Mustafa Serdar Bölük, Bilal Bahadır Akbulut, Taşkın Yurtseven, Hüseyin Biçeroğlu
{"title":"Novel Barium-Enhanced 3-Dimensional-Printed Spine Model for Pedicle Screw Training: A Cost-Effective Solution and Educational Validation.","authors":"Mustafa Serdar Bölük, Bilal Bahadır Akbulut, Taşkın Yurtseven, Hüseyin Biçeroğlu","doi":"10.1227/ons.0000000000001602","DOIUrl":"https://doi.org/10.1227/ons.0000000000001602","url":null,"abstract":"<p><strong>Background and objectives: </strong>Training in pedicle screw placement is crucial for neurosurgery residents, yet access to high-fidelity training models is often limited by cost and availability. This study introduces a novel, cost-effective barium-enhanced 3-dimensional (3D)-printed L4-5 spine model visible under fluoroscopy, aiming to validate its effectiveness as a training tool for novice residents in pedicle screw placement.</p><p><strong>Methods: </strong>A barium-enhanced 3D-printed L4-5 spine model was developed to simulate human bone density and provide radiopacity under fluoroscopy. Ten neurosurgery residents with no prior experience in pedicle screw placement participated in a structured training program using this model. Each resident completed three training sessions, placing four pedicle screws per session, totaling 120 screw placements. Surgical duration, screw placement accuracy, and fluoroscopy usage were recorded. Screw placement accuracy was assessed by two independent blinded evaluators using both a visual grading method and the computed tomography-based Gertzbein-Robbins classification.</p><p><strong>Results: </strong>The analysis demonstrated significant improvement in surgical time across sessions (P < .0001), decreasing from 20:44 ± 4:32 minutes to 13:17 ± 4:04 minutes. The median number of fluoroscopic images decreased from 8.5 (range: 5-18) to 6.0 (range: 5-10), although not statistically significant (P = .312). Visual assessment scores improved, with median breach scores decreasing from 0.25 (0.00-3.00) to 0.00 (0.00-0.25). Similarly, the median Gertzbein-Robins grades improved from 0.50 (0.12-2.88) to 0.12 (0.00-0.62). Visual and computed tomography-based assessments showed excellent correlation (intraclass correlation coefficients = 0.978, 95% CI: 0.953-0.989, P < .001).</p><p><strong>Conclusion: </strong>The barium-enhanced 3D-printed spine model ($1.61/session) provides a highly cost-effective training tool for novice residents, demonstrating significant improvements in surgical efficiency. Although accuracy measures showed promising trends, more extensive studies may be needed to establish definitive improvements in placement precision. The model's radiopacity allows for realistic fluoroscopic imaging, bridging the gap between basic models and more expensive alternatives, which is particularly valuable in resource-limited settings.</p>","PeriodicalId":54254,"journal":{"name":"Operative Neurosurgery","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144058601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pablo Ramon Fruett da Costa, Guilherme Oliveira de Paula, Helen Michaela de Oliveira, Ana Paula de Siqueira Silva, Gabriella Oliveira Caetano, Julie G Pilitsis, Eduardo Joaquim Lopes Alho, Paulo Roberto Franceschini, Tiago da Silva Freitas, Bernardo Assumpção de Monaco
{"title":"Cyanoacrylate Adhesive With Titanium Plate Fixation for Deep Brain Stimulation Leads: A Case Series and Technical Note.","authors":"Pablo Ramon Fruett da Costa, Guilherme Oliveira de Paula, Helen Michaela de Oliveira, Ana Paula de Siqueira Silva, Gabriella Oliveira Caetano, Julie G Pilitsis, Eduardo Joaquim Lopes Alho, Paulo Roberto Franceschini, Tiago da Silva Freitas, Bernardo Assumpção de Monaco","doi":"10.1227/ons.0000000000001604","DOIUrl":"https://doi.org/10.1227/ons.0000000000001604","url":null,"abstract":"<p><strong>Background and objectives: </strong>Deep brain stimulation (DBS) is a highly effective therapeutic intervention for managing neurological disorders, including Parkinson disease. However, conventional lead fixation methods, such as covering devices, often lead to complications, including cranial deformities and electrode migration. The aim of our study was to present a novel technique that integrates n-butyl-2-cyanoacrylate adhesive with a titanium \"dog-bone\" plate for DBS lead fixation, to enhance both esthetic and functional outcomes.