Addiction Science & Clinical Practice最新文献

{"title":"Patient perceptions of the use of e-cigarettes in smoking treatment programs: a qualitative analysis.","authors":"Sidney V Rojas, Kelly A Kyanko, Rachel Wisniewski, Katherine O'Connor, Rina Li, Grace Xiang, Mahathi Vojjala, Olivia Wilker, Scott E Sherman, Elizabeth R Stevens","doi":"10.1186/s13722-025-00575-w","DOIUrl":"https://doi.org/10.1186/s13722-025-00575-w","url":null,"abstract":"<p><strong>Background: </strong>E-cigarettes may serve as a safer alternative to combustible cigarettes and may be more effective than currently available nicotine replacement therapy (NRT). Little is known about the perceptions of using e-cigarettes as part of a smoking treatment program. The objective of this study was to gain insight into patient-level factors to consider when developing smoking treatment programs that incorporate e-cigarettes.</p><p><strong>Methods: </strong>Qualitative analysis of in-depth interviews with 14 participants enrolled in the e-cigarette treatment arm of a tobacco treatment intervention pilot randomized trial comparing the impact of behavioral counseling paired with e-cigarettes or NRT on smoking outcomes. Participants were prompted to share their experiences with the products and the study overall. Transcripts were coded according to the principles of framework analysis for applied research. Codes were organized into themes using the principles of grounded theory.</p><p><strong>Results: </strong>Themes suggest that while there is an eagerness to try e-cigarettes as a new tool for smoking cessation, there is apprehension regarding what it means to \"quit\" if switching to e-cigarettes. Reflecting on the transitional purpose of e-cigarettes and potential health concerns associated with their use, many participants differentiated between the short-term goal to quit combustible cigarettes and the long-term goal to quit e-cigarettes.</p><p><strong>Conclusions: </strong>Including e-cigarettes as an option in smoking treatment regimens may be an opportunity to re-engage people who smoke who have tried and failed to quit with other forms of treatment. Participants found it challenging to establish what it means to quit cigarettes with e-cigarettes due to addiction and other health concerns. Clear guidelines are needed for integrating e-cigarettes into smoking cessation programs.</p><p><strong>Trial registrations: </strong>ClinicalTrials.gov Identifier: NCT04465318.</p>","PeriodicalId":54223,"journal":{"name":"Addiction Science & Clinical Practice","volume":"20 1","pages":"45"},"PeriodicalIF":3.7,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144183431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preoperative evaluation of alcohol consumption in older patients.","authors":"Vera Guttenthaler, Maria Wittmann, Jan Menzenbach","doi":"10.1186/s13722-025-00569-8","DOIUrl":"10.1186/s13722-025-00569-8","url":null,"abstract":"<p><strong>Purpose: </strong>This sub-analysis of the PROPDESC-study (Pre-Operative Prediction of postoperative delirium by appropriate Screening-study) evaluated the alcohol consumption of older patients with two different assessment tools (single sentence question and Alcohol Use Disorder Identification Test-Consumption (AUDIT-C)) and compared the results in regards to detection, reliability, and quantification of patient´s alcohol consumption.</p><p><strong>Methods: </strong>During their anesthesiological pre-clinic visit 1084 patients older than 59 years were asked whether they consume alcohol daily and 668 of them additionally answered the AUDIT-C questionnaire.</p><p><strong>Results: </strong>According to the SSQ 11.72% of the patients consumed alcohol daily. In the AUDIT-C sub-group 25.90% reported moderate to high alcohol consumption while infrequent or very low alcohol intake was reported by 41.92%. In the subgroup 31.89% of the patients stated alcohol abstinence. About one quarter (25.13%) of patients who denied daily alcohol intake but scored positive on the AUDIT-C displayed levels of alcohol consumption ranging from moderate (11.20%) to high (13.87%) according to the AUDIT-C.</p><p><strong>Conclusion: </strong>Reliable information about alcohol consumption is related to the method of questioning. The AUDIT-C evaluates the patient´s alcohol intake precisely and identifies more older patients with possibly health- and surgery-relevant alcohol consumption levels. The validated AUDIT-C provides an objective assessment to the physician during the pre-clinic anesthesiologic consultation. Additionally, handing out a questionnaire to the patient encourages initiative and self-assessment and could also relieve both, the physician and the patient from sensing a moral evaluation of alcohol consumption.