Operative NeurosurgeryPub Date : 2025-03-01Epub Date: 2024-07-05DOI: 10.1227/ons.0000000000001281
Connor Berlin, Richard J Chung, Brian Park, David Ben-Israel, Juan P Sardi, Chun-Po Yen, Justin S Smith
{"title":"Iliac Accessory Rod Technique for Rod Fracture Prevention in Long Fusion Constructs: 2-Dimensional Operative Video.","authors":"Connor Berlin, Richard J Chung, Brian Park, David Ben-Israel, Juan P Sardi, Chun-Po Yen, Justin S Smith","doi":"10.1227/ons.0000000000001281","DOIUrl":"10.1227/ons.0000000000001281","url":null,"abstract":"","PeriodicalId":54254,"journal":{"name":"Operative Neurosurgery","volume":" ","pages":"451"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141535964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Operative NeurosurgeryPub Date : 2025-03-01Epub Date: 2024-07-31DOI: 10.1227/ons.0000000000001294
Keannette Russell, William Chase Johnson, Fadi Al Saiegh, Lee Birnbaum, Alexander Coon, Justin Mascitelli
{"title":"Management of a Twisted Flow Diverting Stent With a Balloon Mounted Cardiac Stent in a Pediatric Aneurysm: A Technical Report.","authors":"Keannette Russell, William Chase Johnson, Fadi Al Saiegh, Lee Birnbaum, Alexander Coon, Justin Mascitelli","doi":"10.1227/ons.0000000000001294","DOIUrl":"10.1227/ons.0000000000001294","url":null,"abstract":"<p><strong>Background and importance: </strong>Giant aneurysms can present technical challenges during treatment with flow diversion including inability to access the aneurysm outflow directly. Encircling the aneurysm with a microwire/microcatheter has been well described; however, it can result in a twisted stent because of catheter twisting during the reduction maneuver, which, in turn, could lead to thromboembolic complications.</p><p><strong>Case presentation: </strong>Here, we describe a novel technique to manage the twist of the flow diverter in a giant internal carotid artery aneurysm using a combination of angioplasty and off-label placement of a balloon-mounted cardiac stent within the flow diverter.</p><p><strong>Conclusion: </strong>At 1 year, the aneurysm is completely occluded on digital subtraction angiography and MRI, and the patient is neurologically intact.</p>","PeriodicalId":54254,"journal":{"name":"Operative Neurosurgery","volume":" ","pages":"432-437"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141857139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Operative NeurosurgeryPub Date : 2025-03-01Epub Date: 2024-08-12DOI: 10.1227/ons.0000000000001310
Thomas Petutschnigg, Levin Häni, Johannes Goldberg, Tomas Dobrocky, Eike I Piechowiak, Andreas Raabe, C Marvin Jesse, Ralph T Schär
{"title":"Microsurgical Repair of Ventral Cerebrospinal Fluid Leaks in Spontaneous Intracranial Hypotension: Efficacy and Safety of Patch-Sealing Versus Suturing.","authors":"Thomas Petutschnigg, Levin Häni, Johannes Goldberg, Tomas Dobrocky, Eike I Piechowiak, Andreas Raabe, C Marvin Jesse, Ralph T Schär","doi":"10.1227/ons.0000000000001310","DOIUrl":"10.1227/ons.0000000000001310","url":null,"abstract":"<p><strong>Background and objectives: </strong>In patients with spontaneous intracranial hypotension (SIH), microsurgical repair is recommended in Type 1 (ventral) dural leaks, when conservative measures fail. However, there is lacking consensus on the optimal surgical technique for permanent and safe closure of ventral leaks.</p><p><strong>Methods: </strong>We performed a retrospective analysis of surgically treated SIH patients with Type 1 leaks at our institution between 2013 and 2023. Patients were analyzed according to the type of surgical technique: (1) Microsurgical suture vs (2) extradural and intradural patching (sealing technique). End points were resolution of spinal longitudinal epidural cerebrospinal fluid collection (SLEC), change in brain SIH-Score (Bern-Score), headache resolution after 3 months, surgery time, complications, and reoperation rates.