Qatar Medical Journal最新文献

{"title":"A comparison of Gam-COVID-Vac vaccination and non-vaccination on neurological symptoms and immune response in post-COVID-19 syndrome.","authors":"Saulesh Kurmangaliyeva, Akzhan Madenbayeva, Saltanat Urazayeva, Kristina Baktikulova, Kairat Kurmangaliyev","doi":"10.5339/qmj.2025.6","DOIUrl":"10.5339/qmj.2025.6","url":null,"abstract":"<p><p>The post-COVID-19 syndrome may present with a range of neurological symptoms such as headaches, sleep disorders, and dizziness. The objective of this study was to examine the effectiveness of the Gam-COVID-Vac vaccine in mitigating the neurological symptoms of post-COVID-19 syndrome. The study involved 95 patients diagnosed with the neurological form of long COVID-19, who were divided into two groups according to their vaccination status. The immunological parameters of humoral immunity were evaluated by enzyme-linked immunosorbent assay (ELISA), while the parameters of cellular immunity were evaluated using flow cytometry. Administration of the vaccination resulted in a reduction in clinical symptoms of the neurological form of long COVID-19. Statistically significant differences (<i>p</i> = 0.035) were found in symptoms such as headaches, sleep disturbances, and dizziness, especially in central nervous system (CNS) disorders, between the groups that received the vaccination and those that did not. More than 90% of patients had elevated levels of Receptor Binding Domain (RBD) immunoglobulin G against the viral S-protein (>2,500 BAU/ml), indicating strong humoral immunity regardless of vaccination status. An increase in B-lymphocyte (CD3^-CD19⁺) counts was noted in both groups, with levels significantly higher in the group that received the vaccination (<i>p</i> < 0.03). Analysis of T-cell profiles and NK (natural killer) cell levels showed no changes. The study suggests that administration of Gam-COVID-Vac vaccination could reduce the occurrence of CNS symptoms in individuals with post-COVID-19 syndrome. Although certain neurological symptoms may continue, immunization has a beneficial influence on their progression. The results emphasize the crucial role of an increased humoral immune response in individuals with post-COVID-19 syndrome, but do not show significant changes in T-cell immune parameters.</p>","PeriodicalId":53667,"journal":{"name":"Qatar Medical Journal","volume":"2025 1","pages":"6"},"PeriodicalIF":0.0,"publicationDate":"2025-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11938678/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143722196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of morphine versus fentanyl patient-controlled analgesia for postoperative pain management in colorectal surgery.","authors":"Adnan Saad Eddin, Hazem Selim, Roaa Suleiman, Jeena Thomas","doi":"10.5339/qmj.2025.7","DOIUrl":"10.5339/qmj.2025.7","url":null,"abstract":"<p><strong>Introduction: </strong>Postoperative pain management is crucial for recovery from surgery. Patient-controlled analgesia (PCA) with morphine and fentanyl are commonly used, but their comparative efficacy remains uncertain. This study aims to evaluate opioid consumption and pain control in patients receiving PCA morphine versus PCA fentanyl after colorectal surgery.</p><p><strong>Methodology: </strong>A retrospective analysis of adult patients undergoing elective colorectal surgery was conducted. Patients were divided into two groups based on PCA morphine or PCA fentanyl use. Outcomes measured were opioid consumption in morphine equivalents, numerical pain scores expressed as Numerical Rating Scale (NRS), patient demand, and side effects within the first 48 hours postoperatively.</p><p><strong>Results: </strong>Of 370 patients screened, 152 met the inclusion criteria. No significant differences were found in total opioid consumption (median: 38 vs. 28.5 mg, <i>p</i> = 0.095), patient demand (median: 46.5 vs. 35, <i>p</i> = 0.156), or NRS (median: 4 vs. 3.5, <i>p</i> = 0.348). Side effects were comparable between groups. Subgroup analysis revealed higher opioid consumption and demand in females taking fentanyl compared to morphine. Age was negatively correlated with pain-related outcomes, and smokers showed higher opioid consumption and higher pain scores.</p><p><strong>Conclusions: </strong>PCA morphine and fentanyl provide similar postoperative pain relief in colorectal surgery patients, with no significant differences in opioid consumption or side effects. Female patients may respond better to morphine, and age and smoking status significantly influence pain management outcomes. Further prospective studies are recommended to better define these findings and inform postoperative pain strategies.