Nano Futures最新文献

{"title":"Nanobiohybrids and bacterial carriers: a novel pathway to targeted cancer therapy","authors":"Diyar Salahuddin Ali, Hazha Omar Othman, Sarhang Hayyas Mohammed, Rebwar Omar Hassan, Zahraa Sarkawt Faethullah, Roza Ibrahim Kareem and Slim Smaoui","doi":"10.1088/2399-1984/ad7802","DOIUrl":"https://doi.org/10.1088/2399-1984/ad7802","url":null,"abstract":"The new strategies in this regard of nanotechnology and biotechnology guarantee new, efficient modalities for cancer therapy. In this study, we explore nanobiohybrids, the bacterium-targeted cancer treatment approach that presents a new category of therapeutic carriers for treating cancer. We specifically focus on bacteriomimetics, where bacteria are used as natural carriers for therapeutic agents. These bacteria possess the ability of pathotropism in localizing themselves around tumor tissues, even hypoxic areas that are generally refractory to standard therapies. By engineering the surface of these bacteria, we enhance how they target tumor cells so that treatment is delivered specifically to the tumor microenvironment with no or minimal systemic side effects. Furthermore, these synthetic nanoparticles inculcated into these bacterial systems stabilize drugs and also provide a way for controlled release, which is important to maintain therapeutic effectiveness. Our results established that such nanobiohybrids are capable of efficient delivery of chemotherapeutic agents and of conducting a local real-time therapeutic response from the perspective of personalized cancer treatment. This research implies a huge development in targeted therapy against cancer, and further work has focused on optimizing these biohybrid systems for clinical applications.","PeriodicalId":54222,"journal":{"name":"Nano Futures","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142252830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The use of orthogonal analytical approaches to profile lipid nanoparticle physicochemical attributes","authors":"Callum G Davidson, Rand Abdulrahman, Panida Punnabhum, Michael Cairns, Nicholas J W Rattray, Robin Capomaccio, Kevin Treacher, Yvonne Perrie, Zahra Rattray","doi":"10.1088/2399-1984/ad70e6","DOIUrl":"https://doi.org/10.1088/2399-1984/ad70e6","url":null,"abstract":"Lipid nanoparticles (LNPs) have become a major disruptor within the drug delivery field of complex RNA molecules. The wide applicability of prototype nanomedicines has the potential to fill clinical requirements for use against current untreatable diseases. The uptake and implementation of analytical technologies to evaluate these prototype nanomedicines have not experienced similar growth rates, thus hindering the translation of LNPs. Here, we evaluate a model RNA-LNP formulation with a selection of routine and high-resolution orthogonal analytical techniques across studies on the manufacturing process parameter impact and formulation stability evaluation under refrigerated and ultra-low temperatures. We analysed a model cationic RNA-complexed LNP formulation via the process impact on formulation critical quality attributes, short-term refrigerated stability evaluation and frozen-storage stability using zetasizer dynamic light scattering and nanoparticle tracking analysis. We also evaluated freeze-/thaw-induced stress on LNP formulation using high-resolution field-flow fractionation. Statistical analysis and correlations between techniques were conducted to further enhance our understanding of LNP formulation design and its physicochemical attributes to facilitate LNP formulation clinical translation.","PeriodicalId":54222,"journal":{"name":"Nano Futures","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142222673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Navigating the frontiers of graphene quality control to enable product optimisation and market confidence","authors":"Sofia Marchesini, Keith R Paton, Andrew J Pollard","doi":"10.1088/2399-1984/ad523e","DOIUrl":"https://doi.org/10.1088/2399-1984/ad523e","url":null,"abstract":"With graphene and related two-dimensional (2D) materials now enhancing products used in everyday life, the scale of industrial production of many different types of 2D nanomaterials requires quality control (QC) processes that can be performed rapidly, non-destructively, in-line and in a cost-effective manner. These materials must be repeatably produced with targeted material properties, to