</p><p><strong>Results: </strong>In total, 85 (66% women) patients with consecutive SIH (mean age 47 ± 11 years) underwent transdural microsurgical repair. The leak was sutured in 53 (62%) patients (suture group) and patch-sealed in 32 (38%) patients (sealing group). We found no significant difference in the rates of residual SLEC and resolution of headache between suture and sealing groups (13% vs 22%, P = .238 and 89% vs 94%, P = .508). No changes were found in the postoperative Bern-Score between suture and sealing groups (1.4 [±1.6] vs 1.7 [±2.1] P = 1). Mean surgery time was significantly shorter in the sealing group than in the suture group (139 ± 48 vs 169 ± 51 minutes; P = .007). Ten patients of the suture and 3 of the sealing group had a complication (23% vs 9%, P = .212), whereas 6 patients of the suture and 2 patients of the sealing group required reoperation (11% vs 6%, P = .438).</p><p><strong>Conclusion: </strong>Microsurgical suturing and patch-sealing of ventral dural leaks in patients with SIH are equally effective. Sealing alone is a significantly faster technique, requiring less spinal cord manipulation and may therefore minimize the risk of surgical complications.</p>","PeriodicalId":54254,"journal":{"name":"Operative Neurosurgery","volume":" ","pages":"379-385"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11809960/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141918061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Operative NeurosurgeryPub Date : 2025-03-01Epub Date: 2024-12-02DOI: 10.1227/ons.0000000000001422
Michael A Jensen, Joseph S Neimat, Panagiotis Kerezoudis, Rushna Ali, R Mark Richardson, Casey H Halpern, Steven G Ojemann, Francisco A Ponce, Kendall H Lee, Laura M Haugen, Fiona E Permezel, Bryan T Klassen, Douglas Kondziolka, Kai J Miller
{"title":"Principles of Stereotactic Surgery.","authors":"Michael A Jensen, Joseph S Neimat, Panagiotis Kerezoudis, Rushna Ali, R Mark Richardson, Casey H Halpern, Steven G Ojemann, Francisco A Ponce, Kendall H Lee, Laura M Haugen, Fiona E Permezel, Bryan T Klassen, Douglas Kondziolka, Kai J Miller","doi":"10.1227/ons.0000000000001422","DOIUrl":"10.1227/ons.0000000000001422","url":null,"abstract":"<p><strong>Background and objectives: </strong>Stereotactic procedures are used to manage a diverse set of patients across a variety of clinical contexts. The stereotactic devices and software used in these procedures vary between surgeons, but the fundamental principles that constitute safe and accurate execution do not. The aim of this work is to describe these principles to equip readers with a generalizable knowledge base to execute and understand stereotactic procedures.</p><p><strong>Methods: </strong>A combination of a review of the literature and empirical experience from several experienced surgeons led to the creation of this work. Thus, this work is descriptive and qualitative by nature, and the literature is used to support instead of generate the ideas of this framework.</p><p><strong>Results: </strong>The principles detailed in this work are categorized based on 5 clinical domains: imaging, registration, mechanical accuracy, target planning and adjustment, and trajectory planning and adjustment. Illustrations and tables are used throughout to convey the concepts in an efficient manner.</p><p><strong>Conclusion: </strong>Stereotactic procedures are complex, requiring a thorough understanding of each step of the workflow. The concepts described in this work enable functional neurosurgeons with the fundamental knowledge necessary to provide optimal patient care.</p>","PeriodicalId":54254,"journal":{"name":"Operative Neurosurgery","volume":" ","pages":"303-321"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11809997/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142774865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Operative NeurosurgeryPub Date : 2025-03-01Epub Date: 2024-07-26DOI: 10.1227/ons.0000000000001298
Zirun Zhao, Spencer Raub, Jacob Ruzevick