</p>","PeriodicalId":53667,"journal":{"name":"Qatar Medical Journal","volume":"2025 1","pages":"7"},"PeriodicalIF":0.0,"publicationDate":"2025-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11947460/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143733210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical outcome of OviTex reinforced tissue matrix in hernia repair: A systematic review and meta-analysis.","authors":"Ahmad R Al-Qudimat, Seif B Altahtamouni, Kalpana Singh, Omar M Aboumarzouk, Mohamed Elakkad","doi":"10.5339/qmj.2025.22","DOIUrl":"10.5339/qmj.2025.22","url":null,"abstract":"<p><p><b>Background:</b> This review provides a comprehensive and current overview of the clinical outcomes associated with the use of OviTex reinforced tissue matrix (RTM) in hernia repair. <b>Methods:</b> We conducted a systematic review and meta-analysis according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Our search included research publications related to clinical outcomes involving the use of OviTex RTM in hernia repair up to August 2023. We extensively examined and extracted relevant data from databases such as Embase, PubMed, and Scopus. The meta-analysis included comparisons related to body mass index (BMI) in hernia treatment, primary abdominal wall hernias treated with OviTex, and other relevant factors. The quality of the included studies was assessed using the MINORS (Methodological Index for Non-Randomized Studies) scale. Our systematic review protocol was registered with PROSPERO (International Prospective Register of Systematic Reviews) under registration number CRD42023456009. <b>Results:</b> A total of 9 observational studies involving 990 patients from three countries (USA, Netherlands, and Germany) were included in our study. Pooled results show that the risk of the OviTex group was lower than that of the comparison group (pooled risk ratio (RR) = 0.84; 95% confidence interval (CI): 0.67-1.05; <i>Z</i> = -1.514; <i>p</i> = 0.13). The prevalence rate of primary abdominal wall hernia among the included studies ranged from a minimum of 43% (95% CI: 30-58) to a maximum of 81% (95% CI: 64-91%), the risk was not significantly higher in the comparison group compared with the OviTex group (pooled RR = 1.11; 95% CI: 0.29-4.30; <i>Z</i> = 0.155; <i>p</i> = 0.877), the prevalence of laparoscopic surgery was 12% (95% CI: 6-19%), the BMI was favorable in the comparison group but was not statistically significant (mean difference = 25; 95% CI: -0.02, 0.52; <i>p</i> = 0.073). <b>Conclusion:</b> OviTex RTM has shown promising outcomes in abdominal wall reconstruction and hernia repair. However, it is crucial to conduct further research and clinical studies to confirm these findings and unlock the capabilities of OviTex across different medical scenarios.</p>","PeriodicalId":53667,"journal":{"name":"Qatar Medical Journal","volume":"2025 1","pages":"22"},"PeriodicalIF":0.0,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12107482/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144163666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intralesional steroid injection for Mondor's disease: A new approach based on a post-surgical case series.","authors":"Wen-Tsao Ho","doi":"10.5339/qmj.2025.2","DOIUrl":"10.5339/qmj.2025.2","url":null,"abstract":"","PeriodicalId":53667,"journal":{"name":"Qatar Medical Journal","volume":"2025 1","pages":"2"},"PeriodicalIF":0.0,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11931438/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143712116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship of neurotrophin levels with stress-induced urinary incontinence in multiparous premenopausal women.","authors":"Kübranur Ünal, Musa Latif Çöllüoğlu, Elif Erdem, Cansu Özbas, Özhan Özdemir","doi":"10.5339/qmj.2025.3","DOIUrl":"10.5339/qmj.2025.3","url":null,"abstract":"<p><strong>Objective: </strong>Urinary incontinence (UI) is involuntary urine leakage, mainly due to a feeling of high pressure in the abdominal part, the immediate and urgent need for micturition, or both. Neurotrophins (NTs) are a family of peptides that play a role in the regulation of nerve cells. Their effects on the lower urinary tract organs may provide a perspective to understand the development and diagnosis of UI. This study aims to investigate NT levels to understand how these molecules change in multiparous premenopausal women who suffer from stress-related UI. The study also evaluates diagnostic and distinguishing capabilities of NTs for these disorders.