Annual Review of Cancer Biology-Series最新文献_第5页

WNT and β-Catenin in Cancer: Genes and Therapy 癌症的WNT和β-儿茶素基因及其治疗

IF 7.7 2区医学

Annual Review of Cancer Biology-Series Pub Date : 2020-03-09 DOI: 10.1146/annurev-cancerbio-030419-033628

R. Jackstadt, M. Hodder, O. Sansom

引用次数: 32

Is There a Clinical Future for IDO1 Inhibitors After the Failure of Epacadostat in Melanoma? Epacadostat治疗黑色素瘤失败后，IDO1抑制剂有临床前景吗？

IF 7.7 2区医学

Annual Review of Cancer Biology-Series Pub Date : 2020-03-09 DOI: 10.1146/annurev-cancerbio-030419-033635

Benoit J. Van den Eynde, N. van Baren, J. Baurain

引用次数: 104

Lactate and Acidity in the Cancer Microenvironment 癌症微环境中的乳酸和酸性

IF 7.7 2区医学

Annual Review of Cancer Biology-Series Pub Date : 2020-03-09 DOI: 10.1146/annurev-cancerbio-030419-033556

S. Parks, W. Mueller‐Klieser, J. Pouysségur

{"title":"Lactate and Acidity in the Cancer Microenvironment","authors":"S. Parks, W. Mueller‐Klieser, J. Pouysségur","doi":"10.1146/annurev-cancerbio-030419-033556","DOIUrl":"https://doi.org/10.1146/annurev-cancerbio-030419-033556","url":null,"abstract":"Fermentative glycolysis, an ancient evolved metabolic pathway, is exploited by rapidly growing tissues and tumors but also occurs in response to the nutritional and energetic demands of differentiated tissues. The lactic acid it produces is transported across cell membranes through reversible H+/lactate−symporters (MCT1 and MCT4) and is recycled in organs as a major metabolic precursor of gluconeogenesis and an energy source. Concentrations of lactate in the tumor environment, investigated utilizing an induced metabolic bioluminescence imaging (imBI) technique, appear to be dominant biomarkers of tumor response to irradiation and resistance to treatment. Suppression of lactic acid formation by genetic disruption of lactate dehydrogenases A and B in aggressive tumors reactivated OXPHOS (oxidative phosphorylation) to maintain xenograft tumor growth at a halved rate. In contrast, disruption of the lactic acid transporters MCT1/4 suppressed glycolysis, mTORC1, and tumor growth as a result of intracellular acidosis. Furthermore, the global reduction of tumor acidity contributes to activation of the antitumor immune responses, offering hope for future clinical applications.","PeriodicalId":54233,"journal":{"name":"Annual Review of Cancer Biology-Series","volume":" ","pages":""},"PeriodicalIF":7.7,"publicationDate":"2020-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-cancerbio-030419-033556","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45539729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 58

Cancer-Associated Cachexia: A Systemic Consequence of Cancer Progression 癌症相关性恶病质：癌症进展的系统性后果

IF 7.7 2区医学

Annual Review of Cancer Biology-Series Pub Date : 2020-03-09 DOI: 10.1146/annurev-cancerbio-030419-033642

A. Biswas, Swarnali Acharyya

引用次数: 25

The Role of Translation Control in Tumorigenesis and Its Therapeutic Implications 翻译控制在肿瘤发生中的作用及其治疗意义

IF 7.7 2区医学

Annual Review of Cancer Biology-Series Pub Date : 2020-03-09 DOI: 10.1146/annurev-cancerbio-030419-033420

Yichen Xu, D. Ruggero

{"title":"The Role of Translation Control in Tumorigenesis and Its Therapeutic Implications","authors":"Yichen Xu, D. Ruggero","doi":"10.1146/annurev-cancerbio-030419-033420","DOIUrl":"https://doi.org/10.1146/annurev-cancerbio-030419-033420","url":null,"abstract":"As a convergent mechanism downstream of most oncogenic signals, control of mRNA translation has emerged as a key driver in establishing and tuning gene expression at specific steps in cancer development. Translation control is the most energetically expensive molecular process in the cell that needs to be modulated upon adaption to limited cellular resources, such as cellular stress. It thereby serves as the Achilles’ heel for cancer cells, particularly in response to changes in the microenvironment as well as to nutrient and metabolic shifts characteristic of cancer cell growth and metastasis. In this review, we discuss emerging discoveries that reveal how cancer cells modulate the translation machinery to adapt to oncogenic stress, the mechanisms that guide mRNA translation specificity in cancer, and how this selective mode of gene regulation provides advantages for cancer progression. We also provide an overview of promising preclinical and clinical efforts aimed at targeting the unique vulnerabilities of cancer cells that rely on the remodeling of mRNA translation for their infinite growth and survival.","PeriodicalId":54233,"journal":{"name":"Annual Review of Cancer Biology-Series","volume":" ","pages":""},"PeriodicalIF":7.7,"publicationDate":"2020-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-cancerbio-030419-033420","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49109586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 34

Biomarkers for Response to Immune Checkpoint Blockade 免疫检查点阻断反应的生物标志物

IF 7.7 2区医学

Annual Review of Cancer Biology-Series Pub Date : 2020-03-09 DOI: 10.1146/annurev-cancerbio-030419-033604

