Translational Medicine at UniSa最新文献

{"title":"The Time for a Consensus Regarding the Coeliac Disease Diagnosis in Adults has come: Balancing the Pros and Cons of Omitting the Biopsy","authors":"C. Ciacci, Julio C Bao","doi":"10.37825/2239-9747.1027","DOIUrl":"https://doi.org/10.37825/2239-9747.1027","url":null,"abstract":"","PeriodicalId":54170,"journal":{"name":"Translational Medicine at UniSa","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2022-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49179160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Possible Association of Telomere Length with Sleep Duration. A Preliminary Pilot study in a Sicilian Cohort with Centenarians.","authors":"C. Caruso","doi":"10.37825/2239-9747.1026","DOIUrl":"https://doi.org/10.37825/2239-9747.1026","url":null,"abstract":"","PeriodicalId":54170,"journal":{"name":"Translational Medicine at UniSa","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2022-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48655122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of BPIFB4 in Immune System and Cardiovascular Disease: the Lesson from Centenarians","authors":"F. Montella, V. Lopardo, Monica Cattaneo, A. Carrizzo, C. Vecchione, A. Puca, E. Ciaglia","doi":"10.37825/2239-9747.1024","DOIUrl":"https://doi.org/10.37825/2239-9747.1024","url":null,"abstract":"","PeriodicalId":54170,"journal":{"name":"Translational Medicine at UniSa","volume":"1 1","pages":""},"PeriodicalIF":1.5,"publicationDate":"2022-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41487149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Translating the Results of a Selective Decontamination of the Digestive Tract Trial into Efficacious Real-Life Interventions.","authors":"Ornella Piazza, Giovanni Boccia, Carolina Ciacci, Francesco De Caro, Amelia Filippelli, Gianluigi Franci, Pasquale Pagliano","doi":"10.37825/2239-9747.1038","DOIUrl":"https://doi.org/10.37825/2239-9747.1038","url":null,"abstract":"Recommended Citation Piazza, Ornella; Boccia, Giovanni; Ciacci, Carolina; De Caro, Francesco; Filippelli, Amelia; Franci, Gianluigi; and Pagliano, Pasquale (2022) \"Translating the results of a Selective Decontamination of the Digestive Tract trial into efficacious real-life interventions,\" Translational Medicine @ UniSa: Vol. 24 : Iss. 2 , Article 4. Available at: https://doi.org/10.37825/2239-9747.1038","PeriodicalId":54170,"journal":{"name":"Translational Medicine at UniSa","volume":"24 2","pages":"24-25"},"PeriodicalIF":1.5,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10354863/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9840761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abdominal Aortic Aneurysm: Natural History, Pathophysiology and Translational Perspectives.","authors":"Giulio Accarino,&nbsp;Antonio N Giordano,&nbsp;Martina Falcone,&nbsp;Adriana Celano,&nbsp;Maria G Vassallo,&nbsp;Giovanni Fornino,&nbsp;Umberto M Bracale,&nbsp;Carmine Vecchione,&nbsp;Gennaro Galasso","doi":"10.37825/2239-9747.1037","DOIUrl":"https://doi.org/10.37825/2239-9747.1037","url":null,"abstract":"<p><p>An abdominal aortic aneurysm (AAA) is a degenerative pathology that affects the infrarenal segment of the aorta, leading to its progressive dilatation and eventually rupture. The infrarenal segment is involved in 80% of the aortic aneurisms, and represents alone 30% of all aneurysms. The natural history of the disease is characterized by the progressive increase of the aortic diameter associated with proportionally higher risk of rupture, particularly for cases with diameter greater than 5.5 cm. In case of rupture the mortality rate is very high, independently from the endovascular or surgical treatment. The most important risk factors are older age, smoking, hypertension, dyslipidemia, and family history of AAA. The most frequent form is \"atherosclerotic\", but infectious, collagen disease-related, immune dysregulation-related, and post-traumatic AAA have also been described. Albeit multiple pathogenetic hypotheses have been proposed, the role of metallo-proteinases in the degeneration of the aortic wall seem to play a central role. Early detection of AAA is crucial for the identification and treatment before the onset of potentially life-threatening complications. Moreover, the individual risk stratification is fundamental for the clinical management and follow-up. The growing knowledge about the pathophysiology of AAA has the potential to lead to significant translational advances. The challenge for the next years is to employ bioinformatic and genetic models, also based on artificial intelligence and machine learning approach, to develop novel screening methods and to stratify individuals at higher-risk or in the early stages of AAA.