</p><p><strong>Methods: </strong>In this cross-sectional case-control study, multiparous premenopausal women underwent a urodynamic examination, a stress cough test, and were evaluated with an International Consultation on Incontinence Questionnaire-Short Form (ICIQ-SF). Participants were divided into three groups: 29 healthy women in the control group and two patient groups consisting of 26 women diagnosed with stress urinary incontinence (SUI) and 33 women diagnosed with mixed urinary incontinence (MUI). Nerve growth factor (NGF), brain-derived neurotrophic factor, neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4) levels in serum were measured by enzyme-linked immunosorbent assay. The body mass index (BMI) and ICIQ-SF scores of the patients were also calculated. The data obtained were compared between the groups. Receiver-operating characteristic analysis was performed to determine the role of NTs in diagnosing UI.</p><p><strong>Results: </strong>The result showed that serum NGF and NT-3 levels were significantly low in both incontinence subtypes compared to the control group (<i>p</i> < 0.05). BMI scores and number of vaginal deliveries were higher in incontinence subtypes compared to the control group, and ICIQ-SF scores were higher in the MUI group.</p><p><strong>Conclusion: </strong>The differences in serum NGF and NT-3 levels were observed in multiparous premenopausal patients with UI. There was a decrease in serum NGF levels in MUI patients and serum NT-3 levels in SUI patients. Although the changes in serum NGF and NT-3 levels were significant, their discriminatory potential was weak or moderate.</p>","PeriodicalId":53667,"journal":{"name":"Qatar Medical Journal","volume":"2025 1","pages":"3"},"PeriodicalIF":0.0,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11932043/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143712119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The prevalence of depression and anxiety symptoms and their associated factors among patients with cancer in Qatar: A cross-sectional study.","authors":"Majid Alabdulla, Shuja Reagu, Moza Alishaq, Noora Al Hammadi, Mohammed Hassan Elkordy, Hafedh Ghazouani, Ahmed H Assar","doi":"10.5339/qmj.2025.4","DOIUrl":"10.5339/qmj.2025.4","url":null,"abstract":"<p><strong>Background: </strong>Cancer is a significant global health challenge. One of the biggest health issues that cancer patients face is depression and anxiety. This has a significant impact on their quality of life and treatment outcomes.</p><p><strong>Aim: </strong>The aim of this study was to investigate the frequency of depression and anxiety among cancer patients in Qatar.</p><p><strong>Materials and methods: </strong>This study was a cross-sectional design using the Patient Health Questionnaire-9 (PHQ-9) and Generalized Anxiety Disorder-7 (GAD-7) scales. A total of 500 cancer patients were surveyed from the National Center for Cancer Care and Research in Doha.</p><p><strong>Results: </strong>The study found that a significant proportion of cancer patients suffered from depression, with an average PHQ-9 score indicating mild levels of severity. Depression was commonly categorized as mild, with a smaller percentage experiencing moderate, moderate-to-severe, or severe depression. Additionally, patients were predominantly anxious, as reflected by an average GAD-7 score, with most patients experiencing mild to moderate symptoms, while a few experienced moderate or severe anxiety. These findings highlight the significant prevalence of both depression and anxiety among cancer patients, pointing to the importance of comprehensive mental health support. Moreover, patients with advanced-stage cancer, those in their 40s and 60s, those undergoing radiotherapy or hormone therapy, and female patients were found to be more susceptible to depression and anxiety.</p><p><strong>Conclusion: </strong>Treatment of mental health issues is essential to enhancing the effectiveness of cancer treatment. Cancer patients can have a higher quality of life and better adherence to cancer treatments when mental illnesses such as depression and anxiety are identified and treated early. Furthermore, most patients reported having depression and anxiety, according to the study, which showed that these conditions were more common in Qatar than in other countries. Several demographic groups have been linked to higher rates of depression and anxiety, including women, middle-aged adults, people with stage IV cancer, and patients receiving therapies such as radiotherapy and chemotherapy.