reduce the costs associated with nonconformity of products, and so multiple QC methods that can monitor different material properties are required. Herein, we describe different measurands and associated techniques that either have the potential to be used for QC, or are already being used in this way, whether that off-line, at-line or in-line. The advantages and disadvantages of different techniques are detailed, as well as possible solutions that can ensure confidence in these methods and lead to measurement traceability in this growing industry.","PeriodicalId":54222,"journal":{"name":"Nano Futures","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141507014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Overlapping top gate electrodes based on low temperature atomic layer deposition for nanoscale ambipolar lateral junctions","authors":"Christopher Fuchs, Lena Fürst, Hartmut Buhmann, Johannes Kleinlein and Laurens W Molenkamp","doi":"10.1088/2399-1984/ad4c33","DOIUrl":"https://doi.org/10.1088/2399-1984/ad4c33","url":null,"abstract":"We present overlapping top gate electrodes for the formation of gate defined lateral junctions in semiconducting layers as an alternative to the back gate/top gate combination and to the split gate configuration. The optical lithography microfabrication of the overlapping top gates is based on multiple layers of low-temperature atomic layer deposited hafnium oxide, which acts as a gate dielectric and as a robust insulating layer between two overlapping gate electrodes exhibiting a large dielectric breakdown field of . The advantage of overlapping gates over the split gate approach is confirmed in model calculations of the electrostatics of the gate stack. The overlapping gate process is applied to Hall bar devices of mercury telluride in order to study the interaction of different quantum Hall states in the nn′, np, pn and pp′ regime.","PeriodicalId":54222,"journal":{"name":"Nano Futures","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141171188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Turning CO2 into Sustainable Graphene: A Comprehensive Review of Recent Synthesis Techniques and Developments","authors":"M. S. Sorayani Bafqi, Nargiz Aliyeva, Havva Baskan Bayrak, Semih Dogan, Burcu Saner Okan","doi":"10.1088/2399-1984/ad4fd5","DOIUrl":"https://doi.org/10.1088/2399-1984/ad4fd5","url":null,"abstract":"\u0000 The synthesis of graphene through environmentally friendly and efficient methods has posed a persistent challenge, prompting extensive research in recent years to access sustainable source and attain high quality graphene competing with the one obtained from graphite ores. Addressing this challenge becomes even more intricate when aiming to convert captured CO2 into graphene structures, encountering hurdles stemming from the inherent stability of the CO2 molecule and its steadfast transformation. Together with CO2, there is a great potential to create carbon source by using natural biomass, cellulosic plant sources and industrial wastes. This comprehensive review delves into the recent synthesis techniques and developments, exploring both direct and indirect pathways for the integration of CO2 that strive to overcome the complexities associated with transforming CO2 into graphene. The review critically analyzes CO2 capturing mechanisms designed for air, ocean, and alternative sources, outlining the progress made in harnessing captured CO2 as a feedstock for graphene production by evaluating captured CO2 values. This review consolidates the recent advancements by providing a roadmap for future research directions in the sustainable synthesis of graphene from captured CO2 in the pursuit of a greener, circular economy.","PeriodicalId":54222,"journal":{"name":"Nano Futures","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141103544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perspectives for III-Nitride photonic platforms","authors":"Philippe Boucaud, N. Bhat, M. Gromovyi, M. El Kurdi, Antoine Reserbat-Plantey, Minh Tuan Dau, Mohamed Al Khalfioui, B. Alloing, Benjamin Damilano, Fabrice Semond","doi":"10.1088/2399-1984/ad41aa","DOIUrl":"https://doi.org/10.1088/2399-1984/ad41aa","url":null,"abstract":"\u0000 The development of photonic platforms for the visible or ultra-violet spectral range represents a major challenge. In this article, we present an overview of the technological solutions available on the