Annual Review of Cancer Biology-Series最新文献_第2页

The Effects of Clonal Heterogeneity on Cancer Immunosurveillance 克隆异质性对肿瘤免疫监测的影响

IF 7.7 2区医学

Annual Review of Cancer Biology-Series Pub Date : 2023-01-17 DOI: 10.1146/annurev-cancerbio-061521-101910

K. Dijkstra, Yin Wu, C. Swanton

{"title":"The Effects of Clonal Heterogeneity on Cancer Immunosurveillance","authors":"K. Dijkstra, Yin Wu, C. Swanton","doi":"10.1146/annurev-cancerbio-061521-101910","DOIUrl":"https://doi.org/10.1146/annurev-cancerbio-061521-101910","url":null,"abstract":"Intratumor heterogeneity (ITH) is associated with tumor progression in several clinical and experimental settings and contributes to therapeutic resistance. Its relation to cancer immunosurveillance is complex. Clonally heterogeneous tumors are associated with decreased immunosurveillance and are less responsive to immune checkpoint inhibition, but the mechanistic basis underlying these observations remains unclear. One possibility is that tumors that are under active immunosurveillance are relatively homogeneous because immunosurveillance prevents the outgrowth of immunogenic subclones. Alternatively, high ITH might directly impair immunosurveillance due to lower dosages of subclonal antigens, competition between antigens and immunodominance, the induction of detrimental T cell differentiation programs, or negative feedback loops. Here we review the evidence for these scenarios and outline hypotheses that could underlie the negative association between clonal heterogeneity and cancer immunosurveillance. Expected final online publication date for the Annual Review of Cancer Biology, Volume 7 is April 2023. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.","PeriodicalId":54233,"journal":{"name":"Annual Review of Cancer Biology-Series","volume":" ","pages":""},"PeriodicalIF":7.7,"publicationDate":"2023-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42485615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Cancer-Associated Fibroblasts: Lessons from Pancreatic Cancer 癌症相关成纤维细胞：从癌症中吸取的教训

IF 7.7 2区医学

Annual Review of Cancer Biology-Series Pub Date : 2023-01-17 DOI: 10.1146/annurev-cancerbio-061421-035400

M. Sherman, M. Pasca di Magliano

{"title":"Cancer-Associated Fibroblasts: Lessons from Pancreatic Cancer","authors":"M. Sherman, M. Pasca di Magliano","doi":"10.1146/annurev-cancerbio-061421-035400","DOIUrl":"https://doi.org/10.1146/annurev-cancerbio-061421-035400","url":null,"abstract":"Cancer-associated fibroblasts (CAFs) are present in all malignancies. Arguably, in none are they as prevalent as they are in pancreatic ductal adenocarcinoma (PDAC), where they often outnumber cancer cells. The origin and function of CAFs are still not completely understood, and attempts to target this cell population as a component of combination therapy have so far not succeeded. Our understanding of pancreatic CAFs is in rapid evolution. Heterogeneity of CAFs is the key concept to understand this cell population. We discuss heterogeneity of origin, with recent findings challenging the notion that CAFs uniformly derive from pancreatic stellate cells, and instead suggesting that multiple types of resident fibroblasts contribute to CAF expansion. Heterogeneity in gene expression divides CAFs in different subpopulations. Most importantly, heterogeneity in function underlies the complexity of CAFs. CAFs deposit components of the extracellular matrix, contributing to the high interstitial pressure in pancreatic cancer. CAFs serve as “feeder” cells for cancer cells by providing metabolites, thus mitigating the effect of the low-nutrient environment of PDAC. At the same time, CAFs regulate the function of the immune system, inhibiting antitumor immune responses. Understanding the functional role of different CAF populations and the drivers of each of their functional roles is key to devising new ways to target this cell population in PDAC. Expected final online publication date for the Annual Review of Cancer Biology, Volume 7 is April 2023. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.","PeriodicalId":54233,"journal":{"name":"Annual Review of Cancer Biology-Series","volume":" ","pages":""},"PeriodicalIF":7.7,"publicationDate":"2023-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48693509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

The Potent and Paradoxical Biology of Cellular Senescence in Cancer 癌症细胞衰老的有效性和悖论生物学

IF 7.7 2区医学

Annual Review of Cancer Biology-Series Pub Date : 2023-01-17 DOI: 10.1146/annurev-cancerbio-061421-124434