</p>","PeriodicalId":53667,"journal":{"name":"Qatar Medical Journal","volume":"2025 1","pages":"4"},"PeriodicalIF":0.0,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11934930/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143712118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the types of microorganisms causing cerebrospinal fluid shunt infection in King Abdullah University Hospital in Jordan.","authors":"Sulieman Daoud, Atef Hulliel, Sultan Jarrar, Amer Jaradat, Mohammad Jamous, MajdM Al Barakat, Aseel Rabadi, Nataly Al-Zu'bi","doi":"10.5339/qmj.2025.11","DOIUrl":"https://doi.org/10.5339/qmj.2025.11","url":null,"abstract":"<p><strong>Background: </strong>Ventriculoperitoneal shunt (VPS) placement treats hydrocephalus by draining excess cerebrospinal fluid (CSF). Despite advances, infections remain a common complication, resulting in significant morbidity and mortality. Infection rates range from 7.2 to 18%, with common pathogens being <i>Staphylococcus epidermidis</i> and <i>Staphylococcus aureus</i>. Risk factors include young age, postoperative CSF leakage, prolonged surgery, and previous infections. The aim of this study was to describe the prevalence of CSF shunt infections at King Abdullah University Hospital (KAUH), assess infection rates in pediatric and adult patients, and report causative microorganisms.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on all patients with CSF shunt-related infections in our hospital (KAUH) over the last 17 years (2005-2023). The patients' demographics, laboratory results, and details of causative microorganisms were collected.</p><p><strong>Results: </strong>Of the 579 patients who underwent CSF shunting at KAUH in Jordan, 59 (10.1%) had a positive CSF culture for shunt infection. The majority of the patients were children (83.1%) with a median age of 9 months and a higher proportion of male patients (57.6%). Most of the infections were due to congenital anomalies (74.6%). The median time to infection was 13 days, with 13.5% experiencing recurrent infections. Recurrent infection rates were found to be significantly higher in pediatric patients (<i>p</i> = 0.00007). The most common pathogens were <i>Acinetobacter baumannii</i> (47.5%) and <i>Staphylococcus</i> species (40.7%). Analysis by age group showed a significant association between age and <i>Acinetobacter baumannii</i> infections (<i>p</i> = 0.008).</p><p><strong>Conclusion: </strong>The study provided demographic and microbiological data on VPS infections, with <i>Acinetobacter baumannii</i> being the most common causative organism. Treatment of these infections remains challenging, highlighting the need for more comparative research on different treatment options.</p>","PeriodicalId":53667,"journal":{"name":"Qatar Medical Journal","volume":"2025 1","pages":"11"},"PeriodicalIF":0.0,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12076085/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144081869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lues maligna in a patient living with HIV: A case report.","authors":"Jaime Eugenio Espinosa-Mora, Mauricio Alejandro Saldana-Ruiz, Karla Monserrat Ramírez-Pintor, Federico Ortiz-Alonso, Mauricio Linnery Rendón-Saldivar, Luis Alberto Perona-Ramírez","doi":"10.5339/qmj.2025.27","DOIUrl":"10.5339/qmj.2025.27","url":null,"abstract":"<p><strong>Background: </strong>Malignant syphilis is a rare form of secondary syphilis that occurs mainly in patients living with human immunodeficiency virus (HIV), with approximately 15 cases reported in the last century. We present the case of a patient treated in our institution.</p><p><strong>Case presentation: </strong>A 25-year-old male patient presented with round lesions in the form of ulcerations with blackish crust on the plantar area and inner edge of the right foot. VDRL (venereal disease research laboratory) test and ELISA (enzyme-linked immunosorbent assay) were performed for the diagnosis of syphilis and HIV, respectively, which were positive. Subsequently, the patient was hospitalized, and ceftriaxone was indicated due to the lack of crystalline penicillin G in the hospital. Four days later, he had complete improvement of the skin lesions. The patient is currently stable and has no recurrence of skin lesions.</p><p><strong>Discussion: </strong>Due to the lack of supplies in our unit, we chose ceftriaxone, which is used in patients with penicillin allergies. The use of this drug has shown good outcomes in different reviews.</p><p><strong>Conclusion: </strong>Due to the use of appropriate treatment, the patient is currently stable and has no recurrence of skin lesions. Malignant syphilis should be considered as part of the differential diagnosis in patients who present with nodulo-ulcerative lesions and have a positive treponemal or non-treponemal test.</p>","PeriodicalId":53667,"journal":{"name":"Qatar Medical Journal","volume":"2025 1","pages":"27"},"PeriodicalIF":0.0,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12124229/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of SLC5A5 gene expression in tumor tissues on refractoriness to radioactive iodine treatment of differentiated thyroid carcinomas.","authors":"Aslı Erten, Zeynel Abidin Sayiner, Suna Erkılıç, Sibel Oğuzkan Balcı, Ersin Akarsu","doi":"10.5339/qmj.2025.5","DOIUrl":"10.5339/qmj.2025.5","url":null,"abstract":"<p><strong>Background and objective: </strong>The majority of thyroid cancer patients have a good prognosis. Even in advanced disease, the radioactive iodine (RAI) response improves the prognosis. However, RAI refractoriness poses a significant challenge for these patients. The objective of the study was to assess the expression of SCL5A5 as a potential marker for predicting future resistance to radioiodine treatment.