{"title":"Commentary: Endoscopic Transorbital Resection of a Temporal Pole Cavernoma: 2-Dimensional Operative Video.","authors":"Zirun Zhao, Spencer Raub, Jacob Ruzevick","doi":"10.1227/ons.0000000000001298","DOIUrl":"10.1227/ons.0000000000001298","url":null,"abstract":"","PeriodicalId":54254,"journal":{"name":"Operative Neurosurgery","volume":" ","pages":"443-444"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141762653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Step-by-Step Description of Percutaneous Full-Endoscopic C2 Ganglionectomy: An Anatomic Feasibility Study in Human Cadavers.","authors":"Chen Li, Ye Jiang, Lutao Yuan, Cong Luo, Tengfei Liu, Yifan Tang, Yong Yu","doi":"10.1227/ons.0000000000001309","DOIUrl":"10.1227/ons.0000000000001309","url":null,"abstract":"<p><strong>Background and objectives: </strong>The percutaneous full-endoscopic C2 ganglionectomy (PEC2G), an innovative procedure developed for the surgical treatment of intractable occipital neuralgia, was firstly reported by us in 2021. However, a universally accepted and well-articulated protocol modality remains elusive. The primary objective of this anatomic investigation was to meticulously elucidate the standard procedural steps of PEC2G and assess the anatomic features supporting the safe implementation of PEC2G.</p><p><strong>Methods: </strong>Eighteen fresh adult cadavers were incorporated into this study. From this sample, 3 cadavers were subjected to bilateral PEC2G. Each procedure was documented and assessed, leading to the formulation of standard procedure criteria for PEC2G. Subsequently, 10 sets of anatomic parameters pertinent to this procedure were identified, quantified, and analyzed in 15 cadavers after complete bilateral endoscopic exposure of the C2 ganglion. An assessment of the technical feasibility and potential constraints associated with PEC2G was conducted, providing invaluable insights into the procedure's anatomic considerations.</p><p><strong>Results: </strong>All 3 cadavers successfully underwent the PEC2G without any observed complications, such as dura tears or vertebral artery injuries. The C2 inferior articular process emerged as the optimal bony target for puncture, with the C2 pedicle serving as the standard guiding landmark en route to the C2 ganglion. In the 15 cadavers subjected to the planned procedure, 10 sets of anatomic parameters were quantified, establishing a foundational understanding of the anatomy in the context of PEC2G procedure. The results demonstrated that the characteristic of anatomic data pertinent to surgical site supported the safe implementation of PEC2G.</p><p><strong>Conclusion: </strong>This study contributes the standard surgical steps and crucial anatomic parameters relevant to PEC2G. The characteristic of anatomic data bolsters the safety credentials of this technique, which offers a reliable approach to achieve C2 ganglionectomy. These insights undeniably establish a robust foundation for the ongoing refinement and broader adoption of PEC2G.</p>","PeriodicalId":54254,"journal":{"name":"Operative Neurosurgery","volume":" ","pages":"407-417"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11809976/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141918103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Operative NeurosurgeryPub Date : 2025-03-01Epub Date: 2024-12-02DOI: 10.1227/ons.0000000000001423
Michael A Jensen, Joseph S Neimat, Panagiotis Kerezoudis, Rushna Ali, R Mark Richardson, Casey H Halpern, Steven Ojemann, Francisco A Ponce, Kendall H Lee, Laura M Haugen, Bryan T Klassen, Douglas Kondziolka, Kai J Miller
{"title":"A General Framework for Characterizing Inaccuracy in Stereotactic Systems.","authors":"Michael A Jensen, Joseph S Neimat, Panagiotis Kerezoudis, Rushna Ali, R Mark Richardson, Casey H Halpern, Steven Ojemann, Francisco A Ponce, Kendall H Lee, Laura M Haugen, Bryan T Klassen, Douglas Kondziolka, Kai J Miller","doi":"10.1227/ons.0000000000001423","DOIUrl":"10.1227/ons.0000000000001423","url":null,"abstract":"<p><strong>Background and objectives: </strong>Identifying and characterizing sources of targeting error in stereotactic procedures is essential to maximizing accuracy, potentially improving surgical outcomes. We aim to describe a generic framework which characterizes sources of stereotactic inaccuracy.