market. We discuss the pros and cons associated with heterogeneous or monolithic integration. We specifically focus on the III-nitride platform for integrated photonics. The III-nitrides offer every building block needed for a universal platform. We discuss the additional opportunities offered by combining III-nitride semiconductors with other materials such as two-dimensional materials.","PeriodicalId":54222,"journal":{"name":"Nano Futures","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140672291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Roadmap for unconventional computing with nanotechnology","authors":"Giovanni Finocchio, Jean Anne C Incorvia, Joseph S Friedman, Qu Yang, Anna Giordano, Julie Grollier, Hyunsoo Yang, Florin Ciubotaru, Andrii V Chumak, Azad J Naeemi, Sorin D Cotofana, Riccardo Tomasello, Christos Panagopoulos, Mario Carpentieri, Peng Lin, Gang Pan, J Joshua Yang, Aida Todri-Sanial, Gabriele Boschetto, Kremena Makasheva, Vinod K Sangwan, Amit Ranjan Trivedi, Mark C Hersam, Kerem Y Camsari, Peter L McMahon, Supriyo Datta, Belita Koiller, Gabriel H Aguilar, Guilherme P Temporão, Davi R Rodrigues, Satoshi Sunada, Karin Everschor-Sitte, Kosuke Tatsumura, Hayato Goto, Vito Puliafito, Johan Åkerman, Hiroki Takesue, Massimiliano Di Ventra, Yuriy V Pershin, Saibal Mukhopadhyay, Kaushik Roy, I- Ting Wang, Wang Kang, Yao Zhu, Brajesh Kumar Kaushik, Jennifer Hasler, Samiran Ganguly, Avik W Ghosh, William Levy, Vwani Roychowdhury, Supriyo Bandyopadhyay","doi":"10.1088/2399-1984/ad299a","DOIUrl":"https://doi.org/10.1088/2399-1984/ad299a","url":null,"abstract":"In the ‘Beyond Moore’s Law’ era, with increasing edge intelligence, domain-specific computing embracing unconventional approaches will become increasingly prevalent. At the same time, adopting a variety of nanotechnologies will offer benefits in energy cost, computational speed, reduced footprint, cyber resilience, and processing power. The time is ripe for a roadmap for unconventional computing with nanotechnologies to guide future research, and this collection aims to fill that need. The authors provide a comprehensive roadmap for neuromorphic computing using electron spins, memristive devices, two-dimensional nanomaterials, nanomagnets, and various dynamical systems. They also address other paradigms such as Ising machines, Bayesian inference engines, probabilistic computing with p-bits, processing in memory, quantum memories and algorithms, computing with skyrmions and spin waves, and brain-inspired computing for incremental learning and problem-solving in severely resource-constrained environments. These approaches have advantages over traditional Boolean computing based on von Neumann architecture. As the computational requirements for artificial intelligence grow 50 times faster than Moore’s Law for electronics, more unconventional approaches to computing and signal processing will appear on the horizon, and this roadmap will help identify future needs and challenges. In a very fertile field, experts in the field aim to present some of the dominant and most promising technologies for unconventional computing that will be around for some time to come. Within a holistic approach, the goal is to provide pathways for solidifying the field and guiding future impactful discoveries.","PeriodicalId":54222,"journal":{"name":"Nano Futures","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140582933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Roadmap on Printable Electronic Materials for Next-Generation Sensors","authors":"Vincenzo Pecunia, Luisa Petti, J. Andrews, Riccardo Ollearo, G. Gelinck, Bahareh Nasrollahi, Javith Mohammed Jailani, Ning Li, Jong H. Kim, T. Ng, Hanru Feng, Zhizhou Chen, Yupeng Guo, Liang Shen, E. Lhuillier, Lidia Kuo, V. Sangwan, M. Hersam, Beatrice Fraboni, L. Basiricò, A. Ciavatti","doi":"10.1088/2399-1984/ad36ff","DOIUrl":"https://doi.org/10.1088/2399-1984/ad36ff","url":null,"abstract":"\u0000 The dissemination of sensors is key to realizing a sustainable, ‘intelligent’ world, where everyday objects and environments are equipped with sensing capabilities to advance the sustainability and quality of our lives—e.g., via smart homes, smart cities, smart healthcare, smart logistics, Industry 4.0, and precision agriculture. The realization of the full potential of these applications critically depends on the availability of easy-to-make, low-cost sensor technologies. Sensors