</p>","PeriodicalId":54170,"journal":{"name":"Translational Medicine at UniSa","volume":"24 2","pages":"30-40"},"PeriodicalIF":1.5,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10354862/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9840762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"GM Allotypes and COVID-19. A Pilot Study Performed on Sicilian Patients.","authors":"Mattia E Ligotti,&nbsp;Anna Calabrò,&nbsp;Giulia Accardi,&nbsp;Anna Aiello,&nbsp;Calogero Caruso,&nbsp;Claudia Colomba,&nbsp;Danilo Di Bona,&nbsp;Giovanni Duro,&nbsp;Aryan M Namboodiri,&nbsp;Antonino Tuttolomondo,&nbsp;Janardan P Pandey,&nbsp;Giuseppina Candore","doi":"10.37825/2239-9747.1039","DOIUrl":"https://doi.org/10.37825/2239-9747.1039","url":null,"abstract":"<p><p>Several studies suggest that genetic variants that influence the onset, maintenance and resolution of the immune response might be fundamental in predicting the evolution of COVID-19. In the present paper, we analysed the distribution of GM allotypes (the genetic markers of immunoglobulin γ chains) in symptomatic and asymptomatic COVID-19 patients and in healthy controls, all born and residing in Sicily. Indeed, the role played by GM allotypes in immune responses and infection control is well known. Our findings show that the GM23 allotype is significantly reduced in healthy controls. Interestingly, in a previous study, Sicilians carrying the GM23 allotype were associated with the risk of developing a symptomatic Human Cytomegalovirus infection. However, a note of caution should be considered, due to the small sample size of patients and controls.</p>","PeriodicalId":54170,"journal":{"name":"Translational Medicine at UniSa","volume":"24 2","pages":"26-29"},"PeriodicalIF":1.5,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10354864/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10226563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Possible Association of Telomere Length With Sleep Duration. A Preliminary Pilot Study in a Sicilian Cohort with Centenarians.","authors":"Anna Aiello,&nbsp;Giulia Accardi,&nbsp;Sawan Alì,&nbsp;Calogero Caruso,&nbsp;Maxine Chen,&nbsp;Immaculata De Vivo,&nbsp;Mattia Emanuela Ligotti,&nbsp;Giovanni Scapagnini,&nbsp;Sergio Davinelli,&nbsp;Giuseppina Candore","doi":"10.37825/2239-9754.1031","DOIUrl":"https://doi.org/10.37825/2239-9754.1031","url":null,"abstract":"<p><p>Telomere length (TL) is considered a biomarker of ageing although this topic is still debated. Also, sleep pattern changes are physiological part of the normal ageing process. In fact, it is widely recognized that sleep duration declines with age, leading to dysregulation of circadian rhythms. The aim of our study was to analyse the possible association of sleep duration with TL in a sample of 135 subjects with ages ranging from 20 to 111 years, recruited from Palermo and neighbouring municipalities in Sicily (Italy). Preliminary data suggest that relative TL (RTL) decreases with age in both men and women. However, at older ages, the difference between men and women tends to narrow. Nonagenarian and centenarian women do not show RTL values significantly different from those observed in adult and old women (40-89 years aged). Moreover, to analyse the relationship between TL and sleep, we stratified sleep duration into greater or lesser than 8-h periods. We found that centenarians, who daily sleep 8 hours or more, have longer RTL than centenarians who sleep fewer than 8 hours. Although the relatively small sample size of centenarians, we provide preliminary evidence that sleep duration may affect the RTL of centenarians. To the best of our knowledge, this is the first study to examine the relationship between centenarians, RTL and sleep duration. Further studies with greater sample size of centenarians are required to replicate and extend these data.</p>","PeriodicalId":54170,"journal":{"name":"Translational Medicine at UniSa","volume":"24 1","pages":"24-29"},"PeriodicalIF":1.5,"publicationDate":"2021-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9673914/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40711856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Globularia alypum L</i>. Modulates Inflammatory Markers in Human Colon and Shows a Potential Antioxidant Role in Myeloid Leukemic Cells.","authors":"Najla Hajji,&nbsp;Elodie Hudik,&nbsp;Paola Iovino,&nbsp;Nacim Zouari,&nbsp;Hichem Sebai,&nbsp;Oliver Nusse,&nbsp;Carolina Ciacci","doi":"10.37825/2239-9754.1030","DOIUrl":"https://doi.org/10.37825/2239-9754.1030","url":null,"abstract":"<p><p><i>Globularia alypum</i> (GA), a plant of the <i>Globulariacea</i> family, has long been used as a traditional cure for inflammatory and metabolic illnesses. In addition to various <i>in vitro</i> model studies, the current work focuses on the antioxidant and anti-inflammatory properties of GA in human colon biopsies. The phenol components in GA aqueous extract (GAAE) were identified by Liquid Chromatography-Electrospray Ionization Mass Spectrometry. The antioxidant ability of GAAE was tested <i>in vitro</i> utilizing chemiluminescence and flow cytometry using fluorescent yeasts n conjunction with PLB-985-human myeloid leukemia cells. Experiments on human colon biopsies after a biopsy challenge with Escherichia coli-lipopolysaccharides aimed to see if GAAE had an anti-inflammatory impact on human colon inflammation. Western blotting was used to assess the expression of several inflammatory markers. According to the findings, GAAE had a significant influence on hydrogen peroxide and cellular reactive oxygen species. GAAE inhibited the activities of cyclooxygenase 2 and nuclear factor B in inflamed biopsies, indicating anti-inflammatory action. The present study is the first to show that GA has a beneficial effect on human colon inflammation, thanks to its significant antioxidant activity <i>in vitro</i>. According to these preliminary data, GA may be utilized to treat a range of human inflammatory illnesses.