</p><p><strong>Methods: </strong>We assembled a list of stereotactic systems: ROSA, Neuromate, Mazor Renaissance, ExcelsiusGPS, Cirq, STarFix (FHC), Nexframe, ClearPoint, CRW, and Leksell. We searched the literature for qualitative and quantitative work identifying and quantifying potential sources of inaccuracy and describing each system's implementation using Standards for Reporting Qualitative Research guidelines. Our literature search spanned 1969 to 2024, and various studies were included, with formats ranging from phantom studies to systematic reviews. Keyword searches were conducted, and the details about each system were used to create a framework for identifying and describing the unique targeting error profile of each system.</p><p><strong>Results: </strong>We describe and illustrate the details of various sources of stereotactic inaccuracies and generate a framework to unify these sources into a single framework. This framework entails 5 domains: imaging, registration, mechanical accuracy, target planning and adjustment, and trajectory planning and adjustment. This framework was applied to 10 stereotactic systems.</p><p><strong>Conclusion: </strong>This framework provides a rubric to analyze the sources of error for any stereotactic system. Illustrations allow the reader to understand sources of error conceptually so that they may apply them to their practice.</p>","PeriodicalId":54254,"journal":{"name":"Operative Neurosurgery","volume":" ","pages":"322-336"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11809961/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142774846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Operative NeurosurgeryPub Date : 2025-03-01Epub Date: 2024-07-12DOI: 10.1227/ons.0000000000001274
Sergio Corvino, Amin Kassam, Amedeo Piazza, Francesco Corrivetti, Felice Esposito, Giorgio Iaconetta, Matteo de Notaris
{"title":"Navigating the Intersection Between the Orbit and the Skull Base: The \"Mirror\" McCarty Keyhole During Transorbital Approach: An Anatomic Study With Surgical Implications.","authors":"Sergio Corvino, Amin Kassam, Amedeo Piazza, Francesco Corrivetti, Felice Esposito, Giorgio Iaconetta, Matteo de Notaris","doi":"10.1227/ons.0000000000001274","DOIUrl":"10.1227/ons.0000000000001274","url":null,"abstract":"<p><strong>Background and objectives: </strong>McCarty keyhole (MCK) is the most important entry point during orbitocranial and cranio-orbital approaches; nevertheless, its anatomic coordinates have never been detailedly described from transorbital perspective. To provide the spatial coordinates for intraorbital projection of the \"mirror\" MCK by using the well-established main anatomic-surgical bony landmarks met along transorbital corridor.</p><p><strong>Methods: </strong>MCK was identified in 15 adult dry skulls (30 sides) on exocranial surface of pterional region based on the well-defined external bony landmarks: on the frontosphenoid suture, 5 to 6 mm behind the joining point (JP) of frontozygomatic suture (FZS), frontosphenoid suture (FSS), and sphenozygomatic suture (SZS). A 1-mm burr hole was performed and progressively enlarged to identify the intracranial and intraorbital compartments. Exit site of the intraorbital part of burr hole was referenced to the FZS on the orbital rim, the superior orbital fissure, and the inferior orbital fissure and to the JP of FZS, FSS, and SZS. To electronically validate the results, 3-dimensional photorealistic and interactive models were reconstructed with photogrammetry. Finally, for a further validation, McCarty mirror keyhole was also exposed, based on results achieved, through endoscopic transorbital approach in 10 head specimens (20 sides).