Medicine and Health最新文献_第8页

Correlation of Iatrogenic mild hyperkalaemia and bradyarrhythmia: a problem of polypharmacy in elderly 医源性轻度高钾血症与慢性心律失常的相关性:老年人多重用药的一个问题

IF 0.2

Medicine and Health Pub Date : 2017-12-22 DOI: 10.17576/MH.2017.1202.17

Ahmad Nh, T. L. Tan

引用次数: 5

A short cut to definitive airway in open tracheal injury: a case report 开放性气管损伤通往最终气道的捷径:1例报告

IF 0.2

Medicine and Health Pub Date : 2017-12-22 DOI: 10.17576/MH.2017.1202.20

Saifful Ni, A. A. Bakar, T. Tan

引用次数: 0

Aspartic acid racemization method for age estimation in human tissues: a review 人体组织年龄估计的天冬氨酸消旋化方法综述

IF 0.2

Medicine and Health Pub Date : 2017-12-22 DOI: 10.17576/MH.2017.1202.01

T. Gumpangseth, P. Mahakkanukrauh

{"title":"Aspartic acid racemization method for age estimation in human tissues: a review","authors":"T. Gumpangseth, P. Mahakkanukrauh","doi":"10.17576/MH.2017.1202.01","DOIUrl":"https://doi.org/10.17576/MH.2017.1202.01","url":null,"abstract":"The amino acid racemization is a chemical reaction process that depends on the property change of proteins in the organism. There is change in the concentration of L-and D-amino acids in during life and after death, as well. This change leads to the relationship with aging process. Aspartic acid (Asp) is non-essential amino acid which is commonly utilized on racemization because it has most rapidly accumulated of D-aspartic acids of all amino acids. Therefore, aging is related to the interconversion of amino acids, which is a useful tool for age estimation in forensic science. Aspartic acid racemization can occur in many human structures e.g. teeth, bone, articular cartilage, intervertebral disc, yellow ligament, skin, lung parenchyma, aorta, and eye-lens. Additionally, the relationship between aspartic acid racemization and age can be used for investigation of protein turnover and pathological diseases. There are different aspartic acid preparation methods which obtain different results. In this review, we describe aspartic acid racemization method, several factors of racemization, application of racemization for age estimation including several preparation methods based on racemization in both teeth and bones.","PeriodicalId":53946,"journal":{"name":"Medicine and Health","volume":"144 1","pages":"156-169"},"PeriodicalIF":0.2,"publicationDate":"2017-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77507793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Study of Association of TGF-ß1 Polymorphism with Breast Density in a Tertiary Medical Center of Malaysia 马来西亚三级医疗中心TGF-ß1多态性与乳腺密度的相关性研究

