Lancet Child & Adolescent Health最新文献_第6页

Quality improvement programmes in paediatric sepsis from a global perspective 从全球视角看儿科败血症质量改进计划

IF 19.9 1区医学

Lancet Child & Adolescent Health Pub Date : 2024-08-12 DOI: 10.1016/S2352-4642(24)00142-1

Daniela C de Souza MD PhD , Raina Paul MD , Rebeca Mozun MD PhD , Jhuma Sankar MD , Roberto Jabornisky MD , Emma Lim MD , Amanda Harley PhD , Samirah Al Amri MD , Maha Aljuaid MD , Suyun Qian MD , Prof Luregn J Schlapbach MD PhD , Andrew Argent MD , Niranjan Kissoon MBBS

{"title":"Quality improvement programmes in paediatric sepsis from a global perspective","authors":"Daniela C de Souza MD PhD , Raina Paul MD , Rebeca Mozun MD PhD , Jhuma Sankar MD , Roberto Jabornisky MD , Emma Lim MD , Amanda Harley PhD , Samirah Al Amri MD , Maha Aljuaid MD , Suyun Qian MD , Prof Luregn J Schlapbach MD PhD , Andrew Argent MD , Niranjan Kissoon MBBS","doi":"10.1016/S2352-4642(24)00142-1","DOIUrl":"10.1016/S2352-4642(24)00142-1","url":null,"abstract":"<div><p>Sepsis is a major contributor to poor child health outcomes around the world. The high morbidity, mortality, and societal cost associated with paediatric sepsis render it a global health priority, as summarised in Paper 1 of this Series. Sepsis is characterised by a dysregulated host response to infection that manifests as organ failure, and children are uniquely susceptible to sepsis, as discussed in Paper 2. The focus of this third Series paper is quality improvement in paediatric sepsis. The 2017 WHO resolution on sepsis outlined key aims to reduce the burden of sepsis. As of 2024, only a small number of countries have implemented systematic, paediatric-focused quality improvement programmes to raise sepsis awareness, enhance recognition of sepsis, promote timely treatment, and provide long-term support for paediatric sepsis survivors. We examine programme successes and systematic barriers to quality improvement targeting paediatric sepsis. We highlight the need for programme design to consider the entire patient journey, starting with prevention, caregiver awareness, recognition at home, education of the health-care workforce, development of health-care systems, and establishment of long-term family and survivor support extending beyond the intensive care unit. Building on lessons learnt from existing quality improvement programmes, we outline implementation strategies and measures to enable benchmarking. Ultimately, quality improvement on a global scale can only be accelerated through a global learning platform focusing on paediatric sepsis.</p></div>","PeriodicalId":54238,"journal":{"name":"Lancet Child & Adolescent Health","volume":"8 9","pages":"Pages 695-706"},"PeriodicalIF":19.9,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141979678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The burden and contemporary epidemiology of sepsis in children 儿童败血症的负担和当代流行病学

IF 19.9 1区医学

Lancet Child & Adolescent Health Pub Date : 2024-08-12 DOI: 10.1016/S2352-4642(24)00140-8

R Scott Watson MD MPH , Enitan D Carrol MD MBChB , Michael J Carter MRCPCH DPhil , Niranjan Kissoon MBBS , Suchitra Ranjit MD FCCM , Prof Luregn J Schlapbach MD PhD