P. Romesser, S. Lowe

{"title":"The Potent and Paradoxical Biology of Cellular Senescence in Cancer","authors":"P. Romesser, S. Lowe","doi":"10.1146/annurev-cancerbio-061421-124434","DOIUrl":"https://doi.org/10.1146/annurev-cancerbio-061421-124434","url":null,"abstract":"Cellular senescence is a tumor-suppressive program that promotes tissue homeostasis by identifying damaged cells for immune-mediated clearance. Thus, the ability to evade senescence and the ensuing immune surveillance is a hallmark of cancer. Reactivation of senescence programs can result in profound immune-mediated tumor regressions or sensitize tumors to immunotherapy, although the aberrant persistence of senescent cells can promote tissue decline and contribute to the side effects of some cancer therapies. In this review, we first briefly describe the discovery of senescence as a tumor-suppressive program. Next, we highlight the dueling good and bad effects of the senescence-associated secretory program (SASP) in cancer, including SASP-dependent immune effects. We then summarize the beneficial and deleterious effects of senescence induction by cancer therapies and strategies in development to leverage senescence therapeutically. Finally, we highlight challenges and unmet needs in understanding senescence in cancer and developing senescence-modulating therapies. Expected final online publication date for the Annual Review of Cancer Biology, Volume 7 is April 2023. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.","PeriodicalId":54233,"journal":{"name":"Annual Review of Cancer Biology-Series","volume":" ","pages":""},"PeriodicalIF":7.7,"publicationDate":"2023-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47803622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

AI in Computational Pathology of Cancer: Improving Diagnostic Workflows and Clinical Outcomes? 人工智能在癌症计算病理学中的应用:改善诊断工作流程和临床结果?

IF 7.7 2区医学

Annual Review of Cancer Biology-Series Pub Date : 2023-01-17 DOI: 10.1146/annurev-cancerbio-061521-092038

D. Cifci, G. P. Veldhuizen, S. Foersch, Jakob Nikolas Kather

{"title":"AI in Computational Pathology of Cancer: Improving Diagnostic Workflows and Clinical Outcomes?","authors":"D. Cifci, G. P. Veldhuizen, S. Foersch, Jakob Nikolas Kather","doi":"10.1146/annurev-cancerbio-061521-092038","DOIUrl":"https://doi.org/10.1146/annurev-cancerbio-061521-092038","url":null,"abstract":"Histopathology plays a fundamental role in the diagnosis and subtyping of solid tumors and has become a cornerstone of modern precision oncology. Histopathological evaluation is typically performed manually by expert pathologists due to the complexity of visual data. However, in the last ten years, new artificial intelligence (AI) methods have made it possible to train computers to perform visual tasks with high performance, reaching similar levels as experts in some applications. In cancer histopathology, these AI tools could help automate repetitive tasks, making more efficient use of pathologists’ time. In research studies, AI methods have been shown to have an astounding ability to predict genetic alterations and identify prognostic and predictive biomarkers directly from routine tissue slides. Here, we give an overview of these recent applications of AI in computational pathology, focusing on new tools for cancer research that could be pivotal in identifying clinical biomarkers for better treatment decisions. Expected final online publication date for the Annual Review of Cancer Biology, Volume 7 is April 2023. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.","PeriodicalId":54233,"journal":{"name":"Annual Review of Cancer Biology-Series","volume":" ","pages":""},"PeriodicalIF":7.7,"publicationDate":"2023-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44789886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

The Role of Phase-Separated Condensates in Fusion Oncoprotein–Driven Cancers 相分离凝聚物在融合癌蛋白驱动的癌症中的作用

IF 7.7 2区医学

Annual Review of Cancer Biology-Series Pub Date : 2023-01-13 DOI: 10.1146/annurev-cancerbio-061421-122050

Hazheen K. Shirnekhi, Bappaditya Chandra, R. Kriwacki

{"title":"The Role of Phase-Separated Condensates in Fusion Oncoprotein–Driven Cancers","authors":"Hazheen K. Shirnekhi, Bappaditya Chandra, R. Kriwacki","doi":"10.1146/annurev-cancerbio-061421-122050","DOIUrl":"https://doi.org/10.1146/annurev-cancerbio-061421-122050","url":null,"abstract":"Fusion oncoproteins (FOs) resulting from in-frame chromosomal translocations are associated with many aggressive cancers with poor patient outcomes. Several FOs are now understood to perform their oncogenic functions within biomolecular condensates formed through liquid-liquid phase separation (LLPS). Two classes of phase-separating FOs have emerged, those that form nuclear condensates and alter chromatin biology, including gene expression, and those that form cytoplasmic condensates and promote aberrant signaling, including RAS/MAPK signaling. The amino acid sequences of the FOs within these classes display LLPS-prone intrinsically disordered regions and folded domains that synergistically interact with themselves and other biomolecules to promote condensate formation. This review summarizes the roles of LLPS in the oncogenic functions of these two FO classes, provides examples of FOs that inhibit physiological LLPS in normal cells, and discusses the sequence features commonly associated with LLPS and their enrichment in many FOs. Expected final online publication date for the Annual Review of Cancer Biology, Volume 7 is April 2023. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.","PeriodicalId":54233,"journal":{"name":"Annual Review of Cancer Biology-Series","volume":" ","pages":""},"PeriodicalIF":7.7,"publicationDate":"2023-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47676186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Targeting Driver Oncogenes and Other Public Neoantigens Using T Cell Receptor-Based Cellular Therapy. 利用基于T细胞受体的细胞治疗靶向驱动癌基因和其他公共新抗原。