IF 0.2

Medicine and Health Pub Date : 2017-12-22 DOI: 10.17576/MH.2017.1202.15

W. Rohani, S. Athirah, A. Nasriah, M. Mohaslida, T. F. Murniwati, M. J. Norhasiza, R. HusbaniM.A., A. Elinah

{"title":"Study of Association of TGF-ß1 Polymorphism with Breast Density in a Tertiary Medical Center of Malaysia","authors":"W. Rohani, S. Athirah, A. Nasriah, M. Mohaslida, T. F. Murniwati, M. J. Norhasiza, R. HusbaniM.A., A. Elinah","doi":"10.17576/MH.2017.1202.15","DOIUrl":"https://doi.org/10.17576/MH.2017.1202.15","url":null,"abstract":"Early detection of breast cancer risk by screening tools such as mammography can reduces the cost of treatment management and the prognosis of the disease. The level of breast density of in mammogram is one of the potential cofounder factor for breast cancer risk. The development of mammary epithelial cells is determined by the genetic factor. Transforming growth factor-beta (TGF-s) gene involves in the regulation of cell proliferation and cell division. This study aimed to assess the association of TGF-s1 polymorphisms with breast density among women who underwent breast screening using mammogram. The detection of genotypes for three polymorphisms of TGF-s1 assigned as rs1800469, rs1800470 and rs4803455 were performed using PCR-RFLP technique. The allele and genotype frequencies were calculated for control group that consists of BIRADS 1 and BIRADS 2 class whilst case group consisted of BIRADS 3 and BIRADS 4 class. Two polymorphisms (rs1800469 and rs1800470) yielded a significant association with breast density with p value of 0.004 and 0.003, respectively. However, the third polymorphism, rs4803455 did not yield a significant association (p value=0.090). Haplotype association analysis might suggest the haplotype GAA conferred susceptibility (p value= 0.02, OR=2.21[1.07-4.55]) rather than haplotype AAC predispose a protective effect (p value=0.004, OR=0.40[0.21-0.77]) to breast density development. This preliminary data on single and haplotype association might reveal the association of polymorphisms of TGF-s1 with breast density and give an insight on the role of polymorphism in predisposing to breast density development.","PeriodicalId":53946,"journal":{"name":"Medicine and Health","volume":"214 1","pages":"312-320"},"PeriodicalIF":0.2,"publicationDate":"2017-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77561384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Septic hip dislocation with a preserved femoral head: successful outcome following open reduction 脓毒性髋关节脱位伴保留股骨头:切开复位后的成功结果

IF 0.2

Medicine and Health Pub Date : 2017-12-22 DOI: 10.17576/MH.2017.1202.18

Muhammad Jamil, A. Rashid, S. Ibrahim

引用次数: 0

Comparing sterofundin to 0.9% sodium chloride infusion in managing diabetic ketoacidosis: a pilot study 对比甾体醌与0.9%氯化钠输注治疗糖尿病酮症酸中毒:一项初步研究

IF 0.2

Medicine and Health Pub Date : 2017-12-22 DOI: 10.17576/MH.2017.1202.03

H. Rossman, Mahathar Aw, N. Muhamad

{"title":"Comparing sterofundin to 0.9% sodium chloride infusion in managing diabetic ketoacidosis: a pilot study","authors":"H. Rossman, Mahathar Aw, N. Muhamad","doi":"10.17576/MH.2017.1202.03","DOIUrl":"https://doi.org/10.17576/MH.2017.1202.03","url":null,"abstract":"Fluid replacement is the mainstay treatment for diabetic ketoacidosis (DKA). Currently, the best choice of fluids is still debatable. An amount of 0.9% sodium chloride is commonly used. Sterofundin® is an alternative crystalloid that is assumed to expedite resolution of acidosis. Advantages in sterofundin content being smaller significant ion difference (SID) to plasma and lower chloride content. The main objective of the study was to compare rate of acidosis resolution in DKA patients between treatment with 0.9% normal saline and Sterofundin over 12 hrs. Other objectives were to compare significant ion difference (SID), 12-hr blood ketone clearance and electrolyte balance between the two groups. The study was a prospective open labelled randomized control trial. This study was conducted over 6 months. Sample size of 18 was obtained with 9 for each arm. Main difference between two groups was initial median 2-hr pH level improvement (NS = +0.006 vs. Sterofundin = +0.05, P=0.063), however not being significant. Ketone, anion gap reduction, bicarbonate normalisation, sodium, chloride, urea and creatinine levels failed to show any significant differences between both groups. Twelve-hour median chloride levels increments were higher in the NS group (+11) compared to the sterofundin group (+6). There was no difference between mortality and morbidity. Comparing the two fluid groups, there was no significant biochemical differences during treatment of DKA. This was a pilot study that can initiate further clinical trials.","PeriodicalId":53946,"journal":{"name":"Medicine and Health","volume":"11 1","pages":"179-192"},"PeriodicalIF":0.2,"publicationDate":"2017-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83862827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

External marker in bisecting-angle-technique: a new approach to minimize dental radiographic error 对角技术中的外部标记:一种减少牙科放射成像误差的新方法

