Translational Medicine at UniSa最新文献_第2页

Lessons from Sicilian Centenarians for Anti-Ageing Medicine. The Oxi-Inflammatory Status. 西西里百岁老人抗衰老医学的经验教训。氧炎性状态。

IF 1.5

Translational Medicine at UniSa Pub Date : 2022-09-26 eCollection Date: 2022-01-01 DOI: 10.37825/2239-9754.1036

Calogero Caruso, Giulia Accardi, Anna Aiello, Anna Calabrò, Mattia E Ligotti, Giuseppina Candore

引用次数: 0

KL-6 in ARDS and COVID-19 Patients. ARDS 和 COVID-19 患者中的 KL-6

IF 1.1

Translational Medicine at UniSa Pub Date : 2022-09-16 eCollection Date: 2022-01-01 DOI: 10.37825/2239-9754.1035

Ornella Piazza, Giuliana Scarpati, Giovanni Boccia, Massimo Boffardi, Pasquale Pagliano

{"title":"KL-6 in ARDS and COVID-19 Patients.","authors":"Ornella Piazza, Giuliana Scarpati, Giovanni Boccia, Massimo Boffardi, Pasquale Pagliano","doi":"10.37825/2239-9754.1035","DOIUrl":"10.37825/2239-9754.1035","url":null,"abstract":"The Acute Respiratory Distress Syndrome (ARDS) is a common, devastating clinical pattern characterized by life-threatening respiratory failure. In ARDS there is an uncontrolled inflammatory response that results in alveolar damage, with the exudation of protein-rich pulmonary-edema fluid in the alveolar space. Although severe COVID-19 lung failure (CARDS) often meets diagnostic criteria of traditional ARDS, additional features have been reported, such as delayed onset, binary pulmonary compliant states, and hypercoagulable profile. Increased levels of Krebs von den Lungen 6 (KL-6, also known as MUC1) have been reported in both ARDS and CARDS. KL-6 is a transmembrane protein expressed on the apical membrane of most mucosal epithelial cells and it plays a critical role in lining the airway lumen. Abnormalities in mucus production contribute to severe pulmonary complications and death from respiratory failure in patients with diseases such as cystic fibrosis, chronic obstructive pulmonary disease, and acute lung injury due to viral pathogens. Nevertheless, it is not clear what role KL-6 plays in ARDS/CARDS pathophysiology. KL-6 may exert anti-inflammatory effects through the intracellular segment, as proven in animal models of ARDS, while its extracellular segment will enter the blood circulation through the alveolar space when the alveolar epithelial cells are damaged. Therefore, changes in plasma KL-6 levels may be useful in ARDS and CARDS phenotyping, and KL-6 might guide future clinical trials in 'personalized medicine' settings.","PeriodicalId":54170,"journal":{"name":"Translational Medicine at UniSa","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2022-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9673987/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40503909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acute Coronary Syndrome in Patients with SARS-CoV-2 Infection: Pathophysiology and Translational Perspectives. SARS-CoV-2感染患者的急性冠状动脉综合征:病理生理学和翻译观点

IF 1.5

Translational Medicine at UniSa Pub Date : 2022-08-29 eCollection Date: 2022-01-01 DOI: 10.37825/2239-9754.1034

Francesco P Cancro, Michele Bellino, Luca Esposito, Stefano Romei, Mario Centore, Debora D'Elia, Mario Cristiano, Angelantonio Maglio, Albino Carrizzo, Barbara Rasile, Carmine Alfano, Carmine Vecchione, Gennaro Galasso