</p>","PeriodicalId":54223,"journal":{"name":"Addiction Science & Clinical Practice","volume":"20 1","pages":"44"},"PeriodicalIF":3.7,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12093839/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144121264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determinants of implementing the 15-method in Danish general practice using the consolidated framework for implementation science.","authors":"Peter Næsborg Schøler, Jens Søndergaard, Sanne Rasmussen, Kristina Hasselbalch Volke, Per Nilsen, Anette Søgaard Nielsen","doi":"10.1186/s13722-025-00571-0","DOIUrl":"10.1186/s13722-025-00571-0","url":null,"abstract":"<p><strong>Background: </strong>Excessive alcohol consumption is a significant global health issue, often unaddressed in primary care. The 15-method, a three-step opportunistic screening and treatment tool premised on Motivational Interviewing and integrated within the Screening, Brief Intervention and Referral to Treatment framework, offers a structured approach for healthcare professionals to identify and treat alcohol-related problems. The present study aimed to assess healthcare professionals' perceptions of determinants for early-stage implementation of the 15-method in Danish general practice and to classify these determinants using the Consolidated Framework for Implementation Research (CFIR).</p><p><strong>Methods: </strong>This qualitative study involved individual interviews and group interviews with general practitioners and nurses (N = 28) from 12 general practices participating in the Identification and Treatment of Alcohol Problems in Primary Care (iTAPP) study, a stepped-wedge cluster randomized controlled trial evaluating the effectiveness of the 15-method in Danish general practice. Interviews were semi-structured, guided by the CFIR framework, and analyzed using directed content analysis. Determinants were rated for their influence on implementation.</p><p><strong>Results: </strong>Key facilitators included the 15-method's adaptability, strong evidence base, relative advantage, and compatibility with existing practices. Barriers included structural characteristics in the practices and local conditions. A central finding revealed a tension between patients' motivation and healthcare professionals' opportunities and capabilities to deliver the 15-method. Mixed determinants highlighted the complexity of implementing the 15-method across diverse practices.</p><p><strong>Conclusion: </strong>Implementing the 15-method in Danish general practice is feasible but requires addressing specific barriers and leveraging facilitators. A multifaceted implementation strategy tailored to individual practices may be necessary to address the variations in contexts and resources across different practices with an emphasis on increasing healthcare professionals' capabilities and opportunities to deliver the intervention.</p>","PeriodicalId":54223,"journal":{"name":"Addiction Science & Clinical Practice","volume":"20 1","pages":"43"},"PeriodicalIF":3.7,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12083036/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient-elected low-dose intravenous naloxone for rapid buprenorphine induction: a case report.","authors":"Pouya Azar, Jessica Machado, Jane J Kim, James S H Wong, Mohammadali Nikoo, Victor W Li","doi":"10.1186/s13722-025-00572-z","DOIUrl":"https://doi.org/10.1186/s13722-025-00572-z","url":null,"abstract":"<p><strong>Background: </strong>Buprenorphine is a common partial opioid agonist treatment for opioid use disorder (OUD). Despite its efficacy, major challenges to induction include the significant time consumption and the difficult requirement for patients to be in moderate opioid withdrawal.</p><p><strong>Case presentation: </strong>We present the case of a 31-year-old man with severe OUD and regular fentanyl use who was successfully initiated on buprenorphine-naloxone using low-dose intravenous naloxone in ten minutes and administered 300 mg of extended-release injectable buprenorphine within two hours. This involved the rapid administration of small doses of intravenous naloxone with an assessment of withdrawal symptoms after each dose. Buprenorphine-naloxone is immediately administered once moderate withdrawal is reached.</p><p><strong>Conclusions: </strong>Low-dose intravenous naloxone provides an alternative method of buprenorphine induction that limits the experience of withdrawal to a shorter time window compared to existing protocols.</p>","PeriodicalId":54223,"journal":{"name":"Addiction Science & Clinical Practice","volume":"20 1","pages":"42"},"PeriodicalIF":3.7,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12079928/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144081943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Digital interventions as part of routine addiction care in Sweden: healthcare staff perceptions of what works.","authors":"Elisabeth Petersén, Hanna Augustsson Öfverström, Magnus Johansson, Christopher Sundström, Anne H Berman","doi":"10.1186/s13722-025-00570-1","DOIUrl":"10.1186/s13722-025-00570-1","url":null,"abstract":"<p><strong>Background: </strong>Every year about three million people die globally due to harmful alcohol use. The treatment gap remains high: only about 14% of individuals with problematic alcohol use access treatment. The implementation of digital interventions, addressing problematic alcohol use, into healthcare can be one way of reducing the treatment gap. However, little is known about how healthcare staff perceive the integration of digital interventions in routine addiction care. The aim of the study was to identify and describe healthcare staff's experiences of perceived benefits of digital interventions for patients with alcohol use disorders (AUD), introduced in recent years within routine specialized addiction care in Sweden. The aim was further to explore how the use of such interventions in this setting could be further developed.