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on 32 patients with medication-refractory Parkinson disease or parkinsonism who had previously undergone DBS surgery using this fixation technique. The method involved applying n-butyl-2-cyanoacrylate around the lead at the burr-hole site, followed by secondary stabilization with a titanium plate. Intraoperative imaging confirmed lead positioning, and patients were monitored for up to 21.6 months (±10.2) for migration, infection, and esthetic satisfaction.</p><p><strong>Results: </strong>All 32 patients showed successful lead fixation without cases of migration, displacement, or mechanical failure over the follow-up. No postoperative infections, seizures, or meningitis were reported, indicating a favorable safety profile. The method provided a smooth cranial contour, with high patient satisfaction, especially among those with alopecia or thin skin. In addition, the technique potentially reduced operative time because of the rapid polymerization of the adhesive, thereby minimizing risks associated with prolonged surgeries.</p><p><strong>Conclusion: </strong>The combination of n-butyl-2-cyanoacrylate and a titanium \"dog-bone\" plate for DBS lead fixation offers an effective, aesthetically superior, and cost-efficient alternative to conventional methods. The reduced complication rates and enhanced patient satisfaction suggest that this technique may represent a viable future standard for DBS procedures. Further multicenter studies are recommended to validate these findings.</p>","PeriodicalId":54254,"journal":{"name":"Operative Neurosurgery","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144049765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
William H Hicks, Jeffrey I Traylor, Kelsey Schmitt, Haldo Trevino, Bradley S Guidry, Babu G Welch, Jonathan A White, Rafael De Oliveira Sillero
{"title":"Long-Term Outcomes of Surgical Clipping of Woven EndoBridge-Eligible Middle Cerebral Artery Bifurcation Aneurysms.","authors":"William H Hicks, Jeffrey I Traylor, Kelsey Schmitt, Haldo Trevino, Bradley S Guidry, Babu G Welch, Jonathan A White, Rafael De Oliveira Sillero","doi":"10.1227/ons.0000000000001589","DOIUrl":"https://doi.org/10.1227/ons.0000000000001589","url":null,"abstract":"<p><strong>Background and objectives: </strong>Endosaccular flow disruption with the Woven EndoBridge (WEB) embolization device emerged as an alternative treatment for wide-necked bifurcation aneurysms (WNBAs). Previous studies used pooled aneurysm locations to conclude the efficacy of the WEB device, failing to account for locational differences in outcomes, most notably at the middle cerebral artery (MCA). Thus, we analyzed characteristics and outcomes among a cohort of WEB-eligible MCA bifurcation aneurysms treated surgically.</p><p><strong>Methods: </strong>We retrospectively reviewed a prospectively maintained aneurysm database at UT Southwestern between 2002 and 2022. WEB-eligible aneurysms met the criteria of a dome-to-neck ratio ≥1, a neck diameter >4.0 mm or a dome-to-neck ratio of ≤2, and an aneurysm diameter of 3.0-11.0 mm. Both unruptured and ruptured aneurysms were included. The end points assessed were functional status changes (modified Rankin scale [mRS]), complication rates, aneurysm recurrence, residual, morbidity, and mortality.</p><p><strong>Results: </strong>One hundred two patients met radiographic inclusion criteria as WEB-eligible WNBA who underwent microsurgical clipping. Eighty-five (83.3%) aneurysms were unruptured. Patients with ruptured aneurysms presented with a worse mRS and experienced more significant improvements in functional status at the final follow-up. Regardless of rupture status, outcomes with open surgery were excellent, with a 99% treatment success rate, 4.9% morbidity rate, and 0% mortality rate. Among unruptured MCA WNBAs, functional outcomes showed a final mRS ≤2 in 94.1% of patients and an improved or stable functional status in 91.8%. Microsurgical treatment of unruptured MCA WNBA carried a 5.9% thromboembolic complication rate.</p><p><strong>Conclusion: </strong>Outcomes of WEB-eligible MCA WNBAs are comparable with the high success rates in large, heterogeneous series of MCA aneurysms and superior to those in WEB cohorts. Functional outcomes remain excellent regardless of treatment strategy; however, surgical treatment may offer higher complete occlusion rates, lower retreatment rates, and lower complication rates than endovascular treatment with WEB.