{"title":"Acute Coronary Syndrome in Patients with SARS-CoV-2 Infection: Pathophysiology and Translational Perspectives.","authors":"Francesco P Cancro, Michele Bellino, Luca Esposito, Stefano Romei, Mario Centore, Debora D'Elia, Mario Cristiano, Angelantonio Maglio, Albino Carrizzo, Barbara Rasile, Carmine Alfano, Carmine Vecchione, Gennaro Galasso","doi":"10.37825/2239-9754.1034","DOIUrl":"https://doi.org/10.37825/2239-9754.1034","url":null,"abstract":"Acute coronary syndromes (ACS) may complicate the clinical course of patients with Coronavirus Disease 2019 (COVID-19). It is still unclear whether this condition is a direct consequence of the primary disease. However, several mechanisms including direct cellular damage, endothelial dysfunction, in-situ thrombosis, systemic inflammatory response, and oxygen supply-demand imbalance have been described in patients with COVID-19. The onset of a prothrombotic state may also be facilitated by the endothelial dysfunction secondary to the systemic inflammatory response and to the direct viral cell damage. Moreover, dysfunctional endothelial cells may enhance vasospasm and platelet aggregation. The combination of these factors promotes atherosclerotic plaque instability, thrombosis and, consequently, type 1 myocardial infarction. Furthermore, severe hypoxia due to extensive pulmonary involvement, in association with other conditions described in COVID-19 such as sepsis, tachyarrhythmias, anemia, hypotension, and shock, may lead to mismatch between oxygen supply and demand, and cause type 2 myocardial infarction. A deeper understanding of the potential pathophysiological mechanisms underlying ACS in patients with COVID-19 could help the therapeutic management of these very high-risk patients.","PeriodicalId":54170,"journal":{"name":"Translational Medicine at UniSa","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2022-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9673986/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40503911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The Time for a Consensus Regarding the Coeliac Disease Diagnosis in Adults has come: Balancing the Pros and Cons of Omitting the Biopsy 就成人乳糜泻诊断达成共识的时机已经到来：平衡省略活检的利弊

IF 1.5

Translational Medicine at UniSa Pub Date : 2022-03-08 DOI: 10.37825/2239-9747.1027

C. Ciacci, Julio C Bao

引用次数: 0

Possible Association of Telomere Length with Sleep Duration. A Preliminary Pilot study in a Sicilian Cohort with Centenarians. 端粒长度与睡眠时间的可能关联。西西里百岁老人队列的初步试点研究。

IF 1.5

Translational Medicine at UniSa Pub Date : 2022-02-25 DOI: 10.37825/2239-9747.1026

C. Caruso

引用次数: 0

Role of BPIFB4 in Immune System and Cardiovascular Disease: the Lesson from Centenarians BPIFB4在免疫系统和心血管疾病中的作用：百岁老人的经验教训

IF 1.5

Translational Medicine at UniSa Pub Date : 2022-02-23 DOI: 10.37825/2239-9747.1024

F. Montella, V. Lopardo, Monica Cattaneo, A. Carrizzo, C. Vecchione, A. Puca, E. Ciaglia

引用次数: 1

Translating the Results of a Selective Decontamination of the Digestive Tract Trial into Efficacious Real-Life Interventions. 将选择性去污消化道试验的结果转化为有效的现实生活干预措施。

IF 1.5

Translational Medicine at UniSa Pub Date : 2022-01-01 DOI: 10.37825/2239-9747.1038

Ornella Piazza, Giovanni Boccia, Carolina Ciacci, Francesco De Caro, Amelia Filippelli, Gianluigi Franci, Pasquale Pagliano

引用次数: 0

Abdominal Aortic Aneurysm: Natural History, Pathophysiology and Translational Perspectives. 腹主动脉瘤:自然史、病理生理学和翻译观点。

IF 1.5

Translational Medicine at UniSa Pub Date : 2022-01-01 DOI: 10.37825/2239-9747.1037

Giulio Accarino, Antonio N Giordano, Martina Falcone, Adriana Celano, Maria G Vassallo, Giovanni Fornino, Umberto M Bracale, Carmine Vecchione, Gennaro Galasso