{"title":"The burden and contemporary epidemiology of sepsis in children","authors":"R Scott Watson MD MPH , Enitan D Carrol MD MBChB , Michael J Carter MRCPCH DPhil , Niranjan Kissoon MBBS , Suchitra Ranjit MD FCCM , Prof Luregn J Schlapbach MD PhD","doi":"10.1016/S2352-4642(24)00140-8","DOIUrl":"10.1016/S2352-4642(24)00140-8","url":null,"abstract":"<div><p>Sepsis is a dysregulated host response to infection that leads to life-threatening organ dysfunction. Half of the 50 million people affected by sepsis globally every year are neonates and children younger than 19 years. This burden on the paediatric population translates into a disproportionate impact on global child health in terms of years of life lost, morbidity, and lost opportunities for children to reach their developmental potential. This Series on paediatric sepsis presents the current state of diagnosis and treatment of sepsis in children, and maps the challenges in alleviating the burden on children, their families, and society. Drawing on diverse experience and multidisciplinary expertise, we offer a roadmap to improving outcomes for children with sepsis. This first paper of the Series is a narrative review of the burden of paediatric sepsis from low-income to high-income settings. Advances towards improved operationalisation of paediatric sepsis across all age groups have facilitated more standardised assessment of the Global Burden of Disease estimates of the impact of sepsis on child health, and these estimates are expected to gain further precision with the roll out of the new Phoenix criteria for sepsis. Sepsis remains one of the leading causes of childhood morbidity and mortality, with immense direct and indirect societal costs. Although substantial regional differences persist in relation to incidence, microbiological epidemiology, and outcomes, these cannot be explained by differences in income level alone. Recent insights into post-discharge sequelae after paediatric sepsis, ranging from late mortality and persistent neurodevelopmental impairment to reduced health-related quality of life, show how common post-sepsis syndrome is in children. Targeting sepsis as a key contributor to poor health outcomes in children is therefore an essential component of efforts to meet the Sustainable Development Goals.</p></div>","PeriodicalId":54238,"journal":{"name":"Lancet Child & Adolescent Health","volume":"8 9","pages":"Pages 670-681"},"PeriodicalIF":19.9,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2352464224001408/pdfft?md5=e73d3b088ad5162dd9687577b54fdb1c&pid=1-s2.0-S2352464224001408-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141979680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rare and severe adverse events in children with inflammatory bowel disease - Authors' reply 炎症性肠病患儿罕见的严重不良事件 - 作者的回复

IF 19.9 1区医学

Lancet Child & Adolescent Health Pub Date : 2024-08-12 DOI: 10.1016/S2352-4642(24)00197-4

Renz C W Klomberg , Nicholas M Croft , Lissy de Ridder

引用次数: 0

Advancing neonatal phototherapy after 70 years of global impact 新生儿光疗在全球产生影响 70 年后取得进展。

IF 19.9 1区医学

Lancet Child & Adolescent Health Pub Date : 2024-08-09 DOI: 10.1016/S2352-4642(24)00195-0

Daniele De Luca , Vinod K Bhutani

引用次数: 0

Responsive caregiving: conceptual clarity and the need for indicators 响应式护理：概念的明确性和指标的必要性。

IF 19.9 1区医学

Lancet Child & Adolescent Health Pub Date : 2024-08-06 DOI: 10.1016/S2352-4642(24)00194-9

Maureen M Black , Frances Aboud , Sk Masum Billah , Ilan Cerna-Turoff , Rakhi Dandona , Sayaka Horiuchi , Marzia Lazzerini , Maria Muñiz , Kathleen Strong , Child Health Accountability Tracking Technical Advisory Group

引用次数: 0

Bridging the gap: a call for inclusive policy making in youth mental health care 缩小差距：呼吁在青少年心理保健方面制定包容性政策。

IF 19.9 1区医学

Lancet Child & Adolescent Health Pub Date : 2024-08-05 DOI: 10.1016/S2352-4642(24)00209-8

Katerina Drakos

引用次数: 0

Correction to Lancet Child Adolesc Health 2024; published online July 29. https://doi.org/10.1016/S2352-4642(24)00145-7 https://doi.org/10.1016/S2352-4642(24)00145-7.