</p><p><strong>Methods: </strong>This study was conducted as an exploratory qualitative interview study with 16 informants from addiction care staff in Stockholm, Sweden. The informants came from three different groups: clinical managers, staff referring outpatients to digital interventions from within addiction care, and therapists from an e-support unit. The interviews were recorded, transcribed, and analyzed with thematic analysis.</p><p><strong>Results: </strong>Three themes illustrated the benefits of digital interventions in routine addiction care, and future development areas. The theme An easy way in reflected the importance of easy access to addiction care where care would be flexible and available to everyone. Meeting individual patient needs raised the question of how to adapt treatment formats to the patients' individual needs. Smoothly interlocking organizational gears highlighted the need for structure and cooperation between digital care and in-person care. Each theme included three additional subthemes.</p><p><strong>Conclusions: </strong>The study identifies key factors for successfully integrating digital interventions in addiction care, highlighting the importance of staff engagement, structured workflows, training, and ongoing evaluation using a sociological framework.</p>","PeriodicalId":54223,"journal":{"name":"Addiction Science & Clinical Practice","volume":"20 1","pages":"41"},"PeriodicalIF":3.7,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12067725/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144032310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Repetitive transcranial magnetic stimulation for stimulant use disorders (STIMULUS): protocol for a multi-site, double-blind, randomized controlled trial.","authors":"Zahraa Atoui, Donald Egan, Manish Kumar Jha, Karen Hartwell, Russell Toll, Susan Sonne, Brenda Brunner-Jackson, Geetha Subramaniam, Jenna L McCauley, Madhukar Trivedi, Kathleen Brady","doi":"10.1186/s13722-025-00567-w","DOIUrl":"10.1186/s13722-025-00567-w","url":null,"abstract":"<p><strong>Background: </strong>Cocaine and methamphetamine use disorders (CcUD/MtUD) have serious public health, medical, and psychiatric consequences. Yet, there are no U.S. Food and Drug Administration (FDA) approved treatments available. The STIMULUS study is a multi-site trial, sponsored by the National Drug Abuse Treatment Clinical Trials Network (CTN), that aims to investigate the feasibility and preliminary efficacy of repetitive transcranial magnetic stimulation (rTMS) as a potential treatment for moderate to severe CcUD/MtUD.</p><p><strong>Methods: </strong>The study is a double-blind, sham-controlled trial seeking to recruit 160 participants with a current moderate to severe CcUD or MtUD diagnosis, randomized to receive active rTMS (10-Hz stimulation at 120% motor threshold over the left dorsolateral prefrontal cortex) or sham. Feasibility is assessed by a target of at least 20 treatment sessions administered within an 8-week period. Additionally, the study aims to evaluate the efficacy of rTMS in reducing stimulant use and craving, the impact of rTMS on mood, anxiety, sleep, and other measures, and the utility of electroencephalography as a treatment response biomarker.</p><p><strong>Discussion: </strong>Studies exploring rTMS for stimulant use disorders remain limited by small sample sizes, as well as great heterogeneity in defined study population, treatment parameters, retention in treatment, and number of sessions. In this paper, we highlight key study design decisions, such as safety, sham procedure, and schedule flexibility.</p><p><strong>Conclusion: </strong>We hope that the data collected will lay the groundwork for a robust randomized controlled trial of rTMS as a therapeutic intervention for individuals with CcUD/MtUD.</p><p><strong>Trial registration: </strong>http://www.</p><p><strong>Clinicaltrials: </strong>gov . Identifier: NCT04907357. TRIAL DATA SET: https://clinicaltrials.gov/study/NCT04907357?tab=table .</p><p><strong>Protocol: </strong>Version 7.0, 11/10/2023.</p>","PeriodicalId":54223,"journal":{"name":"Addiction Science & Clinical Practice","volume":"20 1","pages":"40"},"PeriodicalIF":3.7,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12060337/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144032592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subtypes and service utilization among opioid use disorder patients at a community health center: findings from a medically underserved urban area of the Northeastern United States.","authors":"Orrin D Ware, Jamey J Lister, Sarah E Cooper, Andrew H Kim, Holly H Lister, N Andrew Peterson, Stephen Fioravanti, Kristen Gilmore Powell, Stephanie C Marcello, Bethany Joseph","doi":"10.1186/s13722-025-00564-z","DOIUrl":"https://doi.org/10.1186/s13722-025-00564-z","url":null,"abstract":"<p><strong>Background: </strong>Opioid use disorder often co-occurs with other mental health and substance use disorders. Identifying clusters of individuals receiving treatment for opioid use disorder based on co-diagnosed conditions, healthcare plans, and service utilization over a seven-year treatment period provides insight into service needs. Objectives included [1] characterizing the sample [2], examining subtypes of the sample using cluster analysis, and [3] identifying differences in Current Procedural Terminology by subtype to examine service utilization among identified clusters.