{"title":"Abdominal Aortic Aneurysm: Natural History, Pathophysiology and Translational Perspectives.","authors":"Giulio Accarino, Antonio N Giordano, Martina Falcone, Adriana Celano, Maria G Vassallo, Giovanni Fornino, Umberto M Bracale, Carmine Vecchione, Gennaro Galasso","doi":"10.37825/2239-9747.1037","DOIUrl":"https://doi.org/10.37825/2239-9747.1037","url":null,"abstract":"An abdominal aortic aneurysm (AAA) is a degenerative pathology that affects the infrarenal segment of the aorta, leading to its progressive dilatation and eventually rupture. The infrarenal segment is involved in 80% of the aortic aneurisms, and represents alone 30% of all aneurysms. The natural history of the disease is characterized by the progressive increase of the aortic diameter associated with proportionally higher risk of rupture, particularly for cases with diameter greater than 5.5 cm. In case of rupture the mortality rate is very high, independently from the endovascular or surgical treatment. The most important risk factors are older age, smoking, hypertension, dyslipidemia, and family history of AAA. The most frequent form is \"atherosclerotic\", but infectious, collagen disease-related, immune dysregulation-related, and post-traumatic AAA have also been described. Albeit multiple pathogenetic hypotheses have been proposed, the role of metallo-proteinases in the degeneration of the aortic wall seem to play a central role. Early detection of AAA is crucial for the identification and treatment before the onset of potentially life-threatening complications. Moreover, the individual risk stratification is fundamental for the clinical management and follow-up. The growing knowledge about the pathophysiology of AAA has the potential to lead to significant translational advances. The challenge for the next years is to employ bioinformatic and genetic models, also based on artificial intelligence and machine learning approach, to develop novel screening methods and to stratify individuals at higher-risk or in the early stages of AAA.","PeriodicalId":54170,"journal":{"name":"Translational Medicine at UniSa","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10354862/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9840762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

GM Allotypes and COVID-19. A Pilot Study Performed on Sicilian Patients. 转基因同种异体与COVID-19西西里病人的初步研究。

IF 1.5

Translational Medicine at UniSa Pub Date : 2022-01-01 DOI: 10.37825/2239-9747.1039

Mattia E Ligotti, Anna Calabrò, Giulia Accardi, Anna Aiello, Calogero Caruso, Claudia Colomba, Danilo Di Bona, Giovanni Duro, Aryan M Namboodiri, Antonino Tuttolomondo, Janardan P Pandey, Giuseppina Candore

引用次数: 0

Possible Association of Telomere Length With Sleep Duration. A Preliminary Pilot Study in a Sicilian Cohort with Centenarians. 端粒长度与睡眠时间的可能关联。西西里百岁老人队列的初步试点研究。

IF 1.5

Translational Medicine at UniSa Pub Date : 2021-12-23 eCollection Date: 2021-01-01 DOI: 10.37825/2239-9754.1031

Anna Aiello, Giulia Accardi, Sawan Alì, Calogero Caruso, Maxine Chen, Immaculata De Vivo, Mattia Emanuela Ligotti, Giovanni Scapagnini, Sergio Davinelli, Giuseppina Candore

{"title":"Possible Association of Telomere Length With Sleep Duration. A Preliminary Pilot Study in a Sicilian Cohort with Centenarians.","authors":"Anna Aiello, Giulia Accardi, Sawan Alì, Calogero Caruso, Maxine Chen, Immaculata De Vivo, Mattia Emanuela Ligotti, Giovanni Scapagnini, Sergio Davinelli, Giuseppina Candore","doi":"10.37825/2239-9754.1031","DOIUrl":"https://doi.org/10.37825/2239-9754.1031","url":null,"abstract":"Telomere length (TL) is considered a biomarker of ageing although this topic is still debated. Also, sleep pattern changes are physiological part of the normal ageing process. In fact, it is widely recognized that sleep duration declines with age, leading to dysregulation of circadian rhythms. The aim of our study was to analyse the possible association of sleep duration with TL in a sample of 135 subjects with ages ranging from 20 to 111 years, recruited from Palermo and neighbouring municipalities in Sicily (Italy). Preliminary data suggest that relative TL (RTL) decreases with age in both men and women. However, at older ages, the difference between men and women tends to narrow. Nonagenarian and centenarian women do not show RTL values significantly different from those observed in adult and old women (40-89 years aged). Moreover, to analyse the relationship between TL and sleep, we stratified sleep duration into greater or lesser than 8-h periods. We found that centenarians, who daily sleep 8 hours or more, have longer RTL than centenarians who sleep fewer than 8 hours. Although the relatively small sample size of centenarians, we provide preliminary evidence that sleep duration may affect the RTL of centenarians. To the best of our knowledge, this is the first study to examine the relationship between centenarians, RTL and sleep duration. Further studies with greater sample size of centenarians are required to replicate and extend these data.","PeriodicalId":54170,"journal":{"name":"Translational Medicine at UniSa","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2021-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9673914/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40711856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2