</p>","PeriodicalId":54254,"journal":{"name":"Operative Neurosurgery","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144026494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Innovative Technique of Anchoring the Upper End of the Cervical Plate With C1 Anterior Arch Screw for Upper Cervical Tumors.","authors":"Pankaj Kumar Singh, Ramesh Sharanappa Doddamani, Sivaraman Kumarasamy, Deepak Agarwal, Poodipedi Sarat Chandra, Shashank Sharad Kale","doi":"10.1227/ons.0000000000001591","DOIUrl":"https://doi.org/10.1227/ons.0000000000001591","url":null,"abstract":"<p><strong>Background and objectives: </strong>Upper cervical spine bony tumors pose a challenge to surgeons because of their extensiveness and proximity to vital structures. Reconstruction following resection is necessary to prevent instability. Our objective is to describe a technical note on the C1 anterior arch screw with mesh cage reconstruction for anchoring the upper end of the cervical plate after resection of the upper cervical tumor.</p><p><strong>Methods: </strong>A retrospective review of patients with primary bony tumors of the upper cervical spine after surgical resection between 2018 and 2022 was included in the study. Imaging workup included computed tomography, MRI, and computed tomography angiogram.</p><p><strong>Results: </strong>A total of 4 patients with primary bony tumors of the upper cervical spine underwent C1 anterior screw fixation with mesh cage reconstruction. The mean age was 33.8 ± 14.3 years. Tumor extent was C2-C4 in 2 patients (50%) and C2 in 2 patients (50%). Three patients had a spinal instability neoplastic score of >12 and were deemed unstable preoperatively, mandating the stabilization procedure. All patients underwent surgical resection: gross total resection (1, 25%), near-total excision (1, 25%), and tumor decompression (2, 50%). Surgery was staged in 3 patients (75%) because of the extensiveness of the tumor and massive blood loss. There was no perioperative mortality. The mean postoperative Nurick grading score was 1.5 ± 1.3 (range 0-3). All patients were ambulatory and showed neurological improvement postoperatively with a mean follow-up of 37.5 ± 21.9 months and evidence of fusion on the latest imaging.</p><p><strong>Conclusion: </strong>Radical resection of tumors involving the upper cervical spine requiring C2 corpectomy is challenging. En bloc resection is not always feasible. Neurosurgeons can consider using the anterior arch as an anchor point. The use of neuronavigation facilitates the precise placement of the C1 arch screws.</p>","PeriodicalId":54254,"journal":{"name":"Operative Neurosurgery","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144057167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shravan Atluri, Ethan Cline, Anthony Guidotti, John Na, Mario Zanaty, Ondrej Choutka
{"title":"Macrovascular Decompression of the Optic Nerve: Technical Case Instruction: 2-Dimensional Operative Video.","authors":"Shravan Atluri, Ethan Cline, Anthony Guidotti, John Na, Mario Zanaty, Ondrej Choutka","doi":"10.1227/ons.0000000000001607","DOIUrl":"https://doi.org/10.1227/ons.0000000000001607","url":null,"abstract":"","PeriodicalId":54254,"journal":{"name":"Operative Neurosurgery","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144005903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Commentary: A Midline-Sparing Minimally Invasive Approach for Resection of a C2 Dumbbell Schwannoma: 2-Dimensional Surgical Video.","authors":"Harsh Jain, Alan R Tang, Scott L Zuckerman","doi":"10.1227/ons.0000000000001613","DOIUrl":"https://doi.org/10.1227/ons.0000000000001613","url":null,"abstract":"","PeriodicalId":54254,"journal":{"name":"Operative Neurosurgery","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144055562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ryan W Turlip, Yohannes Ghenbot, Daksh Chauhan, Richard J Chung, Stephen Miranda, Mert Marcel Dagli, Hasan S Ahmad, Jang W Yoon
{"title":"Synovial Cyst Resection Using Biportal Endoscopic Technique: 2-Dimensional Operative Video.","authors":"Ryan W Turlip, Yohannes Ghenbot, Daksh Chauhan, Richard J Chung, Stephen Miranda, Mert Marcel Dagli, Hasan S Ahmad, Jang W Yoon","doi":"10.1227/ons.0000000000001620","DOIUrl":"https://doi.org/10.1227/ons.0000000000001620","url":null,"abstract":"","PeriodicalId":54254,"journal":{"name":"Operative Neurosurgery","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144053625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mohammad Bilal Alsavaf, Moataz D Abouammo, Jaskaran Singh Gosal, Maithrea S Narayanan, Govind S Bhuskute, Chandrima Biswas, Guilherme Mansur, Kyle K VanKoevering, Kathleen Kelly, Kyle C Wu, Ricardo L Carrau, Daniel M Prevedello
