Annual Review of Cancer Biology-Series最新文献

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The Role of Autophagy in Cancer. 自噬在癌症中的作用。

IF 7.7 2区医学

Annual Review of Cancer Biology-Series Pub Date : 2017-03-01 DOI: 10.1146/annurev-cancerbio-041816-122338

Naiara Santana-Codina, Joseph D Mancias, Alec C Kimmelman

引用次数: 127

Stress-Induced Mutagenesis: Implications in Cancer and Drug Resistance. 应激诱导的突变：癌症和耐药性的影响。

IF 4.7 2区医学

Annual Review of Cancer Biology-Series Pub Date : 2017-03-01 DOI: 10.1146/annurev-cancerbio-050216-121919

Devon M Fitzgerald, P J Hastings, Susan M Rosenberg

{"title":"Stress-Induced Mutagenesis: Implications in Cancer and Drug Resistance.","authors":"Devon M Fitzgerald, P J Hastings, Susan M Rosenberg","doi":"10.1146/annurev-cancerbio-050216-121919","DOIUrl":"10.1146/annurev-cancerbio-050216-121919","url":null,"abstract":"Genomic instability underlies many cancers and generates genetic variation that drives cancer initiation, progression, and therapy resistance. In contrast with classical assumptions that mutations occur purely stochastically at constant, gradual rates, microbes, plants, flies, and human cancer cells possess mechanisms of mutagenesis that are upregulated by stress responses. These generate transient, genetic-diversity bursts that can propel evolution, specifically when cells are poorly adapted to their environments-that is, when stressed. We review molecular mechanisms of stress-response-dependent (stress-induced) mutagenesis that occur from bacteria to cancer, and are activated by starvation, drugs, hypoxia, and other stressors. We discuss mutagenic DNA break repair in Escherichia coli as a model for mechanisms in cancers. The temporal regulation of mutagenesis by stress responses and spatial restriction in genomes are common themes across the tree of life. Both can accelerate evolution, including the evolution of cancers. We discuss possible anti-evolvability drugs, aimed at targeting mutagenesis and other variation generators, that could be used to delay the evolution of cancer progression and therapy resistance.","PeriodicalId":54233,"journal":{"name":"Annual Review of Cancer Biology-Series","volume":"1 ","pages":"119-140"},"PeriodicalIF":4.7,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5794033/pdf/nihms905152.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35793382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

p53: Multiple Facets of a Rubik's Cube. p53：魔方的多个方面。

IF 4.7 2区医学

Annual Review of Cancer Biology-Series Pub Date : 2017-03-01 Epub Date: 2016-10-17 DOI: 10.1146/annurev-cancerbio-050216-121926

Yun Zhang, Guillermina Lozano

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引用次数: 0

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