克隆异质性对肿瘤免疫监测的影响

IF 4.7 2区医学 Q1 ONCOLOGY

Annual Review of Cancer Biology-Series Pub Date : 2023-01-17 DOI:10.1146/annurev-cancerbio-061521-101910

K. Dijkstra, Yin Wu, C. Swanton

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引用次数: 1

摘要

在一些临床和实验环境中，瘤内异质性（ITH）与肿瘤进展有关，并导致治疗耐药性。它与癌症免疫监测的关系是复杂的。克隆异质性肿瘤与免疫监测减少有关，对免疫检查点抑制反应较低，但这些观察结果的机制基础尚不清楚。一种可能性是，处于主动免疫监测下的肿瘤相对同质，因为免疫监测可以防止免疫原性亚克隆的生长。或者，由于亚克隆抗原的低剂量、抗原和免疫优势之间的竞争、有害T细胞分化程序的诱导或负反馈回路，高ITH可能直接损害免疫监测。在此，我们回顾了这些情况的证据，并概述了克隆异质性与癌症免疫监测之间负相关的假设。《癌症生物学年度评论》第7卷预计最终在线出版日期为2023年4月。请参阅http://www.annualreviews.org/page/journal/pubdates用于修订估算。

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The Effects of Clonal Heterogeneity on Cancer Immunosurveillance

Intratumor heterogeneity (ITH) is associated with tumor progression in several clinical and experimental settings and contributes to therapeutic resistance. Its relation to cancer immunosurveillance is complex. Clonally heterogeneous tumors are associated with decreased immunosurveillance and are less responsive to immune checkpoint inhibition, but the mechanistic basis underlying these observations remains unclear. One possibility is that tumors that are under active immunosurveillance are relatively homogeneous because immunosurveillance prevents the outgrowth of immunogenic subclones. Alternatively, high ITH might directly impair immunosurveillance due to lower dosages of subclonal antigens, competition between antigens and immunodominance, the induction of detrimental T cell differentiation programs, or negative feedback loops. Here we review the evidence for these scenarios and outline hypotheses that could underlie the negative association between clonal heterogeneity and cancer immunosurveillance. Expected final online publication date for the Annual Review of Cancer Biology, Volume 7 is April 2023. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

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来源期刊

Annual Review of Cancer Biology-Series Medicine-Oncology

CiteScore

14.50

自引率

1.30%

发文量

期刊介绍： The Annual Review of Cancer Biology offers comprehensive reviews on various topics within cancer research, covering pivotal and emerging areas in the field. As our understanding of cancer's fundamental mechanisms deepens and more findings transition into targeted clinical treatments, the journal is structured around three main themes: Cancer Cell Biology, Tumorigenesis and Cancer Progression, and Translational Cancer Science. The current volume of this journal has transitioned from gated to open access through Annual Reviews' Subscribe to Open program, ensuring all articles are published under a CC BY license.