CSS and OS (<i>P </i><<i> </i>0.001). After PSM, surgical resection still showed significant benefits in terms of both CSS and OS (<i>P </i><<i> </i>0.001). Surgery combined with chemotherapy increased the median CSS by at least 63 months and the median OS by at least 76 months. Subgroup analysis of the Chemo&Surg group revealed that the timing of surgery was not an independent influencing factor for either CSS or OS.</p><p><strong>Conclusions: </strong>We found that performing additional surgery, in addition to systematic therapy, for GIST liver metastasis resulted in improved CSS and OS. These benefits were not affected by the timing of surgery during systemic treatment.</p>","PeriodicalId":54275,"journal":{"name":"Gastroenterology Report","volume":"12 ","pages":"goae095"},"PeriodicalIF":3.8,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11587995/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142717662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Supplementation with probiotics, prebiotics, and synbiotics in patients with chronic functional constipation: a randomized, double-blind, placebo-controlled pilot clinical trial.","authors":"Ana Terrén Lora, Bruno F Penadés, Sara López Oliva, Sari Arponen, Gülşah Okutan, Guerthy Melissa Sánchez Niño, Ismael San Mauro Martín","doi":"10.1093/gastro/goae101","DOIUrl":"https://doi.org/10.1093/gastro/goae101","url":null,"abstract":"<p><strong>Background: </strong>Functional constipation includes a set of gastrointestinal symptoms unexplainable by an identifiable underlying physical cause or pathology. The prevalence of this condition is high and there is a need to develop strategies to reduce it. Probiotics, prebiotics, and synbiotics may be an alternative treatment for chronic functional constipation.</p><p><strong>Methods: </strong>To compare the efficacy of dietary supplementation on symptoms of patients who suffer from chronic functional constipation. An exploratory, randomized, double-blind, placebo-controlled pilot clinical trial was conducted with 74 patients diagnosed with chronic functional constipation who were divided into four treatment groups-Group A: probiotics; Group B: prebiotics; Group C: synbiotics; Group D: placebo. Each patient was treated for 8 weeks. At the beginning and end of treatment, data were collected by administering questionnaires and scales, including the Bristol stool scale, on gastrointestinal symptoms, bowel movements, and sociodemographic and anthropometric characteristics.</p><p><strong>Results: </strong>Stool frequency increased in all four study groups, and greatest difference was observed in the synbiotics group (2.8 ± 1.3 vs. 5.9 ± 2.6; <i>P</i> < 0.001). Stool consistency improved only in the active treatment groups. Based on the evaluation of gastrointestinal symptoms, participants treated with prebiotics, probiotics and synbiotics showed the greatest improvement in abdominal pain (8.28 ± 2.63 vs. 6.56 ± 2.62; <i>P</i> = 0.009), gastroesophageal reflux (4.60 ± 2.66 vs. 3.45 ± 2.42; <i>P</i> = 0.039) and constipation symptoms (13.00 ± 3.97 vs. 8.71 ± 3.35; <i>P</i> = 0.003), respectively. As for quality of life, the main changes were observed in physical health domains, with a placebo effect.</p><p><strong>Conclusions: </strong>The present study provides evidence supporting the efficacy of dietary supplementation with probiotics, prebiotics, and synbiotics in patients with chronic functional constipation after 8 weeks of treatment.</p>","PeriodicalId":54275,"journal":{"name":"Gastroenterology Report","volume":"12 ","pages":"goae101"},"PeriodicalIF":3.8,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11552633/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142632324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>TNFSF15</i> variant predicts disease progression in Chinese patients with Crohn's disease.","authors":"Qi Zhang, Wei Wang, Bingjie Xiang, Dezheng Lin, Jun Hu, Junzhang Zhao, Jue Lin, Tao Liu, Jun Deng, Min Zhang, Min Zhi","doi":"10.1093/gastro/goae103","DOIUrl":"https://doi.org/10.1093/gastro/goae103","url":null,"abstract":"<p><strong>Background: </strong>The genetic variant of tumor necrosis factor superfamily member 15 (<i>TNFSF15</i>) is associated with Crohn's disease (CD) and the development of intestinal fibrosis and stricturing. We aimed to investigate its predictive role in disease progression and the impact of ileal fibrosis-associated protein expression in Chinese patients with CD.</p><p><strong>Methods: </strong>We genotyped the single nucleotide polymorphism rs6478109 within the <i>TNFSF15</i> gene in 428 CD patients and 450 health controls to assess its association with CD. Genotype-phenotype correlation analyses were performed. Mucosal samples from non-diseased terminal ileum were analyzed for TL1A and fibrosis-associated protein expression using western blot and immunohistochemistry.</p><p><strong>Results: </strong>The G allele frequency of rs6478109 was significantly higher among CD patients compared with health controls (63.3% vs. 46.7%, <i>P </i><<i> </i>0.001). Patients with GG genotype were more predisposed to develop the stricturing phenotype, compared with those with AA + AG genotypes with a hazard ratio of 1.426 (95% confidence interval: 1.029-1.977, <i>P </i>=<i> </i>0.033). This trend was similarly observed in patients utilizing biological agents, with a hazard ratio of 4.396 (95% confidence interval: 1.780-10.854, <i>P </i>=<i> </i>0.001). Furthermore, increased TL1A, pro-fibrotic proteins, and TGFβ1/Smad3 pathway activation were observed in non-diseased ileal mucosa of patients with GG genotype compared with those with AA genotype.</p><p><strong>Conclusions: </strong>The <i>TNFSF15</i> risk genotype GG could promote the expression of pro-fibrotic proteins and may serve as a predictor for stricturing CD.</p>","PeriodicalId":54275,"journal":{"name":"Gastroenterology Report","volume":"12 ","pages":"goae103"},"PeriodicalIF":3.8,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11552634/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142632305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New perspectives in liver diseases with challenges.","authors":"Calvin Q Pan, Nancy Reau","doi":"10.1093/gastro/goae098","DOIUrl":"https://doi.org/10.1093/gastro/goae098","url":null,"abstract":"","PeriodicalId":54275,"journal":{"name":"Gastroenterology Report","volume":"12 ","pages":"goae098"},"PeriodicalIF":3.8,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11549057/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142632287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}