IF 0.2

Medicine and Health Pub Date : 2017-12-22 DOI: 10.17576/MH.2017.1202.14

Azizah Ahmad Fauzi, Muhamad Aqil Aa, Z. MohdAmirul, A. Atika

{"title":"External marker in bisecting-angle-technique: a new approach to minimize dental radiographic error","authors":"Azizah Ahmad Fauzi, Muhamad Aqil Aa, Z. MohdAmirul, A. Atika","doi":"10.17576/MH.2017.1202.14","DOIUrl":"https://doi.org/10.17576/MH.2017.1202.14","url":null,"abstract":"Bisecting-angle-technique is a method used to improve patient comfort during periapical radiography. This technique is usually performed without X-ray beam aiming device and has been commonly associated with dental radiographic error. \u0000The use of external marker as a beam aiming device in bisecting-angle-technique is potentially effective to reduce the number of errors occurring during periapical radiography. In this study, 240 periapical radiographs were taken by undergraduate dental students. Periapical radiographs were taken using traditional method of bisecting-angle-technique (BAT), bisecting-angle-technique with the use of external marker (BAT-M) and the standard method in periapical radiography; paralleling technique (PT). All radiographic images were evaluated and errors were classified and tabled according to the type and number of errors. Chi-square test was used to compare the total number of radiographic errors made using these three techniques. One of the most common errors with BAT was cone cut error (13.8%). This error had been markedly reduced to 1.3% and 2.5% by implementation of BAT-M and PT, respectively. The total number of errors was also found to be significantly lesser for BAT-M compared to BAT, p< 0.05.","PeriodicalId":53946,"journal":{"name":"Medicine and Health","volume":"7 1","pages":"304-311"},"PeriodicalIF":0.2,"publicationDate":"2017-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79435413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Age estimation by using aspartic acid racemization from purified elastin of aorta 用纯化主动脉弹性蛋白天冬氨酸消旋法估计年龄

IF 0.2

Medicine and Health Pub Date : 2017-12-22 DOI: 10.17576/MH.2017.1202.02

P. Komutrattananont, P. Mahakkanukrauh

{"title":"Age estimation by using aspartic acid racemization from purified elastin of aorta","authors":"P. Komutrattananont, P. Mahakkanukrauh","doi":"10.17576/MH.2017.1202.02","DOIUrl":"https://doi.org/10.17576/MH.2017.1202.02","url":null,"abstract":"Age estimation is the one of biological profiles which plays an important role in identification in forensic field. The application of biochemical approach known as aspartic acid racemization in human provides more accuracy and less error of estimated age in age determination. During aging, amino acids within protein transform between D-and L-form (racemization), which results in increasing concentration of D-amino acids. This change of amino acids is related to aging. Aspartic acid has been generally applied in racemization because it has fastest rate of racemization. Racemization of aspartic acid not only takes place in teeth and many kinds of bone, but also can occur in the flexible structure which contain mostly elastin. For example, skin yellow ligament, lung parenchyma, and aorta. Elastin is essential protein which is comprised most composition of several structures and it is major content in the elastic fibers. Additionally, elastin is the longest lasting protein in the body with slow metabolic turnover rate. Recently, there is a purification technique to obtain only single protein in human aorta. There was a good correlation between degree of racemization (D/L ratio) and age. Therefore, aspartic acid racemization by purifies elastin from aorta is a one of indicator for age estimation. This review provides an overview of aspartic acid racemization, elastin protein, purification method bases on racemization and the application of D/L ratio by purified of elastin in artery for age estimation.","PeriodicalId":53946,"journal":{"name":"Medicine and Health","volume":"21 4 1","pages":"170-178"},"PeriodicalIF":0.2,"publicationDate":"2017-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86759979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Flavonoid component determination and apoptotic induction evaluation of houttuynia cordata thunb extract on human acute leukemic cells 鱼腥草提取物对人急性白血病细胞的黄酮类成分测定及诱导凋亡评价

IF 0.2

Medicine and Health Pub Date : 2017-12-22 DOI: 10.17576/MH.2017.1202.04

Boonyawee Nithithariyasophon, Chaowanee Wangchauy, Paweena Pradniwat, S. Chanprasert