</p><p><strong>Results: </strong>Intraorbital projection of MCK was identified on the FSS on intraorbital surface, 1.5 ± 0.5 mm posterior to JP, 11.5 ± 1.1 mm posterior to the FZS on orbital rim following the suture, 13.0 ± 1.2 mm from most anterior end of superior orbital fissure, 15.5 ± 1.4 mm from the most anterior end of the inferior orbital fissure in vertical line, on measurements under direct macroscopic visualization (mean ± SD). These values were electronically confirmed on the photogrammetric models with mean difference within 1 mm.</p><p><strong>Conclusion: </strong>To be aware of exact position of intraorbital projection of MCK during an early stage of transorbital approaches provides several surgical, clinical, and aesthetic advantages.</p>","PeriodicalId":54254,"journal":{"name":"Operative Neurosurgery","volume":" ","pages":"391-398"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141592138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Operative NeurosurgeryPub Date : 2025-03-01Epub Date: 2024-07-12DOI: 10.1227/ons.0000000000001273
Spyridon K Karadimas, Michael A Silva, Robert M Starke
{"title":"Occipital Interhemispheric Transtentorial Approach for Microsurgical Treatment of Posterior Midbrain Arteriovenous Malformation: 2-Dimensional Operative Video.","authors":"Spyridon K Karadimas, Michael A Silva, Robert M Starke","doi":"10.1227/ons.0000000000001273","DOIUrl":"10.1227/ons.0000000000001273","url":null,"abstract":"","PeriodicalId":54254,"journal":{"name":"Operative Neurosurgery","volume":" ","pages":"445-446"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141592139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Operative NeurosurgeryPub Date : 2025-03-01Epub Date: 2024-07-22DOI: 10.1227/ons.0000000000001287
Yamenah Ambreen, Matthieu Weber, Justin Baum, Peter J Kneuertz, David S Xu
{"title":"Rotational Latissimus Dorsi Flap for Lateral Repair of Thoracic Cerebrospinal Fluid-Pleural Fistula: Case Report.","authors":"Yamenah Ambreen, Matthieu Weber, Justin Baum, Peter J Kneuertz, David S Xu","doi":"10.1227/ons.0000000000001287","DOIUrl":"10.1227/ons.0000000000001287","url":null,"abstract":"<p><strong>Background and importance: </strong>Giant calcified thoracic discs are challenging surgical pathologies that tend to be more centrally located and calcified. This complicates the removal process and potentiates the formation of dural defects, resulting in persistent cerebrospinal fluid (CSF) leaks and the formation of pleural fistulas. The typical intervention for this is CSF diversion through external ventricular drain or lumbar drain placement, followed by direct repair. However, if all these measures fail, subsequent salvage techniques have not been described previously.</p><p><strong>Clinical presentation: </strong>A 45-year-old man with past medical history of obesity (body mass index: 58), hypertension, and type 2 diabetes mellitus presented to the emergency department with thoracic myelopathy symptoms. MR demonstrated a giant calcified thoracic discs at T7-T8 with severe spinal cord compression. Intraoperatively, the disc was found fused to the dura and removal caused a large ventrolateral dural dehiscence. CSF diversion and direct repair were attempted unsuccessfully, so a salvage procedure with a rotational pedicled latissimus dorsi flap was performed. The patient's latissimus dorsi was exposed and resected from attachments, maintaining thoracodorsal blood supply, while removing thoracodorsal innervation. The flap was then rotated into the previous corpectomy site. The dural defect was repaired with a sealant patch, overlayed with a parietal pleural flap and the latissimus dorsi flap. By the patient's last follow-up, he had full functional independence at home.</p><p><strong>Conclusion: </strong>We present a surgical case highlighting the challenges of managing postoperative CSF-pleural fistula occurring after giant calcified thoracic disc removal and the successful use of a novel rotational latissimus dorsi flap to definitively repair the fistula after unsuccessful primary interventions.</p>","PeriodicalId":54254,"journal":{"name":"Operative Neurosurgery","volume":" ","pages":"427-431"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141735662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}