</p>","PeriodicalId":54170,"journal":{"name":"Translational Medicine at UniSa","volume":"24 1","pages":"13-23"},"PeriodicalIF":1.5,"publicationDate":"2021-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9673913/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40711927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of BPIFB4 in Immune System and Cardiovascular Disease: The Lesson from Centenarians.","authors":"Francesco Montella,&nbsp;Valentina Lopardo,&nbsp;Monica Cattaneo,&nbsp;Albino Carrizzo,&nbsp;Carmine Vecchione,&nbsp;Elena Ciaglia,&nbsp;Annibale Alessandro Puca","doi":"10.37825/2239-9754.1029","DOIUrl":"https://doi.org/10.37825/2239-9754.1029","url":null,"abstract":"<p><p>Recent discoveries have shed light on the participation of the immune system in the physio pathology of the cardiovascular system underpinning the importance of keeping the balance of the first to preserve the latter. Aging, along with other risk factors, can challenge such balance triggering the onset of cardiovascular diseases. Among several mediators ensuring the proper cross-talk between the two systems, bactericidal/permeability-increasing fold-containing family B member 4 (BPIFB4) has been shown to have a pivotal role, also by sustaining important signals such as eNOS and PKC-alpha. In addition, the Longevity-associated variant (LAV), which is an haplotype allele in BPIFB4 characterized by 4 missense polymorphisms, enriched in homozygosity in Long Living Individuals (LLIs), has been shown to be efficient, if administered systemically through gene therapy, in improving many aspects of cardiovascular diseases (CVDs). This occurs mainly through a fine immune system remodeling across: 1) a M2 macrophage polarizing effect, 2) a favorable redistribution of the circulating monocyte cell subsets and 3) the reduction of T-cell activation. Furthermore, LAV-BPIFB4 treatment induced a desirable recovery of the inflammatory balance by mitigating the pro-inflammatory factor levels and enhancing the anti-inflammatory boost through a mechanism that is partially dependent on SDF-1/CXCR4 axis. Importantly, the remarkable effects of LAV-BPIFB4 treatment, which translates in increased BPIFB4 circulating levels, mirror what occurs in long-living individuals (LLIs) in whom the high circulating levels of BPIFB4 are protective from age-related and CVDs and emphasize the reason why LLIs are considered a model of successful aging. Here, we review the mechanisms by which LAV-BPIFB4 exerts its immunomodulatory activity in improving the cardiovascular-immune system dialogue that might strengthen its role as a key mediator in CVDs.</p>","PeriodicalId":54170,"journal":{"name":"Translational Medicine at UniSa","volume":"24 1","pages":"1-12"},"PeriodicalIF":1.5,"publicationDate":"2021-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9673912/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40711855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DPO: Diffuse Pulmonary Ossification - A Diagnostic Challenge.","authors":"G Rea,&nbsp;G Giacobbe,&nbsp;D Caroppo,&nbsp;S Iovine,&nbsp;R Lieto,&nbsp;M Bocchino,&nbsp;T Valente,&nbsp;A Maglio,&nbsp;A Vatrella","doi":"10.37825/2239-9754.1032","DOIUrl":"https://doi.org/10.37825/2239-9754.1032","url":null,"abstract":"<p><p>Diffuse pulmonary ossification (DPO) is a rare condition of DLD (diffuse lung disease) characterized by the presence of metaplastic ectopic bone in the lungs and is less frequent in patients without a clear background of lung diseases. DPO is characterized by very small calcific nodules, often with bone mature located in both lungs and often in peripheral areas of the lungs. Two patterns of DPO have been recognized dendriform and nodular. The dendriform type is less common and is characterized by a coral-like network of bone spiculae along the alveolar septa and is often related to interstitial fibrosis or chronic obstructive lung disease [1]. Recent literature papers indicate that DPO may be a predictor of pulmonary fibrosis, is related to Usual Interstitial Pneumonia (UIP) pattern, and has a higher correlation with Idiopathic Pulmonary Fibrosis (IPF). We present a case of a 41-years-old male with persistent bronchitis who underwent a chest X-ray (CXR) that showed multiple pulmonary small calcified nodules in both lungs. These findings were then defined with a high-resolution computed tomography of the chest (HRCT) that showed multiple small nodules spread in both lungs with a \"tree-like pattern\". A lung biopsy was performed to confirm the radiological diagnostic hypothesis of DPO, and further pathological examination showed multifocal areas of mature bone tissue within the lung parenchyma.</p>","PeriodicalId":54170,"journal":{"name":"Translational Medicine at UniSa","volume":"24 1","pages":"30-34"},"PeriodicalIF":1.5,"publicationDate":"2021-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9673915/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40711928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}