S. Ganesan, J. Mehnert

{"title":"Biomarkers for Response to Immune Checkpoint Blockade","authors":"S. Ganesan, J. Mehnert","doi":"10.1146/annurev-cancerbio-030419-033604","DOIUrl":"https://doi.org/10.1146/annurev-cancerbio-030419-033604","url":null,"abstract":"Immune checkpoint blockade (ICB) has significant clinical activity in diverse cancer classes and can induce durable remissions in even refractory advanced disease. However, only a minority of cancer patients treated with ICB have long-term benefits, and ICB treatment is associated with significant, potentially life-threatening, autoimmune side effects. There is a great need to develop biomarkers of response to guide patient selection to maximize the chance of benefit and prevent unnecessary toxicity, and current biomarkers do not have optimal positive or negative predictive value. A variety of potential biomarkers are currently being developed, including those based on assessment of checkpoint protein expression, evaluation of tumor-intrinsic features including mutation burden and viral infection, evaluation of features of the tumor immune microenvironment including nature of immune cell infiltration, and features of the host such as composition of the gut microbiome. Better understanding of the underlying fundamental mechanisms of immune response and resistance to ICB, along with the use of complementary assays that interrogate distinct features of the tumor, the tumor microenvironment, and host immune system, will allow more precise use of these therapies to optimize patient outcomes.","PeriodicalId":54233,"journal":{"name":"Annual Review of Cancer Biology-Series","volume":" ","pages":""},"PeriodicalIF":7.7,"publicationDate":"2020-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-cancerbio-030419-033604","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43807365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 24

RNA Modifications in Cancer: Functions, Mechanisms, and Therapeutic Implications 癌症的RNA修饰：功能、机制和治疗意义

IF 7.7 2区医学

Annual Review of Cancer Biology-Series Pub Date : 2020-03-09 DOI: 10.1146/annurev-cancerbio-030419-033357

Huilin Huang, Hengyou Weng, Xiaolan Deng, Jianjun Chen

引用次数: 54

AMP-Activated Protein Kinase: Friend or Foe in Cancer? amp活化蛋白激酶:癌症的朋友还是敌人?

IF 7.7 2区医学

Annual Review of Cancer Biology-Series Pub Date : 2020-03-09 DOI: 10.1146/annurev-cancerbio-030419-033619

Diana Vara-Ciruelos, M. Dandapani, D. Hardie

引用次数: 20

Nongenetic Mechanisms of Drug Resistance in Melanoma 黑色素瘤耐药性的非遗传机制

IF 7.7 2区医学

Annual Review of Cancer Biology-Series Pub Date : 2020-03-09 DOI: 10.1146/annurev-cancerbio-030419-033533

V. Rebecca, M. Herlyn

{"title":"Nongenetic Mechanisms of Drug Resistance in Melanoma","authors":"V. Rebecca, M. Herlyn","doi":"10.1146/annurev-cancerbio-030419-033533","DOIUrl":"https://doi.org/10.1146/annurev-cancerbio-030419-033533","url":null,"abstract":"Resistance to targeted and immune-based therapies limits cures in patients with metastatic melanoma. A growing number of reports have identified nongenetic primary resistance mechanisms including intrinsic microenvironment- and lineage plasticity–mediated processes serving critical functions in the persistence of disease throughout therapy. There is a temporally shifting spectrum of cellular identities fluidly occupied by therapy-persisting melanoma cells responsible for driving therapeutic resistance and metastasis. The key epigenetic, metabolic, and phenotypic reprogramming events requisite for the manifestation and maintenance of so-called persister melanoma populations remain poorly understood and underscore the need to comprehensively investigate actionable vulnerabilities. Here we attempt to integrate the field's observations on nongenetic mechanisms of drug resistance in melanoma. We postulate that the future design of therapeutic strategies specifically addressing therapy-persisting subpopulations of melanoma will improve the curative potential of therapy for patients with metastatic disease.","PeriodicalId":54233,"journal":{"name":"Annual Review of Cancer Biology-Series","volume":" ","pages":""},"PeriodicalIF":7.7,"publicationDate":"2020-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-cancerbio-030419-033533","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46584390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

Regulatory T Cells in Cancer 肿瘤中的调节性T细胞

IF 7.7 2区医学

Annual Review of Cancer Biology-Series Pub Date : 2020-03-09 DOI: 10.1146/annurev-cancerbio-030419-033428

G. Plitas, A. Rudensky

{"title":"Regulatory T Cells in Cancer","authors":"G. Plitas, A. Rudensky","doi":"10.1146/annurev-cancerbio-030419-033428","DOIUrl":"https://doi.org/10.1146/annurev-cancerbio-030419-033428","url":null,"abstract":"The immune system has evolved complex effector mechanisms to protect the host against a diversity of pathogenic organisms and regulatory adaptations that can curtail pathological sequelae of inflammatory events, prevent autoimmunity, and assist in tissue repair. Cancers, by virtue of their local manifestations of tissue dysfunction and destruction, inflammation, and genomic instability, can evoke these protective mechanisms, which support the progression of tumors and prevent their immune eradication. Central to these processes is a subset of CD4+ T cells, known as regulatory T (Treg) cells, that express the X chromosome–linked transcription factor FOXP3. In addition to their critical role in controlling autoimmunity and suppressing inflammatory responses in diverse biological settings, Treg cells are ubiquitously present in the tumor microenvironment where they promote tumor development and progression by dampening antitumor immune responses. Furthermore, Treg cells can directly support the survival of transformed cells through the elaboration of growth factors and interacting with accessory cells in tumors such as fibroblasts and endothelial cells. Current insights into the biology of tumor-associated Treg cells have opened up opportunities for their selective targeting in cancer, with the goal of alleviating their suppression of antitumor immune responses while maintaining overall immune homeostasis.","PeriodicalId":54233,"journal":{"name":"Annual Review of Cancer Biology-Series","volume":" ","pages":""},"PeriodicalIF":7.7,"publicationDate":"2020-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-cancerbio-030419-033428","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44313839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 52