IF 7.7 2区医学

Annual Review of Cancer Biology-Series Pub Date : 2023-01-01 DOI: 10.1146/annurev-cancerbio-061521-082114

Tijana Martinov, Philip D Greenberg

{"title":"Targeting Driver Oncogenes and Other Public Neoantigens Using T Cell Receptor-Based Cellular Therapy.","authors":"Tijana Martinov, Philip D Greenberg","doi":"10.1146/annurev-cancerbio-061521-082114","DOIUrl":"https://doi.org/10.1146/annurev-cancerbio-061521-082114","url":null,"abstract":"T cell reactivity to tumor-specific neoantigens can drive endogenous and therapeutically induced antitumor immunity. However, most tumor-specific neoantigens are unique to each patient (private) and targeting them requires personalized therapy. A smaller subset of neoantigens includes epitopes that span recurrent mutation hotspots, translocations, or gene fusions in oncogenic drivers and tumor suppressors, as well as epitopes that arise from viral oncogenic proteins. Such antigens are likely to be shared across patients (public), uniformly expressed within a tumor, and required for cancer cell survival and fitness. Although a limited number of these public neoantigens are naturally immunogenic, recent studies affirm their clinical utility. In this review, we highlight efforts to target mutant KRAS, mutant p53, and epitopes derived from oncogenic viruses using T cells engineered with off-the-shelf T cell receptors. We also discuss the challenges and strategies to achieving more effective T cell therapies, particularly in the context of solid tumors.","PeriodicalId":54233,"journal":{"name":"Annual Review of Cancer Biology-Series","volume":"7 1","pages":"331-351"},"PeriodicalIF":7.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10470615/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10150304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Development of Tissue-Agnostic Treatments for Patients with Cancer 癌症患者组织不可知治疗的进展

IF 7.7 2区医学

Annual Review of Cancer Biology-Series Pub Date : 2022-04-11 DOI: 10.1146/annurev-cancerbio-060921-021828

S. Lemery, L. Fashoyin-Aje, L. Marcus, S. Casak, Julie A. Schneider, M. Theoret, P. Kluetz, R. Pazdur, J. Beaver

引用次数: 2

Novel Mouse Models for Cancer Immunology. 癌症免疫学的新型小鼠模型。

IF 4.7 2区医学

Annual Review of Cancer Biology-Series Pub Date : 2022-04-01 Epub Date: 2022-01-18 DOI: 10.1146/annurev-cancerbio-070620-105523

Kelli A Connolly, Brittany Fitzgerald, Martina Damo, Nikhil S Joshi

引用次数: 0

Oncohistones: Hijacking the histone code. 组蛋白:劫持组蛋白代码。

IF 7.7 2区医学

Annual Review of Cancer Biology-Series Pub Date : 2022-04-01 DOI: 10.1146/annurev-cancerbio-070120-102521

Varun Sahu, Chao Lu

{"title":"Oncohistones: Hijacking the histone code.","authors":"Varun Sahu, Chao Lu","doi":"10.1146/annurev-cancerbio-070120-102521","DOIUrl":"https://doi.org/10.1146/annurev-cancerbio-070120-102521","url":null,"abstract":"Chromatin dysfunction has been implicated in a growing number of cancers especially in children and young adults. In addition to chromatin modifying and remodeling enzymes, mutations in histone genes are linked to human cancers. Since the first reports of hotspot missense mutations affecting key residues at histone H3 tail, studies have revealed how these so-called \"oncohistones\" dominantly (H3K27M and H3K36M) or locally (H3.3G34R/W) inhibit corresponding histone methyltransferases and misregulate epigenome and transcriptome to promote tumorigenesis. More recently, widespread mutations in all four core histones are identified in diverse cancer types. Furthermore, an \"oncohistone-like\" protein EZHIP has been implicated in driving childhood ependymomas through a mechanism highly reminiscent of H3K27M mutation. We will review recent progresses on understanding the biochemical, molecular and biological mechanisms underlying the canonical and novel histone mutations. Importantly, these mechanistic insights have identified therapeutic opportunities for oncohistone-driven tumors.","PeriodicalId":54233,"journal":{"name":"Annual Review of Cancer Biology-Series","volume":"6 ","pages":"293-312"},"PeriodicalIF":7.7,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9802661/pdf/nihms-1860508.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10480574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

CRISPR Screens to Identify Regulators of Tumor Immunity. 通过 CRISPR 筛选确定肿瘤免疫调节剂。

IF 4.7 2区医学

Annual Review of Cancer Biology-Series Pub Date : 2022-04-01 Epub Date: 2021-12-23 DOI: 10.1146/annurev-cancerbio-070120-094725

Martin W LaFleur, Arlene H Sharpe

引用次数: 0