IF 19.9 1区医学

Lancet Child & Adolescent Health Pub Date : 2024-08-01 DOI: 10.1016/S2352-4642(24)00205-0

引用次数: 0

Otitis media sequelae and hearing in adolescence after administration of an 11-valent conjugate pneumococcal vaccine in infancy: a prospective cohort study with long-term follow-up of the ARIVAC trial 婴儿期接种 11 价肺炎球菌结合疫苗后的中耳炎后遗症和青春期听力：对 ARIVAC 试验进行长期跟踪的前瞻性队列研究。

IF 19.9 1区医学

Lancet Child & Adolescent Health Pub Date : 2024-07-31 DOI: 10.1016/S2352-4642(24)00128-7

Prof Eric A F Simões MD , Phyllis Carosone-Link MSPH , Diozele M Sanvictores BS , Kristin M Uhler PhD , Marilla Lucero MD , Veronica Tallo MD , Prof Kenny H Chan MD

{"title":"Otitis media sequelae and hearing in adolescence after administration of an 11-valent conjugate pneumococcal vaccine in infancy: a prospective cohort study with long-term follow-up of the ARIVAC trial","authors":"Prof Eric A F Simões MD , Phyllis Carosone-Link MSPH , Diozele M Sanvictores BS , Kristin M Uhler PhD , Marilla Lucero MD , Veronica Tallo MD , Prof Kenny H Chan MD","doi":"10.1016/S2352-4642(24)00128-7","DOIUrl":"10.1016/S2352-4642(24)00128-7","url":null,"abstract":"<div><h3>Background</h3><p>Pneumococcal conjugate vaccines (PCVs) have been shown in randomised controlled trials and epidemiological studies to prevent acute otitis media caused by vaccine serotype pneumococci, although their role in preventing complications of acute otitis media is less clear. We hypothesised that the 11-valent PCV would reduce the long-term sequelae of acute otitis media, including moderate-to-severe ear disease and hearing loss.</p></div><div><h3>Methods</h3><p>This prospective cohort study, referred to as 11PCV study, included follow-up after 16–20 years of children previously enrolled in 2000–04, at age 6 weeks to 6 months, in the randomised, placebo-controlled, ARIVAC trial of 11-valent PCV for the prevention of radiographical pneumonia. The ARIVAC trial and this 11PCV study were conducted at six study centres in Bohol, Philippines. Ear disease was classified using video-otoscopy review and observations derived from the ear exam. The final classification of the worst ear disease was mild (ie, acute otitis media, otitis media with effusion, healed perforation, or tympanosclerosis), moderate (ie, dry perforation or adhesive otitis media), or severe (chronic suppurative otitis media). Hearing loss was assessed following a standard schema and classified according to the worst ear as mild (>15 to 30 dB puretone average) or moderate-to-profound (>30 dB pure tone average). We calculated the relative and absolute risk reduction in the primary outcome of moderate-to-severe ear disease and the secondary outcomes of mild or moderate-to-profound hearing loss in adolescents who previously received the 11-valent PCV compared with those who received placebo during infancy in ARIVAC.</p></div><div><h3>Findings</h3><p>Of the 15 593 children assessed for eligibility in ARIVAC, 12 194 were randomly assigned and 8926 were alive and could be located for enrolment in this 11PCV study between Sept 19, 2016, and Dec 13, 2019. 8321 (4188 in the vaccine group and 4133 in the placebo group) completed follow-up of the 11PCV study by March 30, 2020, and had sufficient data to classify ear disease and be included in the primary outcome analysis. The primary outcome of the absolute risk reduction in moderate-to-severe ear disease in the vaccine group (310 [7·4%] of 4188) versus those in the placebo group (356 [8·6%] of 4133) was 1·2% (95% CI 0·0–2·4; p=0·046) and the relative risk reduction was 14·1% (0·0 to 26·0). There were no differences in secondary outcomes of mild hearing loss or moderate-to-profound hearing loss between the vaccine and placebo groups.</p></div><div><h3>Interpretation</h3><p>The absolute risk reduction for moderate-to-severe ear disease in adolescence of 1·2% (12 per 1000 children) was almost three times higher than the 0·45% reduction (4·5 per 1000 children) in radiographical pneumonia in the first 2 years of life shown in ARIVAC. Administration of 11-valent PCV in infancy was associated with absolute and relative risk redu","PeriodicalId":54238,"journal":{"name":"Lancet Child & Adolescent Health","volume":"8 9","pages":"Pages 647-655"},"PeriodicalIF":19.9,"publicationDate":"2024-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2352464224001287/pdfft?md5=ae3e8862e73098b8a04ac2f96d7f784b&pid=1-s2.0-S2352464224001287-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141891463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The camaraderie behind a 20-year follow-up study 20 年跟踪研究背后的友情。