{"title":"Comparative Cadaveric Study and Anatomic Limitations of the Nasofrontal Trephination: A Novel Endoscopic Corridor for Enhanced Exposure of The Odontoid and Occipital Condyle Regions.","authors":"Mohammad Bilal Alsavaf, Moataz D Abouammo, Jaskaran Singh Gosal, Maithrea S Narayanan, Govind S Bhuskute, Chandrima Biswas, Guilherme Mansur, Kyle K VanKoevering, Kathleen Kelly, Kyle C Wu, Ricardo L Carrau, Daniel M Prevedello","doi":"10.1227/ons.0000000000001590","DOIUrl":"https://doi.org/10.1227/ons.0000000000001590","url":null,"abstract":"<p><strong>Background and objectives: </strong>The endoscopic endonasal approach (EEA) serves as the primary minimally invasive route to the ventral craniovertebral junction (CVJ). However, anatomic constraints limit its caudal reach. Multiport endoscopic approaches may complement a standard EEA providing additional reach. This anatomic study evaluates the EEA's anatomic limitations in accessing the CVJ and examines how contralateral nasofrontal trephination (CNT) port may overcome these constraints.</p><p><strong>Methods: </strong>Thirty-two cadaveric specimens underwent EEA and CNT dissections. Key measurements included the nasoaxial line (NAxL) angle, anteroposterior frontal sinus distance, interorbital distance, and distance of odontoid process from the hard palate line. Area of exposure and surgical freedom were quantified using a surgical navigation. A clinical case treated using the CNT approach has been included to demonstrate the technique, instrument utilization, successful healing, and absence of complications.</p><p><strong>Results: </strong>CNT significantly enhanced area of exposure of both odontoid (1720.41 vs 1086.62 mm2, P = <.001) and occipital condyle targets (613.32 vs 446.15 mm2, P = <.001), while EEA provided significant greater surgical freedom for both odontoid (1121.91 vs 1030.58 mm3, P = <.001) and occipital condyle (888.25 vs 827.74 mm3, P = <.001). Frontal sinus anteroposterior distance strongly correlated with CNT odontoid exposure (r = 0.889, P < .001) but not with the occipital condyle (r = -0.009, P = .966). CNT offered a wider angle of attack compared with EEA (49.8° vs 16.5°, P = <.001). NAxL angle inversely correlated with the distance of the odontoid process from the hard palate line level (r = -0.757, P < .001), while showing no significant correlation with EEA exposure area.</p><p><strong>Conclusion: </strong>CNT augments traditional EEA by enhancing inferior access during the management of complex CVJ pathologies. Although NAxL angle may provide guidance in determining the inferior extent of the EEA, anatomic variability and its poor correlation with exposure area limit its standalone utility in surgical planning.</p>","PeriodicalId":54254,"journal":{"name":"Operative Neurosurgery","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144057693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jessica Y Tong, Nicholas G Candy, Jeffrey Sung, Alistair K Jukes, Dinesh Selva
{"title":"Transorbital Approach to the Cavernous Sinus After an Exenteration.","authors":"Jessica Y Tong, Nicholas G Candy, Jeffrey Sung, Alistair K Jukes, Dinesh Selva","doi":"10.1227/ons.0000000000001609","DOIUrl":"https://doi.org/10.1227/ons.0000000000001609","url":null,"abstract":"<p><strong>Background and objectives: </strong>To describe a novel technique of transorbital access to the lateral wall of the cavernous sinus (CS) after exenteration.</p><p><strong>Methods: </strong>Cadaveric dissection study. Seven heads (13 orbits) were dissected after total orbital exenteration. The technique was centered on creation of an osteotomy within the greater wing of sphenoid, bordered by the superior and inferior orbital fissures to access the middle cranial fossa. V2 within the foramen rotundum was used as a guide to enter the interdural plane of the lateral CS wall. Results were expressed as the mean value ±1 SD.