{"title":"Flavonoid component determination and apoptotic induction evaluation of houttuynia cordata thunb extract on human acute leukemic cells","authors":"Boonyawee Nithithariyasophon, Chaowanee Wangchauy, Paweena Pradniwat, S. Chanprasert","doi":"10.17576/MH.2017.1202.04","DOIUrl":"https://doi.org/10.17576/MH.2017.1202.04","url":null,"abstract":"Development of resistance to currently used drugs and side effects of several allopathic drugs have led to increased emphasis on plant materials uses as a source of medicines for a wide variety of human illnesses including leukemia. Houttuynia cordata Thunb (H.cordata), a Northern Thailand local plant and commonly known as Plucao, has various biological activities such as anti-inflammatory, anti-cancer and anti-leukemic activities. We aimed to determine active flavonoid components of H.cordata and to investigate the effect of H.cordata ethanolic extract on apoptotic induction on human acute lymphoblastic leukemia cells. In this study, we found that H.cordata ethanolic extract had total flavonoid of 231.21 ± 4.19 mg QE/g dried H.cordata. The extract analyzed by quantitative LC-MS consists of several flavonoid components including hyperin 6.35 ± 0.41, quercetin 0.34 ± 0.02, isoquercetin 1.10 ± 0.03, and rutin 0.88 ± 0.04 (%w/w). The cytotoxicity results showed dose dependent decrease in growth of Jurkat leukemic cells. Blebbing pattern of cell apoptosis was found in cells treated with H.cordata ethanolic extract for 24 and 48 hrs. Moreover, we found that the extract could substantially induce Jurkat cell death through apoptosis at both 12 and 24 hrs. In conclusion, these results indicated that H.cordata ethanolic extract which is composed of several flavonoids, possesses anti-leukemic activity through apoptotic induction in Jurkat leukemia cells.","PeriodicalId":53946,"journal":{"name":"Medicine and Health","volume":"33 1","pages":"193-201"},"PeriodicalIF":0.2,"publicationDate":"2017-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89064453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Effects of gelam honey on oxidative stress in lung cancer cells 明胶蜂蜜对肺癌细胞氧化应激的影响

IF 0.2

Medicine and Health Pub Date : 2017-12-22 DOI: 10.17576/MH.2017.1202.05

G. Gunasekaran, C. Fitri, S. Chandrashegkar, A. B. H. Amalnina, S. Raishan, Z. N. Faiznani, N. Ismail, Y. A. M. Yusof, J. Goon

{"title":"Effects of gelam honey on oxidative stress in lung cancer cells","authors":"G. Gunasekaran, C. Fitri, S. Chandrashegkar, A. B. H. Amalnina, S. Raishan, Z. N. Faiznani, N. Ismail, Y. A. M. Yusof, J. Goon","doi":"10.17576/MH.2017.1202.05","DOIUrl":"https://doi.org/10.17576/MH.2017.1202.05","url":null,"abstract":"Gelam honey was reported to exhibit anti-oxidative, anti-tumour and anti-inflammatory properties against many types of cancer. The main aim of the present study was to evaluate the effect of Gelam honey on the oxidative stress level of human lung cancer cells. IC50 of Gelam honey was identified by treating A549 cells with different doses of honey (50-200 mg/ml). The cells were divided into four groups and induced with stress using hydrogen peroxide (H2O2) accordingly: control, H2O2, Gelam honey, H2O2 + Gelam honey. After 24 hrs of treatment, oxidative stress markers such as malondialdehyde (MDA) and protein carbonyl, were determined. Induction of oxidative stress significantly increased the levels of MDA (p<0.05) but had no effect on protein carbonyl levels. Treatment with Gelam honey was found to reduce MDA levels (p<0.05) in A549 cells exposed to H2O2 but had no effect on the level of protein carbonyl. Interestingly, Gelam honey treatment alone had no effects on the levels of MDA and protein carbonyl. In conclusion, Gelam honey reduces lipid peroxidation but not protein oxidation in human lung cancer cells subjected to oxidative stress.","PeriodicalId":53946,"journal":{"name":"Medicine and Health","volume":"190 1","pages":"202-209"},"PeriodicalIF":0.2,"publicationDate":"2017-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76807849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3