</p><p><strong>Methods: </strong>This study uses secondary data from the electronic medical records of a community health center in a large urban area in the Northeastern United States from 2015 to 2021. The study sample included N = 705 adults who had an opioid use disorder diagnosis as indicated by the community health center's electronic medical records. Measures include [1] age [2], race and ethnicity [3], sex [4], healthcare plan(s) [5], co-occurring mental health disorder [6], co-occurring substance use disorder [7], co-occurring mental health disorder or substance use disorder, and [8] Current Procedural Terminology codes for behavioral health service utilization. Cluster analysis was used to examine the sample. These clusters were then analyzed for service utilization with a one-way analysis of variance.</p><p><strong>Results: </strong>The cluster analysis identified six clusters with an average silhouette of 0.5, indicating good clustering. These six clusters were operationalized as [1] Medicare/Medicaid healthcare plan with substance use disorder needs [2], Private pay and charity care healthcare plan with cocaine use disorder needs [3], Medicare/Medicaid and other publicly-funded healthcare plans with mood disorder needs [4], Private healthcare plan with low co-occurring disorder needs [5], Other publicly-funded healthcare plan with cannabis use disorder needs [6], Medicare/Medicaid healthcare plan with mental health disorder needs. Service utilization differed between these clusters with cluster mean differences for psychotherapy sessions (F = 8.55, p < 0.001), psychiatric sessions (F = 22.72, p < 0.001), and group therapy sessions (F = 10.76, p < 0.001).</p><p><strong>Conclusions: </strong>This study highlights the importance of comprehensive and integrated treatment for substance use disorders and mental health disorders, particularly for those in underserved communities. Healthcare coverage, a socioeconomic factor that impacts access to care, is critical in distinguishing treatment needs and utilization.</p>","PeriodicalId":54223,"journal":{"name":"Addiction Science & Clinical Practice","volume":"20 1","pages":"39"},"PeriodicalIF":3.7,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12060499/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143999909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implementing buprenorphine for opioid use disorder in veterans health administration primary care: a qualitative analysis.","authors":"Aline Lott, Anissa N Danner, Carol A Malte, Hope A Salameh, Diana Bachowski, Adam J Gordon, Hildi J Hagedorn, Madeline C Frost, Emily C Williams, Andrew J Saxon, Ryan S Trim, Eric J Hawkins","doi":"10.1186/s13722-025-00568-9","DOIUrl":"https://doi.org/10.1186/s13722-025-00568-9","url":null,"abstract":"<p><strong>Background: </strong>Medications for opioid use disorder are evidence-based, guideline-recommended treatments. While buprenorphine can be prescribed in nonspecialized office-based settings, it is underutilized. Using a multifaceted implementation initiative, the Veterans Health Administration (VHA) sought to expand access to buprenorphine in nonspecialized office-based settings, including primary care clinics. The purpose of this qualitative evaluation was to assess and describe primary care clinicians' perspectives on delivering buprenorphine care during the first year of the initiative.</p><p><strong>Methods: </strong>Using a snowball sampling approach, individualized emails were sent to primary care clinicians participating in a VHA initiative (n = 43) inviting them to be interviewed. Individual semi-structured interviews were conducted September 2019 through January 2020, and were audio-recorded, transcribed, and analyzed using thematic analysis. The Consolidated Framework for Implementation Research (CFIR), a meta-theoretical framework of five domains associated with successful adoption of interventions, was used to organize findings.</p><p><strong>Results: </strong>Of 43 clinicians invited, 19 responded and were interviewed (44.2%). Findings represented two CFIR domains: Inner Setting and Characteristics of Individuals. For Inner Setting, three themes were identified as influencing implementation during the first year of the initiative. Clinicians reported a shared receptivity to implement buprenorphine, organizational support from pharmacy services and leadership, as well as cohesive relationships among implementation team members and collaboration with outside clinics. Noted barriers included fit within primary care workflows and lack of staff, time and access to onsite laboratory services and buprenorphine. For Characteristics of Individuals, two themes were identified that may facilitate clinicians' willingness to provide buprenorphine care. Namely, clinicians reported positive attitudes about and experiences delivering opioid use disorder care and a willingness to learn/do something new.</p><p><strong>Conclusions: </strong>While implementation strategies should be tailored to individual clinic needs, prioritizing factors identified in this evaluation may support successful implementation of buprenorphine delivery in primary care.