</p><p><strong>Results: </strong>The lateral CS wall was precisely visualized with identification of cranial nerves III to V2 back to the anterior portion of the Gasserian ganglion. To enable this level of exposure, the osteotomy created within the greater wing of sphenoid was a triangular window with a height of 12.7 ± 1.5 mm (range 10.0-15.0 mm), bordered superiorly by the superior orbital fissure to a linear dimension of 12.8 ± 2.5 mm (range 8.0-18.0 mm), and inferiorly by the inferior orbital fissure to an extent of 12.1 ± 3.9 mm (range 0.9-15.0 mm). The distances from the orbital apex to the intracavernous cranial nerves V1 and V2, and V3 within the foramen ovale were 22.9 ± 3.6 mm (range 17.0-31.0 mm), 25.2 ± 5.0 mm (range 17.5-36.0 mm), and 27.8 ± 5.9 mm (range 18.0-41.0 mm), respectively. The distance between the orbital apex and anterior Gasserian ganglion approximated the maximum surgical corridor achieved with this technique, which was 31.8 ± 4.8 mm (range 26.0-44.0 mm).</p><p><strong>Conclusion: </strong>The transorbital approach to the lateral CS wall is a feasible corridor of access after exenteration. It provides an alternative interdural pathway, thereby obviating the need for additional transcranial or endonasal access routes. Such a technique is in its infancy and surgical series are required to verify it in the clinical setting.</p>","PeriodicalId":54254,"journal":{"name":"Operative Neurosurgery","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144052160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Connor C Jacob, Ludovica Pasquini, Kerry-Ann S Mitchell, Lucas P Carlstrom, Daniel M Prevedello
{"title":"Cranial Reconstruction for Infiltrative Meningioma Using 68Ga-DOTATATE Positron Emission Tomography/Computed Tomography and Individual Patient Solutions CaseDesigner®: A Case Series.","authors":"Connor C Jacob, Ludovica Pasquini, Kerry-Ann S Mitchell, Lucas P Carlstrom, Daniel M Prevedello","doi":"10.1227/ons.0000000000001596","DOIUrl":"https://doi.org/10.1227/ons.0000000000001596","url":null,"abstract":"<p><strong>Background and objectives: </strong>Meningioma with bone involvement presents challenges for complete resection and cranial reconstruction. 68Ga-dodecanetetreaacetic acid tyrosine-3-octreotide (DOTATATE) positron emission tomography (PET)/computed tomography (CT) has emerged as an excellent modality for localizing invasive meningiomas because of molecular interaction with somatostatin receptor-2. We present a novel technique to design 3-dimensional-printed artificial cranioplasty, using combined fine-slice CT, MRI, and 68Ga-DOTATATE PET/CT with Individual Patient Solutions (IPS) CaseDesigner® software. This study's objective was to generate proof-of-concept work for a novel artificial cranioplasty protocol that combines customized cranial implant software and DOTATATE PET/CT.</p><p><strong>Methods: </strong>Three patients with invasive bone meningiomas were retrospectively identified. For each patient, the proposed protocol combines CT, MRI, and 68Ga-DOTATATE PET/CT imaging to generate a 3-dimensional cranial reconstruction within the Karl Leibinger Surgical (KLS) Martin-IPS CaseDesigner® software. Subsequently, the virtual rendering is used to manufacture a customized polyetheretherketone (PEEK) implant, along with a guiding component, which ensures precise delineation of surgical borders before craniectomy. Finally, cranioplasty with the customized implant is performed using standard techniques.</p><p><strong>Results: </strong>The described preoperative cranioplasty design protocol was performed for each patient. Tumor invasion was visualized using 68Ga-DOTATATE PET/CT. Patient 1 presented with a recurrent right frontal meningioma with invasion into anterior skull base. In this case, IPS CaseDesigner® was used to create a mirror image PEEK implant for the left orbit and affected cranium. Patients 2 and 3 had intraosseous meningiomas invading the frontal bone; customized PEEK implants were tailored to the side of the planned craniectomy for both patients and were successfully placed without complication. Postoperatively, all patients remained neurologically intact and were discharged without complications. In all patients, the PEEK implants exhibited appropriate cranial continuity and integrity.</p><p><strong>Conclusion: </strong>68Ga-DOTATATE PET/CT has high sensitivity and specificity for detecting meningiomas during preoperative planning, particularly when the tumor involves bone. IPS CaseDesigner® demonstrates excellent utility for planning and constructing customized cranioplasties tailored to each patient for skull reconstruction.</p>","PeriodicalId":54254,"journal":{"name":"Operative Neurosurgery","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144049050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}