based on printable electronic materials offer the ideal platform: they can be fabricated through simple methods (e.g., printing and coating) and are compatible with high-throughput roll-to-roll processing. Moreover, printable electronic materials often allow the fabrication of sensors on flexible/stretchable/biodegradable substrates, thereby enabling the deployment of sensors in unconventional settings. Fulfilling the promise of printable electronic materials for sensing will require materials and device innovations to enhance their ability to transduce external stimuli—light, ionizing radiation, pressure, strain, force, temperature, gas, vapours, humidity, and other chemical and biological analytes. This Roadmap brings together the viewpoints of experts in various printable sensing materials—and devices thereof—to provide insights into the status and outlook of the field. Alongside recent materials and device innovations, the roadmap discusses the key outstanding challenges pertaining to each printable sensing technology. Finally, the Roadmap points to promising directions to overcome these challenges and thus enable ubiquitous sensing for a sustainable, ‘intelligent’ world.","PeriodicalId":54222,"journal":{"name":"Nano Futures","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140215455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ab initio guided atomistic modelling of nanomaterials on exascale high-performance computing platforms","authors":"J. J. Gutiérrez Moreno","doi":"10.1088/2399-1984/ad32d2","DOIUrl":"https://doi.org/10.1088/2399-1984/ad32d2","url":null,"abstract":"\u0000 The continuous development of increasingly powerful supercomputers makes theory-guided discoveries in materials and molecular sciences more achievable than ever before. On this ground, the incoming arrival of exascale supercomputers (running over 10^18 floating point operations per second) is a key milestone that will tremendously increase the capabilities of high-performance computing (HPC). The deployment of these massive platforms will enable continuous improvements in the accuracy and scalability of ab initio codes for materials simulation. Moreover, the recent progress in advanced experimental synthesis and characterisation methods with atomic precision has led ab initio-based materials modelling and experimental methods to a convergence in terms of system sizes. This makes it possible to mimic full-scale systems in silico almost without the requirement of experimental inputs. This article provides a perspective on how computational materials science will be further empowered by the recent arrival of exascale HPC, going alongside a mini-review on the state-of-the-art of HPC-aided materials research. Possible challenges related to the efficient use of increasingly larger and heterogeneous platforms are commented on, highlighting the importance of the co-design cycle. Also, some illustrative examples of materials for target applications, which could be investigated in detail in the coming years based on a rational nanoscale design in a bottom-up fashion, are summarised.","PeriodicalId":54222,"journal":{"name":"Nano Futures","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140248679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"One (photon), two(-dimensional crystals), a lot (of potential): a quick snapshot of a rapidly evolving field","authors":"Salvatore Cianci, E. Blundo, Marco Felici","doi":"10.1088/2399-1984/ad285b","DOIUrl":"https://doi.org/10.1088/2399-1984/ad285b","url":null,"abstract":"\u0000 We present a concise overview of the state of affairs in the development of single-photon sources based on two-dimensional (2D) crystals, focusing in particular on transition-metal dichalcogenides and hexagonal boron nitride. We briefly discuss the current level of advancement (i) in our understanding of the microscopic origin of the quantum emitters (QEs) identified in these two material systems, and (ii) in the characterization of the optical properties of these emitters; then, we survey the main methods developed to enable the dynamic control of the QEs' emission energy. Finally, we summarize the main results stemming from the coupling of QEs embedded in 2D materials with photonic and plasmonic structures.","PeriodicalId":54222,"journal":{"name":"Nano Futures","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139843384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}