</p>","PeriodicalId":54223,"journal":{"name":"Addiction Science & Clinical Practice","volume":"20 1","pages":"38"},"PeriodicalIF":3.7,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12042572/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144033095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Forging hospital and community partnerships to enable care coordination for opioid use disorder.","authors":"Zoe Lindenfeld, Berkeley Franz, Alden Yuanhong Lai, José A Pagán, Cheyenne Fenstemaker, Cory E Cronin, Ji Eun Chang","doi":"10.1186/s13722-025-00565-y","DOIUrl":"https://doi.org/10.1186/s13722-025-00565-y","url":null,"abstract":"<p><strong>Background: </strong>Programs that aim to increase access to substance use disorder (SUD) treatment in hospital-based settings have proliferated in recent years. These efforts include transitional opioid programs (TOPs), which navigate patients to community-based SUD treatment programs post-discharge. Successful navigation from TOPs to outpatient treatment hinges on effective coordination between hospitals and post-discharge endpoints, yet it is unclear how hospitals can best develop effective partnerships with outpatient treatment organizations. The objective of this study is to synthesize the common themes underpinning the development of partnerships to facilitate care transitions between TOPs and ongoing SUD treatment.</p><p><strong>Methods: </strong>Qualitative study with staff and providers from hospitals affiliated with four safety-net health systems (n = 21) and leaders from community-based organizations (CBOs) and treatment facilities that had established referral partnerships with one of the four health systems in our study (n = 4).</p><p><strong>Results: </strong>Analysis of interview transcripts revealed seven common themes that underpinned the development of care transitions partnerships: (1) Active, intentional outreach; (2) Responding to a community need; (3) External Enabling Factors; (4) Leveraging reputations and community connections; (5) Focusing on operations; (6) Reciprocal relationships; and (7) Building Infrastructure and Processes to Ensure Collaboration. The seven identified themes were categorized into three groups corresponding to different partnership development stages. The first group revolves around the initial stage of meeting and developing a relationship (themes #1-4). The second set focuses on navigating and resolving challenges that arise in the partnership (themes #5-6). Lastly, the third group pertains to sustaining a partnership long-term (theme #7).</p><p><strong>Conclusions: </strong>This study identifies seven core themes underlying the development of care transition partnerships for SUD patients within four safety net health systems and their CBO partners. These themes demonstrate how partner organizations can establish the trust, reciprocity, and commitment necessary to support patients through the critical transition period.</p>","PeriodicalId":54223,"journal":{"name":"Addiction Science & Clinical Practice","volume":"20 1","pages":"37"},"PeriodicalIF":3.7,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12020205/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143999815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel online vaping intervention and smoking prevention program for young adults who vape: protocol for a randomized controlled trial.","authors":"Denise D Tran, Jordan P Davis, Keegan Buch, Adam M Leventhal, Sarah W Feldstein Ewing, Eric R Pedersen","doi":"10.1186/s13722-025-00566-x","DOIUrl":"https://doi.org/10.1186/s13722-025-00566-x","url":null,"abstract":"<p><strong>Background: </strong>E-cigarette use (i.e., vaping) is prevalent among young adults in the U.S. Studies show that young adults who vape are more likely to initiate cigarette smoking than young adults who do not vape. Despite this, little research on vaping interventions and prevention of smoking for young adults who vape exist.</p><p><strong>Methods: </strong>A 2-arm pilot randomized controlled trial (RCT) will be conducted by recruiting young adults ages 18-24 who reported vaping at least once per week in the past 30 days and having never smoked cigarettes at baseline. Participants will be recruited via social media ads and be randomly assigned to an intervention arm, which will be the Live Free From E-cigarettes (LIFFE) mobile-based program (n = 50), or a waitlist control arm (n = 50). The primary outcomes are biochemically verified 7-day point prevalence abstinence for nicotine vaping, vaping reduction, and smoking susceptibility. Outcomes are measured at 2-, 4-, and 8-weeks after randomization.</p><p><strong>Discussion: </strong>This is the first RCT to evaluate the effectiveness of a mobile-based intervention that targets smoking susceptibility while also supporting vaping cessation or vaping reduction in young adults. Findings may inform future efforts to prevent transition to cigarette smoking and vaping cessation and reduction in young adults.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov: NCT06129123; Date of registration: 11/10/2023.</p>","PeriodicalId":54223,"journal":{"name":"Addiction Science & Clinical Practice","volume":"20 1","pages":"36"},"PeriodicalIF":3.7,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12010681/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144065088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}