IF 19.9 1区医学

Lancet Child & Adolescent Health Pub Date : 2024-07-31 DOI: 10.1016/S2352-4642(24)00204-9

Megan Tatum

引用次数: 0

Intimate partner violence against adolescent girls: regional and national prevalence estimates and associated country-level factors 针对少女的亲密伴侣暴力行为：地区和国家流行率估计数及相关的国家一级因素

IF 19.9 1区医学

Lancet Child & Adolescent Health Pub Date : 2024-07-29 DOI: 10.1016/S2352-4642(24)00145-7

LynnMarie Sardinha PhD , Ilknur Yüksel-Kaptanoğlu PhD , Mathieu Maheu-Giroux ScD , Claudia García-Moreno MD

{"title":"Intimate partner violence against adolescent girls: regional and national prevalence estimates and associated country-level factors","authors":"LynnMarie Sardinha PhD , Ilknur Yüksel-Kaptanoğlu PhD , Mathieu Maheu-Giroux ScD , Claudia García-Moreno MD","doi":"10.1016/S2352-4642(24)00145-7","DOIUrl":"10.1016/S2352-4642(24)00145-7","url":null,"abstract":"<div><h3>Background</h3><p>Intimate partner violence is a serious public health problem and negatively affects short-term and long-term health, development, and wellbeing of adolescent girls. Global estimates from WHO have shown that adolescent girls aged 15–19 years experience high rates of intimate partner violence. We aimed to estimate the lifetime and past-year prevalence and patterns of physical or sexual intimate partner violence against adolescent girls by male partners across 161 countries and areas, and to examine the country-level factors, including the prevalence of child marriage, associated with the lifetime and past-year prevalence of intimate partner violence in this age group.</p></div><div><h3>Methods</h3><p>These analyses used the 2018 global, regional, and country estimates on intimate partner violence published by WHO and economic, social, and political metadata from subject-specific databases. Drawing on data from the WHO Global Database on Prevalence of Violence Against Women, we used hierarchical Bayesian modelling techniques to estimate lifetime and past-year prevalence of physical or sexual (or both) intimate partner violence against adolescent girls aged 15–19 years by country. Linear regression methods were used to examine contextual social, economic, and political factors associated with intimate partner violence against adolescent girls in the 101 countries (lifetime prevalence) and 105 countries (past-year prevalence) for which these metadata were available.</p></div><div><h3>Findings</h3><p>The estimated global prevalence of physical or sexual intimate partner violence against ever-partnered adolescent girls aged 15–19 years was 24% (95% uncertainty interval 21–28) in their lifetime and 16% (14–19) in the past year. Prevalence varied greatly across countries and regions, with lifetime prevalence ranging from 6% (3–11) in Georgia to 49% (35–64) in Papua New Guinea. Overall, the prevalence of both lifetime (154 countries) and past-year (157 countries) intimate partner violence against adolescent girls was higher in low-income and lower-middle-income countries and regions than in high-income countries and regions. Countries with higher rates of female secondary school enrolment and those with inheritance laws that are more gender-equal had lower prevalence of intimate partner violence against adolescent girls. Lower-income countries and societies with a high prevalence of child marriage had higher prevalence of physical or sexual intimate partner violence against adolescent girls.</p></div><div><h3>Interpretation</h3><p>Our findings highlight the widespread prevalence of intimate partner violence against adolescent girls across the globe and its relationship with country-level contextual factors. They emphasise the need for promoting and ensuring policies and programmes that increase and ensure gender equality. Countries should strive to provide secondary education for all girls, ensure equal property rights for women,","PeriodicalId":54238,"journal":{"name":"Lancet Child & Adolescent Health","volume":"8 9","pages":"Pages 636-646"},"PeriodicalIF":19.9,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2352464224001457/pdfft?md5=da4fe445673c951cdf370a1914c26d4a&pid=1-s2.0-S2352464224001457-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141862361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0