</p><p><strong>Materials and methods: </strong>Radioactive iodine-refractory papillary thyroid carcinoma (RAIR-PTC) and iodine-sensitive papillary thyroid carcinoma (PTC) were included in the study. Demographic and clinicopathological data were retrospectively analyzed. RNA samples were converted to cDNA. Gene expression reactions were performed using synthesized solute carrier family 5 member 5 (SLC5A5) and glyceraldehyde-3-phosphate dehydrogenase (GADPH) primer samples.</p><p><strong>Results: </strong>Of the patients, 51 (61.4%) had iodine-sensitive PTC and 32 (38.5%) were RAIR-PTC. Patients were followed up for 8 ± 6.4 years. The mean age at diagnosis was higher in the RAIR-PTC group (56.56 ± 15.22 years vs. 46.82 ± 12.43 years, p = 0.002). The PTC group had higher SLC5A5 gene expression than RAIR-PTC. In addition, no statistically significant correlation was observed between basal thyroglobulin levels and tumor standardized uptake value-maximum (SUV-max) on fluorodeoxyglucose positron emission tomography (p = 0.304).</p><p><strong>Conclusion: </strong>SLC5A5 gene expression is reduced in radioactive iodine-refractory thyroid carcinoma. Furthermore, the decreased expression status of the SLC5A5 gene before preablative iodine treatment may serve as a predictive indicator of future resistance to RAI therapy.</p>","PeriodicalId":53667,"journal":{"name":"Qatar Medical Journal","volume":"2025 1","pages":"5"},"PeriodicalIF":0.0,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11934929/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143712117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preoperative management of diabetes mellitus: A comparative narrative review of the recommendations of three professional organizations with Hamad Medical Corporation guidelines.","authors":"Fathima Fahda M Jamiu, Nudzejma Gostevcic, Yasser M Hammad, Sohel M G Ahmed","doi":"10.5339/qmj.2025.23","DOIUrl":"10.5339/qmj.2025.23","url":null,"abstract":"<p><strong>Background: </strong>Diabetes mellitus (DM) is a prevalent condition that requires careful management in the perioperative setting to reduce surgical risks and optimize patient outcomes. The preoperative care of diabetic patients is complex because glucose control must be balanced with minimizing hypoglycemic or hyperglycemic events during surgery. A variety of diabetic medications such as insulin, dipeptidyl-peptidase-4 inhibitors, glucagon-like peptide-1 receptor agonists, sodium-glucose cotransporter-2 inhibitors, and biguanides such as metformin present unique challenges and considerations due to their different mechanisms, benefits, and potential adverse effects. In recent years, professional organizations have developed recommendations on the perioperative management of these therapies, although there remain some variations in guidelines related to medication cessation and dosage adjustments. Standardized protocols in preoperative DM care remain a topic of interest to ensure consistent and safe practices across healthcare settings, and further collaborative research efforts could provide clarity and consensus in managing this diverse patient population.</p><p><strong>Objective: </strong>The objective of this study was to provide an overview of guidelines and practices to support healthcare professionals in delivering improved preoperative care for diabetic patients. This initiative aims to enhance surgical outcomes and minimize the occurrence of complications.</p><p><strong>Methods: </strong>This is a comparative review that provides a systematic comparison of the similarities and differences in the guidelines and recommendations of three professional organizations along with Hamad Medical Corporation. All guidelines were from official websites including Hamad Medical Corporation.</p><p><strong>Conclusion: </strong>Although the reviewed guidelines for the preoperative care of diabetes patients share some similarities, there are also a number of differences due to outdated data and expert opinions, and therefore differ in practices around the world. While the key elements are agreed upon, more research and global collaboration are needed to create consistent guidelines and improve patient outcomes.</p>","PeriodicalId":53667,"journal":{"name":"Qatar Medical Journal","volume":"2025 1","pages":"23"},"PeriodicalIF":0.0,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12109678/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144163688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}